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- | ST-502 / Biogen
Journal: High Prevalence of ST502 Carrying an OXA-24 Carbapenemase gene in Carbapenem-Nonsusceptible Acinetobacter baumannii-calcoaceticus Isolates in Romania. (Pubmed Central) - Jun 19, 2022
All isolates were resistant to piperacillin/tazobactam, ceftazidime, and ciprofloxacin; 88.5% to gentamicin; and 90.4% to trimethoprim/sulfamethoxazole...In these isolates, tobramycin and colistin might be the remaining therapeutic options. Due to differences in gentamicin and tobramycin resistance in these isolates, surveillance data should not group gentamicin, tobramycin, and amikacin together as aminoglycosides.
- | ST-502 / Biogen
Retrospective data, Journal: Multidrug-resistant Klebsiella pneumoniae: a retrospective study in Manaus, Brazil. (Pubmed Central) - Mar 11, 2022
MLST analysis demonstrated a great diversity of STs among the strains, totaling 12 different STs (ST11, ST23, ST198, ST277, ST307, ST340, ST378, ST462, ST502, ST3991, ST3993 and ST5209). Three of these (ST11, ST23 and ST340) belong to CG258.
- ||||| ST-502 / Biogen
$SGMO @ #ADPD21 (3/9-3/14) will be presenting poster for ST-502 #Parkinson's Disease reporting on-target human alphasynuclein #repression activity >99% ! $BIIB (Twitter) - Mar 6, 2021
- | Vynfinit (vintafolide) / Novartis
Journal: Pre-clinical studies of EC2629, a highly potent folate- receptor-targeted DNA crosslinking agent. (Pubmed Central) - Jan 14, 2021
When evaluated against FR-positive patient derived xenograft (PDX) models of ovarian (ST070), endometrial (ST040) and triple negative breast cancers (ST502, ST738), EC2629 showed significantly greater anti-tumor activity compared to their corresponding standard of care treatments. Taken together, these studies thus demonstrated that EC2629, with its distinct DNA reacting mechanism, may be useful in treating FR-positive tumors, including those that are classified as drug resistant.
- || gentamicin sulfate / Generic mfg.
Clinical, Journal: Population structure of KPC carbapenemase-producing Klebsiella pneumoniae in a long-term acute-care rehabilitation facility: identification of a new lineage of clonal group 101, associated with local hyperendemicity. (Pubmed Central) - Nov 2, 2020
All the CG101 isolates had a capsule locus type KL17...Analysing WGS data, we were able to ascertain the common origin of some isolates imported from other hospitals, and to track several clusters of in-LTACRF cross-transmissions. The results revealed that, in peculiar epidemiological settings such as LTACRF, new KPC-Kp clones different from those prevailing in acute-care hospitals and associated with uncommon resistance and virulence determinants can successfully emerge and disseminate.
- | ceftriaxone / Generic mfg.
Journal: Non-typeable Streptococcus pneumoniae infection in a medical center in Taiwan after wide use of pneumococcal conjugate vaccine. (Pubmed Central) - Oct 22, 2020
Invasive infection can occur in newborns or young infants. Most of the isolates remained susceptible to penicillin and ceftriaxone.
- || ST-502 / Biogen
Clinical, Journal: Whole-Genome-Sequence-Based Characterization of Extensively Drug-Resistant Acinetobacter baumannii Hospital Outbreak. (Pubmed Central) - Oct 22, 2020
Genome analysis initially revealed two clones, one carrying bla on Tn2006 (ST-1305, ST-195, and ST-218) and another carrying bla on pMAL-1 (ST-502 and ST-2059, a new ST), with the latter having two subclones, as revealed using the Bayesian transmission network...A pMAL-2 plasmid was circulating between the two clones. The approaches implemented in this study and the obtained findings facilitate the tracking of outbreak scenarios in Lebanon and the region at large.
- || Branigen (acetyl-L-carnitine) - Mitsubishi Tanabe, Sigma Tau, Dong / A, ST-502 / Biogen
Clinical, Journal: Molecular characterization of multidrug-resistant Klebsiella pneumoniae belonging to CC258 isolated from outpatients with urinary tract infection in Brazil. (Pubmed Central) - Jun 18, 2020
The approaches implemented in this study and the obtained findings facilitate the tracking of outbreak scenarios in Lebanon and the region at large. These results raise a concern about epidemiological surveillance related to colonization of patients discharged from hospitals in order to prevent both occurrence and spread of resistant bacterial infections in the community.