- |||||||||| Xadago (safinamide) / Meiji Seika, Zambon, Supernus Pharma
Journal, Adverse events: Respiratory Alkalosis as an Adverse Effect of Safinamide? (Pubmed Central) - Nov 15, 2024
Respiratory alkalosis is a multifactorial acid-base disorder, mostly associated with psychological factors and anxiety induced hyperventilation.Safinamide is a new drug for the treatment of Parkinson's disease with promising results in terms of efficacy and safety. However, there is only a limited number of studies on safinamide.Respiratory alkalosis could be an adverse effect of safinamide through several different mechanisms.
- |||||||||| amitriptyline / Generic mfg.
Signal Detection and Bioinformatics Analysis of Amitriptyline: A Pharmacovigilance Study Using FAERS Study () - Nov 4, 2024 - Abstract #ISPOREU2024ISPOR_EU_895;
Further pharmacoepidemiologic and pharmacogenetic investigations are warranted to elucidate the underlying mechanisms and establish the causal relationship between amitriptyline and cerebral microhaemorrhage. Clinicians should be aware of the potential risk and consider close monitoring and appropriate management strategies for patients on this medication.
- |||||||||| amitriptyline / Generic mfg.
Review, Journal: Abortive and Prophylactic Therapies to Treat Migraine in Pregnancy: A Review. (Pubmed Central) - Nov 4, 2024
This article aims to provide a concise overview of the existing research on the acute and prophylactic use of medications to treat migraines in pregnant and lactating women. Furthermore, it presents recommendations for healthcare professionals managing pregnant females presenting with migraine in clinical settings.
- |||||||||| Tarlige (mirogabalin) / Daiichi Sankyo
Retrospective data, Review, Journal: Non-opioid psychiatric medications for chronic pain: systematic review and meta-analysis. (Pubmed Central) - Oct 25, 2024
The study assessed the effectiveness of duloxetine, mirogabalin, pregabalin, gabapentin, and tricyclic antidepressants (TCAs), including serotonin-norepinephrine reuptake inhibitors (SNRIs), across various chronic pain conditions such as fibromyalgia, neuropathic pain, and chronic low back pain...Conversely, treatments for neuropathic pain and chronic low back pain, including those with amitriptyline and desipramine, did not show significant benefits...No consistent long-term benefits were observed for any of the drugs studied, raising questions about their sustained efficacy in chronic pain management. These findings highlight the need for further research to understand better the role of psychiatric medications in managing specific chronic pain conditions without prematurely concluding that they are ineffective or unsuitable for these purposes.
- |||||||||| mirtazapine / Generic mfg.
CHRONIC URTICARIA/ANGIOEDEMA IN A 16-YEAR-OLD FEMALE WITH RESISTANT PRURITUS CONTROLLED BY MIRTAZAPINE (Monitor 06; Hall A) - Oct 24, 2024 - Abstract #ACAAI2024ACAAI_1290;
Other medications include sedating antihistamines, steroids, H2-blockers, leukotriene antagonists, cyclosporine, methotrexate and omalizumab...She had been trialed on and failed second- and first-generation antihistamines, hydroxyzine, oral steroids, omalizumab, and hydroxychloroquine...A trial of amitriptyline caused tachycardia and syncope...Mirtazapine has been shown to treat itch in lymphoma, uremia, cholestasis. For chronic idiopathic urticaria, further studies are needed to determine optimal use and dosage.
- |||||||||| amitriptyline / Generic mfg.
Journal: The Antidepressant Drug Amitriptyline Affects Human SH-SY5Y Neuroblastoma Cell Proliferation and Modulates Autophagy. (Pubmed Central) - Oct 16, 2024
Decrease viability and clonogenic activity were still observed in autophagy deficient Atg5-/- MEF and following pre-treatment of SH-SY5Y culture with the autophagy inhibitor chloroquine, suggesting that they were independent from autophagy modulation. Our findings demonstrate that amitriptyline acts on pathways crucial for cell and tissue homeostasis (i.e., autophagy and proliferation) and pose the basis for further studies on the potential therapeutic application of amitriptyline, as well as the consequences of its use for long-term treatments.
- |||||||||| Two Cases of Interstitial Cystitis and Nephrology Consultation () - Oct 12, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_4985;
She was started on hydroxychloroquine with no response after 3 months then switched to methotrexate without any reduction in bladder pain...At this point, nephrology was consulted for a trial of off-label cyclosporine therapy prior to offering cystectomy.Case #2: A 39-year-old Chinese male developed ulcerating eosinophilic interstitial cystitis with hematuria and pyuria from ketamine use vs primary cystitis...The patient was treated with trials of antibiotics, fesoterodine, oxybutynin, trospium chloride, and mirabegron over the course of 3 years...Multidisciplinary management and early involvement of nephrology may result in improved outcomes in patients suffering from interstitial cystitis. Given the complex and potentially intransigent nature of the disease, nephrologists should be aware of potential standard and off-label treatments for these patients..
- |||||||||| morphine sulphate / Generic mfg., amitriptyline / Generic mfg., methadone / Generic mfg.
CASE REPORT: KETAMINE USE IN REFRACTORY NEUROPATHIC PAIN OF MALIGNANT PERIPHERAL NERVE SHEATH TUMOUR () - Oct 11, 2024 - Abstract #ASCOMOS2024ASCOMOS_303;
CONCLUSION Parenteral burst ketamine and oral ketamine are effective adjuncts in managing refractory cancer-related neuropathic pain, especially in patients intolerant to opioids and methadone. Further research is necessary to understand the efficacy and safety of ketamine in this context.
- |||||||||| Clinical, Retrospective data, Journal: Preventive Medications in Pediatric Migraine: A Network Meta-Analysis. (Pubmed Central) - Oct 10, 2024
Flunarizine (RoM, 0.46; 95% CI, 0.26-0.81), levetiracetam (RoM, 0.47; 95% CI, 0.30-0.72), riboflavin (RoM, 0.50; 95% CI, 0.32-0.77), cinnarizine (RoM, 0.64; 95% CI, 0.46-0.88), topiramate (RoM, 0.70; 95% CI, 0.55-0.89), and amitriptyline (RoM, 0.73; 95% CI, 0.54-0.97) were also associated with reduction in migraine frequency, but these findings were drawn from individual studies...Compared with placebo, propranolol and cinnarizine (RoM, 0.45; 95% CI, 0.28-0.72), pregabalin (RoM, 0.57; 95% CI, 0.33-0.96), valproate (RoM, 0.60; 95% CI, 0.49-0.72), levetiracetam (RoM, 0.62; 95% CI, 0.50-0.77), and cinnarizine (RoM, 0.64; 95% CI, 0.54-0.76) were significantly associated with reduction in headache intensity...None of the drugs were associated with improved quality of life or attack duration, underscoring the need for further research to develop more comprehensive treatment strategies and explore the potential of combination therapies, especially those involving vitamins. Future studies should focus on validating these findings and expanding the treatment landscape for pediatric migraine management.
- |||||||||| amitriptyline / Generic mfg.
Journal: Amitriptyline at low dose for burning mouth syndrome. (Pubmed Central) - Oct 7, 2024
Other antidepressants, such as amitriptyline, bupropion, imipramine and desipramine, have limited evidence supporting their efficacy and are associated with adverse effects. No abstract available
- |||||||||| Clinical, Review, Journal: Preventive drug treatments for adults with chronic migraine: a systematic review with economic modelling. (Pubmed Central) - Oct 4, 2024
The adverse events review included 40 randomised controlled trials with 25,891 participants; 3 additional drugs, amitriptyline, atogepant and rimegepant, were included...Consensus was reached on the top three recommendations for future research on medications to prevent chronic migraine: (1) calcitonin gene-related peptide monoclonal antibodies and Botox versus calcitonin gene-related peptide monoclonal antibodies, (2) candesartan versus placebo and (3) flunarizine versus placebo...63. See the NIHR Funding and Awards website for further award information.
- |||||||||| Journal: Evaluation of outcomes of clinical phenotyping-based treatment for bladder pain syndrome/interstitial cystitis. (Pubmed Central) - Sep 23, 2024
Patients with Hunner's lesions (HL) (CP4) underwent hydro distension and ablation of the lesion, followed by intravesical instillation of heparin and hydrocortisone...Overall, 16% (4/25) patients had unsatisfactory, 56% (14/25) attained good, and 28% (7/25) had an excellent response at the completion of the study. Using clinical phenotyping-based features indicative of etiology could potentially improve treatment outcomes by targeting the specific pathological processes contributing to the patients' symptoms.
- |||||||||| Journal: Evolving trends of pharmaceutical poisonings associated with QRS complex prolongation. (Pubmed Central) - Aug 28, 2024
Amitriptyline, nortriptyline, doxepin, imipramine, noxiptiline, bupropion, flecainide, carvedilol, propranolol, diphenhydramine, and lamotrigine poisonings were independent predictors of QRS complex prolongation...Bupropion, diphenhydramine, and antidysrhythmics are increasingly common causes of QRS complex prolongation, each associated with numerous severe outcomes in poisoning. Greater safety measures to protect patients from cardiovascular toxicity from these pharmaceuticals are warranted.
- |||||||||| amitriptyline / Generic mfg., fluoxetine / Generic mfg.
Identification of venom fractions as TREK-1 modulators using Qube 384 automated patch clamp system (MCP Hall A) - Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_12242;
Here, we have developed a robust hTREK-1 screening assay on the Qube 384 platform. The optimized screening assay was successfully employed in the screening of a venom library, detecting peptides with both inhibitory and potentiating modalities.Djillani et al., 2019, Front Pharmacol 2019; 10: 379
- |||||||||| Subtype selectivity of clinically-used sodium channel inhibitors (MCP Hall A) - Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_12238;
The likely explanation is likely two-fold: first, cardiac atrial and ventricular muscle has much more negative resting potential (near -88 mV) than most neurons (typically -85 to -60 mV), so that a larger fraction of channels are in the resting state with weak drug binding, and second, cardiac muscle cells have a high density of sodium channels, so that inhibition of a substantial fraction of sodium channels can be tolerated with minimal functional consequences. The strong state-dependence of drug action also likely accounts for functional selectivity of drug on neurons to inhibit pathophysiological conditions like pain and epilepsy without major disruption of normal functions.
- |||||||||| amitriptyline / Generic mfg., naproxen / Generic mfg.
Does spreading depression rewire cortical pain networks? (MCP Hall A) - Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_3647;
The strong state-dependence of drug action also likely accounts for functional selectivity of drug on neurons to inhibit pathophysiological conditions like pain and epilepsy without major disruption of normal functions. C57BL6-ChR2 mice received i.p. amitriptyline or normal saline for 4
- |||||||||| aripiprazole / Generic mfg., amitriptyline / Generic mfg., haloperidol / Generic mfg.
Optimization of a multiplexed, cell-based assay of neuronal function (MCP Hall A) - Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_494;
In contrast, dosing with the inhibitory or anti-psychotic compounds led to decreases in all three neural network characteristics. In total, this study shows that the Maestro Pro is a valuable tool for optimizing in vitro neural models and detecting electrophysiological changes from neuroactive compounds.
- |||||||||| amitriptyline / Generic mfg., gabapentin / Generic mfg.
Review, Journal: Chronic Cough: Evaluation and Management. (Pubmed Central) - Aug 22, 2024
Common etiologies in children include protracted bacterial bronchitis, asthma, bronchiectasis, upper airway cough syndrome, and gastroesophageal reflux disease. Because of the high likelihood of spontaneous resolution, children with a dry cough without wheezing or exertional dyspnea may be observed for 2 weeks.
- |||||||||| Journal: Changing trends in anabolic-androgenic steroid use within Scottish prisons: Detection, prevalence, and quantitation. (Pubmed Central) - Aug 20, 2024
Most AAS samples were tablets (77.0%), although they were also detected in powders, herbal material, e-cigarettes, and a fragmented soap bar-type sample. There was a large variation in the concentration of AASs in the tablets and powders seized from the Scottish prisons, demonstrating AASs are another highly variable component of the polydrug use situation in prisons, the effects of which need to be examined further.
- |||||||||| amitriptyline / Generic mfg.
Journal: Modulating a model membrane of sphingomyelin by a tricyclic antidepressant drug. (Pubmed Central) - Aug 17, 2024
Tricyclic medicine such as amitriptyline (AMT) hydrochloride, initially developed to treat depression, is also used to treat neuropathic pain, anxiety disorder, and migraines...Small-angle X-ray scattering (SAXS) measurements on multilamellar vesicles (MLVs) have revealed that the AMT molecules partition into the hydrophobic core of the lipid membrane, modifying the organization of lipids in the membrane. The modified physical state of less rigid membrane and the transformed electrostatics of the membrane could influence its interaction with synaptic vesicles and neurotransmitters making higher availability of the neurotransmitters in the synaptic cleft.
- |||||||||| Journal: Pharmaceutical Pollution of the English National Parks. (Pubmed Central) - Aug 14, 2024
The modified physical state of less rigid membrane and the transformed electrostatics of the membrane could influence its interaction with synaptic vesicles and neurotransmitters making higher availability of the neurotransmitters in the synaptic cleft. Thirty-one APIs were detected, with metformin, caffeine, and paracetamol showing the highest mean concentrations and cetirizine, metformin, and fexofenadine being the most frequently detected...Fourteen locations had concentrations of either amitriptyline, carbamazepine, clarithromycin, diltiazem, metformin, paracetamol, or propranolol above levels of concern for fish, invertebrates, and algae or for selection for antimicrobial resistance..
- |||||||||| Reimbursement, Retrospective data, US reimbursement, Journal, Medicare: Impact of comprehensive medication reviews on potentially inappropriate medication discontinuation in Medicare beneficiaries. (Pubmed Central) - Aug 12, 2024
Thirty-one APIs were detected, with metformin, caffeine, and paracetamol showing the highest mean concentrations and cetirizine, metformin, and fexofenadine being the most frequently detected...Fourteen locations had concentrations of either amitriptyline, carbamazepine, clarithromycin, diltiazem, metformin, paracetamol, or propranolol above levels of concern for fish, invertebrates, and algae or for selection for antimicrobial resistance.. Among Medicare beneficiaries who are using a PIM, CMR receipt was associated with PIM discontinuation, suggesting that greater CMR use could facilitate PIM reduction for all racial and ethnic groups.
- |||||||||| amitriptyline / Generic mfg.
Preclinical, Journal: Amitriptyline protects afferent synapses in the cochlea against excitotoxic trauma in vitro. (Pubmed Central) - Aug 11, 2024
Furthermore, we found that the protective effects of amitriptyline are likely mediated by suppressing apoptosis factors that were upregulated during excitotoxic trauma. In conclusion, our results suggest that amitriptyline could protect afferent synapses in the cochlea from NICS, making it a potential drug candidate for hearing protection.
- |||||||||| amitriptyline / Generic mfg.
Journal: Potentially inappropriate anticholinergic drug use among older adults in primary healthcare: prevalence and determinants. (Pubmed Central) - Aug 6, 2024
A 8.9% (95% CI 0.074-0.107) of the older adults were exposed to one or more potentially inappropriate anticholinergics, and amitriptyline was the most used (2.0%)...This study underscores the importance of vigilance in prescribing anticholinergic medications to older adults, particularly those with higher medication burdens and mental health diagnoses. By identifying factors associated with potentially inappropriate use, healthcare providers can better tailor medication regimens to mitigate risks and optimize the well-being of older adults.
- |||||||||| A severe case of trigeminal trophic syndrome (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_3259;
If left untreated, TTS can progress to involve the cheek and pre-auricular skin. Extensive ulceration may represent secondary infection.
- |||||||||| Dupixent (dupilumab) / Sanofi, Regeneron
Dupilumab associated psoriatic arthritis (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_2000;
driven inflammation. The role of IL-4/IL-13 in restraining psoriatic inflammation has also been evaluated clinically, with patients with psoriasis showing significant improvement in PASI scores, so it is not surprising that the opposite strategy, blocking the functions of IL-4 and IL-13 as in the case of treatment with dupilumab, may be occasionally detrimental for psoriatic disease spectrum inflammation.
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