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13 Diseases |  |
542 Trials |
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542 Trials |  |
5582 News |  |
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- | sevoflurane / Generic mfg.
Journal: Environmental Effects of Propofol Versus Sevoflurane for Maintenance Anesthesia. (Pubmed Central) - Oct 16, 2024
No abstract available
- || Review, Journal: Anesthetic Management of Acute Ischemic Stroke Undergoing Mechanical Thrombectomy: An Overview. (Pubmed Central) - Oct 16, 2024
Effective blood pressure management, tailored airway strategies, and vigilant postoperative monitoring are essential to optimize outcomes. This review underscores the importance of coordinated care, incorporating multimodal monitoring and maintaining neuroprotection throughout the perioperative period.
- | sevoflurane / Generic mfg.
Biomarker, Clinical, Journal: OXY-SCORE and Volatile Anesthetics: A New Perspective of Oxidative Stress in EndoVascular Aneurysm Repair-A Randomized Clinical Trial. (Pubmed Central) - Oct 16, 2024
Compared to sevoflurane, desflurane had a positive effect on oxidative stress during EVAR. The OXY-SCORE could provide a more comprehensive perspective on oxidative stress in this patient population.
- || sevoflurane / Generic mfg.
Biomarker, Clinical, Journal, Surgery: Desflurane Versus Sevoflurane and Postoperative Cardiac Biomarkers in Older Adults Undergoing Low- to Moderate-Risk Noncardiac Surgery-Secondary Analysis of a Prospective, Observer-Blinded, Randomized Clinical Trial. (Pubmed Central) - Oct 16, 2024
It seems likely that desflurane does not exert significant clinical meaningful cardioprotective effects in older adults. Thus, our results do not support the use of desflurane in patients undergoing low- to moderate-risk noncardiac surgery.
- sevoflurane / Generic mfg., isoflurane / Generic mfg., midazolam hydrochloride / Generic mfg.
FRONTAL EEG MONITORING REDUCES ANESTHESIA REQUIREMENT DURING LIVER TRANSPLANTATION () - Oct 15, 2024 - Abstract #AASLD2024AASLD_1973;
Previous research shows that anesthetic reduction is associated with improved time to extubation and post-operative delirium. fEEG is a novel tool to improve the clinical course and prognosis of liver transplant recipients.
- | sevoflurane / Generic mfg., isoflurane / Generic mfg.
Preclinical, Journal: Sodium leak channels in the central amygdala modulate the analgesic potency of volatile anaesthetics in mice. (Pubmed Central) - Oct 14, 2024
fEEG is a novel tool to improve the clinical course and prognosis of liver transplant recipients. The analgesic potencies of volatile anaesthetics are partially mediated by modulation of NALCN in CeAGABA neurones.
- | sevoflurane / Generic mfg.
Journal: A Case Report of Changes in Regional Cortical Blood Volume and Oxygenation During Induction of General Anaesthesia with Sevoflurane Versus Propofol in a Paediatric Moyamoya Disease, Evaluated by Near-Infrared Spectroscopy. (Pubmed Central) - Oct 14, 2024
However, the TOI (rCBO) levels during both anaesthesia inductions were constantly higher than these respective baseline values (64% in the slow induction, 71% in the rapid induction), and these mean change values in each of the anaesthesia induction were about the same. The present results suggested that both the slow induction method with sevoflurane and the rapid induction method with propofol might be safe and effective for anaesthesia induction in paediatric patients with moyamoya disease.
- | sevoflurane / Generic mfg.
Journal: Novel insights into sevoflurane-induced developmental neurotoxicity mechanisms. (Pubmed Central) - Oct 11, 2024
Sevo disrupts mitochondrial autophagy via USP30 upregulation, exacerbating neurotoxicity and activating NLRP1 inflammasome-mediated inflammation. Sevo neurotoxicity is mediated through the H19/miR-152-3p/USP30 axis, implicating microglial regulation of neuronal pyroptosis.
- | sevoflurane / Generic mfg.
Preclinical, Journal: GDNF facilitates cognitive function recovery following neonatal surgical-induced learning and memory impairment via activation of the RET pathway and modulation of downstream effectors PKM? and Kalirin in rats. (Pubmed Central) - Oct 9, 2024
Moreover, GDNF may exert its influence by upregulating the expression of PKM? and Kalirin, consequently enhancing the development of dendrites and dendritic spines.
- | sevoflurane / Generic mfg.
Preclinical, Journal, Surgery: Inhibition of the P38 MAPK/NLRP3 Pathway Mitigates Cognitive Dysfunction and Mood Alterations in Aged Mice after Abdominal Surgery Plus Sevoflurane. (Pubmed Central) - Oct 9, 2024
and Kalirin, consequently enhancing the development of dendrites and dendritic spines. Our study suggests that anesthesia and surgical procedures induce alterations in mood and cognition, which may be intricately linked to the P38 MAPK/NLRP3 pathway.
- | sevoflurane / Generic mfg.
Journal, Surgery: Effect of anesthetic technique on antitumor immunity in patients undergoing surgery for gall bladder cancer: A prospective randomized comparative study. (Pubmed Central) - Oct 9, 2024
At the same time, Sevoflurane modulates T-helper cells-based immunity to increase TH17 cells in patients with gall bladder cancer. Multiple larger studies will be required to validate the results and provide useful recommendations.
- || sevoflurane / Generic mfg.
Clinical, Journal, Surgery: Effect of Propofol Versus Sevoflurane on Erections during Narcosis in Transurethral Surgery: The PENIS Trial. (Pubmed Central) - Oct 9, 2024
P4
This research has received ethical clearance from the local ethics committee (KEK code 2023-01682). The trial is registered on the Swiss National Clinical Trials Portal (SNCTP000005681) and on ClinicalTrial.gov (NCT06378645).
- | colchicine / Generic mfg.
Preclinical, Journal, Surgery: Colchicine prevents perioperative myocardial injury in cardiac surgery by inhibiting the formation of neutrophil extracellular traps: evidence from rat models. (Pubmed Central) - Oct 7, 2024
NETs were significantly elevated during the perioperative period of cardiac surgery. Colchicine significantly mitigated myocardial injury in cardiac surgery by inhibiting neutrophil extracellular traps formation, with PAD-4 inhibition being one of its mechanisms.
- | sevoflurane / Generic mfg.
Journal: SIRT1-driven mechanism: sevoflurane's interference with mESC neural differentiation via PRRX1/DRD2 cascade. (Pubmed Central) - Oct 7, 2024
Sevoflurane may inhibit PKM2 dimerization and NRF2 signaling pathway activation by inhibiting the expression of SIRT1 and its downstream genes Prrx1 and DRD2, ultimately inhibiting mESCs differentiation into mNSCs. These findings contribute to our understanding of the molecular basis of sevoflurane-induced neural toxicity, presenting a potential avenue for therapeutic intervention in sevoflurane-induced perturbation in the differentiation of mESCs into mNSCs by modulating the SIRT1/PRRX1/DRD2/PKM2/NRF2 axis.
- | sevoflurane / Generic mfg.
Preclinical, Journal: Childhood anaesthesia and autism risk: population and murine study. (Pubmed Central) - Oct 7, 2024
Early childhood exposure to general anaesthesia is associated with an increased risk of autism. Repeated exposure to sevoflurane in mice induces autism-like behaviours, suggesting a potential link between anaesthesia and the development of autism.
- | sevoflurane / Generic mfg.
Preclinical, Journal: The combination of post-mortem sevoflurane ventilation and in situ topical cooling provides improved 6h lung preservation in an uncontrolled DCD porcine model. (Pubmed Central) - Oct 6, 2024
Preservation of uDCD lungs with a combination of static lung inflation, topical cooling and sevoflurane treatment maintains good pulmonary function up to 6h post-mortem with excellent early post-lung transplant function. These interventions may significantly expand the clinical utilization of uDCD donor lungs.
- || fentanyl citrate / Generic mfg., sevoflurane / Generic mfg.
PK/PD data, Journal: Assessment of the antinociceptive effect of a single fentanyl bolus dose in children: A pharmacokinetic and pharmacodynamic analysis based on the nociception level index during sevoflurane general anesthesia. (Pubmed Central) - Oct 4, 2024
These interventions may significantly expand the clinical utilization of uDCD donor lungs. The Nociception Level Index showed superior capability compared to traditional hemodynamic variables in discriminating different nociception-antinociception levels during varying fentanyl concentrations in children under sevoflurane anesthesia.
- | sevoflurane / Generic mfg.
New P1 trial, Tumor cell: Effect of Propofol and Sevoflurane Anesthesia on HSP70 Expression in Tumor Cells (clinicaltrials.gov) - Oct 4, 2024
P1, N=10, Not yet recruiting, Sponsor: Saint Petersburg State University, Russia
- | sevoflurane / Generic mfg.
Journal: Inhalation of hydrogen gas mitigates sevoflurane-induced neuronal apoptosis in the neonatal cortex and is associated with changes in protein phosphorylation. (Pubmed Central) - Oct 3, 2024
H2 inhalation modified cellular transport pathways that depend on hyperphosphorylated proteins including microtubule-associated protein family. These modifications may be involved in the protective mechanisms of H2 against sevoflurane-induced neuronal cell death.
- | sevoflurane / Generic mfg.
Journal, Surgery: Effects of prophylactic nalbuphine on emergence agitation and postoperative pain in pediatric patients undergoing ENT surgery with sevoflurane anesthesia. (Pubmed Central) - Oct 2, 2024
In summary, the results of this study demonstrated that prophylactic natbuphine could minimize the incidence of EA in pediatric patients following ENT surgery without increasing the extubating time and PACU duration. http://www.chictr.org.cn, identifier [ChiCTR2300070046].
- || sevoflurane / Generic mfg.
Clinical, Journal: The effect of two different modes of anaesthesia maintenance on postoperative delirium in elderly patient with low preoperative mini-cog score. (Pubmed Central) - Oct 2, 2024
P
Low Mini-Cog score was an indicator of a higher risk of early postoperative delirium. Sevoflurane is more likely to cause postoperative delirium than TIVA.
- | sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
Enrollment open, Trial completion date, Trial primary completion date: Dexmedetomidine Reduces Sevoflurane MAC-BAR During Pneumoperitoneum (clinicaltrials.gov) - Oct 1, 2024
P4, N=90, Recruiting, Sponsor: Fujian Provincial Hospital
Sevoflurane is more likely to cause postoperative delirium than TIVA. Not yet recruiting --> Recruiting | Trial completion date: Nov 2025 --> Dec 2024 | Trial primary completion date: Sep 2024 --> Dec 2024
- | sevoflurane / Generic mfg.
Journal, Compliance: Evaluation of General Anesthesia and Sedation and Follow-Up Compliance in Pediatric Dental Procedures: A Comprehensive Analysis of Long-Term Outcomes and Gender Differences. (Pubmed Central) - Sep 27, 2024
Our findings indicated that general anesthesia with inhalational agents and muscle relaxants was the most frequently used method (1260 instances), followed by nitrous oxide sedation (163 instances) and sevoflurane GA with a laryngeal mask airway (158 instances)...Overall, our results highlight the importance of tailored anesthesia and sedation plans, as well as follow-up protocols, in pediatric dentistry. This study provides valuable insights for practitioners in selecting appropriate anesthesia and sedation types and developing strategies to improve follow-up compliance and treatment success.
- | sevoflurane / Generic mfg., isoflurane / Generic mfg.
Journal: Links between mutations in functionally separate arms of mitochondrial complex I and responses to volatile anesthetics. (Pubmed Central) - Sep 27, 2024
This study provides valuable insights for practitioners in selecting appropriate anesthesia and sedation types and developing strategies to improve follow-up compliance and treatment success. Mutations in different arms of Complex I resulted in different behavioral sensitivities and toxicities to isoflurane and sevoflurane, indicating that (i) the anesthetics have mechanisms of action that involve arms of Complex I to different extents and (ii) the lack of behavioral hypersensitivity does not preclude susceptibility to anesthetic toxicity.
- | sevoflurane / Generic mfg.
Journal: Sevoflurane Confers Protection Against the Malignant Phenotypes of Lung Cancer Cells via the microRNA-153-3p/HIF1?/KDM2B Axis. (Pubmed Central) - Sep 26, 2024
Sevoflurane decreased HIF1? expression through upregulation of miR-153-3p, thereby reducing KDM2B transcription to restrict the malignant phenotypes of LC A549 cells.
- | sevoflurane / Generic mfg., isoflurane / Generic mfg.
Journal: Agents That Came in From the Cold: Enflurane, Isoflurane, Desflurane, and Sevoflurane. (Pubmed Central) - Sep 24, 2024
expression through upregulation of miR-153-3p, thereby reducing KDM2B transcription to restrict the malignant phenotypes of LC A549 cells. No abstract available
- | sevoflurane / Generic mfg.
Journal: Lidocaine combined with general anesthetics impedes metastasis of breast cancer cells via inhibition of TGF-?/Smad-mediated EMT signaling by reprogramming tumor-associated macrophages. (Pubmed Central) - Sep 23, 2024
(TGF-?) derived from TAMs increased EMT signaling in TNBC cells, and that lidocaine affected cancer cells as well as M2-TAMs, inducing M2 to M1 reprogramming and decreasing TGF-?/Smads-mediated EMT signaling in TNBC cells, leading to inhibition of cancer metastasis and recurrence. These findings suggest lidocaine combined with general anesthetics as a potential therapeutic approach for the inhibition of recurrence and metastasis of breast cancer patients undergoing curative resection.
- | Journal: The Bioenergetics of Traumatic Brain Injury and its Long-Term Impact for Brain Plasticity and Function. (Pubmed Central) - Sep 21, 2024
Mitochondrial dysfunction leads to pathological manifestations such as oxidative stress, inflammation, and calcium imbalance that threaten brain plasticity and function. Hence, targeting mitochondrial function may have great potential to lessen the outcomes of TBI.
- | sevoflurane / Generic mfg.
Preclinical, Journal: Gut Microbiota-Metabolite-Brain Axis Reconstitution Reverses Sevoflurane-Induced Social and Synaptic Deficits in Neonatal Mice. (Pubmed Central) - Sep 21, 2024
Cholestyramine treatment mimics the protective effects of FMT. The gut microbiota-metabolite-brain axis underlies social dysfunction caused by sevoflurane exposure in early age, and bile acid regulation may be a promising intervention to this impairment.
- | sevoflurane / Generic mfg.
Journal, Surgery: Novel technique of switching TIVA and sevoflurane during epilepsy surgery for combined intraoperative motor evoked potentials monitoring and electrocorticography: an illustrative case report. (Pubmed Central) - Sep 21, 2024
The gut microbiota-metabolite-brain axis underlies social dysfunction caused by sevoflurane exposure in early age, and bile acid regulation may be a promising intervention to this impairment. Intraoperative switch of anesthetic agents according to specific intraoperative requirements may be useful for cases of brain surgery requiring both ECoG recordings and MEP monitoring.
- | sevoflurane / Generic mfg.
Preclinical, Journal: Repeated postnatal sevoflurane exposure impairs social recognition in mice by disrupting GABAergic neuronal activity and development in hippocampus. (Pubmed Central) - Sep 21, 2024
This resulted in impaired electrophysiological function in adult GABAergic neurones, leading to social recognition deficits. These findings reveal a potential electrophysiological mechanism underlying the long-term social recognition deficits induced by sevoflurane and highlight the crucial role of CA2 GABAergic neurones in social interactions.
- | sevoflurane / Generic mfg., isoflurane / Generic mfg.
Journal: Hypothermia and rewarming times during general anesthesia in Hispaniolan Amazon parrots (Amazona ventralis): A comparative study between isoflurane, sevoflurane and desflurane. (Pubmed Central) - Sep 20, 2024
Sevoflurane prolonged warming time. Hypothermia may be associated with an increased likelihood of bradyarrhythmia in parrots anesthetized with inhalants.
- || Bridion (sugammadex) / Merck (MSD)
Clinical, Journal: Effect of sugammadex with neostigmine on postoperative bowel function and on recovery of neuromuscular functions: A randomized controlled trial. (Pubmed Central) - Sep 20, 2024
The addition of neostigmine to sugammadex did not affect bowel function recovery. However, combining 20 ?g/kg neostigmine with 1.5?mg/kg sugammadex or 2?mg/kg sugammadex alone antagonized moderate-depth nondepolarizing neuromuscular blockade with similar efficacy.
- | sevoflurane / Generic mfg.
Trial completion, Trial completion date: DSA-RCT-1: The Effect of DSA on Recovery of Anaesthesia in Children (Het Effect Van DSA Op Het Herstel Na Anesthesie Bij Kinderen). (clinicaltrials.gov) - Sep 19, 2024
P=N/A, N=112, Completed, Sponsor: Erasmus Medical Center
However, combining 20 ?g/kg neostigmine with 1.5?mg/kg sugammadex or 2?mg/kg sugammadex alone antagonized moderate-depth nondepolarizing neuromuscular blockade with similar efficacy. Recruiting --> Completed | Trial completion date: Jul 2024 --> Feb 2024
- | sevoflurane / Generic mfg.
Preclinical, Journal: Sevoflurane anesthesia during late gestation induces cognitive disorder in rat offspring via the TLR4/BDNF/TrkB/CREB pathway. (Pubmed Central) - Sep 14, 2024
Sevo upregulated TLR4 and impeded BDNF/TrkB/CREB signaling transduction in the hippocampus of rat offspring; TAK-242 administration reversed these effects. In conclusion, Sevo anesthesia during late gestation impairs the learning and memory ability of rat offspring possibly by promoting neuroinflammation and disturbing lipid metabolism via the TLR4/BDNF/TrkB/CREB pathway.
- ||| sevoflurane / Generic mfg.
Retrospective data, Review, Journal, Adverse events: Impact of Sevoflurane and Propofol on Perioperative Respiratory Adverse Events in Pediatrics: A Systematic Review and Meta-analysis. (Pubmed Central) - Sep 13, 2024
While propofol presents an elevated risk of apnea, it concurrently yields a significant reduction in laryngospasm, vomiting, and agitation. Consequently, propofol emerges as a favorable anesthetic option for pediatric patients.
- | ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma
Journal: Effect of remimazolam versus propofol on hypotension after anesthetic induction in patients undergoing coronary artery bypass grafting: A randomized controlled trial. (Pubmed Central) - Sep 12, 2024
Consequently, propofol emerges as a favorable anesthetic option for pediatric patients. Remimazolam may offer improved hemodynamic stability during anesthetic induction in patients undergoing CABG, suggesting its potential advantage over propofol for patients with significant coronary artery disease in terms of hemodynamic stability.
- || sevoflurane / Generic mfg.
Clinical, Journal, Surgery: Desflurane versus sevoflurane anesthesia and postoperative recovery in older adults undergoing minor- to moderate-risk noncardiac surgery - A prospective, randomized, observer-blinded, clinical trial. (Pubmed Central) - Sep 12, 2024
Despite previous reports, we did not observe significant faster recovery times after desflurane anesthesia. Both volatile anesthetics may be appropriate for same-day discharge in older adults.
- || sevoflurane / Generic mfg.
Retrospective data, Review, Journal: Effect of general anesthesia drugs on GFAP/Iba-1 expression: a meta-analysis. (Pubmed Central) - Sep 12, 2024
Ten randomized controlled animal experiments were included in this analysis, utilizing different general anesthetics such as sevoflurane and propofol compared to untreated control groups...This meta-analysis highlights the impact of general anesthetics on GFAP expression in animal models, emphasizing the importance of understanding the neuroinflammatory response associated with anesthesia administration. Further research is warranted to elucidate the underlying molecular pathways and explore possible therapeutic interventions to mitigate adverse effects associated with anesthesia administration.
- | sevoflurane / Generic mfg.
Journal: The protective mechanism of sevoflurane in pulmonary arterial hypertension via downregulation of TRAF6. (Pubmed Central) - Sep 10, 2024
The beneficial impact of sevoflurane on pathological changes of lung and cell phenotype of PASMCs were reversed by overexpression of TRAF6. In summary, our study suggested the protective properties of sevoflurane in targeting PAH by downregulating TRAF6 expression, providing a novel avenue for the management of PAH.
- | fentanyl citrate / Generic mfg., sevoflurane / Generic mfg.
Journal, Surgery: Decrease of the peak heights of EEG bicoherence indicated insufficiency of analgesia during surgery under general anesthesia. (Pubmed Central) - Sep 9, 2024
In summary, our study suggested the protective properties of sevoflurane in targeting PAH by downregulating TRAF6 expression, providing a novel avenue for the management of PAH. Superior to standard anesthesia monitoring, pBICs are better indicators of analgesia during surgery.
- | sevoflurane / Generic mfg.
Journal: Fluid management in the septic peri-operative patient. (Pubmed Central) - Sep 9, 2024
Individualized and GDFT using BS is the preferred approach for fluid resuscitation in septic peri-operative patients. Future research should evaluate the interaction between clinical anaesthesia and EG, its implications on fluid resuscitation, and the impact of GDFT in septic peri-operative patients.
- || dexamethasone / Generic mfg., sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
Clinical, Journal: The Effect of Opioid-Free Anesthesia with Transversus Abdominis Plane Block on Patients Undergoing Laparoscopic Sleeve Gastrectomy: Randomized Controlled Study. (Pubmed Central) - Sep 9, 2024
Sevoflurane, dexamethasone, and muscle relaxants were administered intraoperatively to all patients...The length of the hospital stay was significantly shorter compared with the control group (p =0.002). OFA with TAP results in a significant decrease in the need for antiemetic rescue, a lower level of pain after the surgery, and a shorter hospital stay in contrast with anesthesia based on opioids.
- | sevoflurane / Generic mfg., desmopressin / Generic mfg.
Journal: Intraoperative Transient Central Diabetes Insipidus Status Post-Cerebellopontine Meningioma Resection: A Case Report. (Pubmed Central) - Sep 9, 2024
A literature review found associations with certain anesthetic drugs that have an increased incidence of CDI, including alpha-2 agonists and sevoflurane. Reports have recommended administering desmopressin over vasopressin, especially for neurosurgery cases that warrant a more extended operative period, given that desmopressin has a longer context-sensitive half-life.
- | sevoflurane / Generic mfg.
Preclinical, Journal: Intermittent fasting alleviates postoperative cognitive dysfunction by reducing neuroinflammation in aged mice. (Pubmed Central) - Sep 8, 2024
To summarize, the results of this study indicate that IF may mitigate inflammation in the hippocampal area of the brain. Furthermore, IF appears to provide a safeguard against cognitive impairment and synaptic plasticity impairment brought on by sevoflurane anesthesia.
- | sevoflurane / Generic mfg.
Journal, Video, Surgery: Unveiling the protective role of sevoflurane in video-assisted thoracoscopic surgery associated-acute lung injury: inhibition of ferroptosis. (Pubmed Central) - Sep 8, 2024
In summary, Sev treatment, in comparison to propofol anesthesia, may suppress local lung and systemic inflammatory responses by activating the PI3K/Akt/Nrf2/HO-1 pathway and inhibiting ferroptosis. This cascade of effects contributes to the maintenance of pulmonary epithelial barrier permeability, alleviation of pulmonary injury, and enhancement of intraoperative oxygenation in patients undergoing VATS.
- | vancomycin / Generic mfg.
Journal, IO biomarker: Ameliorative effects of sinapic acid against vancomycin-induced testicular oxidative damage, apoptosis, inflammation, testicular histopathologic disorders and decreased epididymal sperm quality. (Pubmed Central) - Sep 5, 2024
Histopathological results revealed that VCM caused disruption of basement membranes and disorganization of seminiferous tubules, but SNP administration preserved testicular histology. As a result, VCM increased oxidative stress, apoptosis, and autophagy in the testicular tissue of rats, altered testicular histopathology, and decreased sperm quality, while SNP decreased these effects.
- | sevoflurane / Generic mfg.
Observational data, Journal: Prospective Observational Study of Volatile Sedation with Sevoflurane After Aneurysmal Subarachnoid Hemorrhage Using the Sedaconda Anesthetic Conserving Device. (Pubmed Central) - Sep 5, 2024
Sevoflurane appears to be a feasible alternative to intravenous sedation in patients with aSAH without intracranial hypertension, as our study did not show negative effects on ICP, cerebral oxygenation, or brain metabolism. Nevertheless, the risk of a decrease of MAP leading to a consecutive CPP decrease should be considered.
- | sevoflurane / Generic mfg.
Journal: Functional role of lncRNA MEG3 on pyroptosis through interacting with EZH2 and YTHDC1 in postoperative cognitive dysfunction. (Pubmed Central) - Sep 5, 2024
In conclusion, our study elucidates that MEG3 inhibits the NLRP3 inflammasome and hippocampal neuron pyroptosis through the recruitment of EZH2/YTHDC1. These findings shed light on the underlying mechanism of MEG3 in the regulation of POCD and suggest that MEG3 could serve as a potential therapeutic target for the treatment of POCD.
- | sevoflurane / Generic mfg.
Journal: How Much Time Do Focal Treatments for Retinoblastoma Add to Anesthetic Exposure? (Pubmed Central) - Sep 3, 2024
EUAs for children with retinoblastoma can be performed relatively quickly. Interventions such as laser, cryotherapy, or intravitreal injections roughly double the time under anesthesia but in some cases can take much longer (>1 h).