| memantine / Generic mfg. |
NCT00040261: Clinical Trial of Memantine for Major Depression |
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| Completed | 3 | 112 | US | Memantine HCL | National Institute of Mental Health (NIMH) | Depression | | 03/05 | | |
NCT00674219: Memantine Treatment for Obsessive-compulsive Disorder and Generalized Anxiety Disorder |
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| Completed | 3 | 17 | US | Memantine, Namenda | University of California, Los Angeles, Saban Family Foundation | Obsessive-Compulsive Disorder, Generalized Anxiety Disorder | 01/08 | 01/08 | | |
NCT00148616: Memantine for the Treatment of Cognitive Dysfunction and Negative Symptoms in Patients With Chronic Schizophrenia |
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| Terminated | 3 | 13 | Europe | Memantine, Akatinol, Placebos, Placebo | M. Schaefer, MD, Stanley Medical Research Institute | Chronic Schizophrenia | 06/08 | 12/08 | | |
NCT00148590: Memantine for the Prevention of Cognitive Dysfunction and Negative Symptoms in Patients With Acute Schizophrenia |
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| Terminated | 3 | 24 | Europe | Memantine, Akatinol, Placebo | M. Schaefer, MD, Stanley Medical Research Institute | Schizophrenia | 06/08 | 12/08 | | |
| Completed | 3 | 107 | Europe | Memantine-HCl | Merz Pharmaceuticals GmbH | Alzheimer's Disease | 12/08 | 12/08 | | |
| Completed | 3 | 487 | Europe | memantine, Axura | Merz Pharmaceuticals GmbH | Alzheimer's Disease | 11/09 | 11/09 | | |
NCT00857649: Efficacy and Safety of Memantine in Moderate to Severe Alzheimer's Disease |
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| Terminated | 3 | 369 | Canada | Memantine, Ebixa®, Placebo | H. Lundbeck A/S | Alzheimer's Disease | 04/10 | 09/10 | | |
NCT00411398: A 10 Week Open-Label Pilot Study to Evaluate the Effectiveness and Safety of Memantine(Namenda) as Augmentation Therapy in Patients With Generalized Anxiety Disorder |
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| Completed | 3 | 15 | US | Namenda/Memantine | State University of New York - Upstate Medical University | General Anxiety Disorder, Social Anxiety Disorder | 05/10 | 05/10 | | |
NCT00857233: Safety and Tolerability of Memantine in Moderate to Severe Alzheimer's Disease |
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| Terminated | 3 | 297 | Canada | Memantine, Ebixa® | H. Lundbeck A/S | Alzheimer's Disease | 07/10 | 10/10 | | |
NCT01074619: Study on Cognitive Disorders of Multiple Sclerosis |
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| Completed | 3 | 90 | Europe | Memantine, Placebo | University Hospital, Caen, Ministry of Health, France, H. Lundbeck A/S | Multiple Sclerosis | 03/11 | 11/11 | | |
NCT00594737: Open Label Pilot Study of the Effects of Memantine on FDG-PET in Frontotemporal Dementia |
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| Completed | 3 | 17 | Canada | memantine hydrochloride, Ebixa, Namenda | Tiffany Chow, MD, H. Lundbeck A/S | Frontotemporal Dementia | 06/12 | 06/12 | | |
2013-002055-15: CONTROLLED MULTICENTER STUDY ON THE MOOD-STABILIZING EFFECT OF MEMANTINE IN BIPOLAR I DISORDERS STUDIO MULTICENTRICO CONTROLLATO SULL'EFFETTO PROFILATTICO DELLA MEMANTINA NEL DISTURBO BIPOLARE DI TIPO I |
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| Ongoing | 3 | 106 | Europe | Coated tablet, EBIXA, LAMOTRIGINE DOC -GENERIC | UNIVERSITY OF SASSARI, UNIVERSITY OF SASSARI | BIPOLAR I MOOD DISORDERS DISTURBO DELL'UMORE DI TIPO I, MANIC-DEPRESSIVE ILLNESS MALATTIA MANIACO-DEPRESSIVA, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2004-004918-17: A 12-week, open label, multicentre study assessing the efficcay and of Donepezil in patients discontinuing treatment with Memantine monotherapy |
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| | 3 | 30 | Europe | Aricept (donepezil hydrochloride), E2020, Aricept, Aricept | Pfizer Inc., Pfizer Inc, Pfizer Limited, Pfizer, S.A. | Alzheimer\'s disease | | 07/06 | | |
2005-005859-18: EFFECT OF MEMANTINE TREATMENT ON BRAIN FUNCTION AND MORPHOLOGICAL STRUCTURE IN PATIENTS WITH MODERATE TO SEVERE PATIENTS WITH ALZHEIMER S DISEASE A STRUCTURAL MR AND FMRI STUDY |
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| Ongoing | 3 | 30 | Europe | EBIXA*56CPR RIV 10MG, EBIXA*56CPR RIV 10MG | FONDAZIONE SANTA LUCIA | Moderate to severe Alzheimer s disease | | | | |
2006-000860-10: An Open-Label Study Investigating the Specific Effects of Memantine in Institutionalised Patients with Alzheimer’s Disease |
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| | 3 | 40 | Europe | Ebixa, Lu 00-800, Ebixa 10 mg film-coated tablets, Ebixa 10 mg film-coated tablets | H. Lundbeck A/S | Effects of memantine treatment in institutionalised patients with Alzheimer\'s Disease. | | 09/06 | | |
| Completed | 3 | 90 | Europe | Memantine, Chlorhydrate de mémantine (Ebixa®), Vitamin D, Colecalciferol, Vitamin D placebo, Placebo | University Hospital, Angers | Alzheimer Disease | 01/16 | 01/16 | | |
NCT02001103: Memantine add-on for Cognitive and Negative Symptoms of Schizophrenia |
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| Unknown status | 3 | 120 | RoW | Memantine, Ebixa, Placebo | National Taiwan University Hospital | Schizophrenia | 07/16 | 12/17 | | |
NCT03039842: Combination of Dextromethorphan and Memantine in Treating Bipolar Disorder |
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| Unknown status | 3 | 300 | RoW | Dextromethorphan, 30mg dextromethorphan, Memantine, 5mg memantine+valproate, dextromethorphan+memantine, placebo+valproate | National Cheng-Kung University Hospital | Bipolar Disorder II | 12/16 | 12/17 | | |
| Unknown status | 3 | 60 | RoW | Memantine, add-on therapy | National Cheng-Kung University Hospital | AOD Effects and Consequences | 12/16 | 12/17 | | |
NCT02374567: Pharmacovigilance in Gerontopsychiatric Patients |
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| Terminated | 3 | 407 | Europe | Phenobarbital, Phenytoin, Carbamazepine, Oxcarbazepine, Valproic Acid, Lamotrigine, Topiramate, Gabapentin, Levetiracetam, Pregabalin, Lacosamide, Clonazepam, Biperiden, Levomepromazine, Fluphenazine, Perphenazine, Perazine, Thioridazine, Haloperidol, Melperone, Pipamperone, Bromperidol, Benperidol, Sertindole, Ziprasidone, Flupentixol, Chlorprothixene, Zuclopenthixol, Fluspirilene, Pimozide, Clozapine, Olanzapine, Quetiapine, Sulpiride, Tiapride, Amisulpride, Prothipendyl, Risperidone, Aripiprazole, Paliperidone, Diazepam, Oxazepam, Lorazepam, Bromazepam, Clobazam, Alprazolam, Hydroxyzine, Buspirone, Chloral Hydrate, Flurazepam, Nitrazepam, Triazolam, Lormetazepam, Temazepam, Midazolam, Brotizolam, Zopiclone, Zolpidem, Zaleplon, Melatonin, Clomethiazole, Diphenhydramine, Promethazine, Imipramine, Clomipramine, Opipramol, Trimipramine, Amitriptyline, Nortriptyline, Doxepin, Maprotiline, Amitriptyline oxide, Fluoxetine, Citalopram, Paroxetine, Sertraline, Fluvoxamine, Escitalopram, Tranylcypromine, Moclobemide, Mianserin, Trazodone, Mirtazapine, Bupropion, Venlafaxine, Reboxetine, Duloxetine, Agomelatine, Pyritinol, Piracetam, Donepezil, Rivastigmine, Galantamine, Memantine, Nicergoline, Acamprosate, Lithium | Hannover Medical School | Dementia, Depression, Schizophrenia, Psychosomatic Disorders, Anxiety Disorders | 06/17 | 06/17 | | |
| Terminated | 3 | 880 | Europe, Canada, US, RoW | Azeliragon, TTP488, Placebo | vTv Therapeutics | Alzheimer's Disease | 06/18 | 06/18 | | |
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NCT04698525: Comparative Study Between Valproate and Memantine in the Prophylactic Management of Episodic Migraine. |
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| Completed | 3 | 33 | RoW | Valproate Sodium, Diwali, Memantine, Ezagun | Universidad Autonoma de San Luis Potosí | Migraine Headache | 01/20 | 01/20 | | |
| Completed | 3 | 721 | Europe, RoW | Masitinib, AB1010, Placebo, Placebo Oral Tablet, Standard of care | AB Science | Alzheimer Disease | 12/20 | 12/20 | | |
2019-002778-30: Double-blind, randomised, multicenter study to evaluate the efficacy and safety of memantine in adolescents with Bipolar Disorder Studio multicentrico randomizzato in doppio cieco per valutare l'efficacia e la sicurezza della memantina negli adolescenti con Disturbo Bipolare |
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| Not yet recruiting | 3 | 68 | Europe | MEMANTINA ACCORD, [NA], Film-coated tablet, MEMANTINA ACCORD - 10 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PVC/PE/PVDC/ALLUMINIO) - 56 COMPRESSE | IRCCS, OSPEDALE PEDIATRICO BAMBINO GESÙ DI ROMA, Ministero della Salute | Bipolar Disorder Disturbo Bipolare, Bipolar Disorder in adolescents Disturbo bipolare negli adolescenti, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
NCT03858270: Inhibition of α-synuclein Cell-cell Transmission by NMDAR Blocker, Memantine |
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| Recruiting | 3 | 50 | US | Memantine, Namenda, Placebo | Wayne State University | Parkinson Disease | 04/22 | 07/23 | | |
| Completed | 3 | 130 | RoW | Akatinol Memantine 20 mg, Akatinol Memantine 10 mg | Merz Pharmaceuticals GmbH, LLC Merz Pharma, Russia | Vascular Dementia | 06/22 | 06/22 | | |
2021-002179-21: A phase 3 study to evaluate the safety and efficacy of masitinib as add-on therapy in patients with mild to moderate Alzheimer's disease treated with standard of care: cholinesterase inhibitors, memantine |
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| Not yet recruiting | 3 | 600 | Europe | Masitinib, AB1010, Film-coated tablet | AB Science, ABScience, AB Science, ABScience | Alzheimer's disease, Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT06337994: Memantine Hydrochloride for Treatment of Cognitive Dysfunction Due to Traumatic Brain Injury |
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| Recruiting | 3 | 100 | RoW | Memantine Hydrochloride | Assiut University | Treatment of Posttraumatic Cognitive Dysfunction | 06/24 | 12/24 | | |
NRG-BN009, NCT04588246: Testing the Addition of Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in People With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery |
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| Recruiting | 3 | 350 | US | Memantine, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Stereotactic Radiosurgery, Stereotactic External Beam Irradiation, stereotactic external-beam radiation therapy, Stereotactic Radiation Therapy, Stereotactic Radiotherapy, stereotaxic radiation therapy, stereotaxic radiosurgery, Whole-Brain Radiotherapy, WBRT, whole-brain radiation therapy | NRG Oncology, National Cancer Institute (NCI) | Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Digestive System Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma, Metastatic Renal Cell Carcinoma, Prognostic Stage IV Breast Cancer AJCC v8, Recurrent Brain Neoplasm, Stage IV Lung Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8 | 01/25 | 01/30 | | |
NCT00353665: Memantine for Disability in Amyotrophic Lateral Sclerosis (MEDALS) |
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| Completed | 2/3 | 63 | Europe | Memantine (Ebixa), Ebixa, riluzole, rilutek, Placebo | University of Lisbon, H. Lundbeck A/S | Amyotrophic Lateral Sclerosis | 06/08 | 01/09 | | |
NCT01876823: Memantine Plus Es-citalopram in Elderly Depressed Patients With Cognitive Impairment |
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| Completed | 2/3 | 60 | US | es-citalopram, Lexapro, Memantine, Namenda | New York State Psychiatric Institute | Mild Cognitive Impairment, Major Depressive Disorder, Alzheimer's Disease | 03/10 | 03/10 | | |
| Completed | 2/3 | 219 | RoW | Memantine, Placebo | National Cheng-Kung University Hospital, National Science Council, Taiwan | Bipolar Disorders | 10/12 | 10/12 | | |
NCT04035798: add-on Low Dose Memantine in Middle-to-old Aged Bipolar II Disorder Patients |
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| Recruiting | 2/3 | 120 | RoW | Memantine or placebo | National Cheng-Kung University Hospital, Ministry of Science and Technology, Taiwan | Bipolar II Disorder | 07/21 | 07/22 | | |
NCT04857983: Memantine Augmentation of Targeted Cognitive Training in Schizophrenia |
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| Recruiting | 2/3 | 69 | US | Memantine, targeted cognitive training (TCT), Placebo | University of California, San Diego | Schizophrenia, Schizoaffective Disorder | 09/24 | 12/24 | | |
NCT04687566: Dextromethorphan, Memantine Monotherapy, or Combined Use of Dextromethorphan and Memantine in Amphetamine Addiction |
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| Recruiting | 2/3 | 120 | RoW | Dextromethorphan, Memantine, Dextromethorphan and memantine, Placebo | National Cheng-Kung University Hospital, Ministry of Science and Technology, Taiwan | Amphetamine Addiction, Pharmacotherapy | 07/24 | 07/24 | | |
| Recruiting | 2/3 | 800 | Europe | Memantine Hydrochloride Oral Solution, Trazodone Hydrochloride oral solution, Placebo oral solution, Amantadine Hydrochloride Oral Solution | University of Edinburgh, University College, London, University of Warwick, NHS Lothian | Motor Neuron Disease, Amyotrophic Lateral Sclerosis | 09/26 | 12/26 | | |
