Not yet recruiting

4

60

 

South West Sydney Local Health District, South West Sydney Local Health District

Rapid sequence intubation

 

 

Recruiting

4

330

 

Dr. Adrianne Boonstra, The University of Adelaide

Pain (with a pain severity score rated at greater than or equal to seven out of ten) arising from any cause

 

 

Ongoing

4

360

Europe

Precedex, Rapifen, Dolsin, FENTANYL-JANSSEN, Injection*, Precedex, Rapifen, Dolsin, Fentanyl

Fakultní nemocnice Královské Vinohrady

Praeanaesthetic preparation (premedication) for patients scheduled for laparoscopic cholecystectomy

 

 

Ongoing

4

166

Europe

Alfentanil hydrochlorid, esketamine, no, n.a., Infusion, Rapifen, Ketanest S

AMC, AMC

Patients undergoing ERCPs under propofol sedation combined with ketamine or alfentanil given by trained anesthesia nurse. Patiënten die een ERCPs onder propofol sedatie in combinatie met ketamine of alfentanil moeten ondergaan gegeven door getrainde anesthesie verpleegkundige., Patients with an disease of the liver or bile ducts which is treated by means of endoscopic instruments. During this therapy patients will be sedated by trained anesthesia nurses. Patiënten met een ziekte van lever- of galwegen die door middel van endoscopie wordt behandeld. Tijdens deze therapie worden de patiënten door getrainde anesthesie verpleegkundigen gesedeerd., Diseases [C] - Digestive System Diseases [C06]

 

 

Ongoing

4

18

Europe

Dopram, Rapifen®, Doxapram, Alfentanil, Doxapram, Alfentanil

Leids Universitair Medisch Centrum (LUMC), Galleon Pharmaceuticals

acute respiratory insufficiency, including such conditions as opioid and anesthetic-induced respiratory depression, post-anesthetic atelectasis, and central apneas (e.g., apnea of prematurity).

 

 

Not yet recruiting

4

420

Europe

Solution for injection/infusion, Fentanyl, Rapifen

Cancer Registry of Norway, Ministry of Health and Care Services

Many women are experiencing pain under colonoscopy. The present study aims to reduce pain in women undergoing colonoscopy in a bowel cancer screening program in Norway., The present study aims to reduce pain in women undergoing visual examination og the large intestine in a bowel cancer screening program., Body processes [G] - Digestive System and Oral Physiological Phenomena [G10]

 

 

Not yet recruiting

4

60

 

alfentanil will used to inhibit the response of the double-lumen endotracheal intubation

Taizhou Hospital of Zhejiang Province; Taizhou Hospital of Zhejiang Province, Self-funded

Cardiovascular response to double lumen endotracheal intubation

 

 

Recruiting

4

100

 

remimazolam benzenesulfonate ;propofol

The First Affiliated Hospital of Zhengzhou University; The First Affiliated Hospital of Zhengzhou University, self-raised

pain

 

 

Recruiting

4

2000

 

Intravenous remazolam ;Intravenous alfentanil

The First Affiliated Hospital of Zhengzhou University; The First Affiliated Hospital of Zhengzhou University, Self-raised

Postoperative central nervous system dysfunction

 

 

Recruiting

4

90

 

Low-dose alfentanil ;medium-dose alfentanil ;high-dose Alfentanil

The Second Affiliated Hospital of Wenzhou Medical University/ Yuying Children's Hospital; The Second Affiliated Hospital of Wenzhou Medical University/ Yuying Children's Hospital, the Special Project for Significant New Drug Research and Development in the Major National Science and Technology Projects of China

Tonsillar and adenoidal hypertrophy

 

 

Recruiting

4

212

 

2mg/kg propofol ;10ug/kg alfentanil ;

Department of Anesthesiology, The Second Affiliated Hospital of Chongqing Medical University; The Second Affiliated Hospital of Chongqing Medical University, Optional subjects

Outpatient anesthesia

 

 

Recruiting

4

50

RoW

Remimazolam

Tianjin Nankai Hospital

Anesthesia

12/21

12/21

Completed

4

134

 

Anesthesia induction: alfentanil 8ug/kg+ propofol 1.5mg/kg; Maintenance of anesthesia: continuous infusion of propofol 4-12mg/kg/h+alfentanil 0.25ug/kg/min.; Anesthesia induction: remifentanil 0.4ug/kg+ propofol 1.5 mg/kg; Maintenance of anesthesia: continuous infusion of propofol 4-12mg/kg/h+remifentanil 0.05ug/kg/min.

The First Affiliated Hospital of Nanhua University; The First Affiliated Hospital of Nanhua University, General Project of Hunan Natural Science Foundation（2020JJ4545）

Respiratory depression

 

 

Not yet recruiting

4

70

 

Propofol induction ;Remazolam induction

The First Affiliated Hospital of Zhengzhou University; The First Affiliated Hospital of Zhengzhou University, Research funds provided by the department

intracranial aneurysm

 

 

Not yet recruiting

4

520

 

2.5μg/kg alfentanil combined with 2mg/ml propofol ;5.0μg/kg alfentanil combined with 2mg/ml propofol ;7.5μg/kg alfentanil combined with 2mg/ml propofol ;10.0μg/kg alfentanil combined with 2mg/ml propofol

The Second Hospital of Jiaxing; The Second Hospital of Jiaxing, Self-funded

Painless Colonoscopy

 

 

Recruiting

4

100

 

Remimazolm tosilate ;Medium and long chain propofol

Weifang People's Hospital; Weifang People's Hospital, Self-funded

N/A

 

 

Ongoing

4

340

Europe

Propofol, Alfentanil, Propofol, Alfentanil, Emulsion for injection/infusion, Injection/infusion

Region Jönköping, Sweden, Region Östergötland, Sweden, Futurum, Region Jönköpings Län

Patients ≥18 years with cancer in need of subcutaneous venous port will be offered to participate in the trial. The aim of the trial is to determine if patient-controlled sedation (PCS) with propofol and alfentanil reduces pain perception during implantation of subcutaneous venous port (SVP) in cancer patients., Patients ≥18 years with cancer in need of subcutaneous venous port will be offered to participate in the trial., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]

 

 

Not yet recruiting

4

270

 

Low dose Remazolam ;Medium dose Remazolam ;High dose Remazolam ;Low dose Alfentanil ;Medium dose Alfentanil ;High dose Alfentanil ;Low dose Esmketamine ;Medium dose Esmketamine ;High dose Esmketamine

He'nan Provincial People's Hospital; He'nan Provincial People's Hospital, Self-raised

Obesity

 

 

Recruiting

4

390

 

Alfentanil 7 μg/kg was injected intravenously during the induction period, and propofol 2 mg/kg was injected intravenously later; if the patient has physical movement or obvious swallowing movements during the operation, add propofol 0.5 mg/kg ;Alfentanil 7 μg/kg was injected intravenously during the induction period, and remazolam besylate 0.2 mg/kg was injected intravenously later; if the patient has physical movement or obvious swallowing movements during the operation, add benzenesulfonic acid Remazolam 2.5 mg ;Sufentanil 0.1 μg/kg was injected intravenously during the induction period, and remazolam besylate 0.2 mg/kg was injected intravenously later; if the patient exhibits physical movement or obvious swallowing movements during the operation, add benzenesulfonic acid Remazolam 2.5 mg

Xiang'an Hospital of Xiamen University; Xiang'an Hospital of Xiamen University, Yichang Humanwell Pharmaceutical Co., Ltd.

Gastroscope, colonoscopy

 

 

Recruiting

4

360

 

Alfentanil 7μg/kg intravenously, followed by a slow injection of propofol 1.5mg/kg ;Alfentanil 7μg/kg was injected intravenously during the induction period, followed by intravenous injection of remimazolam 0.1 mg/kg ;Alfentanil 7μg/kg was injected intravenously during the induction period, followed by intravenous injection of remimazolam 0.2 mg/kg ;Alfentanil 7μg/kg was injected intravenously during the induction period, followed by intravenous injection of remimazolam 0.3 mg/kg

The Affiliated Hospital of Xuzhou Medical University; The Affiliated Hospital of Xuzhou Medical University, Yichang Humanwell Pharmaceutical Co., Ltd.

N/A

 

 

Not yet recruiting

4

90

 

Male only ;Female only ;Gender is not limited

The Second Hospital of Jiaxing; The Second Hospital of Jiaxing, Self-financing

Painless Gastroscopy

 

 

Not yet recruiting

4

208

 

Induction: Alfentanil 7μg/kg, Remazolam 0.2mg/kg; Maintenance: Remazolam 1mg/kg ;Induction: Alfentanil 7μg/kg, Propofol 1.5mg/kg; Maintenance: Propofol 6-8mg/kg

Xijing Hospital Fourth Military Medical University; Xijing Hospital, Self-financing

Female patients undergoing cervical conization

 

 

Not yet recruiting

4

128

 

The optimal dose of alfentanil was determined for continuous pumping ;Continuous pumping of the same volume of normal saline

Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Self-raised

Burns

 

 

Recruiting

4

90

 

Fentanyl + Propofol ;Alfentanil 5ug/kg + Propofol ;Alfentanil 10ug/kg + Propofol

The First Affiliated Hospital of Gannan Medical University; The First Affiliated Hospital of Gannan Medical University, Self-funded

Endometrial polyps

 

 

Recruiting

4

160

 

saline ;The initial dose of alfentanil was 4 μ g / kg, the additional maintenance dose was 4 μ g / kg, and the additional dose was 4 μ g / kg 10 minutes before the end of the operation ;Infusion of alfentanil at a rate of 0.2μg/kg/min intravenously during the surgery ;Infusion of alfentanil at a rate of 0.4μg/kg/min intravenously during the surgery

Stomatological Hospital Affiliated to Chongqing Medical University; Stomatological Hospital Affiliated to Chongqing Medical University, Stomatology Hospital of Chongqing Medical University

Pediatric oral disease, general anesthesia, emergence agitation

 

 

Not yet recruiting

4

30

 

Alfentanil 10μg/kg+propofol 2mg/kg ;Alfentanil 10μg/kg+remimazolam 0.15mg/kg

Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology; Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Raise independently

Colonic polyps

 

 

Recruiting

4

200

 

Alfentanil 10ug/kg+Rimazolam 0.2mg/kg ;Alfentanil 10ug/kg+Propofol 1.5mg/kg

Department of Anesthesiology, Wuhan No.1 Hospital; Wuhan NO.1 Hospital, Wuhan Municipal Health Commission

lung disease

 

 

Not yet recruiting

4

80

 

Nalbuphine ;Alfentanil

Second Hospital of Hebei Medical University; Second Hospital of Hebei Medical University, Self-financing

ERCP

 

 

Not yet recruiting

4

40

 

Propofol combined with alfentanil

The Seventh Affiliated Hospital of Southern Medical University; The Seventh Affiliated Hospital of Southern Medical University, Self-funded

Gastritis

 

 

Not yet recruiting

4

270

 

Ciprofol intravenous injection ;Remimazolam intravenous injection ;Propofol intravenous injection

Department of Anesthesia Surgery, Gansu Provincial People's Hospital; Gansu Provincial Hospital, National Natural Science Foundation of China

Obstetrics & Gynecology

 

 

Not yet recruiting

4

45

 

Alfentanil is used for epidural labor analgesia

General Hospital of the Northern Theater Command of the Chinese People's Liberation Army; General Hospital of the Northern Theater Command of the Chinese People's Liberation Army, General Hospital of the Northern Theater Command of the Chinese People's Liberation Army

Epidural labor analgesia

 

 

Not yet recruiting

4

390

 

0.1mg/kg remimazolam toislate ; 0.2mg/kg remimazolam toislate ;0.25mg/kg remimazolam toislate

The Second Hospital of Jiaxing; The Second Hospital of Jiaxing, Self-financing

Painless Colonoscopy

 

 

Not yet recruiting

4

80

 

Anesthesia with alfentanil, Remimazolam and propofol ;Anesthesia with fentanyl and propofol

The First Affiliated Hospital of Guangxi Medical University; The First Affiliated Hospital of Guangxi Medical University, Self-funded

Proper use of anesthetics

 

 

Not yet recruiting

4

264

 

Low dose alfentainil ;High dose alfentainil ;sufenainil

The First Affiliated Hospital of Nanchang University; The First Affiliated Hospital of Nanchang University, Self-raised

Cardiovascular operation

 

 

Recruiting

4

300

 

Induction with 1.5mg/kg propofol ;1.5mg/kg propofol + 2ug / kg alfentanil ;1.5mg/kg propofol + 3ug / kg alfentanil ;1.5mg/kg propofol + 4ug / kg alfentanil

Liaoning Provincial People's Hospital; Liaoning Provincial People's Hospital, None

Gastrointestinal dysfunction

 

 

Not yet recruiting

4

100

 

Alfentanil 7 μg/kg, propofol 2 mg/kg ;Alfentanil 7 μg/kg, remazolam besylate 0.2 mg/kg ;Sufentanil 0.1 μg/kg, remazolam besylate 0.2 mg/kg

People’s Hospital of Lishui; People’s Hospital of Lishui, Yichang Renfu Pharmaceutical Co., LTD

Painless gastroenteroscopy

 

 

Recruiting

4

164

 

Remimazolam Tosilate for Injection sedation; Propofol sedation

The First Hospital of Lanzhou University; The First Hospital of Lanzhou University/The First Clinical Medical College of Lanzhou University, Research funding for researchers

gastrointestinal endoscopy

 

 

Not yet recruiting

4

300

 

ciprofol+alfentanil 7μg/kg ;propofol+alfentanil 7μg/kg ;1.3 times the median effective dose of ciprofol + alfentanil 7μg/kg ;1.3 times the median effective dose of propofol + alfentanil 7μg/kg

The Second Affiliated Hospital of Hainan Medical University; The Second Affiliated Hospital of Hainan Medical University, have no

painless digestive endoscopy

 

 

Recruiting

4

360

 

No drug was given before induction of anesthesia, and 5ug/kg of alfentanil was slowly injected during induction of anesthesia, followed by a slow injection of the corresponding dose of cyclopentol, and MOSS/A score was performed immediately after all anesthetic drugs were injected; No drug was given before induction of anesthesia, and 5ug/kg of alfentanil was slowly injected during induction of anesthesia, followed by a slow injection of the corresponding dose of cyclopentol, and MOSS/A score was performed immediately after all anesthetic drugs were injected; No drug was given before induction of anesthesia, and 5ug/kg of alfentanil was slowly injected during induction of anesthesia, followed by a slow injection of the corresponding dose of cyclopentol, and MOSS/A score was performed immediately after all anesthetic drugs were injected; No drug was given before induction of anesthesia, and 5ug/kg of alfentanil was slowly injected during induction of anesthesia, followed by a slow injection of the corresponding dose of cyclopentol, and MOSS/A score was performed immediately after all anesthetic drugs were injected

The First Affiliated Hospital of Zhengzhou University; The First Affiliated Hospital of Zhengzhou University, Self-financing

Gastrointestinal Diseases

 

 

Not yet recruiting

4

90

 

Ropivacaine intra-articular injection ;Alfentanyl plus ropivacaine intra-articular injection ;Estramide plus ropivacaine intra-articular injection

The Central Hospital of Enshi Tujia and Miao Autonomous Prefesture; The Central Hospital of Enshi Tujia and Miao Autonomous Prefesture, National Natural Science Foundation of China

Disease of skeletal motor system

 

 

Not yet recruiting

4

300

 

Ciprofol sedation; Propofol sedation

The First Hospital of Lanzhou University; The First Hospital of Lanzhou University/The First Clinical Medical College of Lanzhou University, Research funding for researchers

hysteroscopic surgery

 

 

Recruiting

4

60

 

Desflurane ;sevoflurane

Fushun Mining Bureau General Hospital of Liaoning Health Industry Group; Fushun Mining Bureau General Hospital of Liaoning Health Industry Group, Fushun Mining Bureau General Hospital of Liaoning Health Industry Group

Peripheral functional tumor

 

 

Not yet recruiting

4

120

 

The biased coin design (BCD) were used,the initial dose of ciprofol was set to 0.2 mg/kg and the dose gradient was 0.04 mg/kg. When movement, choking, swallowing and other reactions, sedation was ineffective (positive). Otherwise, sedation was effective (negative). If sedation is effective, the next patient is 0.95 probability at receiving the same dose and 0.05 probability at lowering a dose gradient. If sedation was not effective, the next patient dose was increased by 0.04 mg/kg. If the Modified Observer's Assessment of Alertness/Sedation Scale(MOAA/S scale) is still> 1 point 3 min after injection of ciprofol, sedation is directly judged to be ineffective. And so on, until 40 cases are completed.; The biased coin design (BCD) were used,the initial dose of ciprofol was set to 0.2 mg/kg and the dose gradient was 0.04 mg/kg. When movement, choking, swallowing and other reactions, sedation was ineffective (positive). Otherwise, sedation was effective (negative). If sedation is effective, the next patient is 0.95 probability at receiving the same dose and 0.05 probability at lowering a dose gradient. If sedation was not effective, the next patient dose was increased by 0.04 mg/kg. If the Modified Observer's Assessment of Alertness/Sedation Scale(MOAA/S scale) is still> 1 point 3 min after injection of ciprofol, sedation is directly judged to be ineffective. And so on, until 40 cases are completed.; The biased coin design (BCD) were used,the initial dose of ciprofol was set to 0.2 mg/kg and the dose gradient was 0.04 mg/kg. When movement, choking, swallowing and other reactions, sedation was ineffective (positive). Otherwise, sedation was effective (negative). If sedation is effective, the next patient is 0.95 probability at receiving the same dose and 0.05 probability at lowering a dose gradient. If sedation was not effective, the next patient dose was increased by 0.04 mg/kg. If the Modified Observer's Assessment of Alertness/Sedation Scale(MOAA/S scale) is still> 1 point 3 min after injection of ciprofol, sedation is directly judged to be ineffective. And so on, until 40 cases are completed.

Baoding NO.1 Central Hospital; Baoding NO.1 Central Hospital, None

painless gastroscopy

 

 

Not yet recruiting

4

442

 

0.075% ropivacaine + 0.2 μg/ml Sufentanil was administered ;0.075% ropivacaine + 4 μg/ml alfentanil

The General Hospital of the PLA Northern Theater Command; The General Hospital of the PLA Northern Theater Command, NO

Epidural labor analgesia

 

 

Not yet recruiting

4

30

 

Alfentanil combined with cyclobenzaprine

Hangzhou Red Cross Hospital; Hangzhou Red Cross Hospital, Self-financing

Body movement during dilatation

 

 

Not yet recruiting

4

66

 

Alfentanil was first injected with a micropump for 10 μg/kg, and the first dose of remazolam was 0.2mg/kg by micropump injection after 30 seconds. The target depth of sedation was set as MOAA/S score ≤ 1 point. If the patient still has a MOAA/S score > 1 or cannot tolerate the examination operation after waiting for 2min, the remedial dose of rimazole is 0.05mg / kg. After each remedial sedation, the patient should wait for 1min, and the examination can be carried out after reaching the sedation requirements.; Alfentanil was first injected with a micropump for 10 μg/kg, and the first dose of propofol was 1.5mg/kg by micropump injection after 30 seconds. The target depth of sedation was set as MOAA/S score ≤ 1. If the patient still has a MOAA/S score > 1 or cannot tolerate the examination operation after waiting for 2min, the rescue dose of propofol is 0.5mg / kg. After each rescue sedation, the patient should wait for 1min, and the examination can be carried out after reaching the sedation requirements.

Lishui People's Hospital; Lishui People's Hospital, none

elderly patients undergoing fiberoptic bronchoscopy

 

 

Not yet recruiting

4

40

 

Targeted control infusion of 0 ng/ml alfentanil; Targeted control infusion of 15ng/ml alfentanil; Targeted control infusion of 30 ng/ml alfentanil; Targeted control infusion of 45 ng/ml alfentanil; Targeted control infusion of 60 ng/ml alfentanil; Targeted control infusion of 75 ng/ml alfentanil; Targeted control infusion of 90 ng/ml alfentanil; Targeted control infusion of 105 ng/ml alfentanil

Shanxi Bethune Hospital; Shanxi Bethune Hospital, Self-financing funds

Painless Ovulation retrieval

 

 

Not yet recruiting

4

176

 

Remazolam ;Ciprofol

Liaoning Provincial People's Hospital; Liaoning Provincial People's Hospital, None

Colonoscopy

 

 

Not yet recruiting

4

160

 

Remimazolam besylate 0.1 mg/kg and alfentanil 5 ug/kg, when movement occurs, add Remimazolam 0.05 mg/kg and alfentanil 2.5 ug/kg ;1% lidocaine 10 ml, and an equal volume of normal saline

Hangzhou Plastic Surgery Hospital; Hangzhou Plastic Surgery Hospital, Yichang Humanwell Pharmaceutical Co., Ltd.

eye surgery

 

 

Recruiting

4

210

 

alfentanil analgesia; fentanyl PCA analgesia

The Second Affiliated Hospital of Hainan Medical University; Interventional Radiology and Vascular Surgery, The Second Affiliated Hospital, Hainan Medical University, funds raised by oneself

Portal hypertension; transjugular intrahepatic portosystemic shunt，TIPS