- |||||||||| moxidectin / Generic mfg.
Enrollment closed: Efficacy and Safety Study of Moxidectin in Adults with Scabies (clinicaltrials.gov) - Oct 29, 2024 P2, N=200, Active, not recruiting, Monthly administration of SMP was effective for the treatment of generalised demodicosis in dogs as it eliminated Demodex mites after two monthly treatments in the laboratory study, and at most after three monthly treatments in the field study. Recruiting --> Active, not recruiting
- |||||||||| emodepside (BAY 44-4400) / Bayer, flubentylosin (ABBV-4083) / AbbVie
Development of alternative treatments for filarial diseases (Convention Center - Hall I-1 (1st Floor); In-Person-Only) - Oct 26, 2024 - Abstract #ASTMH2024ASTMH_4045; The Drugs for Neglected Diseases initiative (DNDi) is investigating emodepside (with Bayer AG) and ABBV-4083 (with the Anti-Wolbachia (AWOL) consortium and AbbVie), along with multiple partners...Recent studies show its strong activity against Trichuris trichiura and hookworm infections in humans. Here, we present emodepside results for Onchocerca volvulus , recent failures, and considerations for patient access to new medicines.
- |||||||||| moxidectin / Generic mfg., albendazole / Generic mfg.
Safety of novel combination treatments for onchocerciasis (Convention Center - Hall I-1 (1st Floor); In-Person-Only) - Oct 26, 2024 - Abstract #ASTMH2024ASTMH_4038; In a new randomized, blinded trial we compare the safety and efficacy of standard doses of IA with IDA, moxidectin (mox)A and moxDA...From this ongoing study it can be concluded that after pre-treatment with ivermectin a single course of IDA, moxA or moxDA are as safe as the standard treatment for onchocerciasis in areas co-endemic for lymphatic filariasis IA. It is planned to assess the macrofilaricidal efficacy after two treatment courses 6 months apart.
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Journal: Treatment of Sarcoptic Mange in Wombats With Topical Moxidectin. (Pubmed Central) - Oct 22, 2024 Here, we presented two clinical scenarios of sarcoptic mange in wombats that were successfully treated with three 100-mL doses of moxidectin applied topically. We recommend this treatment be used where wombats can be identified and monitored throughout their recovery.
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Onchocerciasis Seroprevalence In Bi (Convention Center - Hall I-1 (1st Floor); In-Person-Only) - Oct 11, 2024 - Abstract #ASTMH2024ASTMH_3087; In Bie?, prior to the initiation of MDA, we conducted a cross-sectional survey across three areas to determine suitability for a planned cluster-randomised trial of moxidectin versus ivermectin MDA...The breeding site assessments confirmed the presence of blackfly larvae in all three study areas. Our findings confirm the urgent need for MDA against onchocerciasis in this province.
- |||||||||| moxidectin / Generic mfg., albendazole / Generic mfg.
Moxidectin plus albendazole for lymphatic filariasis: effects through 36 months post-treatment (Convention Center - Room 343/344 (3rd Floor); In-Person-Only) - Oct 11, 2024 - Abstract #ASTMH2024ASTMH_1772; Complete results adjusted for baseline characteristics and infection intensity for all participants will be presented at the meeting. Results from this trial suggest that mass drug administration with MoxA could accelerate LF and onchocerciasis elimination in Africa.
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Journal: Evaluating alternative compounds for strongyloidiasis therapy: Novel insights from larval migration inhibition test. (Pubmed Central) - Oct 7, 2024 Moreover, some diamine and aminoalcohol derivatives showed superior efficacy inhibiting S. ratti motility compared to ivermectin, with five compounds (AA23, AA34, AO2 AO7 and AO14b) also displaying selectivity indexes on HepG2 and Caco2 higher than 1. These findings underscore the potential of these derivatives as promising alternatives for strongyloidiasis treatment, warranting further investigation and in vivo efficacy assessment.
- |||||||||| moxidectin / Generic mfg., albendazole / Generic mfg., praziquantel / Generic mfg.
113 - Innovative Tools for the Control of NTDs. How to Achieve Impact through Access Beyond Drug Donations (Convention Center - Room 357 (3rd Floor); In-Person-Only) - Sep 15, 2024 - Abstract #ASTMH2024ASTMH_588; Special attention to these innovations in pediatric populations and in the opportunities for changes in the expectations for disease control and elimination will also be discussed. The session will include a donor panel to discuss the potential, opportunities and barriers to the introduction and scale up of these and other new tools.
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Journal: The use of quantitative clinical pharmacology approaches to support moxidectin dosing recommendations in lactation. (Pubmed Central) - Aug 15, 2024 As early as two days after dosing, concentrations of moxidectin in breast milk were below the threshold for acceptable daily intake levels established by the European Medicines Agency (EMA) and FDA for secondary exposures from veterinary use, and below the WHO recommended relative infant dose (RID) safety threshold. The analyses were conducted to support prescribers and policy makers on dosing recommendations for moxidectin in lactation.
- |||||||||| moxidectin / Generic mfg., levamisole / Generic mfg.
Review, Journal: Anthelmintic resistance of gastrointestinal nematodes in cattle in Brazil and Argentina - current status and global perspectives. (Pubmed Central) - Aug 14, 2024 The review explores the impact ofclimate, mixed grazing, animal movement and other husbandry practices, and the relationship between ectoparasite control and the emergence of resistant helminths. Notably, the discussion includes the strategic use of drug combinations as a valuable approach to address resistant GINs control in livestock, highlighting its significant potential to mitigate the challenges posed by AHR in the cattle industry of these countries.
- |||||||||| moxidectin / Generic mfg., albendazole / Generic mfg.
Trial completion, Head-to-Head: Moxiped: Efficacy and Safety of MOX/ALB Co-administration in SAC (clinicaltrials.gov) - Aug 13, 2024 P3, N=224, Completed, Notably, the discussion includes the strategic use of drug combinations as a valuable approach to address resistant GINs control in livestock, highlighting its significant potential to mitigate the challenges posed by AHR in the cattle industry of these countries. Active, not recruiting --> Completed
- |||||||||| moxidectin / Generic mfg.
Clinical, Journal: Comparative speed of kill provided by lotilaner (Credelio (Pubmed Central) - Jul 20, 2024 Credelio (lotilaner) has a more rapid onset of acaricidal activity against A. americanum than Simparica Trio (sarolaner-moxidectin-pyrantel) and NexGard (afoxolaner). Only lotilaner's speed of tick kill is sustained throughout the dosing period.
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Journal: Unravelling the Effectiveness of Anthelmintic Treatments on Equine Strongyles on Irish Farms. (Pubmed Central) - Jul 13, 2024 The reduced efficacy of moxidectin was noted on two farms (FECR = 86.90% and 93.50%) and on a third farm with an FECR of 99.50 and a lower HPD interval < 90% at 24.00%. In summary, these findings emphasize the urgent need for alternative strategies in equine strongyle control that reduce reliance on anthelmintics and prioritize effective management practices on Irish equine farms to hinder the impending development of drug-resistant parasite populations.
- |||||||||| moxidectin / Generic mfg., ivermectin topical / Generic mfg.
Journal: Feline sarcoptic mange in Poland: A case series of three cats. (Pubmed Central) - Jun 12, 2024 The clinical presentation of feline scabies appears to be more variable in cats than in dogs. Infestation with S. scabiei should be considered a differential diagnosis for cats presenting with pruritic inflammatory skin disease.
- |||||||||| moxidectin / Generic mfg., albendazole / Generic mfg.
Enrollment closed, Head-to-Head: Moxiped: Efficacy and Safety of MOX/ALB Co-administration in SAC (clinicaltrials.gov) - Jun 6, 2024 P3, N=210, Active, not recruiting, Infestation with S. scabiei should be considered a differential diagnosis for cats presenting with pruritic inflammatory skin disease. Recruiting --> Active, not recruiting
- |||||||||| moxidectin / Generic mfg.
Trial completion date, Trial primary completion date: Efficacy and Safety Study of Moxidectin in Adults with Scabies (clinicaltrials.gov) - Jun 2, 2024 P2, N=200, Recruiting, Not yet recruiting --> Enrolling by invitation Trial completion date: Aug 2024 --> Dec 2024 | Trial primary completion date: Jun 2024 --> Sep 2024
- |||||||||| moxidectin / Generic mfg., albendazole / Generic mfg.
Enrollment open, Head-to-Head: Moxiped: Efficacy and Safety of MOX/ALB Co-administration in SAC (clinicaltrials.gov) - May 22, 2024 P3, N=210, Recruiting, Trial completion date: Aug 2024 --> Dec 2024 | Trial primary completion date: Jun 2024 --> Sep 2024 Not yet recruiting --> Recruiting
- |||||||||| moxidectin / Generic mfg., ivermectin oral / Generic mfg., albendazole / Generic mfg.
Biomarker, Journal: Biomarkers of gastrointestinal nematodes in beef cattle raised in a tropical area. (Pubmed Central) - May 7, 2024 In the second step, pepsinogen was assessed in cattle of the Nelore breed distributed among three groups: infected (not treated with anthelmintic), MOX (treated with moxidectin), and IVM?+?BZD (treated with ivermectin?+?albendazole)...In the second study, a reduction in pepsinogen was found after anthelmintic treatment. Therefore, pepsinogen is a promising biomarker of worms in cattle naturally infected by the genera Haemonchus and Cooperia in tropical areas.
- |||||||||| monepantel (PAA1) / Pharmaust
Journal: Revisiting anthelmintic resistance in sheep flocks from S (Pubmed Central) - Apr 8, 2024 The costs of moxidectin to national programs are needed to quantify whether delivery cost reductions will translate into overall program cost reduction. In each one of the 15 flocks evaluated, animals (n
- |||||||||| moxidectin / Generic mfg., ivermectin oral / Generic mfg.
P3 data, Journal, Adverse events: Onchocerca volvulus microfilariae in the anterior chambers of the eye and ocular adverse events after a single dose of 8 (Pubmed Central) - Mar 20, 2024 The impact of SmfD and mfAC levels before and early after treatment on ocular AEs needs to be better understood before making decisions on the risk-benefit of strategies including DEC. Such decisions should take into account interindividual variability in SmfD, mfAC levels and treatment response and risks to even a small percentage of individuals.
- |||||||||| moxidectin / Generic mfg.
Journal: Efficacy of a spot-on formulation containing 280 (Pubmed Central) - Jan 29, 2024 The percentage of negative cats was higher in the IVP group compared to the control group and the percentage of reduction of fecal larvae counts in the IVP group compared to the control group was 100%. These results show that two administrations of Bravecto Plus
- |||||||||| moxidectin / Generic mfg.
Journal: Extraction and analysis of moxidectin in wombat plasma and faeces. (Pubmed Central) - Jan 29, 2024 These results show that two administrations of Bravecto Plus The methods reported here were used to monitor moxidectin in wombats treated with a single pour-on treatment, and confirmed that the moxidectin concentration in wombat plasma had decreased by more than 90
- |||||||||| moxidectin / Generic mfg.
Journal: The relationship between Intra-Flagellar Transport and upstream protein trafficking pathways and macrocyclic lactone resistance in Caenorhabditis elegans. (Pubmed Central) - Jan 16, 2024 It has recently been shown in the model nematode Caenorhabditis elegans that the sensory cilia of the amphid neurons play an important role in resistance towards macrocyclic lactones such as ivermectin (an avermectin) and moxidectin (a milbemycin) either through reduced uptake or inter-tissue signalling pathways...In total 24 novel C. elegans anthelmintic survival associated genes were identified in this study. When combined with previously known resistance genes, there are now 46 resistance associated genes which are directly involved in amphid, cilia and IFT function.
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