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Trial termination: SEVOCOPD: Sevoflurane in Chronic Obstructive Pulmonary Disease Exacerbation (clinicaltrials.gov) - Dec 28, 2021 P=N/A, N=16, Terminated, Occupational exposure to low-level sevoflurane has no significant effect on the peripheral blood lymphocytes of operating room staff, but this conclusion needs to be confirmed by multicenter and long-term follow-up studies with large samples. Recruiting --> Terminated; Study halted prematurely and will not resume; participants are no longer being examined or receiving intervention The study was terminated prematurely due to inclusion difficulties
- |||||||||| Journal: Evaluation of Quadratus Lumborum Block as Part of an Opioid-Free Anaesthesia for Canine Ovariohysterectomy. (Pubmed Central) - Dec 27, 2021
Anaesthetic protocol consisted of premedication with IM medetomidine (20 μg kg) and SC meloxicam (0.1 mg kg), induction with propofol to effect, and maintenance with sevoflurane in oxygen/medical air...Fentanyl was administered as rescue analgesia during surgery...Methadone was given as rescue analgesia postoperatively when pain score was >3...The QLB may provide additional analgesia for canine ovariohysterectomy. Further studies are needed to assess the specific contribution of the QLB in abdominal analgesia.
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Review, Journal: Early Development of the GABAergic System and the Associated Risks of Neonatal Anesthesia. (Pubmed Central) - Dec 25, 2021 This is followed by an explanation that, due to the prolonged developmental curve of the GABAergic system, the entirety of the negative effects of neonatal anesthesia on learning and behavior in children are not immediately evident, but instead take a substantial amount of time (years) to fully develop. In order to address these concerns going forward, we subsequently offer a variety of in vivo methods which can be used to record these delayed effects.
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Preclinical, Journal: Docosahexaenoic acid supplementation alleviates behavioral memory impairment caused via repeated administration of sevoflurane in aged rats. (Pubmed Central) - Dec 24, 2021 Furthermore, the protein expression levels of Nrf2 and HO-1 were demonstrated to be significantly increased in rats treated with DHA and exposed to repeated sevoflurane anesthesia compared with those in untreated rats that underwent repeated sevoflurane anesthesia. In conclusion, the present study revealed that DHA exerted protective effects against impairments in learning and memory induced by repeated sevoflurane anesthesia in aged rats, which may be associated with the Nrf2/HO-1 signaling pathway.
- |||||||||| Trial primary completion date, Epigenetic controller: EPOPED: Epigenetics in PostOperative Pediatric Emergence Delirium (clinicaltrials.gov) - Dec 23, 2021
P=N/A, N=322, Recruiting, EEG burst suppression was associated with younger age, inhalation anesthetics, propofol bolus, and lower arterial pressure. Trial primary completion date: Jun 2021 --> Dec 2021
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Preclinical, Journal, IO biomarker: Effect of sevoflurane on iron homeostasis and toxicity in the brain of mice. (Pubmed Central) - Dec 23, 2021 The data uncovered a new lesion mechanism of Sev from the role of iron metabolism. This study also suggested that the reduction in iron levels could protect the brain against neurological damage induced by Sev.
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Trial completion date, Trial primary completion date: Volatile Anesthetics in Cardiac Protection (clinicaltrials.gov) - Dec 22, 2021 P4, N=0, Recruiting, This study also suggested that the reduction in iron levels could protect the brain against neurological damage induced by Sev. Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Dec 2021 --> Dec 2022
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Journal: Peri- and intraoperative EEG signatures in newborns and infants. (Pubmed Central) - Dec 22, 2021 Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Dec 2021 --> Dec 2022 We demonstrate significant differences in EEG readouts between newborns and infants which questions our monitoring systems in paediatric anaesthesia.
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Preclinical, Journal: Sevoflurane Promotes Neurodegeneration Through Inflammasome Formation in APP/PS1 Mice. (Pubmed Central) - Dec 21, 2021 Mechanistically, we found that SEVO induced formation of NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome and its downstream caspase 1-mediated production of IL-1β and IL-18, which subsequently deactivated brain-derived neurotrophic factor (BDNF) to promote neurodegeneration. Together, these data suggest that NLRP3 inflammasome is essential for SEVO-induced AD.
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Preclinical, Journal: General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism. (Pubmed Central) - Dec 17, 2021 We discovered that three cycles of sevoflurane anesthesia (2.5%, 1 h) with 2-h intervals between each exposure in late postnatal BTBR mice did not aggravate, but instead improved pathophysiological mechanisms involved with autistic behavior...Most importantly, such changes were associated with reduced autistic behavior in BTBR mice, as sociability was increased in the three-chamber test and repetitive behavior was reduced in the self-grooming test. Our results suggest that anesthetic exposures during neurodevelopment may affect individuals diagnosed with NDDs differently.
- |||||||||| fentanyl citrate / Generic mfg., sevoflurane / Generic mfg., rocuronium / Generic mfg.
Journal: Propofol/Fentanyl/Rocuronium or Sevoflurane Inhalational Induction for Intubation? (Pubmed Central) - Dec 17, 2021 Less blood pressure fluctuations were recorded in IVCIS group patients. Conclusions Inhalational vital capacity induction with sevoflurane provided acceptable intubating conditions and exhibited a safe hemodynamic profile, albeit the duration was more than 12 minutes.
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Preclinical, Journal: Sevoflurane improves myocardial ischemia/reperfusion injury in rats via SIRT1-ERK1/2 pathway. (Pubmed Central) - Dec 16, 2021 Silencing of PTEN reduced sevoflurane-induced OS damage in hippocampal cells of infant rats.Our study demonstrates that PTEN silencing inhibits the OS damage and cell apoptosis in hippocampal cells induced by Sevoflurane through activating MEK1/ERK signaling pathway in infant rats. No abstract available
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Journal: The effects of the general anesthetic sevoflurane on neurotransmission: an experimental and computational study. (Pubmed Central) - Dec 16, 2021 Computational modelling revealed that this effect was triggered by an acceleration of persistent sodium current kinetics and by an increase in voltage dependent potassium current conductance. The overall effect was a reduced variability of GrCs responses elicited by mfs supporting the idea that sevoflurane shapes neuronal communication without silencing neural circuits.
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Journal: Singular and short-term anesthesia exposure in the developing brain induces persistent neuronal changes consistent with chronic neurodegenerative disease. (Pubmed Central) - Dec 16, 2021 To investigate mechanisms by which early life anesthesia exposure could induce long-term neuronal dysfunction, we exposed rats to 1 minimum alveolar concentration sevoflurane at 7 days of life...Contrary to acute exposure, we did not find an increase in apoptosis. Our findings suggest that a limited, early exposure to anesthesia may produce lasting cellular dysfunction through the induction of a sustained energy deficient state, resulting in persistent neuroinflammation and altered proteostasis/toxicity, mimicking aspects of chronic neurodegenerative diseases.
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Preclinical, Journal: Sevoflurane excites nociceptive sensory neurons by inhibiting K conductances in rats. (Pubmed Central) - Dec 16, 2021 Sevoflurane increased the half-width of single action potentials, which resulted from the inhibition of voltage-gated K currents, including the fast inactivating A-type and non-inactivating delayed rectifier K currents. Our study indicates that sevoflurane could exhibit pronociceptive effects on nociceptive sensory neurons by inhibiting K conductances.
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Journal: Sevoflurane Modulates AKT Isoforms in Triple Negative Breast Cancer Cells. An Experimental Study. (Pubmed Central) - Dec 16, 2021 The most significant effects occur at 72 h after 2 mM sevoflurane treatment and consist in increased viability, proliferation and aggressiveness and increased vimentin and HIF expression. (4) Sevoflurane exposure during surgery may contribute to cancer recurrence via AKT3 induced epithelial-mesenchymal transition (EMT) and by all three AKT isoforms enhanced cancer cell survival and proliferation.
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Journal, IO biomarker: Sevoflurane postconditioning reduces hypoxia/reoxygenation injury in cardiomyocytes via up-regulating heat shock proteins 70. (Pubmed Central) - Dec 16, 2021 Moreover, siHSP70 further reversed the effect of SPostC on apoptosis, cell injury, oxidative stress, inflammation, viability and the expressions of HSP70, apoptosis-, and cell cycle-associated factors in HR-induced cardiomyocytes. In conclusion, this study demonstrated that SPostC reduced the HR injury of cardiomyocytes by inducing HSP70 expression.
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Journal: Carbon Footprint of General, Regional, and Combined Anesthesia for Total Knee Replacements. (Pubmed Central) - Dec 16, 2021 All anesthetic approaches had similar carbon footprints (desflurane and nitrous oxide were not used for general anesthesia). Rather than spinal being a default low carbon approach, several choices determine the final carbon footprint: using low-flow anesthesia/total intravenous anesthesia, reducing single-use plastics, reducing oxygen flows, and collaborating with engineers to augment energy efficiency/renewable electricity.
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Clinical, Journal: Effect of Global Ventilation to Perfusion Ratio, for Normal Lungs, on Desflurane and Sevoflurane Elimination Kinetics. (Pubmed Central) - Dec 16, 2021 In addition to the well-known role of the lungs in the early phases of inhaled anesthetic washout, the lungs play a long-overlooked role in modulating the kinetics of tissue washout during the later stages of inhaled anesthetic elimination. The .VA/.Q ratio influences the kinetics of desflurane and sevoflurane elimination throughout the entire elimination, with more pronounced slowing of tissue washout at lower .VA/.Q ratios.
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Journal: Topical sevofluran: a galenic experience. (Pubmed Central) - Dec 16, 2021 To avoid manipulation of this volatile liquid, we have developed a new formulation of sevoflurane in gel form, which has made it possible to successfully apply sevoflurane in the context of painful pathologies where the skin remains intact. Furthermore, these types of new formulations, including sevoflurane microspheres, which we have also developed, could improve the efficacy and safety of topical sevoflurane while reducing the occupational exposure of healthcare staff. This means that the development of new formulations is a field with a very promising future.
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Journal: Electrically evoked and spontaneous neural activity in the subthalamic nucleus under general anesthesia. (Pubmed Central) - Dec 13, 2021 Further prospective studies are needed to better define the impact of anesthesia on patients' outcome. ERNA is a robust electrophysiological signal localized to the dorsal subthalamic nucleus subregion that is largely preserved under GA, indicating it could feasibly guide electrode implantation, either alone or in complementary use with existing methods.
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