| memantine / Generic mfg. |
2005-004498-31: Behaviour and cognition in Alzheimer s disease patients treated with the NMDA receptor antagonist memantine collelation with the apoptotic mechanisms. |
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| Ongoing | 4 | 40 | Europe | EBIXA 10MG 56 CPR RIV, EBIXA 10MG 56 CPR RIV | FONDAZIONE SANTA LUCIA | Treatment of patients with Alzheimer s Disease | | | | |
2007-004897-26: Memantine for the Long Term Management of Neuropsychiatric Symptoms in Alzheimer\'s disease - MAIN-AD |
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| Ongoing | 4 | 300 | Europe | Memantine, Risperidone, Ebixa, Risperdal, Zyprexa, Seroquel, Haloperidol (proprietary), Ebixa, Risperdal, Zyprexa, Seroquel, Haloperidol (proprietary) | King\'s College London, North Essex Partnership NHS Foundation Trust | Alzheimer\'s disease | | | | |
NCT03954613: Evaluation of the Contribution of Regular Cognitive Exercises to Treatment in Patients With Alzheimer's Disease |
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| Recruiting | 4 | 198 | RoW | Ebicomb, Donepezil-Memantine | Neutec Ar-Ge San ve Tic A.Åž | Alzheimer Disease, Cognitive Change | 03/23 | 03/24 | | |
ChiCTR2000035209: Effects of Memantine on glutamate metabolism in patients with moderate to severe depression: a randomized controlled trial. |
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| Not yet recruiting | 4 | 60 | | combination therapy ;Anti-5-ht antidepressant should be administered alone | The Second Affiliated Hospital of Xinxiang Medical University; The Second Affiliated Hospital of Xinxiang Medica University, Henan Provincial Clinical Research Center for Mental and Psychological Diseases opens the project | depression | | | | |
NCT03703856: Biomarker Predictors of Memantine Sensitivity in Patients With Alzheimer's Disease |
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| Recruiting | 4 | 32 | US | Memantine, Placebo | University of California, San Diego | Alzheimer Disease | 06/24 | 06/24 | | |
NCT05430867: Efficacy and Safety of Memantine and Sodium Oligomannate in Patients With Moderate to Severe Alzheimer's Disease |
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| Not yet recruiting | 4 | 150 | NA | Memantine Oral Tablet, Memantine, GV-971 capsule, GV-971 | First Affiliated Hospital Xi'an Jiaotong University | Treatment, Efficacy, Safety, Alzheimer Disease | 07/24 | 12/24 | | |
ChiCTR2300071719: Evaluation of the efficacy and safety of Memantine hydrochloride oral membranes in the treatment of moderate-to-severe and severe senile dementia patients in real-world settings: a multicenter registry study |
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| Not yet recruiting | 4 | 2000 | | N/A | The Second Hospital, Cheeloo College of Medicine, Shandong University; The Second Hospital, Cheeloo College of Medicine, Shandong University, enterprise | Senile dementia | | | | |
2013-002055-15: CONTROLLED MULTICENTER STUDY ON THE MOOD-STABILIZING EFFECT OF MEMANTINE IN BIPOLAR I DISORDERS STUDIO MULTICENTRICO CONTROLLATO SULL'EFFETTO PROFILATTICO DELLA MEMANTINA NEL DISTURBO BIPOLARE DI TIPO I |
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| Ongoing | 3 | 106 | Europe | Coated tablet, EBIXA, LAMOTRIGINE DOC -GENERIC | UNIVERSITY OF SASSARI, UNIVERSITY OF SASSARI | BIPOLAR I MOOD DISORDERS DISTURBO DELL'UMORE DI TIPO I, MANIC-DEPRESSIVE ILLNESS MALATTIA MANIACO-DEPRESSIVA, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2005-005859-18: EFFECT OF MEMANTINE TREATMENT ON BRAIN FUNCTION AND MORPHOLOGICAL STRUCTURE IN PATIENTS WITH MODERATE TO SEVERE PATIENTS WITH ALZHEIMER S DISEASE A STRUCTURAL MR AND FMRI STUDY |
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| Ongoing | 3 | 30 | Europe | EBIXA*56CPR RIV 10MG, EBIXA*56CPR RIV 10MG | FONDAZIONE SANTA LUCIA | Moderate to severe Alzheimer s disease | | | | |
2006-000860-10: An Open-Label Study Investigating the Specific Effects of Memantine in Institutionalised Patients with Alzheimer’s Disease |
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| | 3 | 40 | Europe | Ebixa, Lu 00-800, Ebixa 10 mg film-coated tablets, Ebixa 10 mg film-coated tablets | H. Lundbeck A/S | Effects of memantine treatment in institutionalised patients with Alzheimer\'s Disease. | | 09/06 | | |
2019-002778-30: Double-blind, randomised, multicenter study to evaluate the efficacy and safety of memantine in adolescents with Bipolar Disorder Studio multicentrico randomizzato in doppio cieco per valutare l'efficacia e la sicurezza della memantina negli adolescenti con Disturbo Bipolare |
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| Not yet recruiting | 3 | 68 | Europe | MEMANTINA ACCORD, [NA], Film-coated tablet, MEMANTINA ACCORD - 10 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PVC/PE/PVDC/ALLUMINIO) - 56 COMPRESSE | IRCCS, OSPEDALE PEDIATRICO BAMBINO GESÙ DI ROMA, Ministero della Salute | Bipolar Disorder Disturbo Bipolare, Bipolar Disorder in adolescents Disturbo bipolare negli adolescenti, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
NCT03858270: Inhibition of α-synuclein Cell-cell Transmission by NMDAR Blocker, Memantine |
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| Recruiting | 3 | 50 | US | Memantine, Namenda, Placebo | Wayne State University | Parkinson Disease | 04/22 | 07/23 | | |
2021-002179-21: A phase 3 study to evaluate the safety and efficacy of masitinib as add-on therapy in patients with mild to moderate Alzheimer's disease treated with standard of care: cholinesterase inhibitors, memantine |
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| Not yet recruiting | 3 | 600 | Europe | Masitinib, AB1010, Film-coated tablet | AB Science, ABScience, AB Science, ABScience | Alzheimer's disease, Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT06337994: Memantine Hydrochloride for Treatment of Cognitive Dysfunction Due to Traumatic Brain Injury |
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| Recruiting | 3 | 100 | RoW | Memantine Hydrochloride | Assiut University | Treatment of Posttraumatic Cognitive Dysfunction | 06/24 | 12/24 | | |
NRG-BN009, NCT04588246: Testing the Addition of Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in People With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery |
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| Recruiting | 3 | 350 | US | Memantine, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Stereotactic Radiosurgery, Stereotactic External Beam Irradiation, stereotactic external-beam radiation therapy, Stereotactic Radiation Therapy, Stereotactic Radiotherapy, stereotaxic radiation therapy, stereotaxic radiosurgery, Whole-Brain Radiotherapy, WBRT, whole-brain radiation therapy | NRG Oncology, National Cancer Institute (NCI) | Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Digestive System Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma, Metastatic Renal Cell Carcinoma, Prognostic Stage IV Breast Cancer AJCC v8, Recurrent Brain Neoplasm, Stage IV Lung Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8 | 01/25 | 01/30 | | |
NCT04035798: add-on Low Dose Memantine in Middle-to-old Aged Bipolar II Disorder Patients |
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| Recruiting | 2/3 | 120 | RoW | Memantine or placebo | National Cheng-Kung University Hospital, Ministry of Science and Technology, Taiwan | Bipolar II Disorder | 07/21 | 07/22 | | |
NCT04857983: Memantine Augmentation of Targeted Cognitive Training in Schizophrenia |
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| Recruiting | 2/3 | 69 | US | Memantine, targeted cognitive training (TCT), Placebo | University of California, San Diego | Schizophrenia, Schizoaffective Disorder | 09/24 | 12/24 | | |
NCT04687566: Dextromethorphan, Memantine Monotherapy, or Combined Use of Dextromethorphan and Memantine in Amphetamine Addiction |
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| Recruiting | 2/3 | 120 | RoW | Dextromethorphan, Memantine, Dextromethorphan and memantine, Placebo | National Cheng-Kung University Hospital, Ministry of Science and Technology, Taiwan | Amphetamine Addiction, Pharmacotherapy | 07/24 | 07/24 | | |
| Recruiting | 2/3 | 800 | Europe | Memantine Hydrochloride Oral Solution, Trazodone Hydrochloride oral solution, Placebo oral solution, Amantadine Hydrochloride Oral Solution | University of Edinburgh, University College, London, University of Warwick, NHS Lothian | Motor Neuron Disease, Amyotrophic Lateral Sclerosis | 09/26 | 12/26 | | |
ACTRN12614000619640: The effect of Memantine on cognition disorders induced by Electroconvulsive therapy (ECT) |
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| Recruiting | 2 | 40 | | | Mohammad Abbasinazari, Shahid Beheshti University of Medical Sciences | Post ECT cognition disorders | | | | |
2005-004109-27: A double-blind, placebo-controlled multi-centre trial of memantine in patients with Parkinsons’ disease dementia or dementia with Lewy bodies |
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| Ongoing | 2 | 20 | Europe | Ebixa, Ebixa, Ebixa | Neuropsychiatric clinic | Parkinsons disease (PD)and dementia with Lewy bodies (DLB) are both common disease of the elderly. The majority of patients who survive for more than 10 years with PD eventually develope dementia (PDD). The brain changes and clinical presentations of PDD and DLB are similar. The clinical characteristics are cognitive impairment with pronounced visuospatial and executive impairment, visual hallucinations, parkinsonism, fluctuations in cognition and REM sleep disorder. | | | | |
2007-000503-15: Experimental clinical open study, randomized, experimental group vs control group, for the evaluation of tolerability and the effects on magnetic resonance parameters and cognitive functions of memantine in patients at early stage of relapsing- remitting multiple sclerosis treated with interferon-beta. |
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| Ongoing | 2 | 120 | Europe | EBIXA, EBIXA | AZ. OSPEDALIERA GARIBALDI, S.LUIGI CURRO , ASCOLI TOMASELLI | patients at early stage of relapsing- remitting multiple sclerosis treated with interferon-beta. | | | | |
2007-002117-39: MEMANTINA (Ebixa X) PARA LA DISCAPACIDAD FUNCIONAL EN LA ESCLEROSIS LATERAL AMIOTRÓFICAMEMANTINE (Ebixa R) FOR FUNCTIONAL DISABILITY IN AMYOTROPHIC LATERAL SCLEROSIS . |
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| Ongoing | 2 | 80 | Europe | EBIXA, EBIXA | Jorge Matias-Guiu Guia | Esclerosis Lateral AmiotroficaAmyotrophic lateral Sclerosis | | | | |
2017-004125-32: A randomised, double blind, placebo controlled trial to evaluate the safety, efficacy and pharmakokinetics of Pleconaril as an add on to AchEI/memantine for treatment of patients with Alzheimer’s disease |
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| Ongoing | 2 | 120 | Europe | pleconaril, Capsule, hard | Apodemus Aktiebolag, Apodemus AB | Alzheimer's disease, Alzheimer's disease, Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT04538066: Bryostatin Treatment of Moderately Severe Alzheimer's Disease |
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| Completed | 2 | 117 | US | Bryostatin 1, Placebo | Neurotrope Bioscience, Inc., National Institutes of Health (NIH), National Institute on Aging (NIA) | Alzheimer Disease | 11/22 | 11/22 | | |
NCT05538507: Efficacy of Chinese Traditional Medicine "Smart Soup" in Cognition and Behavior Regulation in Alzheimer's Disease |
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| Recruiting | 2 | 180 | RoW | smart soup, traditional chinese medicine, Donepezil, donepezil pill, Memantine, Memantine Pill, Placebo | Peking Union Medical College Hospital, Tongji University | Alzheimer Disease, Mild Cognitive Impairment | 06/24 | 06/24 | | |
NCT05063851: The Use of Memantine for Prevention of Alzheimer's Disease |
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| Recruiting | 2 | 32 | US | Memantine Hydrochloride Tablets, Placebo | University of Virginia | Alzheimer Disease | 12/25 | 12/25 | | |
AMEND, NCT04789915: Add-on MEmaNtine to Dopamine Modulation to Improve Negative Symptoms at First Psychosis |
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| Recruiting | 1 | 46 | Europe | Memantine, Placebo | Bjorn H. Ebdrup, Lundbeck Foundation, Danish Research Centre for Magnetic Resonance, University of Copenhagen | Psychosis, Negative Symptoms With Primary Psychotic Disorder | 05/25 | 12/26 | | |
TASD, NCT04966546: Targeting Spreading Depolarization After Chronic Subdural Hematoma Surgery |
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| Withdrawn | 1 | 20 | US | Memantine Hydrochloride, Placebo | University of New Mexico | Chronic Subdural Hematoma | 12/25 | 12/25 | | |
ChiCTR-IPR-16008425: Efficacy of quetiapine in behavioral and psychological symptoms of Alzheimer's disease patients |
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| Not yet recruiting | N/A | 120 | | Quetiapine ;Memantine | Changning Mental Health Center; Changning Mental Health Center, Key program of the Changning Science and Technology Committee | Alzheimer's disease | | | | |
NCT05531383: Effect of Early Memantine Administration on Outcome of Patients With Moderate to Severe Traumatic Brain Injury |
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| Active, not recruiting | N/A | 70 | RoW | Memantine Hydrochloride, Namenda | Minia University | Traumatic Brain Injury | 11/23 | 07/24 | | |
| Recruiting | N/A | 60 | RoW | AChE inhibitor monotherapy, Donepezil, AChE inhibitor and NMDA receptor antagonist combination therapy, Donepezil and Memantine combination therapy | University of the Philippines | Alzheimer Disease | 12/23 | 02/25 | | |
FOCI, ChiCTR2200062493: A real-world study of factors related to disease outcome in patients with various types of subjective cognitive impairment, mild cognitive impairment, and dementia |
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| Not yet recruiting | N/A | 500 | | Donepezil ;Memantine ;Sodium oligomannate ;Other medicine | The First Affiliated Hospital of Kunming Medical University; The First Affiliated Hospital of Kunming Medical University, Science and Technology Innovation Team Construction Project of Kunming Medical University (Project No. CXTD202104) | Subjective cognitive impairment, mild cognitive impairment, and dementia | | | | |
