- |||||||||| fluticasone / Generic mfg.
Journal: Impact of imidacloprid exposure on gestational hyperglycemia: A multi-omics analysis. (Pubmed Central) - Jun 23, 2024
For example, the abundance of Oscillibacter was strongly correlated with gut microflora-related metabolites (Icosenoic acid, Lysosulfatide, and fluticasone) and liver differential genes (Grin3b, Lifr, and Spta1). Together, IMI exposure resulted in significant changes in microbial composition, along with alterations in certain metabolites and genes associated with metabolic process, which may promote gestational hyperglycemia.
- |||||||||| Cinqair (reslizumab) / Merck (MSD), UCB, Teva, cendakimab (CC-93538) / AbbVie, BMS, Dupixent (dupilumab) / Sanofi, Regeneron
Retrospective data, Journal: Histological Outcomes of Pharmacological Interventions in Eosinophilic Esophagitis for Adults and Children: A Network Meta-analysis of Randomized Controlled Trials. (Pubmed Central) - May 3, 2024
An important limitation of this study is absence of clinical efficacy data due to insufficient data. Other limitations include heterogeneity of operator, population, and outcome analysis.
- |||||||||| Rezurock (belumosudil) / Romeck Pharma, Sanofi, Jakafi (ruxolitinib) / Incyte, Imbruvica (ibrutinib) / AbbVie, J&J
Clinical guideline, Journal: ERS/EBMT clinical practice guideline on treatment of pulmonary chronic graft-versus-host disease in adults. (Pubmed Central) - Apr 1, 2024
Following the ERS standardised methodology, we conducted systematic reviews to address these questions and used the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach to develop recommendations.The resulting guideline addresses common therapeutic options (inhalation therapy, fluticasone-azithromycin-montelukast, imatinib, ibrutinib, ruxolitinib, belumosudil, extracorporeal photopheresis and lung transplantation), as well as other aspects of general management, such as lung functional and radiological follow-up and pulmonary rehabilitation, for adults with pulmonary cGvHD phenotype bronchiolitis obliterans syndrome. These recommendations include important advancements that could be incorporated in the management of adults with pulmonary cGvHD, primarily aimed at improving and standardising treatment and improving outcomes.
- |||||||||| Review, Journal: Allergic Rhinitis: A Review. (Pubmed Central) - Mar 16, 2024
Patients with allergic rhinitis should be instructed to avoid inciting allergens. Therapies include second-generation H1 antihistamines (eg, cetirizine, fexofenadine, desloratadine, loratadine), intranasal antihistamines (eg, azelastine, olopatadine), and intranasal corticosteroids (eg, fluticasone, triamcinolone, budesonide, mometasone) and should be selected based on the severity and frequency of symptoms and patient preference.
- |||||||||| fluticasone / Generic mfg.
DAILY OR TWICE DAILY TREATMENT WITH TOPICAL STEROIDS RESULTS IN SIMILAR RESPONSE IN EOSINOPHILIC ESOPHAGITIS (Hall A, Poster Hall - Walter E. Washington Convention Center) - Mar 14, 2024 - Abstract #DDW2024DDW_908;
Patients on twice daily dosing were more frequently prescribed fluticasone (36% vs. 18%; p trend < 0.001) and had a higher mean daily steroid dose (1706 mcg vs. 1519 mcg; p = 0.01) (Table 2)...These results can help patients and providers decide how to best take a tCS and to be assured that either regimen is effective. Moreover, given comparable efficacy, a once daily total dose, rather than divided dose, could be considered to increase adherence while reducing the risk for candidal esophagitis.
- |||||||||| montelukast / Generic mfg., azithromycin / Generic mfg., fluticasone / Generic mfg.
Try, Try Again: The Importance of Expanded Genetic Evaluation in Patients With Bronchiectasis of Unclear Etiology (San Diego Convention Center, Room 28C-E (Upper Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_7803;
Broad testing many years later revealed the diagnosis of TRAF3-related immune dysregulation, which has resulted in changes in care and management for the entire family. Therefore, reexamination of previous genetic testing and broadening the scope of genetic testing are key when familial disease and an underlying genetic cause are suspected.
- |||||||||| Breztri Aerosphere (budesonide/formoterol fumarate/glycopyrronium) / AstraZeneca
Vitamin D Supplementation Modifies the Estimated Effects of PM2.5 Exposure on Severe Asthma Exacerbations in Children With Low Vitamin D Levels (San Diego Convention Center, Room 11A-B (Upper Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_7287;
Before randomization, all participants completed a four-week run-in period in which they demonstrated ?75% adherence to a low-dose inhaled corticosteroid (Fluticasone MDI), which was continued throughout the trial... Among youth with mild asthma and low vitamin D levels treated with ICS, vitamin D supplementation may protect against pollution-induced SAEs through antioxidant effects and/or enhancement of corticosteroid responsiveness.
- |||||||||| cetirizine oral / Generic mfg., hydrocortisone / Generic mfg., fluticasone / Generic mfg.
Intracranial Hypertension as an Initial Sign of Adrenal Insufficiency Secondary to Inhaled Corticosteroids in a Child With Asthma (San Diego Convention Center, Area A (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_6526;
9 mL daily, and cetirizine 10 mg daily...She gradually improved and was successfully extubated on day 4 and discharged home on a 2-week hydrocortisone taper...Unfortunately, there is more systemic absorption than originally understood. It is important to increase awareness of the risk and emphasize the importance of utilizing the minimal effective dose of ICS.
- |||||||||| fluticasone / Generic mfg.
Unmasking the Cause of Dyspnea: Partial Anomalous Pulmonary Venous Return in an Adult (San Diego Convention Center, Area I (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_6427;
She was started on a fluticasone inhaler while awaiting further imaging with no resolution of symptoms and increased to a combo long-acting muscarinic antagonist (LAMA), long-acting beta-agonist (LABA), and inhaled corticosteroid (ICS) inhaler with again no resolution...If not revealed in childhood, many patients with PAPVR will remain asymptomatic until they progress to significant pulmonary hypertension. Increased awareness can lead to earlier detection and possibly prevent progression to worse sequelae, including worsening of pulmonary hypertension.
- |||||||||| montelukast / Generic mfg., azithromycin / Generic mfg., fluticasone / Generic mfg.
Treatment of Acute Respiratory Failure Secondary to Chronic Graft-Versus-Host Disease With Fluticasone, Azithromycin, Montelukast, and High-Dose Glucocorticoids (San Diego Convention Center, Area D (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_6242;
He was recently treated as an outpatient with levofloxacin, amoxicillin/clavulanic acid, and albuterol/ipratropium nebulizers for presumed pulmonary infections...Four months after discharge, he completed his prednisone taper and was asymptomatic from a respiratory standpoint, requiring no supplemental oxygen...Recent data has suggested that FAM and steroids can improve mortality in these patients. This case highlights FAM and an extended steroid taper, extrapolated from non-GVHD bronchiolitis obliterans and organizing pneumonia studies, as a possible therapeutic plan for providers to consider in chronic lung GVHD patients after HSCT.
- |||||||||| Dupixent (dupilumab) / Sanofi, Regeneron, Fasenra (benralizumab) / AstraZeneca
Chronic Eosinophilic Pneumonia: Shedding Light on an Under-recognized Syndrome Through a Comprehensive Case Report (San Diego Convention Center, Area D (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_6240;
An 83-year-old male with a past medical history significant for severe asthma on fluticasone-umeclidinium-vilanterol, prednisone 12...It was decided to change the patients dupilumab to benralizumab as there have been reports suggesting worsening of CEP with dupixent...Given the gross amount of pneumonias seen in hospitalized patients who fail to detect any sort of pathogen of origin, eosinophilic pneumonias should be high on a list of differential diagnoses. In chronic pneumonia, CEP should especially be considered when antibiotic courses fail to resolve symptoms or radiographic evidence of pneumonia.
- |||||||||| Dupixent (dupilumab) / Sanofi, Regeneron, Tezspire (tezepelumab-ekko) / AstraZeneca, Amgen, Xolair (omalizumab) / Roche, Novartis
Hyperimmunoglobulin E Syndrome: A Rare Autoimmune Masquerade of Th2 Asthma (San Diego Convention Center, Area H (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_5629;
Dupilumab, an anti-IL4 and IL3 monoclonal antibody, was then used and the patient had control of asthma symptoms, and a decline in serum IgE levels. This case demonstrates a rare autoimmune masquerade of Th2 asthma while also demonstrating novel treatments with biologics.
- |||||||||| fluticasone / Generic mfg.
Acute Asthma Outcomes Comparison: Low and Medium Dose Inhaled Corticosteroids After Hospitalization (San Diego Convention Center, Area F (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_5614;
Physicians may prefer a low dose as the first choice after a hospital admission if a patient is ICS naive to avoid medication side effects. However, additional studies with larger sample sizes should be done to determine the optimal dosing regimen for post-hospital ICS therapy in pediatric asthma populations.
- |||||||||| Nucala (mepolizumab) / GSK
"Cast Away": Journey of a Healthy 7-Year-Old Rescued From Bilateral Airway Casts Due to Plastic Bronchitis (San Diego Convention Center, Area J (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_1879;
However, its efficacy for preventing the recurrence of idiopathic eosinophilic cast bronchitis remains uncertain. If spirometry and FeNO do not normalize, then repeat bronchoscopy/BAL will be conducted to ascertain disease control based on cast recurrence and BAL eosinophils to determine further interventions.
- |||||||||| lestaurtinib (CEP-701) / Teva, Kyowa Kirin
Journal: Integrating Transcriptomic and Structural Insights: Revealing Drug Repurposing Opportunities for Sporadic ALS. (Pubmed Central) - Jan 29, 2024
Additionally, docking analysis revealed NOS3 as the gene that interacts with all the short-listed drugs, suggesting its possible involvement in the mechanisms underlying the therapeutic potential of these drugs in sporadic ALS. Overall, our study provides a systematic framework for identifying potential drug candidates for sporadic ALS therapy and highlights the potential of drug repurposing as a promising strategy for discovering new therapies for neurodegenerative diseases.
- |||||||||| Xhance (fluticasone propionate intranasal spray) / OptiNose
Clinical, Journal: Efficacy of EDS-FLU for Chronic Rhinosinusitis: Two Randomized Controlled Trials (ReOpen1 and ReOpen2). (Pubmed Central) - Jan 20, 2024
Overall, our study provides a systematic framework for identifying potential drug candidates for sporadic ALS therapy and highlights the potential of drug repurposing as a promising strategy for discovering new therapies for neurodegenerative diseases. EDS-FLU is the first nonsurgical treatment demonstrated to reduce symptoms, intrasinus opacification, and exacerbations in replicate randomized clinical trials in CRS, regardless of polyp status.
- |||||||||| fluticasone / Generic mfg., fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
Journal: Single-Cell Sequencing of Lung Macrophages and Monocytes Reveals Novel Therapeutic Targets in COPD. (Pubmed Central) - Dec 26, 2023
COPD lungs harbor transcriptionally distinct lung macrophages and monocytes, reflective of a dysfunctional and hyperinflammatory state. Inhaled corticosteroids and other compounds can modulate the transcriptomic profile of these cells in patients with COPD.
- |||||||||| fluticasone / Generic mfg.
Review, Journal: Topical and oral steroids for otitis media with effusion (OME) in children. (Pubmed Central) - Dec 17, 2023
The potential benefit of treatment may therefore be small and should be balanced with the risk of adverse effects. Future studies should aim to determine which children are most likely to benefit from treatment, rather than offering interventions to all children.
- |||||||||| Jorveza (budesonide orodispersible tablets) / Dr Falk
Review, Journal: Novel corticosteroid formulations in the treatment of eosinophilic esophagitis: what is the evidence? (Pubmed Central) - Nov 3, 2023
Budesonide orodispersible tablet (BOT) and budesonide oral suspension (BOS) both surpassed placebo formulations regarding the efficacy of inducing and maintaining histologic, symptomatic and endoscopic remission...Fluticasone propionate (APT-1011) achieved and maintained histologic and endoscopic responses in the majority of patients, whereas only a positive trend was demonstrated for symptomatic improvement...Current evidence supports long-term treatment with novel corticosteroid formulations, challenging the established treatment paradigm of EoE. BOT appears to be the most effective steroid therapy, although head-to-head comparative trials between STCs are needed.
- |||||||||| Dupixent (dupilumab) / Sanofi, Regeneron
Review, Journal: A Practical Update on Pediatric Eosinophilic Esophagitis. (Pubmed Central) - Oct 28, 2023
Dupilumab recently was approved by FDA and EMA as the first biological therapy for adolescents (?12 years) and adults with active EoE, but other biologics are still under consideration. Due to its chronic course, EoE management requires long-term therapy, a multidisciplinary approach, and regular follow-ups.
- |||||||||| prednisone / Generic mfg., fluticasone / Generic mfg., levocetirizine / Generic mfg.
When A Polyp Is Not A Polyp: Unilateral Nasal Masses And Masqueraders Of Nasal Polyps (Monitor 09) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_691;
She was using Fluticasone 2 sprays/nostril daily and Levocetirizine 5 mg daily...Patient was changed to Fluticasone exhalation therapy and treated with Prednisone for 5 days...Warning signs/red flags for tumors include rapid growth, change in symptom pattern, no response to nasal/systemic steroids or biologics, and crusting/bleeding lesions. A high degree of suspicion, sinus imaging and Otolaryngology referral for biopsy are paramount in these scenarios for accurate diagnosis and treatment.
- |||||||||| fluticasone / Generic mfg.
Review, Journal: Breathe easy: inhalational therapy for feline inflammatory airway disease. (Pubmed Central) - Sep 11, 2023
The review also discusses the mechanics of inhalational therapy and helps clarify why certain medications, such as albuterol (salbutamol), fluticasone or budesonide, are chosen for certain diseases...In compiling their review, the authors searched the veterinary literature for articles in English that discuss inhalational therapy in cats, and which focus primarily on inhaled glucocorticoids and bronchodilators. While most literature on inhalational therapy in cats is based on experimental feline asthma models, there are some studies demonstrating successful treatment in cats with naturally occurring inflammatory airway disease.
- |||||||||| fluticasone / Generic mfg.
Preclinical, Journal: In Vivo Fluticasone Absorption in Surgical Patients. (Pubmed Central) - Sep 11, 2023
Computation fluid dynamic models of the nasal passage are useful models to help predict intranasal particle flow. However, these models do not incorporate or consider the important mucociliary clearance system, leading to absorption of fluticasone throughout the sinonasal cavity far beyond that predicted by these models.
- |||||||||| budesonide / Generic mfg., fluticasone / Generic mfg.
Review, Journal: Impact of inhaled and intranasal corticosteroids on glucose metabolism and diabetes mellitus: A mini review. (Pubmed Central) - Sep 7, 2023
While more research evaluating the risk of ICS/INS for DM-related adverse events is needed, high doses of ICS/INS should be avoided when possible. The following strategies for ICS/INS dose minimization can be considered: Use of non-pharmacological measures (trigger avoidance, smoking cessation, vaccination to avoid infection), control of comorbid conditions, use of non-ICS-containing medications, inter-mittent rather than regular ICS dosing, and appropriate de-escalation of high ICS doses.
- |||||||||| dexamethasone / Generic mfg., fluticasone / Generic mfg.
Journal: A comparative study of human and zebrafish glucocorticoid receptor activities of natural and pharmaceutical steroids. (Pubmed Central) - Sep 1, 2023
The other steroids tested, androgens and progestins, are all antagonists of both GRs with equal or lower potency on zfGR than on hGR. Surprisingly, the lower efficacy and potency on zfGR of aldosterone, forbimenol and the dissociated glucocorticoids is not related to their affinity for the receptors which would suggest that it could be related to less efficacious recruitment of coactivators by zfGR compared to hGR.
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