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- | SJP-0008 / Senju
Journal: A novel combination approach to effectively reduce inflammation and neurodegeneration in multiple sclerosis models. (Pubmed Central) - Apr 8, 2024
A reduction in inflammatory T-cells with an increase in Tregs and myeloid suppressor cells is also found in EAE mice treated with SNJ1945 and 3aza-APL. Thus, a novel combination strategy was tested in chronic EAE mouse model in B10 mice which showed multiple pathological mechanisms could be addressed by simultaneous treatment with calpain inhibitor SNJ1945 and protease-resistant 3aza-APL to achieve a stronger therapeutic effect.
- | SJP-0008 / Senju
Journal: GCL loss in BRAO. (Pubmed Central) - Jan 6, 2023
Thus, a novel combination strategy was tested in chronic EAE mouse model in B10 mice which showed multiple pathological mechanisms could be addressed by simultaneous treatment with calpain inhibitor SNJ1945 and protease-resistant 3aza-APL to achieve a stronger therapeutic effect. Measurement of GCL thickness would be a useful indicator of amelioration of BRAO and CRAO progression in a clinical trial of a putative inhibitor.
- | SJP-0008 / Senju, SP600125 / BMS
Journal: Inhibition of endoplasmic reticulum stress and the downstream pathways protects CD4 T cells against apoptosis and immune dysregulation in sepsis. (Pubmed Central) - Oct 25, 2022
Measurement of GCL thickness would be a useful indicator of amelioration of BRAO and CRAO progression in a clinical trial of a putative inhibitor. Our findings indicate that ER stress inhibitors may play a protective role by reducing CD4 T cell apoptosis and maintaining CD4 T cell function, which may be useful for enhancing the immune function and poor prognosis of patients with sepsis.
- SJP-0008 / Senju
Involvement of calpains and caspases in RGC damage in human iPSCs-derived OV cultured under hypoxia ([Virtual]) - Apr 29, 2022 - Abstract #ARVO2022ARVO_3090;
Calpains and caspases are involved in hypoxia/reoxygenation-induced damage to iPSCs-derived RGCs. Human iPSCs derived RGCs are useful for research where access to human eye tissues is limited.
- || SJP-0008 / Senju
New P1 trial: Single Dose ADME Study of [14C]SJP-0008 in Healthy Male Subjects (clinicaltrials.gov) - Apr 10, 2022
P1, N=6, Completed, Sponsor: Senju Pharmaceutical Co., Ltd.