sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / Generic mfg.
    Effect of sevoflurane on the activation of human neutrophiles in ex vivo models () -  Mar 18, 2022 - Abstract #ISICEM2022ISICEM_190;    
    The dexmedetomidine can prevent neurological disorder in patients with sevoflurane anesthesia and is suggested in postoperative rehabilitation. Conclusions – sevoflurane has a pronounced anti-inflammatory effect due to the suppression of neutrophil hyperactivation; one of the possible mechanisms of the effect of sevoflurane on the function of neutrophils is the phosphorylation of GSK-3β.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Changes in breathing pattern during severe hypothermia and autoresuscitation from hypothermic respiratory arrest in anesthetized mice. (Pubmed Central) -  Mar 17, 2022   
    This study examined the synergistic effects of anesthesia and hypothermia on ventilation in spontaneously breathing adult mice under three different conditions, that is, (1) pentobarbital group (n = 7) in which mice were anesthetized with intraperitoneal pentobarbital of 80 mg/kg, (2) sevoflurane-continued group (n = 7) in which mice were anesthetized with 1 MAC sevoflurane, and (3) sevoflurane-discontinued group (n = 7) in which sevoflurane was discontinued at a body temperature below 22˚C...The changes in the respiratory pattern during rewarming are nearly mirrored images of the changes observed during cooling in all three groups. These observations indicate that adult mice are capable of autoresuscitation from hypothermic respiratory arrest and that anesthesia and hypothermia exert synergistic effects on the occurrence of respiratory arrest while the type of anesthetic affects the breathing pattern that occurs during progressive hypothermia leading to respiratory arrest.
  • ||||||||||  sevoflurane / Generic mfg., midazolam hydrochloride / Generic mfg.
    Trial completion:  End Tidal Anesthetic Concentration in Different Anesthesia Techniques Where Depth of Anesthesia Adjusted With Entropy (clinicaltrials.gov) -  Mar 17, 2022   
    P=N/A,  N=44, Completed, 
    These observations indicate that adult mice are capable of autoresuscitation from hypothermic respiratory arrest and that anesthesia and hypothermia exert synergistic effects on the occurrence of respiratory arrest while the type of anesthetic affects the breathing pattern that occurs during progressive hypothermia leading to respiratory arrest. Recruiting --> Completed
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment open, Surgery, Tumor cell:  Propofol vs Sevo for Paediatric Tumor Surgery (clinicaltrials.gov) -  Mar 16, 2022   
    P4,  N=100, Recruiting, 
    We concluded that in open rhinoplasty surgeries, 20° degree RTP reduces intraoperative blood loss and provides a more bloodless surgical field, as well as reducing edema and ecchymoses around the eyes in the postoperative period. Not yet recruiting --> Recruiting
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  Neurotoxicity of Anesthesia in Middle Aged Patients (clinicaltrials.gov) -  Mar 15, 2022   
    P=N/A,  N=600, Active, not recruiting, 
    Not yet recruiting --> Recruiting Trial completion date: May 2022 --> Sep 2022 | Trial primary completion date: Mar 2022 --> Aug 2022
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Effects of Hypothermic Hypoxia/Reoxygenation Fibroblast Culture Medium Containing Sevoflurane on Cardiomyocytes. (Pubmed Central) -  Mar 11, 2022   
    However, sevoflurane containing hypothermic hypoxia/reoxygenation injury fibroblast culture medium can increase the beating frequency of cardiomyocytes, reduce the mortality of cardiomyocytes, increase the relative expression of Cx43 protein, and decrease the relative expression of CaMKII. The results suggest that the antiarrhythmic effects of sevoflurane on the expression of Cx43 and CaMKII are related to fibroblasts.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  The variability of volatile organic compounds in the indoor air of clinical environments. (Pubmed Central) -  Mar 11, 2022   
    The presence of metabolites from the anaesthetic sevoflurane, and putative-disease biomarkers in room air, indicated that exhaled VOC were a source of background-pollution in clinical breath-testing activity. With the exception of solvents, and PPE waxes, exhaled VOC concentrations above 3 µg mare unlikely to arise from room air contamination, and in the absence of extensive survey-data, this level could be applied as a threshold for inclusion in studies, removing a potential environmental confounding-factor in developing breath-based diagnostics.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Expression Profiles of Immune Cells after Propofol or Sevoflurane Anesthesia for Colorectal Cancer Surgery: A Prospective Double-blind Randomized Trial. (Pubmed Central) -  Mar 11, 2022   
    With the exception of solvents, and PPE waxes, exhaled VOC concentrations above 3 µg mare unlikely to arise from room air contamination, and in the absence of extensive survey-data, this level could be applied as a threshold for inclusion in studies, removing a potential environmental confounding-factor in developing breath-based diagnostics. Propofol-based anesthesia was not superior to sevoflurane-based anesthesia in terms of alleviating suppression of immune cells including natural killer cells and T lymphocytes during colorectal cancer surgery.
  • ||||||||||  Tectin (tetrodotoxin) / WEX Pharma
    Preclinical, Journal:  Sevoflurane modulation of tetrodotoxin-resistant Na+ channels in small-sized dorsal root ganglion neurons of rats. (Pubmed Central) -  Mar 9, 2022   
    Collectively, SEV may upregulate miR-124-3p to inhibit TRAF3 expression, thereby reducing the ubiquitination and degradation of CREB, alleviating hepatic I/R injury. The present results suggest that the inhibition of persistent INa and the modulation of the voltage dependence and inactivation might be, at least in part, responsible for the analgesic effects elicited by sevoflurane.
  • ||||||||||  sevoflurane / Generic mfg.
    A Rare Case of Acute Toxic Leukoencephalopathy: Is Sevoflurane the Culprit? (Poster Hall) -  Mar 6, 2022 - Abstract #AAN2022AAN_2713;    
    We hypothesize that ATL resulted from an idiosyncratic reaction to Sevoflurane in the setting of a genetic predilection. Our case highlights what we believe to be an adverse reaction to a traditionally safe anesthetic.
  • ||||||||||  sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Journal:  The influence of anesthesia and surgery on fear extinction. (Pubmed Central) -  Mar 5, 2022   
    Finally, TNF-α and IL-6 levels in the ventromedial prefrontal cortex were not necessary for the dexmedetomidine treatment effect of surgery-induced fear extinction dysfunction. The study results showed that propofol and surgery selective impaired the cued fear extinction stage in adolescent mice, and dexmedetomidine may unleash a protective effect in preventing postoperative PTSD.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Review, Journal:  Heart Failure after Cardiac Surgery: The Role of Halogenated Agents, Myocardial Conditioning and Oxidative Stress. (Pubmed Central) -  Mar 5, 2022   
    The cardioprotective effects of halogenated agents are based on pre- and postconditioning (sevoflurane, desflurane, or isoflurane) compared to intravenous hypnotics (propofol). We tried to put light on the shadows walking through the line of the halogenated anesthetic drugs' effects in several enzymatic routes and oxidative stress, waiting for the final results of the ACDHUVV-16 clinical trial regarding the genetic modulation of this kind of drugs.
  • ||||||||||  ropivacaine / Generic mfg.
    Clinical, Journal:  Supraclavicular block with Mepivacaine vs Ropivacaine, their impact on postoperative pain: a prospective randomised study. (Pubmed Central) -  Mar 3, 2022   
    P=N/A
    We tried to put light on the shadows walking through the line of the halogenated anesthetic drugs' effects in several enzymatic routes and oxidative stress, waiting for the final results of the ACDHUVV-16 clinical trial regarding the genetic modulation of this kind of drugs. The potential benefit of longer duration of analgesia, associated to a long-acting local anaesthetic agent, during the early postoperative course must be put in perspective of potential worse pain progression following block resolution.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Testosterone: much more for the brain than a sex hormone. (Pubmed Central) -  Mar 3, 2022   
    The authors demonstrate that exogenous testosterone administered to immature mice pups around the time of sevoflurane exposure increased brain levels of testosterone, attenuated tau phosphorylation, inhibited glycogen synthase kinase-3β activation and its interaction/binding with tau, reversed sevoflurane-induced decreases in neuronal activation, and attenuated cognitive impairments. Their well-designed experiments suggest an important role that testosterone plays in balancing several important pathways crucial for neuronal protection and normal function of neuronal circuits in the male mammalian brain.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Trial completion date, Trial primary completion date:  A Study to Compare the Long-term Outcomes After Two Different Anaesthetics (clinicaltrials.gov) -  Mar 2, 2022   
    P3,  N=450, Recruiting, 
    No abstract available Trial completion date: Jun 2022 --> Dec 2025 | Trial primary completion date: Jun 2022 --> Dec 2022
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Neonatal exposure to sevoflurane impairs preference for social novelty in C57BL/6 female mice at early-adulthood. (Pubmed Central) -  Mar 1, 2022   
    Furthurmore, sevoflurane anesthesia could decrease the levels of PSD95 but not Neuroligin-1 in the hippocampus but not cortex of neonatal mice. In conclusion, sevoflurane anesthesia in neonatal period could disturb development of social memory and impair preference for social novelty in female mice at early-adulthood, with the potential mechanism of decreasing PSD95 expression in the hippocampus of C57BL/6 mice.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Potential Influence of Anesthetic Interventions on Breast Cancer Early Recurrence According to Estrogen Receptor Expression: A Sub-Study of a Randomized Trial. (Pubmed Central) -  Mar 1, 2022   
    P3
    As for ER-negative patients, the recurrence risk in the PPA (paravertebral blocks and propofol general anesthesia) group showed no statistical difference compared with the GA (sevoflurane and opioids general anesthesia) group (19.1% versus 23.4%; adjusted HR: 0.80, 95% CI: 0.50-1.30; P = 0.377)...In our study, the effects of early recurrence after breast cancer surgery in both ER-negative and ER-positive patients were similar between regional anesthesia-analgesia and general anesthesia. Large samples of ER-negative patients will be needed to clarify the effects of anesthetic interventions.
  • ||||||||||  sevoflurane / Generic mfg.
    Altered sleep behavior in a genetic mouse model of Alzheimer’s disease following anesthetic exposure (Concourse / Mezzanine) -  Feb 26, 2022 - Abstract #WSS2022WSS_1340;    
    Further, wildtype mice appeared to regain basal sleep/wake behavior, whereas transgenic mice showed a reduction in sleep quality and an alteration of sleep architecture after anesthesia. Spectral EEG-biomarkers, as found in our study, could potentially play a role in predicting cognitive decline after anesthesia.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Ethanol reduces the minimum alveolar concentration of sevoflurane in rats. (Pubmed Central) -  Feb 25, 2022   
    In the low dose ethanol group, the bootstrap estimate was 1.65 vol% (95% CI 1.40-1.98 vol%), and in the high dose ethanol group, it was 1.08 vol% (95% CI 0.73-1.42 vol%). We therefore report that intraperitoneal application of 1 g · kg or 2 g · kg ethanol both resulted in a significant reduction of the MAC of sevoflurane in adult Wistar rats: by 26.3% and 51.8% respectively as compared to placebo.