sevoflurane / Generic mfg. 
Welcome,         Profile    Billing    Logout  
 13 Diseases   542 Trials   542 Trials   5582 News 


«12...5758596061626364656667...9293»
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Assessment of anesthetic gases in a central hospital. (Pubmed Central) -  Aug 1, 2020   
    Six-monthly assessment of nitrous oxide, sevoflurane, and desflurane was made between 2005 and 2016 in different hospital departments...Desflurane was the anesthetic agent more frequently above the upper limit of threshold value. To complement environmental surveillance, it is essential to establish a health surveillance system for professionals exposed to anesthetic agents.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Effect of anesthesia on evoked auditory responses in pediatric auditory brainstem implant surgery. (Pubmed Central) -  Jul 29, 2020   
    Similarity of EABR morphology in the anesthetized versus sedated condition suggests that anesthesia does not have a large effect on far-field evoked potentials. Changes in EABR waveform morphology observed postoperatively may be influenced by other factors such as movements of the surface array.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Resting state networks of the canine brain under sevoflurane anaesthesia. (Pubmed Central) -  Jul 29, 2020   
    Identified RSN are remarkably similar to those identified in awake dogs. This study proves the feasibility of rs-fMRI in anesthetized dogs and describes several RSNs, which may set the basis for investigating pathophysiological characteristics of various canine brain diseases.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  General anesthesia, germ cells and the missing heritability of autism: an urgent need for research. (Pubmed Central) -  Jul 29, 2020   
    The purpose of this paper is to review the evidence demonstrating that GA, and in particular, SVAGs, may in some circumstances adversely impact the molecular program of germ cells, resulting in brain and behavioral pathology in the progeny born of the exposed cells. Further, we exhort the medical and scientific communities to undertake comprehensive experimental and epidemiological research programs to address this critical gap in risk assessment.
  • ||||||||||  sevoflurane / Generic mfg.
    Observational data, Journal:  High concentrations of waste anesthetic gases induce genetic damage and inflammation in physicians exposed for three years: a cross-sectional study. (Pubmed Central) -  Jul 22, 2020   
    Trace concentrations of anesthetics (isoflurane: 5.3 ± 2.5 ppm, sevoflurane: 9.7 ± 5.9 ppm, and nitrous oxide: 180 ± 150 ppm) were above international recommended thresholds...The findings highlight the genetic and inflammatory risks in young physicians exposed to inhalational agents in operating rooms lacking adequate scavenging systems. This potential health hazard can accompany these subjects throughout their professional lives and reinforces the need to reduce ambient air pollution and consequently, occupational exposure.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion:  Anesthetics and Cerebral Oxygenation in LSG (clinicaltrials.gov) -  Jul 22, 2020   
    P4,  N=60, Completed, 
    Recruiting --> Completed | N=60 --> 102 Active, not recruiting --> Completed
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery:  APLICS: Anesthetics to Prevent Lung Injury in Cardiac Surgery (clinicaltrials.gov) -  Jul 21, 2020   
    P1/2,  N=51, Active, not recruiting, 
    Thus, whether an animal exhibits wakefulness or not can be dissociated from cortical connectivity, prompting a re-evaluation of the role of connectivity in level of consciousness. Trial completion date: Sep 2020 --> Mar 2021 | Trial primary completion date: Jul 2020 --> Dec 2020
  • ||||||||||  sevoflurane / Generic mfg.
    Retrospective data, Journal:  TAPB and RSB protects cardiac diastolic function in elderly patients undergoing abdominopelvic surgery: a retrospective cohort study. (Pubmed Central) -  Jul 19, 2020   
    Tissue Doppler imaging characteristics showed a more significant increase e/a (P = 0.005 < 0.05) and decreases in a value (p = 0.009 < 0.05) in the ST group 1 hour after anesthesia induction hemodynamics stability. Maintaining anesthesia with sevoflurane combining with TAPB and RSB was more suitable for protecting cardiac diastolic function than sevoflurane alone in elderly patients with diastolic dysfunction undergoing open abdominal and pelvic surgery.
  • ||||||||||  sevoflurane / Generic mfg.
    New P4 trial, Surgery, Tumor cell:  Propofol vs Sevo for Paediatric Tumor Surgery (clinicaltrials.gov) -  Jul 16, 2020   
    P4,  N=100, Not yet recruiting, 
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Theaflavins Alleviate Sevoflurane-induced Neurocytotoxicity via Nrf2 Signaling Pathway. (Pubmed Central) -  Jul 16, 2020   
    TFs could also down-regulate expression levels of caspase-3 and caspase-9 and cytosol and intranuclear nuclear factor E2-related factor 2 (Nrf2) in rat hippocampal nerve cells, while it up-regulated those of hemeoxygenase 1 (HO-1), NADPH quinine oxidoreductase 1 (NQO1), Glutamate cysteine ligase (GCL) and peroxiredoxin 1 (Prx1). Our study suggests that theaflavins exert protective effects on sevoflurane-induced neurocytotoxicity and therefore could be used as a potential drug for treatment of neuronal injury.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Spectral and Entropic Features Are Altered by Age in the Electroencephalogram in Patients under Sevoflurane Anesthesia. (Pubmed Central) -  Jul 16, 2020   
    Regardless, most current EEG technology used to guide anesthetic management focus on spectral features, and improvements to these devices might involve integration of entropic features of the raw EEG. : WHAT WE ALREADY KNOW ABOUT THIS TOPIC: Age-related changes in the electroencephalograms of anesthetized surgical patients have been explored but not fully characterized WHAT THIS ARTICLE TELLS US THAT IS NEW: Older age is associated with a shift to a less predictable electroencephalogram, which could influence intraoperative monitoring approaches.
  • ||||||||||  sevoflurane / Generic mfg.
    [VIRTUAL] Frequency Dependent Functional Brain Reorganization in Anesthesia Is Specific to Drug Concentration (524a (133)) -  Jul 15, 2020 - Abstract #EMBC2020EMBC_1613;    
    Using fMRI, it has been shown that increasing doses of Sevoflurane cause progressive breakdown in brain functional connectivity, while EEG studies have shown that higher activity in the delta band is a typical signature of unconsciousness...We also found significant band*condition interactive effects in clustering coefficient, efficiency and strength both on local and global scales. Clinical Relevance— Our results can be of aid in understanding the neural substrates for the differential levels of loss of consciousness as well as band-specific cognitive functions experienced in general anesthesia.
  • ||||||||||  sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Trial completion, Enrollment change:  Transbucal Dexmedetomidine for Prevention of Sevoflurane Emergence Agitation in Pre-school Children (clinicaltrials.gov) -  Jul 14, 2020   
    P2/3,  N=90, Completed, 
    These results demonstrated that ACNLE influences the BSR under sevoflurane anesthesia, possibly by activating light-sensitive nonvisual pathways including SCN and increasing of peripheral serum corticosterone levels. Recruiting --> Completed | N=150 --> 90
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Functional connectivity predicts changes in attention observed across minutes, days, and months. (Pubmed Central) -  Jul 11, 2020   
    Furthermore, the sustained attention CPM is sensitive to within-subject state changes induced by propofol as well as sevoflurane, such that individuals show functional connectivity signatures of stronger attentional states when awake than when under deep sedation and light anesthesia. Together, these results demonstrate that fluctuations in attentional state reflect variability in the same functional connectivity patterns that predict individual differences in sustained attention.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Anesthesia with sevoflurane or isoflurane induces severe hypoglycemia in neonatal mice. (Pubmed Central) -  Jul 9, 2020   
    These studies revealed severe hypoglycemia in neonatal mice during anesthesia with sevoflurane or isoflurane. If this phenomenon also occurs in human, our findings would warrant closely monitoring blood glucose level and maintaining it in the normal range in infants receiving inhalational anesthesia.
  • ||||||||||  Trial completion date, Trial primary completion date:  Effect of Type of General Anesthesia Maintenance on Exhaled Nitric Oxide and Eosinophil Blood Count (clinicaltrials.gov) -  Jul 9, 2020   
    P=N/A,  N=60, Recruiting, 
    If this phenomenon also occurs in human, our findings would warrant closely monitoring blood glucose level and maintaining it in the normal range in infants receiving inhalational anesthesia. Trial completion date: Aug 2020 --> Dec 2020 | Trial primary completion date: Aug 2020 --> Dec 2020
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment open, Trial completion date, Trial initiation date, Trial primary completion date:  SPIDERMAN: Sevoflurane PharmacokInetics in ARDS (clinicaltrials.gov) -  Jul 7, 2020   
    P=N/A,  N=30, Recruiting, 
    Combined intravenous and inhaled anesthesia based on sevoflurane-remifentanil prolonged the time until detection of a positive EMG signal during IONM as compared with TIVA with propofol-remifentanil in patients undergoing thyroidectomy. Not yet recruiting --> Recruiting | Trial completion date: Jun 2021 --> Jun 2022 | Initiation date: Aug 2019 --> Feb 2020 | Trial primary completion date: Aug 2019 --> Mar 2022
  • ||||||||||  sevoflurane / Generic mfg.
    [VIRTUAL] Use of Volatile Agents for Sedation in the Intensive Care Unit a National Survey in France (ATS 2020 Virtual) -  Jul 6, 2020 - Abstract #ATSI2020ATS-I_4437;    
    Sevoflurane and isoflurane were mainly used (87.5 and 20.0%, respectively)...More studies about long-term sedation with halogenated agents are needed to increase practitioners' interest and develop their potential advantages. The low rate of mild adverse effects and the users' satisfaction are promising for this potentially important tool of the ICU therapeutic arsenal.