- |||||||||| fluticasone / Generic mfg.
VALIDATION OF EPIGENETIC MARKERS FOR PREDICTION OF RESPONSE TO TOPICAL CORTICOSTEROID TREATMENT IN EOSINOPHILIC ESOPHAGITIS (Poster Hall - San Diego Convention Center) - Apr 25, 2022 - Abstract #DDW2022DDW_1246;
Methods : DNA was extracted from prospectively collected and biobanked esophageal biopsies from newly diagnosed, treatment naïve EoE patients enrolled in a randomized trial of two tCS formulations (budesonide slurry or fluticasone metered dose inhaler)...Conclusion s: We validated three epigenetic biomarkers (CpG methylation sites) for prediction of tCS response in EoE patients in an independent population. While not all previously identified markers replicated, three demonstrated a relatively high predictive probability for response to treatment and thus hold promise for guiding initial treatment in patients with EoE.
- |||||||||| fluticasone / Generic mfg.
Clinical, Journal: Evaluation of the ocular safety associated with the exhalation delivery system with fluticasone. (Pubmed Central) - Apr 19, 2022
P3
Meaningful improvements were seen across multiple response criteria with EDS-FLU, suggesting that the broad treatment effect of EDS-FLU includes objective reduction in polyp grade and improvements in several patient-reported outcomes. No increased risk of elevated IOP was detected with EDS-FLU; the rate of cataract development was similar to EDS-placebo and to that reported with other INCS.
- |||||||||| budesonide / Generic mfg., fluticasone / Generic mfg.
Clinical, Review, Journal: Safety of ciclesonide in children with asthma: A review of randomized controlled trials. (Pubmed Central) - Apr 19, 2022
Data from 13 studies demonstrate that CIC is associated with low rates of oropharyngeal AEs, with no indication of clinically relevant systemic effects in children with asthma. The favorable safety profile and demonstrated improvements in asthma control make CIC an ideal inhaled corticosteroid for the treatment of asthma in children.
- |||||||||| fluticasone / Generic mfg.
Effect of inhaled corticosteroids on urinary calcium excretion in children with persistent asthma () - Apr 19, 2022 - Abstract #BSACI2022BSACI_268;
Conclusions Moderate doses of fluticasone spray affects urinary calcium excretion and this in turn may influence on bone mineral metabolism which in long term may increase the incidence of complications such as bone fractures. Therefore it is wise to consider this detrimental effect of GCSs especially using them for the long period and also in high doses.
- |||||||||| fluticasone / Generic mfg.
Observational data, Journal, HEOR, Real-world evidence: Fluticasone-Based versus Budesonide-Based Triple Therapies in COPD: Real-World Comparative Effectiveness and Safety. (Pubmed Central) - Apr 13, 2022
In a real-world clinical setting of COPD treatment, budesonide-based triple therapy given in two inhalers was generally as effective at reducing exacerbations as fluticasone-based triple therapy. However, the budesonide-based triple therapy was associated with a lower incidence of severe pneumonia and possibly also of all-cause death, especially among patients with no prior exacerbations for whom triple therapy is not recommended.
- |||||||||| fluticasone / Generic mfg.
Journal: Human Lung Mast Cells Impair Corticosteroid Responsiveness in Human Airway Smooth Muscle Cells. (Pubmed Central) - Apr 8, 2022
Conditioned media from resting or FcεR1-activated human lung mast cells were incubated with serum-deprived ASM cells (1:4 dilution, 24 h) to determine their impact on the anti-inflammatory action of fluticasone on ASM cell chemokine expression induced by TNFα (10 ng/ml)...Our study demonstrates for the first time that conditioned media from FcεR1-activated mast cells blunt the anti-inflammatory action of corticosteroids in ASM cells by altering their transactivation properties. Because infiltration of mast cells within the ASM bundles is a defining feature of asthma, mast cell-derived mediators may contribute to the glucocorticoid insensitivity present in severe asthma.
- |||||||||| fluticasone / Generic mfg.
Clinical data, Journal: Technologies for Type 1 Diabetes and Contact Dermatitis: Therapeutic Tools and Clinical Outcomes in a Cohort of Pediatric Patients. (Pubmed Central) - Apr 5, 2022
One patient reported benefit from the off-label use of fluticasone propionate nasal spray...Our study confirms the severity of this dermatological complication that may hinder the spread of new technologies for the management of diabetes. Finally, our findings highlight the importance of establishing close collaboration both with pediatric allergy specialists to prescribe the most suitable treatment and with manufacturing companies to ensure that adhesives of technological devices are free of harmful well-known sensitizers.
- |||||||||| azithromycin / Generic mfg., fluticasone / Generic mfg.
Clinical, Journal: Impact of SARS-CoV-2 Infection Among Non-Invasive Ventilated ALS Patients. (Pubmed Central) - Mar 9, 2022
In summary, we present a network-based, multimodal methodology for single-cell/nucleus genomics-informed drug discovery and has identified fluticasone and mometasone as potential treatments in AD. Prompt medical treatment is recommended for ALS patients with severe disease infected by SARS-CoV-2.
- |||||||||| budesonide / Generic mfg.
Journal: Current options and investigational drugs for the treatment of eosinophilic esophagitis. (Pubmed Central) - Feb 26, 2022
These include monoclonal antibodies (including mepolizumab, reslizumab, benralizumab, dectrekumab, cendakimab, and dupilumab), JAK-STAT blockers, and S1PR agonists, among others...Therapies under investigation potentially can target multiple Th2-associated diseases that converge in EoE patients. Therapeutic strategies require a personalized and patient-centered approach to reduce the burden of the disease, and cost-effectiveness analysis to position their use in a complex therapeutic landscape.
- |||||||||| fluticasone / Generic mfg.
Preclinical, Journal: Sarsasapogenin and fluticasone combination improves DNFB induced atopic dermatitis lesions in BALB/c mice. (Pubmed Central) - Feb 24, 2022
These data specify that SG has been demonstrated as a probable therapy for the treatment of allergic skin diseases in combination with FC by decreasing its dose from 50 to 25 µg/mice to avoid the chronic side effects of FC. Hence, it can be concluded that SG and SG + FC combination significantly improved the AD-like symptoms in the DNFB sensitized mice through mitigating the production of proinflammatory mediators and restoration of oxidative stress markers.
- |||||||||| clindamycin phosphate / Generic mfg., fluticasone / Generic mfg.
A Timeline of Radiological and Symptomatic Improvement in Pediatric Post Infectious Bronchiectasis: A Case Report (Area B, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_4653;
At discharge he was started on inhaled fluticasone, 2L oxygen at night and QID airway clearance...As seen in our patient, there can be partial reversal of bronchiectatic changes in healthy pediatric patients who are diagnosed early and adhere to regular airway clearance4. Close pulmonary follow-up is required to prevent secondary infections which can exacerbate lung damage.
- |||||||||| Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Nulojix (belatacept) / BMS
Chronic Bronchitis Induced by Immunosuppression from Betalacept (Area B, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_2747;
3 months later, repeat chest CT is improved and clinically patient significantly improved with decreased cough, sputum and shortness of breath. This suggests his symptoms were due to an adverse effect of Belatacept.
- |||||||||| vilanterol (GW642444H) / GSK, Breo Ellipta (fluticasone furoate / vilanterol) / GSK, Innoviva
Allergic Bronchopulmonary Aspergillosis Complicating Asthma Presenting as Chronic Recurrent Pneumonia and Hemoptysis (Area I, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_2567;
APBA has a broad clinical presentation ranging from minimally symptomatic dyspnea and wheezing to severe lung parenchymal injury and is radiographically characterized by proximal bronchiectasis. Despite its clinical heterogeneity and infrequency, it should be considered in patients with worsening asthma and/or newly diagnosed bronchiectasis.
- |||||||||| A Rare Case of Chronic Obstructive Pulmonary Disease Associated with HUVS (Area I, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_2545;
Re-induction therapy with intravenous cyclophosphamide and corticosteroids was started for treatment of HUVS following which his complement levels normalized and his kidney function improved...Our case highlights the importance of prompt recognition and timely initiation treatment. Clinicians should maintain a high degree of suspicion in order to avoid catastrophic consequences.
- |||||||||| fluticasone / Generic mfg.
Predicting Pneumonia Events in COPD Patients Using Medical Records (Room 9-10 (South Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_2310;
COPD patients at risk of pneumonia can be identified from routinely available primary care data, highlighting the importance of documenting a detailed medical history. Furthermore, the model developed in the present investigation can assist in identifying these at-risk patients in primary practice.
- |||||||||| Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J
Isolated Pulmonary Sarcoidosis in a 4 Year Old Child (Area E, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_1342;
Younger children present with skin rash, arthritis, and uveitis without pulmonary involvement. Our case is unique for early and isolated complicated pulmonary sarcoidosis in a Caucasian young child.
- |||||||||| fluticasone / Generic mfg.
CTFR Dysfunction in Sjogren Syndrome: A Rare Clinical Association (Area F, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_962;
Fluticasone inhaler was initiated...Our case differed from the other two in that our patient had negative results of genetic testing despite evidence of CTFR dysfunction. Thus far, there have not been human studies showing improvement of SS symptoms with CFTR activators.
- |||||||||| fluticasone / Generic mfg.
A Clustering Analysis of Eosinophilic Asthmatic Patients (Area C, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_902;
Clustering was also applied to subgroups of ICS naive patients one the hand and high dose ICS treated patients (≥1000 µg propionate fluticasone) on the other hand...Clustering on ICC naïve and high dose ICS treated patients also yielded two clusters mainly structured by age, atopic status, intensity of granulocytic airway inflammation.ConclusionOur results points to different phenotypes in eosinophilic asthmatics with the atopic trait being generally associated with an achievable control of the disease with low dose ICS despite eosinophilic airway inflammation. In contrast there is an aggressive eosinophilic phenotype also usually featuring intense airway neutrophilic inflammation, not associated with atopic trait and leading to impaired lung function and poor asthma control despite heavy treatment burden.
- |||||||||| fluticasone / Generic mfg.
IIH and Tertiary AI Associated with Inhaled Fluticasone Discontinuation in a Pediatric Patient () - Feb 4, 2022 - Abstract #AAAAI2022AAAAI_1464;
Ongoing research is needed to learn more about prevention and early recognition of these life-threatening phenomena.AI is due to deficient production or action of glucocorticoids with or without mineralocorticoid and adrenal androgen deficiency.8 Tertiary AI occurs after chronic exogenous steroid use, which leads to suppression of hypothalamic CRH secretion.8 It is diagnosed by low serum cortisol and ACTH, or by ACTH stimulation test.8IIH is diagnosed based on "elevated intracranial pressure with no clinical, laboratory, or radiographic evidence of responsible infection, vascular abnormality, space occupying lesion, or hydrocephalus"4. The pathogenesis of IIH is unclear, but it is associated with obesity, endocrine abnormalities, drugs (including steroid wean), viral infections, nutritional deficiencies, and genetic conditions in children.4
- |||||||||| fluticasone / Generic mfg.
Journal: Pro-and anti-inflammatory effects of glucocorticoid Fluticasone on ovarian and immune functions in commercial-aged laying hens. (Pubmed Central) - Jan 28, 2022
A significant reduction was observed in the ovulation rate, follicular size (P < 0.001), ovarian hormones, immunoglobulins, body weight, and food consummation (P ≤ 0.05) by administering GC Fluticasone. Although a relative anti-inflammatory improvement was created by Fluticasone in the ovarian condition, the administration of this glucocorticoid resulted in a considerable reduction in ovarian hormones and functions of commercial aged laying hens.
- |||||||||| fluticasone / Generic mfg.
Preclinical, Journal: Protective effect of sarsasapogenin in TNBS induced ulcerative colitis in rats associated with downregulation of pro-inflammatory mediators and oxidative stress. (Pubmed Central) - Jan 27, 2022
Thirty Wistar rats were randomized into five groups: (i) Normal control, (ii) Disease control (TNBS), (iii) Sarsasapogenin (SG) (50 µg/rat), (iv) Fluticasone (FC) (50 µg/rat), (v) Sarsasapogenin + Fluticasone (SG + FC) (25 µg/rat)...SG and SG + FC treatment also considerably restored the histopathological changes induced by TNBS. Thus, SG and SG + FC combination could alter the disease progression and could be a hopeful therapeutic target for the management of UC by reducing its dose in combination with FC to elude the long term adverse effects of FC.
- |||||||||| itraconazole / Generic mfg.
Journal: Acute hyperosmolar hyperglycaemic state in cystic fibrosis-related diabetes caused by glucocorticoid and itraconazole interaction. (Pubmed Central) - Jan 26, 2022
We report the case of a 15-year old boy with stable CFRD who developed acute HHS after treatment with glucocorticoids and itraconazole for presumed allergic broncho-pulmonary aspergillosis (ABPA). This case highlights the dangerous and preventable combination of high glucose intake, glucocorticoids and itraconazole inhibition of CYP3A4 (with resultant glucocorticoid accumulation) that can result in a state of life- threatening HHS in an adolescent with previously stable CFRD.
- |||||||||| budesonide / Generic mfg.
Review, Journal: Evidence-based treatments for eosinophilic esophagitis: insights for the clinician. (Pubmed Central) - Jan 26, 2022
Finally, endoscopic dilation should be considered in patients with reduced esophageal caliber or persistent dysphagia despite histological remission. This article provides a state-of-the-art review and updated discussion of current therapies and newly developed options for EoE.
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