sevoflurane / Generic mfg. 
Welcome,         Profile    Billing    Logout  
 13 Diseases   542 Trials   542 Trials   5582 News 


«12...7273747576777879808182...9293»
  • ||||||||||  sevoflurane / generics
    Journal:  Effect of sevoflurane anesthesia on neuromuscular blockade produced by rocuronium infusion in dogs. (Pubmed Central) -  Apr 11, 2019   
    There were significant differences in the TOFR and TOFR between the 1.25 sevoflurane MAC (median: 55 and 77.5 min, respectively) and 1.75 sevoflurane MAC (122.0 and 122.6 min; P=0.020 and P=0.020, respectively), 1.25 sevoflurane MAC and 2.0 sevoflurane MAC (126.0 and 131.4 min; P=0.020 and P=0.020), and 1.5 sevoflurane MAC (97.5 and 121.3 min) and 2.0 sevoflurane MAC (P=0.033 and P=0.032). In dogs, sevoflurane anesthesia produced dose-dependent prolongation of recovery from neuromuscular blockade produced by rocuronium.
  • ||||||||||  sevoflurane / generics
    Preclinical, Journal:  Upregulation of long noncoding RNA Gadd45a is associated with sevoflurane-induced neurotoxicity in rat neural stem cells. (Pubmed Central) -  Apr 9, 2019   
    Notably, Gadd45a was enriched in the cell cycle-relative pathway including mitogen-activated protein kinases and P53 signaling, whereas lncRNA Gadd45a was positively correlated with Gadd45a. These results suggest lncRNA Gadd45a is associated with sevoflurane-induced toxicity, and thus shed light on a new key target for revealing the molecular mechanism of sevoflurane-induced toxicity.
  • ||||||||||  ibuprofen / generics
    Preclinical, Journal:  Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model. (Pubmed Central) -  Apr 9, 2019   
    Our results suggest that (1) cognitive dysfunction is associated with an unbalanced pro-inflammatory and anti-inflammatory response, tauopathy, and gliosis; (2) cognitive dysfunction, gliosis, and tauopathy following laparotomy can persist well beyond the immediate postoperative period; and (3) anti-inflammatory drugs can act rapidly to attenuate inflammatory responses in the brain and negatively modulate neuropathological changes to improve cognition. These findings may have implications for the duration of therapeutic strategies aimed at curtaining cognitive dysfunction following surgery.
  • ||||||||||  Journal:  Electrophysiological Analysis of Voltage-Gated Ion Channel Modulation by General Anesthetics. (Pubmed Central) -  Apr 7, 2019   
    As the body of work regarding the interaction of general anesthetics with VGICs continues to grow, a multidisciplinary approach involving functional, biochemical, structural, and computational techniques, many of which are detailed in other chapters, has increasingly become necessary to solve the molecular mechanism of general anesthetic action on VGICs. Here, we focus on electrophysiological and modeling approaches and methodologies to describe how our work has elucidated the biophysical basis of the inhibition Navs by propofol and the potentiation of Kvs by sevoflurane.
  • ||||||||||  sevoflurane / generics
    Review, Journal:  Fundamentals of fetal toxicity relevant to sevoflurane exposures during pregnancy. (Pubmed Central) -  Apr 5, 2019   
    The mechanisms remain to be elucidated, but may include increased tau protein phosphorylation and abnormal methylation. These findings highlight the need for a global and comprehensive understanding of the potential neurotoxicity of anesthetic exposure in fetuses and its long-term effects.
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment closed, Immunomodulating:  Effects of Anesthesia on Immunity in Cancer (clinicaltrials.gov) -  Apr 5, 2019   
    P4,  N=20, Active, not recruiting, 
    These findings highlight the need for a global and comprehensive understanding of the potential neurotoxicity of anesthetic exposure in fetuses and its long-term effects. Recruiting --> Active, not recruiting
  • ||||||||||  sevoflurane / generics
    Journal:  Genetic damage of operating and recovery room personnel occupationally exposed to waste anaesthetic gases. (Pubmed Central) -  Mar 29, 2019   
    ...Exposure to the anaesthetics was assessed with sevoflurane concentrations and inorganic fluoride levels in post-shift urine samples of the healthcare staff...Both in surrogate tissue (PBLs) and in target tissue (BECs) of the personnel of RUs and ORs of the same hospital, the genotoxicity risk was evident and similar. Originality of this study, in addition to the WAGs exposure confirmation of the healthcare personnel, was the involvement of the RU personnel for the genotoxicity assessment, which was the first time in the scientific literature.
  • ||||||||||  sevoflurane / generics
    Retrospective data, Journal:  Effects of tramadol on emergence agitation after general anesthesia for nasal surgery: A retrospective cohort study. (Pubmed Central) -  Mar 27, 2019   
    Changes in systolic blood pressure in the 2 groups were similar, whereas changes in heart rate during emergence differed depending on the group (P = .020), although pairwise comparisons did not reveal any differences between the groups. Recovery time, postoperative pain scores, and adverse events were similar in the 2 groups.In adult patients undergoing nasal surgery, tramadol infusion decreases the incidence of EA after sevoflurane anesthesia without delaying recovery or increasing the number of adverse events.
  • ||||||||||  Simdax (levosimendan IV) / AbbVie
    Journal:  Impact of Anesthetics on Cardioprotection Induced by Pharmacological Preconditioning. (Pubmed Central) -  Mar 26, 2019   
    Under dexmedetomidine, results were inconsistent; levosimendan induced infarct size reduction (Dex-Lev: 36 ± 6%; p < 0.05 versus Dex-Con) but not milrinone (Dex-Mil: 51 ± 8%; ns versus Dex-Con). The choice of the anesthetic regimen has an impact on infarct size reduction by pharmacological preconditioning.
  • ||||||||||  sevoflurane / generics
    Journal:  Sevoflurane enhanced the clearance of Aβ1-40 in hippocampus under surgery via up-regulating AQP-4 expression in astrocyte. (Pubmed Central) -  Mar 25, 2019   
    The function of glymphatic system is facilitated by aquaporin-4 (AQP-4), a water channel expressed in highly polarized manor in astrocytic endfeet, whose transcription is regulated by nuclear factor of activated T cells 5 (NFAT5). Our results suggest that under brief operation and sevoflurane exposure, surgery may be the main cause of Aβ increase and sevoflurane increase the elimination of Aβ by up-regulating AQP-4 which is the key component in glymphatic system.
  • ||||||||||  Trial completion date, Trial primary completion date:  Paravertebral Nerve Blocks in Neonates (clinicaltrials.gov) -  Mar 22, 2019   
    P4,  N=30, Recruiting, 
    miR-34a inhibitor may effectively protect against sevoflurane-induced hippocampal apoptosis via activation of the Wnt/β-catenin pathway by targeting Wnt1. Trial completion date: Feb 2019 --> Dec 2019 | Trial primary completion date: Feb 2019 --> Dec 2019
  • ||||||||||  sevoflurane / generics
    Journal:  Relationship between Volatile Anesthetics and Tumor Progression: Unveiling the Mystery. (Pubmed Central) -  Mar 21, 2019   
    Isoflurane, haloflurane and enflurane enhance immunosuppression and upregulate hypoxia-inducible-factor 1 and matrix metalloproteinases, leading to the cancer malignant progression, whereas roles of desflurane and sevoflurane are still unclear. As the effects of volatile anesthetics on tumor immunity have been known, it will be beneficial for using selective drugs into anesthesia and operation in cancer patients.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date, Surgery:  Effect of Total Intravenous Anaesthesia With Propofol on Postoperative Pain After Bilateral Third Molar Surgery (clinicaltrials.gov) -  Mar 12, 2019   
    P4,  N=96, Completed, 
    As the effects of volatile anesthetics on tumor immunity have been known, it will be beneficial for using selective drugs into anesthesia and operation in cancer patients. Active, not recruiting --> Completed | Trial completion date: May 2019 --> Mar 2018 | Trial primary completion date: Dec 2018 --> Mar 2018
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date:  Left Ventricular Diastolic Function During Anesthesia Induction (clinicaltrials.gov) -  Mar 12, 2019   
    P=N/A,  N=200, Completed, 
    Active, not recruiting --> Completed | Trial completion date: May 2019 --> Mar 2018 | Trial primary completion date: Dec 2018 --> Mar 2018 Recruiting --> Completed | Trial completion date: Apr 2019 --> Sep 2018 | Trial primary completion date: Apr 2019 --> Sep 2018
  • ||||||||||  Alfenta (alfentanil) / Abbott, Sufenta (sufentanil) / Akorn, Emestop (ramosetron hydrochloride) / Samyang Group
    Enrollment change:  Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis (clinicaltrials.gov) -  Mar 7, 2019   
    P=N/A,  N=27034, Completed, 
    Recruiting --> Completed | Trial completion date: Apr 2019 --> Sep 2018 | Trial primary completion date: Apr 2019 --> Sep 2018 N=48246 --> 27034
  • ||||||||||  Sufenta (sufentanil) / Akorn
    Enrollment open, Surgery:  Regional Anesthesia Versus General Anesthesia (clinicaltrials.gov) -  Feb 21, 2019   
    P=N/A,  N=30, Recruiting, 
    Initiation date: Jan 2019 --> Apr 2019 Not yet recruiting --> Recruiting
  • ||||||||||  sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Enrollment open, Trial initiation date:  Effect of Dexmedetomidine on the Minimum Alveolar Concentration of Sevoflurane (clinicaltrials.gov) -  Feb 20, 2019   
    P4,  N=180, Recruiting, 
    Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting | Initiation date: Dec 2018 --> Feb 2018
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial initiation date, Trial primary completion date:  The Correlation Between Sevoflurane and qNOX (clinicaltrials.gov) -  Feb 19, 2019   
    P=N/A,  N=89, Recruiting, 
    Not yet recruiting --> Recruiting | Initiation date: Dec 2018 --> Feb 2018 Trial completion date: Dec 2018 --> Dec 2019 | Initiation date: Sep 2018 --> Feb 2019 | Trial primary completion date: Dec 2018 --> Aug 2019
  • ||||||||||  Alfenta (alfentanil) / Abbott
    Enrollment open:  Modeling and Application of Triple Drug Response Surface Models (clinicaltrials.gov) -  Feb 19, 2019   
    P=N/A,  N=120, Recruiting, 
    Trial completion date: Dec 2018 --> Dec 2019 | Initiation date: Sep 2018 --> Feb 2019 | Trial primary completion date: Dec 2018 --> Aug 2019 Not yet recruiting --> Recruiting
  • ||||||||||  Sufenta (sufentanil) / Akorn
    New trial, Surgery:  Regional Anesthesia Versus General Anesthesia (clinicaltrials.gov) -  Feb 5, 2019   
    P=N/A,  N=30, Not yet recruiting, 
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery:  Benefits of Total Intravenous Anesthesia Compared With Inhaled Anesthesia in Cardiovascular Surgery (clinicaltrials.gov) -  Jan 30, 2019   
    P=N/A,  N=40, Recruiting, 
    Not yet recruiting --> Completed | Trial completion date: Jul 2019 --> Jan 2019 | Trial primary completion date: May 2019 --> Jan 2019 Trial completion date: Jul 2019 --> Dec 2019 | Trial primary completion date: Jul 2019 --> Dec 2019
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment open:  50% Effective Concentration of Sevoflurane for Immobility (clinicaltrials.gov) -  Jan 25, 2019   
    P=N/A,  N=20, Recruiting, 
    Trial completion date: Jul 2019 --> Dec 2019 | Trial primary completion date: Jul 2019 --> Dec 2019 Not yet recruiting --> Recruiting