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- | almitrine - Public Assistance / Paris Hospitals
Journal: Anti-COVID Drugs (MMV COVID Box) as Leishmanicidal Agents: Unveiling New Therapeutic Horizons. (Pubmed Central) - Mar 28, 2024
In conclusion, our study identifies bortezomib as a promising aspirant for leishmaniasis treatment, demonstrating potent antiparasitic activity, favorable pharmacokinetics, and low toxicity. These findings emphasize the potential repurposing of existing drugs for neglected diseases and highlight the importance of the COVID Box in drug discovery against tropical diseases.
- || almitrine - Public Assistance / Paris Hospitals
Clinical, Review: Unraveling the impact of nitric oxide, almitrine, and their combination in COVID-19 (at the edge of sepsis) patients: a systematic review. (Pubmed Central) - Feb 6, 2024
Well-designed high-quality studies are needed for establishing a stronger quality of evidence. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=367667, identifier CRD42022367667.
- | almitrine - Public Assistance / Paris Hospitals
Preclinical, Journal: Repurposing the Medicines for Malaria Venture's COVID Box to discover potent inhibitors of Toxoplasma gondii, and in vivo efficacy evaluation of almitrine bismesylate (MMV1804175) in chronically infected mice. (Pubmed Central) - Jul 11, 2023
This was determined by quantifying the RNA of living parasites using real-time PCR. The presented results suggest that almitrine may be a promising drug candidate for additional experimental studies on toxoplasmosis and provide further evidence of the potential of the MMV collections as a valuable source of drugs to be repositioned for infectious diseases.
- || Ventavis (iloprost) / Bayer, J&J, University of Copenhagen, almitrine - Public Assistance / Paris Hospitals
Retrospective data, Review, Journal, Surgery: Impact of pharmacological interventions on intrapulmonary shunt during one-lung ventilation in adult thoracic surgery: a systematic review and component network meta-analysis. (Pubmed Central) - Mar 21, 2023
NO results constitute a research hypothesis currently not backed by any direct evidence. The clinical availability of almitrine is limited.
- | almitrine - Public Assistance / Paris Hospitals
Retrospective data, Journal: Efficacy of almitrine as a rescue therapy for refractory hypoxemia in COVID and non-COVID acute respiratory distress syndrome. A retrospective monocenter study. (Pubmed Central) - Mar 9, 2023
Our study reports a highly variable response to almitrine infusion in ARDS patients with refractory hypoxemia. Independent factors associated with a reduced oxygenation response to almitrine infusion were: COVID ARDS, concomitant use of norepinephrine, and non-invasive ventilatory strategy.
- | ifenprodil tartrate / Chiba University Hospital, Olumiant (baricitinib) / Incyte, Eli Lilly, almitrine - Public Assistance / Paris Hospitals
Journal: Aromatic or Hetero-aromatic Directly Attached Tri and Tetrasubstituted Methanes: New Chemical Entities as Anti-infectives. (Pubmed Central) - Mar 7, 2023
Properties of repurposed TRSMs like Almitrine, Ifenprodil, Baricitinib and Remdesivir with their recent progress in Covid-19 therapeutics with their mode of action are also delineated. This perspective is expected to deliver a user guide and reference source for scientists, researchers and academicians in pursuing newly designed TRSMs as therapeutics.
- | almitrine - Public Assistance / Paris Hospitals
Journal: Use of almitrine in spontaneously breathing patients with COVID-19 treated with high-flow nasal cannula oxygen therapy and with persistent hypoxemia. (Pubmed Central) - Jan 5, 2023
Almitrine could be an interesting therapy in spontaneously breathing patients with COVID-19 treated with HFNO and with persistent hypoxemia, given its effects on oxygenation without serious adverse effects regardless of the CT-Scan pattern, and potentially on intubation rate. These preliminary results need to be confirmed by further randomized studies.
- || almitrine - Public Assistance / Paris Hospitals
Review, Journal: Ventilation/Perfusion Mismatch: A Novel Target for COPD Treatment. (Pubmed Central) - Nov 10, 2022
We review the conflicting evidence supporting current treatments for gas-exchange inefficiency and exercise tolerance which act primarily on VA (bronchodilators, anti-inflammatory medications) or Qc (oral and inhaled vasodilators, almitrine and supplemental oxygen). Finally, to address the current knowledge and health-care gaps, we propose two independent clinical research foci that may lead to a better understanding of the role of pulmonary gas-exchange efficiency and activity-related dyspnea in COPD: 1) improved and deeper phenotyping of COPD patients with VA/Qc abnormalities, and, 2) evaluation of existing and novel pharmacological treatments in relation to improved gas-exchange inefficiency, exertional dyspnea, and exercise tolerance across the spectrum of COPD severity.
- | almitrine - Public Assistance / Paris Hospitals
Journal: Effect of intravenous almitrine on intubation or mortality in patients with COVID-19 acute hypoxemic respiratory failure: A multicentre, randomised, double-blind, placebo-controlled trial. (Pubmed Central) - Sep 30, 2022
P3
In patients with COVID-19 acute hypoxemic respiratory failure, low-dose almitrine failed in reducing the need for MV or death at day 7. Programme Hospitalier de Recherche Clinique (PHRC COVID 2020) funded by the French Ministry of Health, Les Laboratoires Servier (Suresnes, France) providing the study drug free of charge.
- | almitrine - Public Assistance / Paris Hospitals
Preclinical, Journal: Drug Repurposing Based on Protozoan Proteome: In Vitro Evaluation of In Silico Screened Compounds against Toxoplasma gondii. (Pubmed Central) - Aug 27, 2022
Almitrine demonstrated a Selectivity Index (provided by the ratio between the Half Cytotoxic Concentration against human foreskin fibroblasts and the Half Effective Concentration against T. gondii tachyzoites) that was higher than 47, whilst being considered a lead compound against T. gondii. Almitrine showed interactions with the Na/K ATPase transporter for Homo sapiens and Mus musculus, indicating a possible mechanism of action of this compound.
- | almitrine - Public Assistance / Paris Hospitals
Trial completion: AIRVM-COVID: Efficacy of Intravenous Almitrine in Reducing the Need for Mechanical Ventilation in Patients With Hypoxemic Acute Respiratory Failure Due to Covid-19-related Pneumonia (clinicaltrials.gov) - May 3, 2022
P3, N=181, Completed, Sponsor: Assistance Publique - H
Almitrine showed interactions with the Na/K ATPase transporter for Homo sapiens and Mus musculus, indicating a possible mechanism of action of this compound. Active, not recruiting --> Completed
- || ritonavir / Generic mfg.
Review, Journal: Covid-19 and Artificial Intelligence: Genome sequencing, drug development and vaccine discovery. (Pubmed Central) - Feb 9, 2022
The growth of AI techniques in health care opened a broad gate for discovering the genomic sequences of the COVID-19 virus and the VOC. AI helps also in the development of vaccines and drugs (including drug repurposing) to obtain potential preventive and therapeutic agents for controlling the COVID-19 pandemic.
- | almitrine - Public Assistance / Paris Hospitals
New trial: Almitrine in COVID-19 Patients With ARDS Treated by HFNO (clinicaltrials.gov) - Jan 30, 2022
P=N/A, N=50, Recruiting, Sponsor: Centre Hospitalier Universitaire de Nice
- | almitrine - Public Assistance / Paris Hospitals
Enrollment closed: AIRVM-COVID: Efficacy of Intravenous Almitrine in Reducing the Need for Mechanical Ventilation in Patients With Hypoxemic Acute Respiratory Failure Due to Covid-19-related Pneumonia (clinicaltrials.gov) - Oct 18, 2021
P3, N=181, Active, not recruiting, Sponsor: Assistance Publique - H
AI helps also in the development of vaccines and drugs (including drug repurposing) to obtain potential preventive and therapeutic agents for controlling the COVID-19 pandemic. Recruiting --> Active, not recruiting
- | almitrine - Public Assistance / Paris Hospitals
Trial completion date, Trial primary completion date: AIRVM-COVID: Efficacy of Intravenous Almitrine in Reducing the Need for Mechanical Ventilation in Patients With Hypoxemic Acute Respiratory Failure Due to Covid-19-related Pneumonia (clinicaltrials.gov) - Sep 28, 2021
P3, N=212, Recruiting, Sponsor: Assistance Publique - H
Recruiting --> Active, not recruiting Trial completion date: Jul 2021 --> Oct 2021 | Trial primary completion date: Jul 2021 --> Oct 2021
- | almitrine - Public Assistance / Paris Hospitals
Journal: Use of Almitrine and Inhaled Nitric Oxide in ARDS Due to COVID-19. (Pubmed Central) - Jul 20, 2021
This combination may be of interest when first-line therapies fail to restore adequate oxygenation. These findings argue for an impaired pulmonary hypoxic vasoconstriction in these patients.
- | almitrine - Public Assistance / Paris Hospitals
Journal: Role of almitrine bismesylate in managing refractory hypoxemia in COVID19 acute respiratory distress syndrome. (Pubmed Central) - Apr 10, 2021
These findings argue for an impaired pulmonary hypoxic vasoconstriction in these patients. No abstract available
- | almitrine - Public Assistance / Paris Hospitals
Trial completion date, Trial primary completion date: AIRVM-COVID: Efficacy of Intravenous Almitrine in Reducing the Need for Mechanical Ventilation in Patients With Hypoxemic Acute Respiratory Failure Due to Covid-19-related Pneumonia (clinicaltrials.gov) - Mar 21, 2021
P3, N=212, Recruiting, Sponsor: Assistance Publique - H
No abstract available Trial completion date: Dec 2020 --> Jul 2021 | Trial primary completion date: Dec 2020 --> Jul 2021
- || almitrine - Public Assistance / Paris Hospitals
Clinical, Observational data, Journal: Almitrine Infusion in Severe Acute Respiratory Syndrome Coronavirus 2-Induced Acute Respiratory Distress Syndrome: A Single-Center Observational Study. (Pubmed Central) - Jan 26, 2021
Almitrine infusion improved oxygenation in severe acute respiratory syndrome coronavirus 2-induced acute respiratory distress syndrome without adverse effects. In a multistep clinical approach to manage severe hypoxemia in this population, almitrine could be an interesting therapeutic option to counteract the loss of hypoxic pulmonary vasoconstriction and redistribute blood flow away from shunting zones.
- || almitrine - Public Assistance / Paris Hospitals
Clinical, Journal: Coronavirus Disease 2019 Acute Respiratory Failure: Almitrine Drug Resuscitation or Resuscitating Patients by Almitrine? (Pubmed Central) - Jan 16, 2021
In a multistep clinical approach to manage severe hypoxemia in this population, almitrine could be an interesting therapeutic option to counteract the loss of hypoxic pulmonary vasoconstriction and redistribute blood flow away from shunting zones. No abstract available
- || Review, Journal: Repurposing existing drugs for the treatment of COVID-19/SARS-CoV-2 infection: A review describing drug mechanisms of action. (Pubmed Central) - Jan 14, 2021
One of the NCI's goals is to screen cancer related drugs for identification of new therapies for COVID-19. https://www.cancer.gov/news-events/cancer-currents-blog/2020/covid-19-cancer-nci-response?cid=eb_govdel.
- | almitrine - Public Assistance / Paris Hospitals
Retrospective data, Journal: Acute Respiratory Distress Syndrome in the forward environment. Retrospective analysis of ARDS cases among French Army war casualties. (Pubmed Central) - Jan 6, 2021
ARDS was frequent and severe among French patients evacuated from war theaters. Improved treatment capacities are needed in the forward environment-for example, a specialized US team can provide ECLS for highly hypoxemic war casualties.
- || almitrine - Public Assistance / Paris Hospitals
Clinical, Journal: Efficacy of Almitrine in The Treatment of Hypoxemia in Sars-Cov-2 Acute Respiratory Distress Syndrome. (Pubmed Central) - Nov 28, 2020
Improved treatment capacities are needed in the forward environment-for example, a specialized US team can provide ECLS for highly hypoxemic war casualties. No abstract available
- || almitrine - Public Assistance / Paris Hospitals
Clinical, Journal: Rescue therapy with inhaled nitric oxide and almitrine in COVID-19 patients with severe acute respiratory distress syndrome. (Pubmed Central) - Nov 6, 2020
In this pilot study of severe C-ARDS patients, iNO-almitrine combination was associated with rapid and significant improvement of oxygenation. These findings highlight the role of pulmonary vascular function in COVID-19 pathophysiology.
- almitrine - Public Assistance / Paris Hospitals
[VIRTUAL] Measuring the IMPACT of Almitrine Marketing Authorisation Withdrawal on Public Health in France () - Oct 3, 2020 - Abstract #ISPOREU2020ISPOR-EU_867;
This model quantifies PH impact of almitrine’s MA withdrawal in terms of serious morbidity, assuming exposure was eliminated. This method can be applied to other products in a range of settings.
- | almitrine - Public Assistance / Paris Hospitals
Enrollment open, Trial completion date, Trial initiation date, Trial primary completion date: AIRVM-COVID: Efficacy of Intravenous Almitrine in Reducing the Need for Mechanical Ventilation in Patients With Hypoxemic Acute Respiratory Failure Due to Covid-19-related Pneumonia (clinicaltrials.gov) - Sep 22, 2020
P3, N=212, Recruiting, Sponsor: Assistance Publique - H
This method can be applied to other products in a range of settings. Not yet recruiting --> Recruiting | Trial completion date: Jul 2020 --> Dec 2020 | Initiation date: May 2020 --> Sep 2020 | Trial primary completion date: Jul 2020 --> Dec 2020
- | almitrine - Public Assistance / Paris Hospitals
Retrospective data, Journal: Effect Of Almitrine Bismesylate And Inhaled Nitric Oxide On Oxygenation In Covid-19 Acute Respiratory Distress Syndrome. (Pubmed Central) - Sep 4, 2020
Not yet recruiting --> Recruiting | Trial completion date: Jul 2020 --> Dec 2020 | Initiation date: May 2020 --> Sep 2020 | Trial primary completion date: Jul 2020 --> Dec 2020 No abstract available
- || almitrine - Public Assistance / Paris Hospitals
Clinical, Journal: Almitrine as a non-ventilatory strategy to improve intrapulmonary shunt in COVID-19 patients. (Pubmed Central) - Sep 4, 2020
No abstract available No abstract available
- || almitrine - Public Assistance / Paris Hospitals
Clinical, Journal: Treating hypoxemic COVID-19 "ARDS" patients with almitrine: The earlier the better? (Pubmed Central) - Sep 4, 2020
No abstract available No abstract available
- | almitrine - Public Assistance / Paris Hospitals
New trial: Almitrine and COVID-19 Related Hypoxemia (clinicaltrials.gov) - May 7, 2020
P, N=17, Completed, Sponsor: Central Hospital, Nancy, France
- ||| almitrine - Public Assistance / Paris Hospitals
What does this mean for potential treatment? The authors say a drug called almitrine (which increases HPV and activates the carotid body) should be studied in trials. Care should be taken they say with calcium channel blockers which may block HPV. (Twitter) - May 5, 2020
- | almitrine - Public Assistance / Paris Hospitals
New P3 trial: AIRVM-COVID: Efficacy of Intravenous Almitrine in Reducing the Need for Mechanical Ventilation in Patients With Hypoxemic Acute Respiratory Failure Due to Covid-19-related Pneumonia (clinicaltrials.gov) - Apr 21, 2020
P3, N=212, Not yet recruiting, Sponsor: Assistance Publique - H