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  • ||||||||||  omeprazole / Generic mfg., fluticasone / Generic mfg.
    Clinical, Journal, Real-world evidence:  EFFICACY OF THERAPY FOR EOSINOPHILIC ESOPHAGITIS IN REAL-WORLD PRACTICE. (Pubmed Central) -  Aug 20, 2021   
    In an analysis of data from a large cohort of patients with EoE in Europe, we found topical steroids to be the most effective at inducing clinical and histologic remission, but PPIs to be the most frequently prescribed. Treatment approaches vary with institution and presence of fibrosis or strictures.
  • ||||||||||  fluticasone / Generic mfg.
    Journal:  The effect of combination inhaled therapy on ventilation distribution measured by SPECT/CT imaging in uncontrolled asthma. (Pubmed Central) -  Aug 14, 2021   
    Twenty-two symptomatic participants with asthma underwent single-photon emission computed tomography (SPECT)/CT imaging with Technegas, before and after 8-wk fluticasone/formoterol (1,000/40 µg/day) treatment...SPECT ventilation defects are overall unresponsive to ICS/LABA, but the response is variable with improvement occurring when small airway dysfunction and ventilation defects are more severe. Persistent ventilation defects which correlate with Scond suggest that mechanisms such as non-ICS responsive inflammation or remodelling underlie these defects.
  • ||||||||||  fluticasone / Generic mfg.
    [VIRTUAL] Interferon gamma (IFN?) pathway deficiency and severe NTM disease () -  Jul 29, 2021 - Abstract #ERS2021ERS_3949;    
    Severe NTM disease was classified as B/L pulmonary disease, multiple organ involvement or multiple sites of extra pulmonary disease. The commonest causative organism was MAI (50.9%), followed by M. chimaera (14%).
  • ||||||||||  montelukast / Generic mfg.
    Retrospective data, Review, Journal:  Efficacy of Montelukast in Allergic Rhinitis Treatment: A Systematic Review and Meta-Analysis. (Pubmed Central) -  Jul 28, 2021   
    No abstract available Montelukast is more effective than placebo in treating the overall symptoms of allergic rhinitis while the combined therapy of montelukast and an oral antihistamine is superior to either montelukast or an oral antihistamine alone.
  • ||||||||||  fluticasone / Generic mfg.
    Journal:  Effect of fluticasone propionate on human nasal fibroblasts exposed to urban particulate matter. (Pubmed Central) -  Jul 4, 2021   
    UPM induces the expression of IL-6, CXCL1, IL-1β, and TNF-α in nasal fibroblasts and this effect is reversed by FP via the STAT3 and NF-κB signalling pathways. These results suggest that FP has therapeutic potential for nasal diseases related to UPM, such as allergic and chronic rhinitis.
  • ||||||||||  Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J, Entyvio (vedolizumab) / Takeda, Xolair (omalizumab) / Roche, Novartis
    Journal:  Pharmacological treatments for eosinophilic esophagitis: current options and emerging therapies. (Pubmed Central) -  Jun 30, 2021   
    Several additional promising therapies are also discussed.Expert opinion: Several therapeutic targets have shown efficacy and will be approved to treat EoE, especially corticosteroid-sparing options and those for patients with multiple Th2-associated diseases. Personalized therapeutic strategies for initial and maintenance treatments of EoE must be rationally designed, to reduce the burden of disease and answer meaningfully the needs of all stakeholders involved in EoE.
  • ||||||||||  fluticasone / Generic mfg.
    Journal:  Inhaled corticosteroid use and the incidence of lung cancer in COPD. (Pubmed Central) -  Jun 22, 2021   
    Observational studies reporting such reduction may have been affected by time-related biases and the inclusion of patients with asthma. The proposition of a randomised trial warrants some caution.
  • ||||||||||  fluticasone / Generic mfg.
    Clinical, Journal:  Efficacy of Vitamin D Supplementation in Allergic Rhinitis. (Pubmed Central) -  Jun 22, 2021   
    The pre-treatment TNSS score in Group B (fluticasone spay with Vit D) was 11.64 ± 3.09 while post-treatment score was 6.3 ± 1.45 with difference in both scores of Group A as 5.34...Though Intranasal steroidal sprays are the first line of management of allergic rhinitis however vitamin D supplementation can have a role in better relief of symptoms when used in conjunction. More multi-institutional studies are encouraged to confirm the validity of results before it can be incorporated in standard treatment guidelines.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    [VIRTUAL] NASOPHARYNGEAL MANTLE CELL LYMPHOMA PRESENTING AS HEARING LOSS: A CASE REPORT () -  Jun 14, 2021 - Abstract #CSCTRMWAFMR2021CSCTR-MWAFMR_30;    
    Throughout the period of his complaints, he was treated with fluticasone for one month and later with a myringotomy tube to manage a diagnosis of Eustachian tube dysfunction...MCL is still an incurable disease despite the recent progress that led to advancement in patients‘ clinical outcomes.12 Early-stage MCL has no standardized therapeutic approach.6 Therapies of MCL depend on the patient‘s age, fitness at presentations, and symptoms at diagnosis.7 12 Therapy is usually aggressive, with most patients receiving a combination of rituximab along with chemotherapy, such as R-CHOP12 14...Deferring treatment in a subset of patients is appropriate. More future advances are warranted to continue to study targeted therapies and individualized approaches to this heterogeneous disease.
  • ||||||||||  meropenem / Generic mfg.
    Journal:  OPTIMIZING MEROPENEM THERAPY FOR SEVERE NOSOCOMIAL INFECTIONS IN NEONATES. (Pubmed Central) -  Jun 6, 2021   
    Stochastic simulations to establish initial dosing regimens to maximize the time above the MIC showed that the mean probabilities to achieve the PK/PD target (PTA) for microorganisms with a MIC of 2 and 8 µg/mL were 0.8 and 0.7 following i.v. bolus of 250 and 500 mg/m/dose q8h, respectively. Meropenem extended 4h infusion would improve PTA in neonates with augmented creatinine clearance.
  • ||||||||||  clarithromycin / Generic mfg.
    Clinical, Journal:  Prospective evaluation of clarithromycin in recurrent chronic rhinosinusitis with nasal polyps. (Pubmed Central) -  Jun 3, 2021   
    Long-term adjuvant use of low-dose clarithromycin for chronic rhinosinusitis patients with recurrent sinonasal polyposis refractory to clinical and surgical treatment has resulted in improved quality of life and nasal endoscopy findings, especially in patients with normal IgE levels. This improvement persisted in the patient group evaluated 12 weeks after the end of the treatment.
  • ||||||||||  fluticasone / Generic mfg.
    Retrospective data, Journal:  Prevention of middle ear barotrauma with oxymetazoline/fluticasone treatment. (Pubmed Central) -  Jun 3, 2021   
    In summary, pretreatment with intranasal oxymetazoline and fluticasone in patients undergoing HBO2 did not significantly reduce MEB. More investigation with larger numbers of participants and prospective studies could further clarify this issue.