fluoxetine / Generic mfg. 
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  • ||||||||||  Addyi (flibanserin) / Sprout Pharma, Xaprila (xaliproden) / Sanofi
    Journal:  Repurposing Drugs for Treatment of Age-Related Macular Degeneration. (Pubmed Central) -  Jul 17, 2023   
    This short review summarizes progress in several classes of drugs considered for repurposing: GPR-143 agonists (L-DOPA), anti-diabetic drugs (metformin, acarbose, empagliflozin, fenofibrate), mitochondrial activators (PU-91), and serotonin pathway drugs (fluoxetine, flibanserin, xaliproden, buspirone). The promises and caveats of repurposing are discussed herein.
  • ||||||||||  Vyvanse (lisdexamfetamine) / Shionogi, Takeda
    Retrospective data, Review, Journal:  Psychopharmacology of eating disorders: Systematic review and meta-analysis of randomized controlled trials. (Pubmed Central) -  Jul 17, 2023   
    Trk-PAMs could provide an interesting avenue for the development of novel therapeutics in this area. The efficacy of different drugs varies across different EDs, warranting additional primary studies recording broad psychopathological and cardiometabolic outcomes besides weight, especially against established psychotherapy interventions.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants. (Pubmed Central) -  Jul 16, 2023   
    Existing antidepressant fluoxetine was also found to potently inhibit TWIK-1/TREK-1 heterodimers. Our study reveals novel potent TWIK-1/TREK-1 inhibitors 2a, 2g, and 2h as potential antidepressants and suggest that the TWIK-1/TREK-1 heterodimer could be a potential novel molecular therapeutic target for antidepressants.
  • ||||||||||  Journal:  Theoretical Study on the Mechanism of Cobalt-Catalyzed C-O Silylation and Stannylation. (Pubmed Central) -  Jul 10, 2023   
    In the current study, we have explored the above issues with density functional theory and have found that stereoselectivity was most likely caused by the oxidative addition of cobalt to the C-O bond of alkenyl acetate with chelation assistance and that transmetalation was most likely the rate-determining step. For Sn-Zn reagents, the transmetalation was achieved by anion and cation pairs, whereas for Si-Zn reagents, the process was facilitated by Co-Zn complexes.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Oxytocin Levels in Children with Separation Anxiety and Their Mothers before and after Treatment. (Pubmed Central) -  Jul 10, 2023   
    A positive correlation was found between changes in the plasma oxytocin levels of children with SAD and the change in anxiety scores. Our results show that the change in plasma oxytocin levels in both children and mothers after treatment suggests that oxytocin may be important in the etiology of SAD.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  A complex relation between levels of adult hippocampal neurogenesis and expression of the immature neuron marker doublecortin. (Pubmed Central) -  Jul 8, 2023   
    We investigated the mechanisms underlying the effects of the antidepressant fluoxetine on behavior and adult hippocampal neurogenesis (AHN)...We discovered two other conditions where a complex relationship occurs between the number of DCX-expressing cells compared to levels of AHN: a chronic antidepressant model where DCX is upregulated and an inflammation model where DCX is downregulated. We concluded that assessing the number of DCX-expressing cells alone to quantify levels of AHN can be complex and that caution should be applied when label retention techniques are unavailable.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Exploitation of expired cellulose biopolymers as hydrochars for capturing emerging contaminants from water. (Pubmed Central) -  Jul 5, 2023   
    Herein, we proposed a green approach whereby expired cellulose biopolymers were converted to hydrochar adsorbents and tested for removing the emerging pharmaceutical contaminants of fluoxetine hydrochloride and methylene blue from water...A hydrochar/magnetite nanocomposite was also synthesized, and its adsorption behavior for both contaminants was tested and it revealed an enhanced percent removal relative to the bare hydrochar by 27.2% and 13.1% for FLX and MB, respectively. This work supports the strategies for zero waste management and the circular economy.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Stroke, depression, and self-harm in later life. (Pubmed Central) -  Jul 3, 2023   
    Current evidence raises concerns about the efficacy and safety of antidepressants for the management and prevention of poststroke clinically significant symptoms of depression. It is unclear if these findings can be generalized to people with severe strokes or to stroke survivors with moderate to severe major depressive episodes.
  • ||||||||||  minoxidil / Generic mfg., fluoxetine / Generic mfg.
    Trichotillomania in childhood, case report () -  Jul 3, 2023 - Abstract #WCD2023WCD_6988;    
    In May 2022 she was evaluated by pediatric psychiatry, she was diagnosed with OCD again, and fluoxetine 40 mg was started at night and 5 months of joint treatment between dermatology, psychiatry and psychology the complete repopulation of hair and fingernails without injuries is achieved...OBSERVATIONS: Trichotillomania is an entity that belongs to the spectrum of impulse control disorder and has good response to serotonin reuptake inhibitors in this case. KEY MESSAGE: It is very important to make parents see the importance of psychiatric treatment since they reject that their children have to receive help from this specialty and drug therapy controls the disorder well as continuing with psychological therapy
  • ||||||||||  fluoxetine / Generic mfg.
    A simple and cost-effective treatment for habit-tic deformity () -  Jul 3, 2023 - Abstract #WCD2023WCD_6160;    
    KEY MESSAGE: It is very important to make parents see the importance of psychiatric treatment since they reject that their children have to receive help from this specialty and drug therapy controls the disorder well as continuing with psychological therapy Case reports of habit-tic deformity include patients treated with adhesive bandages, cyanoacrylate glue, and even fluoxetine...Despite 60 years of habitual nail picking, this combined treatment method effectively
  • ||||||||||  prednisolone / Generic mfg., fluoxetine / Generic mfg.
    A case of Steven-Johnson Syndrome with hyaluronic acid lip fillers () -  Jul 3, 2023 - Abstract #WCD2023WCD_5222;    
    She takes fluoxetine regularly for the past 5 years...We initiated supportive treatments which include intravenous antibiotics, topical corticosteroids of various potency, emollients, oral Prednisolone mouthwash and antiseptic wash...To our best knowledge, this is the first ever case reported where cosmetic procedure has been implicated in a case of SJS. This is particularly relevant with the rising number of cosmetic procedures globally
  • ||||||||||  Review, Journal:  Pharmacotherapy in autism spectrum disorders, including promising older drugs warranting trials. (Pubmed Central) -  Jun 29, 2023   
    Methylphenidate (MPH) studies showed lower efficacy and tolerability for attention deficit hyperactivity disorder (ADHD) than in the typically developing (TD) population; atomoxetine demonstrated lower efficacy but comparable tolerability to TD outcomes...Controlled trials of the selective serotonin reuptake inhibitors citalopram and fluoxetine demonstrated poor tolerability and lack of efficacy for repetitive behaviors...Amitriptyline at approximately 1 mg/ kg/day used cautiously, shows efficacy for sleep, anxiety, impulsivity and ADHD, repetitive behaviors, and enuresis. Both drugs have promising neurotrophic properties.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  5hmC modification regulates R-loop accumulation in response to stress. (Pubmed Central) -  Jun 26, 2023   
    In conclusion, we showed that DNA 5hmC modification negatively regulates R-loop accumulation by the NONO-Tet complex under stress. Our findings provide potential therapeutic targets for depression.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Frontoamygdalar effective connectivity in youth depression and treatment response. (Pubmed Central) -  Jun 22, 2023   
    Our findings provide potential therapeutic targets for depression. Frontoamygdalar effective connectivity shows promise in identifying youth depression diagnosis, and circuits responsible for negative affect regulation are implicated in responsiveness to first-line depression treatments.
  • ||||||||||  paroxetine / Generic mfg.
    Enrollment open, Trial initiation date:  Effects of Paroxetine on Cardiovascular Function in Septic Patients (clinicaltrials.gov) -  Jun 22, 2023   
    P2,  N=20, Recruiting, 
    Frontoamygdalar effective connectivity shows promise in identifying youth depression diagnosis, and circuits responsible for negative affect regulation are implicated in responsiveness to first-line depression treatments. Active, not recruiting --> Recruiting | Initiation date: Feb 2022 --> Jun 2023
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  Possible Involvement of Perineuronal Nets in Anti-Depressant Effects of Electroacupuncture in Chronic-Stress-Induced Depression in Rats. (Pubmed Central) -  Jun 22, 2023   
    In addition, EA and fluoxetine treatments reverse the decrease in PNNs cell density and the ratio of PV and PNN double-positive cells to PV neurons in the medial prefrontal cortex (mPFC) after CUMS...EA treatment did not increase PNNs cell density and the ratio of PV and PNN double-positive cells to PV neurons after PNNs degradation in the mPFC brain region of rats. This finding indicated that the mechanism of acupuncture's anti-depressant effect may be based on reversing the CUMS-induced decline in PNN expression, the functional impairment of ?-aminobutyric acid (GABA) neurons, and the regulation of excitatory synaptic proteins expression.
  • ||||||||||  amitriptyline / Generic mfg., fluoxetine / Generic mfg.
    Journal:  Experimental Study of Antidepressant Properties of Afobazole. (Pubmed Central) -  Jun 20, 2023   
    Afobazole produced an antidepressant effect similar to amitriptyline, but inferior to fluoxetine. The ?1 receptor antagonist BD-1047 in a dose of 5 mg/kg blocked the antidepressant effect of Afobazole, which indicates the involvement of ?1 receptors in the antidepressant effect of the drug.
  • ||||||||||  PK/PD data, Journal:  Use of Physiologically Based Pharmacokinetic Modeling for Hepatically Cleared Drugs in Pregnancy: Regulatory Perspective. (Pubmed Central) -  Jun 19, 2023   
    Pregnancy-related changes in uridine 5'-diphospho-glucuronosyltransferase and transport functions are emerging, and incorporation of such changes in current physiologically based pharmacokinetic modeling software is in progress. Filling this gap is expected to further enhance predictive performance of models and increase the confidence in predicting PK changes in pregnant women for hepatically cleared drugs.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  A subthalamo-parabrachial glutamatergic pathway is involved in stress-induced self-grooming in mice. (Pubmed Central) -  Jun 16, 2023   
    Filling this gap is expected to further enhance predictive performance of models and increase the confidence in predicting PK changes in pregnant women for hepatically cleared drugs. Enhanced self-grooming induced by optogenetic activation of the STN-LPB Glu pathway was attenuated by treatment with fluoxetine (18?mg
  • ||||||||||  Journal:  Changes in Psychotropic Drug Blood Levels After SARS-CoV-2 Vaccination: A Two-Center Cohort Study. (Pubmed Central) -  Jun 10, 2023   
    This study provides the first evidence of major changes in the plasma levels of escitalopram, fluoxetine, trazodone, and quetiapine after COVID-19 vaccination. When planning COVID-19 vaccination for patients treated with these medications, clinicians should monitor rapid changes in bioavailability and consider short-term dose adjustments to ensure safety.
  • ||||||||||  Erbitux (cetuximab) / Eli Lilly, EMD Serono
    Preclinical, Journal:  Thyroarytenoid Oxidative Metabolism and Synaptic Signaling Dysregulation in the Female Pink1-/- Rat. (Pubmed Central) -  Jun 9, 2023   
    Data presented here are useful for identifying biological pathways that may underlie the mechanisms of peripheral dysfunction including neuromuscular synaptic transmission to the TA muscle. These experimental biomarkers have the potential to be targeted as sites for improving the treatment for hypophonia in early-stage PD.