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Preclinical, Journal, Combination therapy: Alphataxin, a Small-Molecule Drug That Elevates Tumor-Infiltrating CD4 T Cells, in Combination With Anti-PD-1 Therapy, Suppresses Murine Renal Cancer and Metastasis. (Pubmed Central) - Dec 14, 2021
P2/3
Lung metastasis was present in monotherapy, but significantly reduced in combination-treated mice. Orally available Alphataxin, the first and only drug developed to increase CD4 T cells, in combination with anti-PD-1, is a powerful therapeutic method that provides long-term remission in renal cell carcinoma and potentially other T cell-responsive cancers by increasing the number of CD4 tumor-infiltrating T cells.
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