sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / generics
    Journal:  Uncontrolled delivery of liquid volatile anaesthetic when using the anaesthetic conserving device. (Pubmed Central) -  May 7, 2019   
    ...The study examined how the temperature of liquid volatile anaesthetics (sevoflurane and isoflurane) and the presence of gas bubbles in the syringe affect the occurrence of auto-pumping when using the anaesthetic conserving device (ACD, AnaConDa™, Sedana Medical, Uppsala, Sweden)...The presence of gas bubbles in the syringe, especially when exposed to a heat source, may provoke auto-pumping with uncontrolled excessive anaesthetic delivery. If auto-pumping is suspected, the syringe pump must be stopped and the ACD removed from the breathing circuit at once.
  • ||||||||||  sevoflurane / generics
    Review, Journal:  Inhaled anesthetic agent sedation in the ICU and trace gas concentrations: a review. (Pubmed Central) -  May 7, 2019   
    In this review, benefits, risks, and technical aspects of inhalational sedation in the ICU are discussed. Further, the potential health effects of occupational long-term low-concentration agent exposure, the staffs' exposure levels in clinical practice, and strategies to minimize the individual gas exposure are reviewed.
  • ||||||||||  sevoflurane / generics
    Journal:  Investigation of possible aqueous phase formation during vaporization of sevoflurane. (Pubmed Central) -  May 7, 2019   
    When the starting water concentration exceeded the azeotropic concentration (5.0% w/w), vaporization increased the water content, reaching 13% w/w at 71 h. Results under the low initial water condition were similar in the Tec 7 vaporizer. An increase in water concentration following vaporization of sevoflurane can only occur when the starting water content is higher than the azeotropic concentration and therefore cannot originate from the dissolved water present in the marketed product because the water concentration in Ultane is 34 times lower than the azeotropic concentration.
  • ||||||||||  sevoflurane / Generic mfg., midazolam hydrochloride / Generic mfg.
    Trial completion date, Trial primary completion date:  General Anesthesia for Endovascular Thrombectomy; A Pilot Study. (clinicaltrials.gov) -  May 7, 2019   
    P=N/A,  N=77, Enrolling by invitation, 
    An increase in water concentration following vaporization of sevoflurane can only occur when the starting water content is higher than the azeotropic concentration and therefore cannot originate from the dissolved water present in the marketed product because the water concentration in Ultane is 34 times lower than the azeotropic concentration. Trial completion date: Dec 2017 --> Dec 2020 | Trial primary completion date: Dec 2017 --> Dec 2020
  • ||||||||||  sevoflurane / generics
    Review, Journal:  Minimum alveolar concentration: Key concepts and a review of its pharmacological reduction in dogs. Part 2. (Pubmed Central) -  May 7, 2019   
    Opioids, lidocaine, NSAIDs, maropitant, acepromazine, and NMDA antagonists have been shown to reduce the MAC of inhaled anesthetics in dogs and allow for clinically important decreases in inhalant anesthetic use. Thus, the use of these agents potentially decrease the adverse cardiovascular and pulmonary effects associated with the use of high concentrations of inhaled anesthetics.
  • ||||||||||  sevoflurane / generics
    Journal:  Computed tomographic features of intra-abdominal hypertension in three dogs. (Pubmed Central) -  May 6, 2019   
    Compression of the caudal vena cava, direct renal compression, and the extension of peritoneal fluid into the vaginal canal and vaginal cavity are consistent with a diagnosis of IAH. Measurement of IAP and detection of these CT features should alert clinicians to the possible presence of IAH in veterinary patients.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery:  Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia (clinicaltrials.gov) -  May 6, 2019   
    P4,  N=8000, Recruiting, 
    In conclusion, in a murine model of breast cancer surgery during sevoflurane anaesthesia, propofol and lidocaine each decreased pulmonary metastasis, while methylprednisolone increased it. Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Dec 2018 --> Dec 2021
  • ||||||||||  sevoflurane / generics, carvedilol / generics
    Journal:  Sevoflurane, Propofol and Carvedilol Block Myocardial Protection by Limb Remote Ischemic Preconditioning. (Pubmed Central) -  May 2, 2019   
    In the healthy volunteer study, there was a reduction in MI size with RIPC in the no-carvedilol group (41.7 ± 4.3% to 30.6 ± 8.5%; p < 0.0001), but not in the carvedilol group (41.0 ± 4.0% to 39.6 ± 5.6%; p = 0.452). We found that the cardioprotective effects of limb RIPC were abolished under propofol or sevoflurane anesthesia and in the presence of carvedilol therapy.
  • ||||||||||  sevoflurane / generics
    Clinical, Journal:  Anesthesia maintenance with propofol versus sevoflurane to reduce postoperative pain: still too early for recommendations? (Pubmed Central) -  May 2, 2019   
    In this issue you will find a paper by Sau Ching Wong et al. entitled "The effect of total intravenous anaesthesia with propofol on postoperative pain after third molar surgery: a double blind randomized controlled trial"(Wong, Leung, and Cheung 2018 ##in press, will be assigned to an 2019-issue##). This paper reports results of a trial conducted in a standard surgical model of pain: the bilateral third molar extraction surgery.
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment closed, Phase classification, Trial completion date, Trial primary completion date:  Neurobiological and Cognitive Changes Following Exposure to Either Sevoflurane- or Propofol-based Anesthesia in Children (clinicaltrials.gov) -  May 2, 2019   
    P3,  N=50, Active, not recruiting, 
    This paper reports results of a trial conducted in a standard surgical model of pain: the bilateral third molar extraction surgery. Recruiting --> Active, not recruiting | Phase classification: P4 --> P3 | Trial completion date: Sep 2018 --> Dec 2019 | Trial primary completion date: Sep 2018 --> Dec 2019
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment closed, Trial primary completion date, Surgery:  APLICS: Anesthetics to Prevent Lung Injury in Cardiac Surgery (clinicaltrials.gov) -  May 1, 2019   
    P1/2,  N=51, Active, not recruiting, 
    Recruiting --> Active, not recruiting | Phase classification: P4 --> P3 | Trial completion date: Sep 2018 --> Dec 2019 | Trial primary completion date: Sep 2018 --> Dec 2019 Recruiting --> Active, not recruiting | Trial primary completion date: Mar 2019 --> May 2019
  • ||||||||||  sevoflurane / generics
    Retrospective data, Journal:  A single-center experience of pediatric foreign-body aspiration: A retrospective 4-year case series. (Pubmed Central) -  Apr 30, 2019   
    ...In cases of FBA diagnosis, rigid bronchoscopy was performed under sevoflurane and propofol anaesthesia supported by controlled ventilation...However, in patients applied with bronchoscopy for FBA, controlled ventilation and appropriate general anesthesia should be generally used. Early bronchoscopic intervention with safe anesthesia and controlled ventilation support will improve the success rates in FBA cases.
  • ||||||||||  ketamine / generics, sevoflurane / generics
    Clinical, Journal:  Safety of Pediatric Peripheral Blood Stem Cell Harvest in Daycare Setting: An Institutional Experience. (Pubmed Central) -  Apr 30, 2019   
    ...A total of 137 donors (median age of 5 years) were induced with sevoflurane and LMA was used in 84 children and face mask in 53...Various combinations of propofol, dexmedetomidine, and ketamine were used with respiratory and hemodynamic stability...The recovery from anesthesia was smooth with a median wake-up time of 20 (5-60) min. This retrospective analysis demonstrates that nonoperating room anesthesia for pediatric age group for PBSC harvest can be safely and successfully accomplished outside the operation room setting by a consultant anesthesiologist.
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment open:  Sevoflurane Human Biomonitoring in Operating Room Personnel (clinicaltrials.gov) -  Apr 29, 2019   
    P=N/A,  N=20, Recruiting, 
    Trial primary completion date: Dec 2018 --> Aug 2019 Not yet recruiting --> Recruiting
  • ||||||||||  sevoflurane / generics
    Preclinical, Journal:  Experimental ex vivo lung perfusion with sevoflurane: effects on damaged donor lung grafts. (Pubmed Central) -  Apr 26, 2019   
    A decrease in MAC may decrease the adverse cardiovascular and pulmonary effects associated with the use of high concentrations of inhaled anesthetics. These findings suggest that the potential of sevoflurane in protecting the lungs donated after cardiac death and reconditioned using EVLP could improve the outcome of these lungs following subsequent transplantation.
  • ||||||||||  sevoflurane / generics
    Journal:  Propofol post-conditioning after temporary clipping reverses oxidative stress in aneurysm surgery. (Pubmed Central) -  Apr 24, 2019   
    Together, our data suggest that propofol post-conditioning (Cp 1.2 µg/mL) may protect the brain from oxidative stress injury up to 7 days post-surgery after temporary parent artery clipping. Furthermore, the neuroprotection induced by propofol post-conditioning may contribute to improvement in cognitive function.
  • ||||||||||  sevoflurane / generics
    Preclinical, Journal:  In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells. (Pubmed Central) -  Apr 24, 2019   
    The curves representing the concentrations of both sevoflurane and isoflurane dissolved in the medium showed similar courses over time, with a plateau reached at one hour after exposure. This protocol was specifically designed to reach precise and controlled concentrations of sevoflurane or isoflurane in vitro to improve our understanding of mechanisms involved in epithelial lung injury during ARDS and to test novel therapies for the syndrome.
  • ||||||||||  sevoflurane / generics
    Journal:  Hepatotoxicity after sevoflurane anaesthesia: a new twist to an old story. (Pubmed Central) -  Apr 23, 2019   
    This protocol was specifically designed to reach precise and controlled concentrations of sevoflurane or isoflurane in vitro to improve our understanding of mechanisms involved in epithelial lung injury during ARDS and to test novel therapies for the syndrome. No abstract available
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Trial completion date, Trial initiation date, Trial suspension, Trial primary completion date:  The Ratio of Hypnotic to Analgesic Potency of Volatile Anesthetics (clinicaltrials.gov) -  Apr 23, 2019   
    P3,  N=90, Suspended, 
    No abstract available Trial completion date: Dec 2019 --> Dec 2020 | Initiation date: Oct 2018 --> Jan 2020 | Not yet recruiting --> Suspended | Trial primary completion date: Aug 2019 --> Aug 2020
  • ||||||||||  ketamine / generics, sevoflurane / generics
    Journal:  Gas Anesthesia Impairs Peripheral Auditory Sensitivity in Barn Owls (Tyto alba). (Pubmed Central) -  Apr 20, 2019   
    This difference already occurred with minimal dosages and was reversibly enlarged with increased isoflurane concentration. Finally, there was evidence for confounding detrimental effects associated with artificial respiration over many hours, which suggested oxygen toxicity.
  • ||||||||||  sevoflurane / generics
    Journal:  Volatile Anesthetics versus Total Intravenous Anesthesia for Cardiac Surgery. (Pubmed Central) -  Apr 20, 2019   
    P4
    Among patients undergoing elective CABG, anesthesia with a volatile agent did not result in significantly fewer deaths at 1 year than total intravenous anesthesia. (Funded by the Italian Ministry of Health; MYRIAD ClinicalTrials.gov number, NCT02105610.).
  • ||||||||||  sevoflurane / generics
    Clinical, Journal:  Surgical pleth index: prediction of postoperative pain in children? (Pubmed Central) -  Apr 19, 2019   
    ...After ethics approval 105 children (2-16 yr) undergoing elective sevoflurane/opioid-based anaesthesia were included...The results suggest that a lower (≤ 40) than previously published (50) target for SPI may be more appropriate in studies investigating SPI guided anaesthesia in children, if the avoidance of moderate-severe postoperative pain is the main goal. ACTRN12616001139460.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  The Impact of a Preoperative Nerve Block on the Consumption of Sevoflurane (clinicaltrials.gov) -  Apr 18, 2019   
    P2/3,  N=50, Not yet recruiting, 
    Our results suggested that sevoflurane and propofol might synergistically possess some cardio-protective properties in patients undergoing CABG. Trial completion date: Dec 2019 --> Dec 2020 | Trial primary completion date: Oct 2019 --> Jun 2020
  • ||||||||||  sevoflurane / generics
    Journal:  A study of intubating conditions: Sevoflurane versus propofol-suxamethonium in children. (Pubmed Central) -  Apr 17, 2019   
    Sevoflurane provides clinically acceptable intubating conditions and can be a suitable alternative to propofol-suxamethonium for endotracheal intubation in children. We recommend the use of sevoflurane to facilitate intubation in elective procedures in children.
  • ||||||||||  sevoflurane / generics
    Biomarker, Journal:  Monitoring early cell damage in physicians who are occupationally exposed to inhalational anesthetics. (Pubmed Central) -  Apr 11, 2019   
    ...Twenty-six young physicians who had been occupationally exposed to the anesthetics isoflurane, sevoflurane, desflurane, and nitrous oxide and who worked in operating rooms using modern anesthesia workstations during their medical residency program, participated in this study...Based on the results, brief occupational exposure to anesthetics does not induce either cytotoxicity or genotoxicity in mononuclear cells under the conditions of this study. Thus, young physicians should undergo additional biomonitoring at the beginning of their careers to determine possible toxic effects on their cells and genetic material, and further investigations are warranted to determine whether a longer exposure to inhalational anesthetics results in mitochondrial depolarization, apoptosis and DNA breaks.