- |||||||||| Ibrance (palbociclib) / Pfizer, Kisqali (ribociclib) / Novartis
Journal, Adverse events: Cyclin-dependent kinase 4/6 inhibitors and cardiotoxic events in breast cancer: A pharmacovigilance study based on the FAERS database. (Pubmed Central) - Nov 16, 2024
Recent trials have highlighted the cardiotoxicity of ribociclib, a CDK4/6 inhibitor, particularly its association with QT prolongation...For the first time, palbociclib has been identified with positive signals for cardiotoxic events at the preferred terms level, including pulmonary oedema, increased blood pressure, myocardial infarction, and cardiac flutter...Our study also highlights significant drug interactions that increase the probability of specific cardiotoxic outcomes, notably with drugs like sertraline, lansoprazole, capecitabine, and torasemide. These findings highlight the need for personalized treatment plans to mitigate cardiotoxic events and improve patient safety.
- |||||||||| torasemide / Generic mfg.
PK/PD data, Review, Journal: A Systematic Critical Review of Clinical Pharmacokinetics of Torasemide. (Pubmed Central) - May 9, 2024
Not yet recruiting --> Recruiting The current review summarizes all available PK parameters of torasemide that may be beneficial for avoiding drug-drug interactions in subjects with renal and hepatic dysfunction and for predicting doses in patients with different diseases.
- |||||||||| torasemide / Generic mfg., midazolam hydrochloride / Generic mfg.
Preclinical, Journal: The loop diuretic torasemide but not azosemide potentiates the anti-seizure and disease-modifying effects of midazolam in a rat model of birth asphyxia. (Pubmed Central) - Jan 1, 2023
Loop diuretics such as furosemide and bumetanide, which act by inhibiting the Na-K-2Cl cotransporter NKCC2 at the thick ascending limb of the loop of Henle, have been shown to exert anti-seizure effects...Because of the urgent medical need to develop new treatments for neonatal seizures and their adverse outcome, we evaluated the effects of azosemide and torasemide, administered alone or in combination with phenobarbital or midazolam, in a rat model of birth asphyxia and neonatal seizures...We assume that either an effect on NKCC1 at the blood-brain barrier and/or cells in the periphery or the NKCC2-mediated diuretic effect of torasemide are involved in the present findings. Our data suggest that torasemide may be a useful option for improving the treatment of neonatal seizures and their adverse outcome.
- |||||||||| Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim, omecamtiv mecarbil (AMG 423) / Amgen, Servier, Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca
Review, Journal: Heart failure: an update from the last years and a look at the near future. (Pubmed Central) - Dec 23, 2022
Ferric derisomaltose had an effect on the primary outcome of CV mortality or HF rehospitalizations in IRONMAN (rate ratio 0.82; 95% confidence interval 0.66-1.02; P = 0.070). Further options for the treatment of HF, including device therapies, cardiac contractility modulation, and percutaneous treatment of valvulopathies, are summarized in this article.
- |||||||||| torasemide / Generic mfg.
Journal: Torasemide-induced Vascular Purpura in the Course of Eosinophilic Granulomatosis with Polyangiitis. (Pubmed Central) - Oct 25, 2022
She was on a constant regimen of oral rosuvastatin 5 mg per day, spironolactone 50 mg per day, metoprolol 150 mg per day, inhaled formoterol 12 μg per day, and ipratropium bromide 20 μg per day...The patient was commenced on prednisone at a dose of 0.5 mg per kg of body weight daily and mycophenolate mofetil at a daily dose of 2 g. The antihypertensive therapy was modified, and torasemide was replaced by spironolactone 25 mg per day...The strongest association with the occurrence of EGPA was found with the use of leukotriene receptor antagonists (montelukast, zafirlukast, pranlukast), although they are commonly used in the treatment of asthma, which is paradoxically one of the complications of the syndrome (13)...A coexistence of several disorders (asthma, nasal polyps, symptoms of peripheral neuropathy) in our patient suggest EGPA could have developed in her years before oral intake of torasemide. The sudden onset of skin symptoms shows torasemide to be possible inducing factor for the development of vascular purpura in patients suffering from EGPA but without previous cutaneous involvement.
- |||||||||| And my legs? () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_3069;
After several consultations, he assessed severe paraparesis with sensory alteration and sphincter involvement, with little chance of recovery.The patient was discharged to a specialized spinal cord injury center with rehabilitation, bladder catheterization, anticoagulant, anticonvulsant medication, and corticosteroids.Faced with a sudden onset with weakness or loss of strength in the lower limbs, we must always rule out spinal cord compression.In the event that the symptoms persist, although a first result does not refer to alterations, we must continue with the diagnostic procedure and even repeat complementary tests, establishing treatment as soon as possible.Spinal cord infarction is a rare cause of paraplegia that constitutes less than 1% of all ischemic infarctions.It is one of the most serious and feared complications of thoracic and/or abdominal aortic aneurysm surgery.It is due to injury to an extravertebral feeding artery or the aorta, more often than due to intrinsic disorders of the spinal artery. There is no specific treatment and corticosteroids, used in the acute phase, have not shown clear long-term improvement.
- |||||||||| And my legs? () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_3068;
After several consultations, he assessed severe paraparesis with sensory alteration and sphincter involvement, with little chance of recovery.The patient was discharged to a specialized spinal cord injury center with rehabilitation, bladder catheterization, anticoagulant, anticonvulsant medication, and corticosteroids.Faced with a sudden onset with weakness or loss of strength in the lower limbs, we must always rule out spinal cord compression.In the event that the symptoms persist, although a first result does not refer to alterations, we must continue with the diagnostic procedure and even repeat complementary tests, establishing treatment as soon as possible.Spinal cord infarction is a rare cause of paraplegia that constitutes less than 1% of all ischemic infarctions.It is one of the most serious and feared complications of thoracic and/or abdominal aortic aneurysm surgery.It is due to injury to an extravertebral feeding artery or the aorta, more often than due to intrinsic disorders of the spinal artery. There is no specific treatment and corticosteroids, used in the acute phase, have not shown clear long-term improvement.
- |||||||||| And my legs? () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_3067;
After several consultations, he assessed severe paraparesis with sensory alteration and sphincter involvement, with little chance of recovery.The patient was discharged to a specialized spinal cord injury center with rehabilitation, bladder catheterization, anticoagulant, anticonvulsant medication, and corticosteroids.Faced with a sudden onset with weakness or loss of strength in the lower limbs, we must always rule out spinal cord compression.In the event that the symptoms persist, although a first result does not refer to alterations, we must continue with the diagnostic procedure and even repeat complementary tests, establishing treatment as soon as possible.Spinal cord infarction is a rare cause of paraplegia that constitutes less than 1% of all ischemic infarctions.It is one of the most serious and feared complications of thoracic and/or abdominal aortic aneurysm surgery.It is due to injury to an extravertebral feeding artery or the aorta, more often than due to intrinsic disorders of the spinal artery. There is no specific treatment and corticosteroids, used in the acute phase, have not shown clear long-term improvement.
- |||||||||| And my legs? () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_3066;
After several consultations, he assessed severe paraparesis with sensory alteration and sphincter involvement, with little chance of recovery.The patient was discharged to a specialized spinal cord injury center with rehabilitation, bladder catheterization, anticoagulant, anticonvulsant medication, and corticosteroids.Faced with a sudden onset with weakness or loss of strength in the lower limbs, we must always rule out spinal cord compression.In the event that the symptoms persist, although a first result does not refer to alterations, we must continue with the diagnostic procedure and even repeat complementary tests, establishing treatment as soon as possible.Spinal cord infarction is a rare cause of paraplegia that constitutes less than 1% of all ischemic infarctions.It is one of the most serious and feared complications of thoracic and/or abdominal aortic aneurysm surgery.It is due to injury to an extravertebral feeding artery or the aorta, more often than due to intrinsic disorders of the spinal artery. There is no specific treatment and corticosteroids, used in the acute phase, have not shown clear long-term improvement.
- |||||||||| Veltassa (patiromer) / Vifor
In Vitro Evaluation of Drug-Drug Interactions of Patiromer With Common Renal and Cardiovascular Drugs (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_1091;
At pH 4.5, <70% recovery was observed with carvedilol, nebivolol and finerenone (5.4 [5.1–5.7], 15.8 [14.8–16.7], 69.6 [69.1–70.1], respectively), and at pH 6.8 with telmisartan (10.8 [10.5–11.1]), bisoprolol fumarate (67.6 [66.5–68.6]), carvedilol (1.6 [1.5–1.7]) and nebivolol (6.9 [6.1–7.6])...11 showed <70% recovery with PAT, mostly at pH 1.2. However, 7 drugs with DDIs at pH 1.2 showed no relevant interactions with patiromer at gradient pH, suggesting DDIs at low pH could be reversed as test drugs became neutral or negatively charged in the intestine, where most drugs are absorbed.
- |||||||||| torasemide / Generic mfg.
PK/PD data, Journal: Pharmacokinetic and pharmacodynamic properties of orally administered torasemide in healthy cats. (Pubmed Central) - Sep 29, 2022
A single torasemide dose leads to a significant increase in diuresis and renin-angiotensin-aldosterone system (RAAS) activation in healthy cats, with high absolute bioavailability, and without clinically relevant adverse effects. Pharmacokinetic parameters indicate that once daily dosing of 0.27 mg/kg may be appropriate in a clinical setting.
- |||||||||| Savaysa (edoxaban) / Daiichi Sankyo, Entresto (sacubitril/valsartan) / Novartis, ROVI Pharmaceuticals Laboratories, Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
Journal: Hypoglycemia in a patient treated with a SGLT2-inhibitor with HFrEF without diabetes mellitus (Pubmed Central) - Sep 14, 2022
Pharmacokinetic parameters indicate that once daily dosing of 0.27 mg/kg may be appropriate in a clinical setting. The presented case raises awareness of the side effect of hypoglycaemia, which occurs very rarely with SGLT2 inhibitors in studies in patients with HFrEF without the presence of diabetes mellitus.
- |||||||||| Bystolic (nebivolol) / Menarini, AbbVie
Journal: CARDIOVASCULAR AND KIDNEY OUTCOMES IN TREATED RESISTANT HYPERTENSIVE PATIENTS. (Pubmed Central) - Aug 27, 2022
Despite significant improvement in BP control the incidence of CV and renal outcomes in rHTN patients were higher than in cHTN patients. The independent predictors of combined CV and renal events were higher baseline systolic blood pressure, citrulline plasma level, and low concentration of endothelial progenitor cells.
- |||||||||| torasemide / Generic mfg.
Journal: A CLINICAL CASE OF SECONDARY HYPERTENSION IN A 20-YEAR-OLD FEMALE WITH COARCTATION OF THE AORTA. (Pubmed Central) - Aug 27, 2022
The independent predictors of combined CV and renal events were higher baseline systolic blood pressure, citrulline plasma level, and low concentration of endothelial progenitor cells. This clinical case presented a rare isolated type of CoA and demonstrates the importance of qualitative examination of young patients with hypertension, including BP measurement on the lower extremities and transthoracic echocardiography with a compulsory examination of the aorta.
- |||||||||| Entresto (sacubitril/valsartan) / Novartis, ROVI Pharmaceuticals Laboratories, Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
Journal: Treatment of patients with heart failure and preserved ejection fraction: reliance on clinical phenotypes (Pubmed Central) - Aug 24, 2022
Nevertheless, the isolation of these phenotypes is advisable to prioritize the choice of drug therapy. Thus, the diuretic treatment (preferably torasemide) should be considered in the presence of congestion, regardless of the HFpEF phenotype; the valsartan + sacubitril and spironolactone treatment is appropriate not only in the shortage of brain natriuretic peptide but also in the presence of concentric left ventricular hypertrophy (except for the amyloidosis phenotype); and the treatment with empagliflozin and statins may be considered in all situations where pro-inflammatory mechanisms are involved.
- |||||||||| hydrochlorothiazide / Generic mfg., torasemide / Generic mfg.
Retrospective data, Journal: The incidence and risk factors analysis of acute kidney injury in hospitalized patients received diuretics: A single-center retrospective study. (Pubmed Central) - Aug 10, 2022
The model for diuretics-AKI achieved the area under the receiver operating characteristic curves (AUC) with 0.79 on 10-fold cross validation. It is urgent to improve the understanding and attention of AKI in patients received diuretics for medical workers, and the assessment of risk factors before the use of diuretics should be contributed to the early prevention, diagnosis and treatment of AKI, and ultimately reducing morbidity and improving prognosis.
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