- |||||||||| Juxtapid (lomitapide) / Novelion, Chiesi
Journal: Identifying potential drug targets in the kinomes of two monogenean species. (Pubmed Central) - Jul 23, 2024
These well-known drugs could be evaluated in future studies for potential repurposing as anti-monogenean agents. The present study contributes valuable data for the development of new antiparasitic candidates for finfish aquaculture.
- |||||||||| Zavzpret (zavegepant nasal spray) / Pfizer
Zavegepant for the acute treatment of cluster headache: A case series () - Jun 18, 2024 - Abstract #AHS2024AHS_412;
This case series aimed to suggest the efficacy of zavegepant as a possible potent therapeutic agent for the treatment of an acute CH attack. In the five cases demonstrated in this study, zavegepant provided significant and rapid onset relief of symptoms of attacks of CH.
- |||||||||| Rozlytrek (entrectinib) / Roche
FDA event, Journal: Repurposing FDA-approved compounds to target JAK2 for colon cancer treatment. (Pubmed Central) - Jun 13, 2024
The long-term inhibitory effect of the ergotamine led to a decrease in colony size, and the toxicity properties were studied using hemolysis assay. Our study shows the potential of targeting JAK2 as a novel approach to colon cancer treatment, and demonstrate that ergotamine as a promising effects as an anti-cancer drug.
- |||||||||| Review, Journal: Intervening in the Premonitory Phase to Prevent Migraine: Prospects for Pharmacotherapy. (Pubmed Central) - Jun 1, 2024
Our study shows the potential of targeting JAK2 as a novel approach to colon cancer treatment, and demonstrate that ergotamine as a promising effects as an anti-cancer drug. Early small studies using domperidone, naratriptan and dihydroergotamine have suggested that this approach could be useful; these studies were methodologically less rigorous
- |||||||||| Vyepti (eptinezumab-jjmr) / Teva, Lundbeck, Qulipta (atogepant) / AbbVie, Nurtec ODT (rimegepant ODT) / Pfizer
Onset, characteristics, treatments, and burden of New Daily Persistent Headache: Initial data from the NDPH Patient Experience Survey (Grand Ballroom 10-12) - Apr 29, 2024 - Abstract #AHS2024AHS_124;
The data thus functionally supports the idea that these cells constitute the ISN. The three most effective acute treatments reported were hydrocodone, dihydroergotamine injections, and tramadol while the three most effective preventive treatments were eptinezumab, atogepant, and rimegepant: the three acute and three preventive treatments were found to be somewhat, very, or completely effective in 46
- |||||||||| dihydroergotamine mesylate injection / Generic mfg., dihydroergotamine mesylate nasal spray / Generic mfg.
Review, Journal: Dihydroergotamine mesylate nasal spray: an acute treatment option for migraine in adults. (Pubmed Central) - Apr 24, 2024
DHE nasal spray could be considered as rescue treatment in patients who have failed other symptomatic therapeutic strategies. Nevertheless, in the perspective of tailored therapy, the intranasal route of administration and the consequent rapid onset of action may represent benefits putatively making DHE a treatment of choice for challenging migraine attacks such as those with nocturnal onset or quickly reaching the climax of both headache and neurovegetative associated symptoms.
- |||||||||| dihydroergotamine mesylate injection / Generic mfg., hyoscine butylbromide oral / Generic mfg.
Journal: Dihydroergotamine Increases Histamine Brain Levels and Improves Memory in a Scopolamine-Induced Amnesia Model. (Pubmed Central) - Apr 17, 2024
Additionally, the effects in memory produced by DHE were blocked by pre-treatment with pyrilamine (20 mg/kg, i.p.) administered 30 min before the training in the NOR paradigm and MWM. These findings allow us to demonstrate that DHE improves memory in a scopolamine-induced amnesia model through increasing histamine levels at the hippocampus due to its activity as an HNMT inhibitor.
- |||||||||| dihydroergotamine mesylate injection / Generic mfg., midodrine hydrochloride / Generic mfg.
Review, Journal: Benefits and Risks of Medications Used in the Management of Hypotension: A Review. (Pubmed Central) - Feb 5, 2024
Additionally, adjunctive agents such as non-steroidal anti-inflammatory agents, caffeine, and monoamine oxidase inhibitors are reviewed for their effects on blood pressure. This review underscores the importance of understanding the efficacy and safety profiles of hypotension treatments to guide healthcare professionals in optimal drug selection and management, emphasizing the need for further research and comparative studies for evidence-based guidelines.
- |||||||||| Review, Journal: Update on monkeypox virus infection: Focusing current treatment and prevention approaches. (Pubmed Central) - Jan 16, 2024
This review underscores the importance of understanding the efficacy and safety profiles of hypotension treatments to guide healthcare professionals in optimal drug selection and management, emphasizing the need for further research and comparative studies for evidence-based guidelines. This review highlights the pathogenesis of the virus, disease manifestations, drugs, and vaccines that are being used and those under pipeline for the treatment and prevention of Mpox.
- |||||||||| Venclexta (venetoclax) / Roche, AbbVie, Walter and Eliza Hall Institute, Foscan (temoporfin) / ABVC BioPharma, Rydapt (midostaurin) / Novartis
Journal: Polypharmacology guided drug repositioning approach for SARS-CoV2. (Pubmed Central) - Aug 13, 2023
As drug resistance is one of the major challenges in antiviral drug discovery, polypharmacology and network pharmacology approaches were employed in the study to identify drugs interacting with multiple targets and drugs such as dihydroergotamine, ergotamine, bisdequalinium chloride, midostaurin, temoporfin, tirilazad, and venetoclax were identified among the multi-targeting drugs. Further, a pathway analysis of the genes related to the multi-targeting drugs was carried which provides insight into the mechanism of drugs and identifying targetable genes and biological pathways involved in SARS-CoV2.
- |||||||||| dihydroergotamine mesylate injection / Generic mfg.
PK/PD data, Review, Journal: The Pharmacokinetics of Drugs Delivered to the Upper Nasal Space. (Pubmed Central) - Aug 3, 2023
This review summarizes the systemic PK of different nasal DHE options that have been, or are being, developed and suggests that delivery of drugs to the upper nasal space (UNS) may represent an optimal target. Further research is required to ascertain if this route could also be utilized for direct administration to the CNS (as an attractive alternative to intrathecal delivery) via the olfactory or trigeminal nerves-but already preclinical data (and some human data) suggest this is entirely possible.
- |||||||||| dihydroergotamine mesylate injection / Generic mfg., sorafenib / Generic mfg.
Journal: Dihydroergotamine mesylate enhances the anti-tumor effect of sorafenib in liver cancer cells. (Pubmed Central) - Apr 25, 2023
These findings suggest that DHE can effectively inhibit cell proliferation and enhance sorafenib anti-cancer activity in liver cancer cells. The current study provides some new insights that DHE asa novel anti-liver cancer therapeutic agent has been shown to improve treatment outcomes of sorafenib, which might be helpful in order to advance sorafenib in liver cancer therapeutics.
- |||||||||| Reyvow (lasmiditan) / Eli Lilly, Daiichi Sankyo
Real-world Treatment Combinations of Migraine-specific Prescription Medications (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_3639;
Conclusions More than 1 in 8 patients using migraine-specific prescription medications used a toolkit combining multiple classes. Patients using IN medication were more likely than the overall included population to use a combination toolkit and frequently combined medications across classes or in the same class with different routes of delivery.
- |||||||||| Trudhesa (dihydroergotamine mesylate intranasal) / Impel Pharma
A Cross-Sectional Survey of Prevailing Opinions from Headache Specialists Regarding Status Migrainosus Management (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_3634;
Although no evidence-based treatment guidelines for SM exist, treatment can include steroids, nerve blocks, nonsteroidal anti-inflammatory drugs, triptans, ergotamine, neuroleptics, and dihydroergotamine mesylate (DHE)...Conclusions Headache specialists treat multiple SM patients per week and value treatments that break the headache and offer sustained pain relief while avoiding ER visits. Although DHE was viewed favorably for SM, it was underutilized and often only as a last resort due to accessibility issues.
- |||||||||| dipyridamole / Generic mfg., dihydroergotamine mesylate injection / Generic mfg.
FDA event, Journal: Potential Inhibitors of SARS-CoV-2 Main Protease (M) Identified from the Library of FDA-Approved Drugs Using Molecular Docking Studies. (Pubmed Central) - Jan 22, 2023
Molecular docking and manual analysis suggest that several drugs may bind and potentially inhibit M. We also performed molecular simulations studies for selected compounds to evaluate protein-drug interactions. Considering bioavailability, lesser toxicity, and route of administration, some of the top-ranked drugs, including lumefantrine (antimalarial), dipyridamole (coronary vasodilator), dihydroergotamine (used for treating migraine), hexoprenaline (anti asthmatic), riboflavin (vitamin B2), and pantethine (vitamin B5) may be taken forward for further in vitro and in vivo experiments to investigate their therapeutic potential.
- |||||||||| Viibryd (vilazodone) / AbbVie
Journal: Drug Repurposing to Inhibit Histamine N-Methyl Transferase. (Pubmed Central) - Jan 22, 2023
HNMT inhibitory activity for dihydroergotamine and vilazodone was corroborated (IC = 72.89 μM and 45.01 μM, respectively) by in vitro assays. Drug repurposing of HNMT was achieved by employing computational studies.
- |||||||||| dihydroergotamine mesylate injection / Generic mfg.
Journal: Peripheral Nerve Blocks: A Tool for Inpatient Pediatric Status Migrainosus. (Pubmed Central) - Nov 25, 2022
PNB can be safely administered in the hospital setting to pediatric patients with status migrainosus. PNB treatment helped achieve target pain control with minimal side effects and reduced the hospital stay duration.
- |||||||||| dihydroergotamine mesylate injection / Generic mfg.
Efficacy of Dihydroergotamine on Headache Alleviation in Children with Migraine Headaches (Anaheim Marriott, Marquis Ballroom Center, Board # 045) - Nov 10, 2022 - Abstract #AAPNCE2022AAP_NCE_2043;
Significant pain relief occurred following a single dose of DHE. Subsequent dosing optimized this effect; however, it is unclear whether this was related to cumulative dose effect or increasing dose size.
- |||||||||| dihydroergotamine mesylate injection / Generic mfg.
Journal: Phytochemical profiling of Clerodendrum paniculatum leaf extracts: GC-MS, LC-MS analysis and comparative evaluation of antimicrobial, antioxidant & cytotoxic effects. (Pubmed Central) - Oct 30, 2022
LC-HRMS analysis of methanolic extract exhibited the presence of 8',10'-dihydroxydihydroergotamine, Khayanthone, Galactonic acid, Calotropin, and 26,26,26,27,27,27-hexafluoro-1alpha,24-dihydroxy vitamin D3 as significant fractions...Methanolic extracts from maceration and the Soxhlet method showed better cytotoxicity against breast and oral cancer cell lines, while the aqueous extract from maceration demonstrated better cytotoxicity against lung cancer cell lines. Methanolic extracts containing tannins, flavonoids, alkaloids, quinones, glycosides, terpenoids, diterpenoids, and phytosterols demonstrated significant bioactivity.
- |||||||||| dihydroergotamine mesylate injection / Generic mfg.
Journal: Screening of potential inhibitors targeting the main protease structure of SARS-CoV-2 via molecular docking. (Pubmed Central) - Oct 25, 2022
N-1H-Indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine, ergotamine, antrafenine, dihydroergotamine, and phthalocyanine outperformed the other compounds in binding conformation and binding free energy over the N3 inhibitor in the crystal structure...To further verify the results of molecular docking, we also carried out molecular dynamics (MD) simulations on the complexes formed by the five compounds and M. The five complexes showed stable affinity in terms of root mean square distance (RMSD), root mean square fluctuation (RMSF), radius of gyration (Rg), and hydrogen bond. It was further confirmed that the five compounds had potential inhibitory effects on SARS-CoV-2 M.
- |||||||||| dihydroergotamine mesylate injection / Generic mfg.
Review, Journal: New Approaches to Shifting the Migraine Treatment Paradigm. (Pubmed Central) - Sep 24, 2022
They now lead us to better formulations of dihydroergotamine for efficacy, convenience, and tolerability, and a 5HT1F-specific acute treatment like the gepants opens new options for acute management...Our improved understanding of applied biomedical engineering has brought forward several tantalizing devices, including the application of currents distant from the target and patient regulated. Whether these advances change the paradigm of migraine treatment and standards of care remains to be seen, and issues such as cost and patient acceptance will help mold it.
- |||||||||| Trudhesa (dihydroergotamine mesylate intranasal) / Impel NeuroPharma
Review, Journal: Delivery of Dihydroergotamine Mesylate to the Upper Nasal Space for the Acute Treatment of Migraine: Technology in Action. (Pubmed Central) - Sep 20, 2022
Results from clinical studies of INP104 demonstrate a favorable pharmacokinetic profile, consistent and predictable dosing, rapid systemic levels known to be effective (similar to other DHE mesylate clinical programs), safety and tolerability on the upper nasal mucosa, and high patient acceptance. POD technology may have the potential to overcome the limitations of traditional nasal delivery systems, while utilizing the nasal delivery benefits of GI tract avoidance, rapid onset, patient convenience, and ease of use.
- |||||||||| dihydroergotamine (PUR3100) / Pulmatrix
Enrollment open: A Study to Assess the Safety, Tolerability, and Pharmacokinetics of PUR3100 in Health Adults (clinicaltrials.gov) - Jun 29, 2022
P1, N=24, Recruiting,
Overall, the results showed that the green silver nanoparticles of T. procumbens could be safe, as they are endowed with potential antimicrobial activity against MDR clinical isolates and human lung carcinoma cells. Not yet recruiting --> Recruiting
- |||||||||| ketorolac / Generic mfg., dihydroergotamine mesylate injection / Generic mfg.
Retrospective data, Journal: Lidocaine infusions for refractory chronic migraine: a retrospective analysis. (Pubmed Central) - May 25, 2022
Lidocaine infusions may be associated with short-term and medium-term pain relief in refractory chronic migraine. Prospective studies should confirm these results.
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