Alfenta (alfentanil) / Abbott 
Welcome,         Profile    Billing    Logout  
  Diseases    Trials    Trials    News 


12345»
  • ||||||||||  ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma, remimazolam tosylate (HR-7056) / Jiangsu Hengrui Pharma
    Journal:  Effectiveness and safety of remimazolam tosilate versus propofol for sedation in patients undergoing gastrointestinal endoscopy: a randomized controlled trial. (Pubmed Central) -  Nov 19, 2024   
    P=N/A, P4
    Co-administration of alfentanil hydrochloride influenced the distribution volume of the central compartment and clearance...Simulation results showed that an initial dose of 0.25 Compared to propofol with alfentanil, remimazolam with alfentanil can be used safely and effectively for sedation in patients undergoing gastrointestinal endoscopy, with less impact on the patient's circulatory and respiratory systems and a lower incidence of adverse events.
  • ||||||||||  Alfenta (alfentanil) / Abbott
    Journal:  Management of adult mechanically ventilated patients: A UK-wide survey. (Pubmed Central) -  Nov 16, 2024   
    Propofol and alfentanil were the most common initial sedative and analgesia (99.5% and 56.9%) respectively...We hope the results in our survey highlight potential future areas of research. South-coast Peri-operative Audit and Research Collaborative (SPARC)Severn Trainee Anaesthetic and Critical Care Research group (STAR)Collaborative research in Anaesthesia in the Northeast (CRANE).
  • ||||||||||  ciprofol injectable emulsion (HSK3486) / Haisco
    Clinical, Journal:  The efficacy and safety of ciprofol versus propofol in patients undergoing painless hysteroscopy: a randomized, double-blind, controlled trial. (Pubmed Central) -  Nov 14, 2024   
    P=N/A
    South-coast Peri-operative Audit and Research Collaborative (SPARC)Severn Trainee Anaesthetic and Critical Care Research group (STAR)Collaborative research in Anaesthesia in the Northeast (CRANE). Ciprofol exhibits comparable efficacy to that of propofol, and is associated with less injection pain rate, fewer adverse events, higher patient satisfaction, and more stable hemodynamics when used for general anesthesia during the painless hysteroscopy.
  • ||||||||||  Alfenta (alfentanil) / Abbott
    Trial completion:  Patient-Controlled Sedation in Port Implantation (PACSPI-2) (clinicaltrials.gov) -  Nov 12, 2024   
    P4,  N=340, Completed, 
    Ciprofol exhibits comparable efficacy to that of propofol, and is associated with less injection pain rate, fewer adverse events, higher patient satisfaction, and more stable hemodynamics when used for general anesthesia during the painless hysteroscopy. Recruiting --> Completed
  • ||||||||||  Alfenta (alfentanil) / Abbott
    Journal:  Predicting Food-Drug Interactions between Piperine and CYP3A4 Substrate Drugs Using PBPK Modeling. (Pubmed Central) -  Oct 26, 2024   
    The predicted area under the curve (AUC) ratios (with and without piperine, following a 7-day intake of 20 mg/day) for six drugs were found to exceed 1.25, with significant increases in AUC observed for ritonavir (31%), nifedipine (34%), cyclosporine (35%), triazolam (36%), alfentanil (39%), and simvastatin (59%) in humans. These findings suggest that caution should be exercised when consuming amounts of black pepper equivalent to a daily intake of 20 mg piperine during treatment with CYP3A4 substrate drugs, as it may significantly alter their pharmacokinetics.
  • ||||||||||  ciprofol injectable emulsion (HSK3486) / Haisco
    Trial completion, Phase classification:  Efficacy and Safety of Ciprofol for General Anaesthesia in Patients Undergoing Transcatheter Aortic Valve Replacement (clinicaltrials.gov) -  Oct 15, 2024   
    P4,  N=124, Completed, 
    These findings suggest that caution should be exercised when consuming amounts of black pepper equivalent to a daily intake of 20 mg piperine during treatment with CYP3A4 substrate drugs, as it may significantly alter their pharmacokinetics. Recruiting --> Completed | Phase classification: PN/A --> P4
  • ||||||||||  Alfenta (alfentanil) / Abbott
    Journal:  PBPK modeling: What is the role of CYP3A4 expression in the gastrointestinal tract to accurately predict first-pass metabolism? (Pubmed Central) -  Oct 3, 2024   
    Sedation and analgesia for short painful procedures in selected pediatric hemato-oncological units with a dedicated protocol may be safely provided by trained and certified Physician Assistants in Anesthesia. The resulting CYP3A4 expression profile and two previously published profiles were applied to PBPK models of seven CYP3A4 substrates (alfentanil, alprazolam, felodipine, midazolam, sildenafil, triazolam, and verapamil) built-in PK-Sim
  • ||||||||||  Alfenta (alfentanil) / Abbott
    Journal, Surgery:  Effects of opioid-sparing general anesthesia on postoperative nausea and vomiting in laparoscopic gynecological surgery. (Pubmed Central) -  Aug 26, 2024   
    In the OSA group, apart from a single dose of 5 ?g/kg of alfentanil for tracheal intubation, no other opioids were used...There were no significant differences in intraoperative vital signs, hemodynamic interventions, or duration of PACU and hospital stay between the two groups. OSA significantly reduced postoperative nausea, pain scores, and the need for rescue analgesics in the PACU without increasing hemodynamic instability in patients undergoing laparoscopic gynecological surgery.
  • ||||||||||  Alfenta (alfentanil) / Abbott
    THE HEMORRHAGIC BRONCHIAL MUCOSAL SYNDROME: A RARE COMPLICATION OF BRONCHOSCOPY (Convention Center Exhibit Hall: Rapid Fire Area 2D) -  Jul 31, 2024 - Abstract #CHEST2024CHEST_1564;    
    Periprocedural coughing precedes all cases. Prevention or mitigation of cough, especially in patients with history of lung transplant, lung cancer, structural lung disease, and comorbidities that increase risk of bleeding, appears crucial in preventing this condition.
  • ||||||||||  Alfenta (alfentanil) / Abbott
    Trial completion date:  Effects of Adding Different Drugs for Preventing Cough Induced by Bronchoscopic Spraying of Local Anesthetics (clinicaltrials.gov) -  Jul 29, 2024   
    P=N/A,  N=90, Recruiting, 
    Prevention or mitigation of cough, especially in patients with history of lung transplant, lung cancer, structural lung disease, and comorbidities that increase risk of bleeding, appears crucial in preventing this condition. Trial completion date: Jul 2024 --> Oct 2024
  • ||||||||||  Alfenta (alfentanil) / Abbott
    New P4 trial:  The efficacy and safety of alfentanil in painless endoscopy (EUDRACT) -  Jul 15, 2024   
    P4,  N=267, Not yet recruiting, 
  • ||||||||||  Alfenta (alfentanil) / Abbott
    A Comparative Analysis of Intravenous Sedation for Ophthalmic Surgery in Elderly and Obese Patients (Exhibit Hall) -  Jun 25, 2024 - Abstract #ASA2024ASA_852;    
    For elderly patients, mean HR change was -0.1 (KE622) vs -4.5 (opioid-622), & mean MAP change was -1.3 (KE622) vs -11.4 (opioid-622). More patients receiving KE622 lost consciousness for both obese (95.2% for KE622 vs 10.7% for opioid-622) & elderly (66.7% for KE622 vs 8.5% for opioid-622) patients.ConclusionWhile opioid & non-opioid 622 mixtures provided adequate analgesia for obese & elderly patients during ophthalmic surgery with no statistical difference in apnea or O2 desaturation, the ketamine-containing mixture led to more hemodynamic stability.
  • ||||||||||  Alfenta (alfentanil) / Abbott, Sufenta (sufentanil) / Akorn
    Enrollment open, Phase classification, Trial primary completion date:  Standardised Drug Provocation Testing in Perioperative Hypersensitivity (clinicaltrials.gov) -  May 15, 2024   
    P=N/A,  N=50, Recruiting, 
    A loading dose of 0.300 Not yet recruiting --> Recruiting | Phase classification: P4 --> PN/A | Trial primary completion date: Oct 2024 --> Oct 2025