Zimhi (naloxone injection) / DMK Pharma, US WorldMeds 
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  • ||||||||||  Kloxxado (naloxone intranasal spray) / Hikma, Zimhi (naloxone injection) / Adamis, US WorldMeds
    Journal:  Nalmefene returns for reversal of opioid overdose. (Pubmed Central) -  Sep 20, 2022   
    No abstract available No abstract available
  • ||||||||||  Zimhi (naloxone injection) / Adamis, US WorldMeds
    Journal:  New Naloxone Concentration Treats Opioid Overdose. (Pubmed Central) -  Feb 10, 2022   
    Zimhi is a single-dose prefilled syringe containing 5 mg/0.5 mL of naloxone. Zimhi is administered subcutaneously or intramuscularly.Nurses should educate patients receiving opioids and their families on how to use Zimhi or other prescribed naloxone products.
  • ||||||||||  Zimhi (naloxone injection) / Adamis, US WorldMeds
    Journal:  The Effects of Intramuscular Naloxone Dose on Mu Receptor Displacement of Carfentanil in Rhesus Monkeys. (Pubmed Central) -  Jan 6, 2021   
    To address this need, a higher dose of NLX has been investigated in a 5 mg IM formulation called ZIMHI but, while the effects of intravenous (IV) and IN administration of NLX on the opioid mu receptor occupancy (RO) have been studied, comparatively little is known about RO for IM administration of NLX...Plasma levels were 4.6 ng/mL, 16.8 ng/mL, and 43.4 ng/mL for the three IM doses, and a significant correlation between percent RO and plasma NLX level was observed (r = 0.80). These results suggest that higher doses of IM NLX result in higher mu RO and could be useful in combating overdoses resulting from potent synthetic opioids.
  • ||||||||||  Zimhi (naloxone injection) / Adamis, US WorldMeds
    NDA:  $ADMP Resubmits ZIMHI NDA (Twitter) -  May 18, 2020