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- | moxidectin / Generic Mfg.
Journal: Aerobic dissipation of avermectins and moxidectin in subtropical soils and dissipation of abamectin in a field study. (Pubmed Central) - Nov 24, 2019
In addition, a field study was carried out to evaluate the dissipation of abamectin after application of a foliar pesticide in an orange crop. A DT of 9 days was determined, which was similar to that obtained under controlled conditions in the climate chamber (12 days), indicating that biotransformation was the primary process influencing the overall dissipation.
- | moxidectin / Generic Mfg.
Journal: Association between infestation by Lynxacarus radovskyi (Acari: Lystrophoridae) and the occurrence of Feline Eosinophilic Granuloma Complex. (Pubmed Central) - Nov 23, 2019
Seven out of the eight cats presented with at least one characteristic injury of the FEGC. In all of them the chosen treatment was moxidectin or spot-on imidacloprid plus corticotherapy on the cats with FEGC, which were effective.
- | moxidectin / Generic Mfg.
Journal: The World Health Organization 2030 goals for onchocerciasis: Insights and perspectives from mathematical modelling: NTD Modelling Consortium Onchocerciasis Group. (Pubmed Central) - Nov 18, 2019
Areas without loiasis that have not yet initiated MDA should implement biannual (preferably with moxidectin) or quarterly MDA from the start...The diagnostic performance of IgG4 Ov16 serology for assessing EOT is currently uncertain. Verification of EOT requires novel diagnostics at the individual- and population-levels.
- | moxidectin / Generic Mfg.
Journal: Benzethonium chloride activates ER stress and reduces proliferation in HNSCC. (Pubmed Central) - Oct 30, 2019
Verification of EOT requires novel diagnostics at the individual- and population-levels. No abstract available
- | moxidectin / Generic Mfg.
Clinical, Journal: Evaluation of the cardiac safety of long-acting endectocide moxidectin in a randomized concentration-QT study. (Pubmed Central) - Sep 28, 2019
Moxidectin had no statistically significant or clinically relevant impact on QT interval at any dose level. The primary mixed effects model analysis revealed no treatment-related impact on the Fridericia-corrected QT interval - plasma concentration gradient (-0.0077, 90% confidence interval (CI) -0.0255 to +0.0101).
- | moxidectin / Generic mfg.
Trial initiation date: StrongMoxy: Efficacy, Safety, and PK of Ascending Dosages of Moxidectin Versus Ivermectin Against Strongyloides Stercoralis (clinicaltrials.gov) - Sep 24, 2019
P2, N=210, Not yet recruiting, Sponsor: Jennifer Keiser
The primary mixed effects model analysis revealed no treatment-related impact on the Fridericia-corrected QT interval - plasma concentration gradient (-0.0077, 90% confidence interval (CI) -0.0255 to +0.0101). Initiation date: Sep 2019 --> Dec 2019
- | moxidectin / Generic Mfg., doxycycline / Generic Mfg.
Clinical, Journal: Efficacy of imidacloprid 10%/moxidectin 2.5% spot on (Advocate®, Advantage Multi®) and doxycycline for the treatment of natural Dirofilaria immitis infections in dogs. (Pubmed Central) - Sep 22, 2019
For the criteria mf concentration, antigen concentration, radiography and echocardiography at 12, 18 and 24 months the non-inferiority for the moxidectin group could be proven for a non-inferiority margin of 15% for the rate difference. Dogs treated with moxidectin and doxycycline became negative for microfilariae and antigens sooner when compared to melarsomine in the present study and to dogs treated with doxycycline combined with ivermectin in studies previously published.
- | moxidectin / Generic Mfg., praziquantel (MSC2499550A) / Merck (MSD)
Journal: Combination Anthelmintic Treatment for Persistent Ancylostoma caninum Ova Shedding in Greyhounds. (Pubmed Central) - Sep 18, 2019
Follow-up fecal examinations were important for verifying the presence or absence of ova shedding despite the use of anthelmintic treatment. Limitations of the current study include small sample size, inclusion of only privately owned greyhounds, and client compliance with fecal collection and animal care.
- | moxidectin / Generic Mfg.
Journal: Multiple resistance to macrocyclic lactones in the sheep scab mite Psoroptes ovis. (Pubmed Central) - Sep 7, 2019
...Following recent work demonstrating resistance of Psoroptes mites to moxidectin, a widely used macrocyclic lactone (ML) treatment for scab, the current study compared the toxicity of three of the commonly administered macrocylic lactone therapeutic treatments (moxidectin, ivermectin and doramectin) to P. ovis from outbreak populations that had appeared unresponsive to treatment...However, considerable variation in response suggested that resistance alone was not responsible for the reported lack of efficacy in all of the submitted cases; lack of response in others may be associated with inappropriate treatment application or management. These data highlight the importance of the appropriate use of these compounds to manage national scab incidence at levels that are consistent with acceptable animal welfare standards, while attempting to reduce the development and spread of resistance.
- | moxidectin / Generic Mfg.
Journal: CUTANEOUS DEMODICOSIS AND UV-INDUCED SKIN NEOPLASIA IN TWO GOELDI'S MONKEYS (CALLIMICO GOELDII). (Pubmed Central) - Aug 30, 2019
...Long-term treatment with ivermectin, imidacloprid-moxidectin, and sarolaner resolved the demodicosis but skin lesions progressed to actinic keratosis and carcinoma...Since the animals had access to ultraviolet (UV) light, as recommended for indoor-housed callitrichids, the skin tumors were likely UV-induced and the mites have settled particularly within impaired regions. Thus, apparent demodicosis can indicate cutaneous immunosuppression and might alert caretakers to adjust the UV regime.
- | moxidectin / Generic Mfg., praziquantel (MSC2499550A) / Merck (MSD)
PK/PD data, Journal: Pharmacokinetics of combination antiparasitic drug preparation for dogs and cats in the form of spot-on solution. (Pubmed Central) - Aug 29, 2019
After topical administration, moxidectin is absorbed and distributed systemically and is slowly removed from the plasma, which manifests itself in detectable concentrations of moxidectin in the blood for 1 month. The present results of pharmacokinetic investigations may promote to the determination of effective therapy strategy and prophylaxis of parasitic diseases in dogs and cats.
- | moxidectin / Generic Mfg.
Clinical, Journal: Acaricidal efficacy of orally administered macrocyclic lactones against poultry red mites (Dermanyssus gallinae) on chicks and their impacts on mite reproduction and blood-meal digestion. (Pubmed Central) - Aug 21, 2019
EPR, MOX or IVM administrated orally to chicks increased the mortality of D. gallinae, significantly slowed down their blood-meal digestion and significantly reduced their reproductive capability which included the oviposition rate, fecundity and egg hatching rate. The present study highlights the potential of MLs in the control of PRMs.
- | moxidectin / Generic Mfg.
Journal: Current anthelmintic treatment is not always effective at controlling strongylid infections in German alpaca herds. (Pubmed Central) - Aug 15, 2019
Gastrointestinal strongylids are common in German alpacas and fenbendazole in particular was not sufficiently effective to reduce strongylid egg excretion. Although the FECRT could not unambiguously determine anthelmintic resistance in the present study, the finding that small ruminant strongylids, especially Haemonchus, are common in alpacas indicates that determination of effective anthelmintic doses, monitoring of efficacy and adapted (selective) treatment regimens must be implemented as part of sustainable deworming practices in this species in accordance with recommendations for ruminants.
- | moxidectin / Generic mfg.
New P2 trial: StrongMoxy: Efficacy, Safety, and PK of Ascending Dosages of Moxidectin Versus Ivermectin Against Strongyloides Stercoralis (clinicaltrials.gov) - Aug 13, 2019
P2, N=210, Not yet recruiting, Sponsor: Jennifer Keiser
- ||| moxidectin / Generic Mfg.
Clinical: .@MedicinesDev Medicines Development for Global Health: @NovoNordisk Buys Moxidectin #RiverBlindness Voucher - subscribe to Biotech Daily https://t.co/4E9331THtC (Twitter) - Aug 13, 2019
- | moxidectin / Generic Mfg., Ergamisol (levamisole) / J&J
Clinical, Journal: Multiple-resistance to ivermectin and benzimidazole of a Haemonchus contortus population in a sheep flock from mainland France, first report. (Pubmed Central) - Aug 8, 2019
As this sheep flock is a transhumant flock, the spread of this multiple-resistant Haemonchus contortus population to the other sheep flocks sharing the same pastures in Pyrenean Mountains is highly likely. From the knowledge of the authors, this is the first report of multi-resistance to ivermectin and benzimidazole of a Haemonchus contortus population in mainland France.
- | moxidectin / Generic mfg.
New P2 trial: EOLoa: Clinical Trial Evaluating the Safety and Efficacy of Moxidectin 2 mg Ivermectin-controlled in Loa Loa Microfilaremic Patients (clinicaltrials.gov) - Aug 7, 2019
P2, N=480, Not yet recruiting, Sponsor: Institut National de la Sant
- | moxidectin / Generic Mfg., Ergamisol (levamisole) / J&J
Journal: Effectiveness of several anthelmintics to control a Strongyloides sp. outbreak in Creole-de-Guadeloupe male kids aged 7 months. (Pubmed Central) - Aug 2, 2019
In addition, levamisole (11.25 mg·kg) and ivermectin (0.3 mg·kg) also failed to control Strongyloides sp., with FECRs of 1.4% and 53.5%, respectively...Albendazole or netobimin at 3 times the dose for sheep may be effective for Strongyloides sp. control in case of severe infection.
- | moxidectin / Generic mfg.
Trial completion date, Trial initiation date: Dose-finding Study of Moxidectin for Treatment of Scabies (clinicaltrials.gov) - Aug 1, 2019
P2, N=18, Not yet recruiting, Sponsor: Medicines Development Limited
control in case of severe infection. Trial completion date: Dec 2019 --> Mar 2020 | Initiation date: May 2019 --> Sep 2019
- | moxidectin / generics
Clinical, Journal: Efficacy of a spot-on combination of fluralaner plus moxidectin (Bravecto Plus) in cats following repeated experimental challenge with a field isolate of Ctenocephalides felis. (Pubmed Central) - Jul 26, 2019
These findings demonstrate complete efficacy of fluralaner plus moxidectin against a flea isolate that was not controlled by fipronil and (S)-methoprene. This study provides confirmation of the consistent, sustained efficacy of topically applied fluralaner in the treatment and control of flea infestations in cats.
- | moxidectin / generics
Review, Journal: The public health control of scabies: priorities for research and action. (Pubmed Central) - Jul 21, 2019
Studies are needed to inform optimum implementation of mass treatment, including the threshold for intervention, target, dosing, and frequency. Frameworks for surveillance, monitoring, and evaluation of control strategies are also necessary.
- | moxidectin / generics
Preclinical, Journal: Moxidectin Effects on Gut Microbiota of Wistar-Kyoto Rats: Relevance to Depressive-Like Behavior. (Pubmed Central) - Jul 20, 2019
Thus, MOX enhanced probiotic species, and suppressed the opportunistic pathogens. Since overall effect of MOX appears to be promoting GM associated with mood enhancement (e.g. Bifidobacterium and Lactobacillus) and suppressing GM associated with inflammation (e.g. Ruminoccus), potential antidepressant and anti-inflammatory effects of MOX in suitable animal models should be investigated.
- | moxidectin / generics
Clinical, Journal: Efficacy and safety of a combination of selamectin plus sarolaner for the treatment and prevention of flea infestations and the treatment of ear mites in cats presented as veterinary patients in the United States. (Pubmed Central) - Jul 11, 2019
...Imidacloprid plus moxidectin (Advantage Multi for Cats, Bayer) was used as a positive control in both studies at the label dosage...Clinical signs of flea allergy dermatitis improved in affected cats following treatment administration. A single topical treatment was also safe and highly effective for the treatment of ear mite infestations in naturally infested cats.
- | moxidectin / Generic mfg.
New P1 trial: A Pharmacokinetic and Safety Study of Moxidectin to Identify an Optimal Dose for Treatment of Children 4 to 11 Years (clinicaltrials.gov) - May 22, 2019
P1, N=27, Not yet recruiting, Sponsor: Medicines Development Limited
- | Clinical, Journal: Survey-based pilot study into the chosen therapy and prophylaxis used by UK primary care veterinary surgeons against canine angiostrongylosis. (Pubmed Central) - Apr 25, 2019
This provides an important starting point for future studies investigating the decision-making for CA amongst UK veterinary surgeons, particularly to clarify whether in a larger cohort an unlicensed drug remains the treatment of choice. The absence of a clear protocol for fenbendazole means that treatment of dogs affected by CA may be suboptimal, increasing the risk of morbidity and mortality.
- clarithromycin / Generic mfg.
In vitro profiling of anthelmintic avermectins against non-tuberculous mycobacteria () - Apr 5, 2019 - Abstract #ECCMID2019ECCMID_1408;
They are approved drugs suitable for oral administration and already in common veterinary use. They could offer an alternative intervention in infections caused by strains resistant to first-line macrolides-based therapies.
- | moxidectin / Generic mfg.
New P2 trial: Dose-finding Study of Moxidectin for Treatment of Scabies (clinicaltrials.gov) - Apr 5, 2019
P2, N=18, Not yet recruiting, Sponsor: Medicines Development Limited
- | moxidectin / Generic mfg.
New P3 trial: Safety and Efficacy of Annual or Biannual Doses of Moxidectin or Ivermectin for Onchocerciasis (clinicaltrials.gov) - Mar 15, 2019
P3, N=1000, Not yet recruiting, Sponsor: Medicines Development Limited
- | moxidectin / Generic mfg., albendazole / Generic mfg.
Trial completion: MOXIDOSE: Efficacy and Safety of Ascending Dosages of Moxidectin and Moxidectin-albendazole Against Trichuris Trichiura (clinicaltrials.gov) - Aug 14, 2018
P2, N=286, Completed, Sponsor: Swiss Tropical & Public Health Institute
They could offer an alternative intervention in infections caused by strains resistant to first-line macrolides-based therapies. Not yet recruiting --> Completed
- | moxidectin / Generic mfg., albendazole / Generic mfg.
New P2 trial: MOXIDOSE: Efficacy and Safety of Ascending Dosages of Moxidectin and Moxidectin-albendazole Against Trichuris Trichiura (clinicaltrials.gov) - Apr 17, 2018
P2, N=280, Not yet recruiting, Sponsor: Swiss Tropical & Public Health Institute
- | moxidectin / Generic mfg.
Trial completion: Effect of a Single Oral Dose of Moxidectin on the Cardiac QT Interval of Healthy Volunteers (clinicaltrials.gov) - Jul 24, 2017
P1, N=60, Completed, Sponsor: Medicines Development Limited
Not yet recruiting --> Completed Active, not recruiting --> Completed
- | moxidectin / Generic mfg.
Enrollment closed: Effect of a Single Oral Dose of Moxidectin on the Cardiac QT Interval of Healthy Volunteers (clinicaltrials.gov) - Feb 27, 2017
P1, N=60, Active, not recruiting, Sponsor: Medicines Development Limited
Active, not recruiting --> Completed Recruiting --> Active, not recruiting
- moxidectin / Generic mfg.
Enrollment open: Effect of a Single Oral Dose of Moxidectin on the Cardiac QT Interval of Healthy Volunteers (clinicaltrials.gov) - Feb 4, 2017
P1, N=60, Recruiting, Sponsor: Medicines Development Limited
Recruiting --> Active, not recruiting Not yet recruiting --> Recruiting
- moxidectin / Generic mfg.
New P1 trial: Effect of a Single Oral Dose of Moxidectin on the Cardiac QT Interval of Healthy Volunteers (clinicaltrials.gov) - Jan 13, 2017
P1, N=60, Recruiting, Sponsor: Medicines Development Limited
- | moxidectin / Generic mfg.
Trial completion: Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection (clinicaltrials.gov) - Mar 14, 2013
P3, N=1497, Completed, Sponsor: World Health Organization
Not yet recruiting --> Recruiting Active, not recruiting --> Completed