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- | Journal: Medication-Induced Weight Change Across Common Antidepressant Treatments : A Target Trial Emulation Study. (Pubmed Central) - Jul 1, 2024
Clinicians could consider potential weight gain when initiating antidepressant treatment. National Institutes of Health.
- | fluoxetine / Generic mfg.
Journal, IO biomarker: Jingqianshu granules mitigates premenstrual depression by regulating orexin signaling. (Pubmed Central) - Jul 1, 2024
In Part 1, the rats were divided into the control group, the model group, the model + Jingqianshu group, and the model + fluoxetine group...However, the current study is still preliminary and the pathogenesis of PMDD is complex. Therefore, more in-depth exploration is needed.
- | fluoxetine / Generic mfg.
Journal: Transcranial direct current stimulation as early augmentation in adolescent obsessive compulsive disorder: A pilot proof-of-concept randomized control trial. (Pubmed Central) - Jul 1, 2024
tDCS is safe and well tolerated for the treatment of OCD in adolescents. However, there is a need for further studies with a larger sample population to confirm the effectiveness of tDCS as early augmentation in OCD in this population.
- ||| Fetzima (levomilnacipran ER) / Pierre Fabre, AbbVie
Clinical, P3 data, Journal: Safety and Efficacy of Levomilnacipran Extended Release in Pediatric Patients Aged 7-17 Years with Major Depressive Disorder: Results of Two Phase 3, Randomized, Double-Blind Studies. (Pubmed Central) - Jun 27, 2024
P3
The high placebo response in this study prevented the detection of an effect of levomilnacipran in children and adolescents. Clinical Trial Registration numbers: NCT02431806 and NCT03569475.
- | fluoxetine / Generic mfg.
Preclinical, Journal: D-Limonene reduces depression-like behaviour and enhances learning and memory through an anti-neuroinflammatory mechanism in male rats subjected to chronic restraint stress. (Pubmed Central) - Jun 27, 2024
Forty rats were randomly divided into five groups: i) control, ii) D-limonene, iii) restraint stress, iv) restraint stress+D-limonene and v) restraint stress+fluoxetine...In this study, D-limonene has been found to have antidepressant-like properties, reducing anhedonic and defensive behaviours and the impairing effects of stress on learning and memory tests. It was observed that D-limonene showed these effects by alleviating neuroinflammation induced by chronic restraint stress in rats.
- || fluoxetine / Generic mfg.
Review, Journal: Emerging Therapeutic Potential of Fluoxetine on Cognitive Decline in Alzheimer's Disease: Systematic Review. (Pubmed Central) - Jun 27, 2024
While more high-quality clinical research is needed to fully understand the mechanisms underlying these effects, fluoxetine is a promising potential treatment for AD patients. If future clinical trials confirm its anti-degenerative and neuroprotective effects, fluoxetine could offer a new therapeutic approach for slowing down the progression of AD.
- | fluoxetine / Generic mfg.
Journal: Clarifying the functional role of serotonin in Meloidogyne graminicola host plant parasitism by immunolocalization and RNA interference. (Pubmed Central) - Jun 26, 2024
In this study, we tested the effects of exogenous serotonin and the pharmacological compounds fluoxetine and methiothepin on the feeding behaviors of Meloidogyne graminicola...Furthermore, we investigated the impact of phytoserotonin on nematode invasion and development in rice by overexpressing OsTDC-3 or supplementing rice plants with tryptamine and found that an increase in phytoserotonin increases nematode pathogenicity. Overall, our study provides insights into the essential role of serotonin in M. graminicola host plant parasitism and proposes that the serotonergic signaling pathway could be a potential target for controlling PPNs.
- | Journal: Off-label higher doses of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder: Safety and tolerability. (Pubmed Central) - Jun 20, 2024
Overall, our study provides insights into the essential role of serotonin in M. graminicola host plant parasitism and proposes that the serotonergic signaling pathway could be a potential target for controlling PPNs. OLHD-SRIs appear to be safe and well tolerated in OCD patients in SED
- | Biomarker, Journal: Precision medicine for psychotic disorders: objective assessment, risk prediction, and pharmacogenomics. (Pubmed Central) - Jun 20, 2024
Finally, we provide an example of how a personalized laboratory report for doctors would look. Overall, our work provides advances for the improved diagnosis and treatment for schizophrenia and other psychotic disorders.
- || Review, Journal: Selective Serotonin Reuptake Inhibitors and Symptoms of Depression in Patients on Chronic Hemodialysis: A Systematic Review. (Pubmed Central) - Jun 19, 2024
In one study, citalopram and psychological interventions were both effective in reducing the symptoms of depression and anxiety and, in another study, sertraline was modestly more effective than CBT at 12 weeks in reducing the symptoms of depression...SSRI administration, at the dosage used in the studies included in the present systematic review, seems safe in most hemodialysis patients. However, the paucity of studies and the limited number of patients included in the trials may suggest that further randomized, controlled studies are needed to determine if SSRIs may be used routinely in daily clinical practice in such a population.
- | sertraline / Generic mfg., fluoxetine / Generic mfg., carbamazepine / Generic mfg.
Journal: The Tissue-Specific Eco-Exposome: Differential Pharmaceutical Bioaccumulation and Disposition in Fish among Trophic Positions. (Pubmed Central) - Jun 18, 2024
Caffeine and sucralose, two common effluent tracers, were quantitated at low micrograms per liter levels in surface water, while an anticonvulsant, carbamazepine, was observed at levels up to 37?ng/L. The selective serotonin reuptake inhibitors (SSRIs) fluoxetine and sertraline and primary metabolites were detected in at least one tissue of all three species at low micrograms per kilogram concentrations..
- | fluoxetine / Generic mfg.
Biomarker, Journal, Metabolomic study: NMR-based metabolomics approach to study the effect and related molecular mechanisms of Saffron essential oil against depression. (Pubmed Central) - Jun 17, 2024
we established a chronic restraint stress (CRS) induced depression model in mice and employed fluoxetine as a reference drug...In summary, SEO effectively mitigates depressive-like behaviors in CRS mice, predominantly via modulation of glycolysis, amino acid metabolism, and energy metabolism, and potentially exerts antidepressant effects through neural regulation. Our study offers insights into small molecule metabolite alterations in CRS mice through a metabolomics lens, providing evidence for the antidepressant potential of plant essential oils and contributing to our understanding of the mechanisms of traditional Chinese medicine in treating depression.
- | agomelatine / Generic mfg., fluoxetine / Generic mfg.
Journal: The Effects of Fluoxetine and Agomelatine on Neurocognitive Functions and Sleep in Patients with Major Depressive Disorder. (Pubmed Central) - Jun 17, 2024
Both drugs improved the neurocognitive functioning in the participants. However, the better effect of agomelatine in improving the TMT-B scores suggests that it is a suitable option for MDD patients with noticeable executive disturbances.
- || Review, Journal: Pharmacological treatment for mental health illnesses in adults receiving dialysis: A scoping review. (Pubmed Central) - Jun 15, 2024
Over half of the studies included were case reports, thus limiting conclusions. More robust data are required to establish effect sizes of pharmacological treatments prior to providing specific recommendations for their use in treating mental health illnesses in patients receiving dialysis.
- | fluoxetine / Generic mfg.
Preclinical, Journal: Investigating the influence of perinatal fluoxetine exposure on murine gut microbial communities during pregnancy and lactation. (Pubmed Central) - Jun 15, 2024
These findings support our understanding of gut health, as dysbiotic development of the gut microbiome has been associated with local and systemic health problems including gastrointestinal morbidities and interrupted growth patterns in infants. Future research should pursue study in human populations and those at high risk for gut microbial dysbiosis and intestinal injury.
- || fluoxetine / Generic mfg.
Review, Journal: The Roles of Endogenous Opioids in Placebo and Nocebo Effects: From Pain to Performance to Prozac. (Pubmed Central) - Jun 14, 2024
A common pathway for such outcomes is the endogenous opioid system. This chapter describes the history of placebo/nocebo in medicine; delineates the current state of the literature related to placebo/nocebo in relation to pain modulation; summarizes research findings related to human performance in sports and exercise; discusses the implications of placebo/nocebo effects among diverse patient populations; and describes placebo/nocebo influences in research related to psychopharmacology, including the relevance of endogenous opioids to new lines of research on antidepressant pharmacotherapies.
- || Cibinqo (abrocitinib) / Pfizer
PK/PD data, Preclinical, Journal: Effects of two commonly used antidepressants amitriptyline and fluoxetine on the pharmacokinetics of abrocitinib in rats. (Pubmed Central) - Jun 13, 2024
It indicated that amitriptyline and fluoxetine could significantly increase the plasma concentration of abrocitinib in rats. Thus, dose adjustment of abrocitinib may be required when it is combined with amitriptyline or fluoxetine in ongoing clinical practice.
- || clozapine / Generic mfg.
Review, Journal: Optimizing antidepressant and clozapine co-prescription in clinical practice: A systematic review and expert recommendations. (Pubmed Central) - Jun 13, 2024
Antidepressant add-on to clozapine is associated with potential benefits in clozapine users as this strategy may contribute to reduce the burden of clozapine-resistant symptoms or of clozapine-induced ADRs. Further studies are needed to determine whether antidepressant add-on can reduce the risk of clozapine discontinuation.
- | Journal: Evening chronotypes with depression report poorer outcomes of SSRIs: A survey-based study of self-ratings. (Pubmed Central) - Jun 12, 2024
Further studies are needed to determine whether antidepressant add-on can reduce the risk of clozapine discontinuation. The idea that variation in circadian factors influences response to antidepressants was supported and encourages exploration of circadian mechanisms of depressive disorders and antidepressant treatments.
- | fluoxetine / Generic mfg.
Journal: Fluoxetine for the Treatment of Abdominal Migraine. (Pubmed Central) - Jun 11, 2024
The idea that variation in circadian factors influences response to antidepressants was supported and encourages exploration of circadian mechanisms of depressive disorders and antidepressant treatments. No abstract available
- | Fintepla (low-dose fenfluramine) / UCB, Nippon Shinyaku
Preclinical, Journal: Enhancing the action of serotonin by three different mechanisms prevents spontaneous seizure-induced mortality in Dravet mice. (Pubmed Central) - Jun 11, 2024
Our data demonstrate that elevating serotonergic function by fluoxetine, fenfluramine, or SR 57227 significantly reduces or eliminates SSIM in Dravet mice in a sex-independent manner. These findings suggest that deficits in serotonergic neurotransmission likely play an important role in the pathogenesis of SSIM, and fluoxetine and fenfluramine, which are US Food and Drug Administration-approved medications, may potentially prevent SUDEP in at-risk patients.
- || amitriptyline / Generic mfg., fluoxetine / Generic mfg.
Clinical, Review, Journal: Management of Depression in Adults: A Review. (Pubmed Central) - Jun 10, 2024
Effective first-line depression treatments include specific forms of psychotherapy and more than 20 antidepressant medications. Close monitoring significantly improves the likelihood of treatment success.
- | atorvastatin / Generic mfg.
Journal: Effect of a high dose atorvastatin as added-on therapy on symptoms and serum AMPK/NLRP3 inflammasome and IL-6/STAT3 axes in patients with major depressive disorder: randomized controlled clinical study. (Pubmed Central) - Jun 10, 2024
P2
Close monitoring significantly improves the likelihood of treatment success. Group 1 received 20
- | ketamine / Generic mfg., fluoxetine / Generic mfg.
Preclinical, Journal: Ketamine and fluoxetine exert similar actions on prelimbic and infralimbic responsivity to lateral septal nucleus stimulation in Wistar rats. (Pubmed Central) - Jun 9, 2024
Actions of ketamine on the LSN-mPFC connection reproduced actions of fluoxetine, consisting of accentuated inhibition of the LSN action on the mPFC. These findings suggest that independent of different actions on neurotransmission, the common final pathway of antidepressants lies in their actions on forebrain structures that are related to emotional regulation.
- | fluoxetine / Generic mfg.
Preclinical, Journal: The 5-HT7 receptor antagonist SB 269970 ameliorates maternal fluoxetine exposure-induced impairment of synaptic plasticity in the prefrontal cortex of the offspring female mice. (Pubmed Central) - Jun 9, 2024
In mPFC slices obtained from fluoxetine-treated mice that were administered SB 269970 both field potentials and LTP magnitude were restored and did not differ from controls. Treatment of fluoxetine-exposed mice with a selective 5-HT7 receptor antagonist, SB 269970, normalizes synaptic transmission and restores the potential for plasticity in the mPFC of mice exposed in utero and postnatally to fluoxetine.
- | etoricoxib / Generic mfg., fluoxetine / Generic mfg., celecoxib oral / Generic mfg.
Preclinical, Journal: Cyclooxygenase-2 inhibitors alleviated depressive and anxious-like behaviors in mice exposed to lipopolysaccharide: Involvement of oxidative stress and neuroinflammation. (Pubmed Central) - Jun 9, 2024
Treatment of fluoxetine-exposed mice with a selective 5-HT7 receptor antagonist, SB 269970, normalizes synaptic transmission and restores the potential for plasticity in the mPFC of mice exposed in utero and postnatally to fluoxetine. In this context, celecoxib (CLX) and etoricoxib (ETR) inhibit cyclooxygenase 2 (COX-2), an enzyme expressed by cells involved in the inflammatory process and found in the brain...From the sixth to the tenth day, one hour after LPS exposure, they were treated orally with CLX (15
- | fluoxetine / Generic mfg.
Journal: Golgi-targeted NIR fluorescent probe with large stokes shift for real-time monitoring of nitric oxide in depression model. (Pubmed Central) - Jun 6, 2024
Moreover, we disclose a significant increase of NO in the depression model and a weak fluorescence evidenced in the fluoxetine-treated depression mice. This study provides a competent tool for studying the function of NO and helping improve the effective treatment of depression diseases.
- || sertraline / Generic mfg., fluoxetine / Generic mfg., escitalopram / Generic mfg.
Preclinical, Review, Journal: Comparing the effect of fluoxetine, escitalopram, and sertraline, on the level of BDNF and depression in preclinical and clinical studies: a systematic review. (Pubmed Central) - Jun 6, 2024
However, most studies used chronic SSRIs treatment, while acute SSRIs were not effectively used and evaluated. In conclusion, it seems that SSRIs are reliable antidepressants, and the improvement effect of SSRIs on depression is not dependent to BDNF level (at least in human studies).
- | fluoxetine / Generic mfg.
Preclinical, Journal: Fluoxetine Can Cause Epileptogenesis and Aberrant Neurogenesis in Male Wild Type Mice. (Pubmed Central) - Jun 4, 2024
In conclusion, fluoxetine could induce considerable adverse effects in wild type mice, including seizure-like activity. Fluoxetine-induced neurogenesis increases could be related to this activity, therefore proneurogenic effects of fluoxetine and other antidepressants, especially in the absence of any behavioral therapeutic effects, should be interpreted with caution.
- | fluoxetine / Generic mfg.
Journal: The beneficial effect of fluoxetine on behavioral and cognitive changes in chronic experimental Chagas disease unveils the role of serotonin fueling astrocyte infection by Trypanosoma cruzi. (Pubmed Central) - Jun 4, 2024
Fx therapy improves behavioral and biological changes and parasite control in the brain tissue. Moreover, in the central nervous system, cytokine-driven Ser/5-HT consumption may favor parasite persistence, disrupting neurotransmitter balance and promoting a neurotoxic environment likely contributing to behavioral and cognitive disorders.
- | fluoxetine / Generic mfg.
Preclinical, Journal: Social-Single Prolonged Stress affects contextual fear conditioning in male and female Wistar rats: Molecular insights in the amygdala. (Pubmed Central) - Jun 3, 2024
Moreover, in the central nervous system, cytokine-driven Ser/5-HT consumption may favor parasite persistence, disrupting neurotransmitter balance and promoting a neurotoxic environment likely contributing to behavioral and cognitive disorders. Male and female Wistar rats (60-day-old) were exposed to Social-SPS protocol and treated with fluoxetine (10
- | donepezil / Generic mfg., galantamine hydrobromide / Generic mfg., fluoxetine / Generic mfg.
Preclinical, Journal: The involvement of neuroinflammation in an animal model of dementia and depression. (Pubmed Central) - Jun 3, 2024
In addition, fluoxetine + donepezil reversed the reduction of IL-10 levels in the hippocampus. The results indicate a pathophysiological interaction between AD and depression, and the association of medications in the future may be a possible therapeutic strategy to reduce inflammation, especially the fluoxetine-associated treatments.
- | imipramine / Generic mfg., venlafaxine / Generic mfg., fluoxetine / Generic mfg.
Journal: Investigation of Herb-Drug Interactions between Xylopia aethiopica, Its Principal Constituent Xylopic Acid, and Antidepressants. (Pubmed Central) - Jun 3, 2024
The results indicate a pathophysiological interaction between AD and depression, and the association of medications in the future may be a possible therapeutic strategy to reduce inflammation, especially the fluoxetine-associated treatments. The AUC of imipramine (AUCIP?=?1966?
- | fluoxetine / Generic mfg.
Journal: Alcohol exacerbates psychosocial stress-induced neuropsychiatric symptoms: attenuation by geraniol. (Pubmed Central) - Jun 2, 2024
The AUC of imipramine (AUCIP?=?1966? From days 1-14, SDS-EtOH co-exposed mice were concurrently treated with geraniol (25 and 50
- | fluoxetine / Generic mfg.
Journal: Fluoxetine-induced acute pancreatitis: Evidence from a positive re-challenge. (Pubmed Central) - Jun 2, 2024
From days 1-14, SDS-EtOH co-exposed mice were concurrently treated with geraniol (25 and 50 No abstract available
- | diltiazem / Generic mfg., fluoxetine / Generic mfg.
Journal: Comparison of the efficacy of diltiazem versus fluoxetine in the treatment of distal esophageal spasm: A randomized-controlled-trial. (Pubmed Central) - Jun 1, 2024
Neither regimen was superior in terms of efficacy. Consequently, it is key to consider side effects and comorbidities when choosing a therapy.
- | fluoxetine / Generic mfg.
Journal: Effects of esketamine and fluoxetine on depression-like behaviors in chronic variable stress: a role of plasma inflammatory factors. (Pubmed Central) - May 30, 2024
Together, our findings provide a novel insight that acute esketamine treatment could rescue CVS-produced depressive-like and anxiety-like behaviors in mice by normalizing the expression of inflammatory cytokines; this effect was similar to the repeated administration of fluoxetine. These results contributed to the understating of rapid anti-depressant effects elicited by esketamine.
- | fluoxetine / Generic mfg.
Journal: ShuYu capsule alleviates emotional and physical symptoms of premenstrual dysphoric disorder: Impact on ALLO decline and GABAA receptor ? subunit in the PAG area. (Pubmed Central) - May 30, 2024
While a low dose of fluoxetine, a classic selective serotonin reuptake inhibitor, is commonly used as a first-line drug to alleviate emotional disorders in PMDD in clinical settings, its mechanism of action is related to ALLO-GABAA receptor function...The observed effects of ShuYu capsules suggest a central mechanism underlying PMDD symptoms, involving ALLO_GABAA receptor function in the PAG region. This study highlights the potential of traditional Chinese medicine in addressing both emotional and physical symptoms associated with PMDD, shedding light on novel therapeutic approaches for this condition.
- | ketamine / Generic mfg.
Journal: Microdosing ketamine in Drosophila does not block serotonin reuptake, but causes complex behavioral changes mediated by glutamate and serotonin receptors. (Pubmed Central) - May 29, 2024
Feeding and locomotion changes were similar to ketamine in the mutant, and we found NMDA receptor antagonism increased feeding, while serotonin receptor agonism increased locomotion, which could explain these effects with ketamine. Ultimately, this work shows that Drosophila is a good model to discern antidepressant mechanisms, and that ketamine does not work on dSERT like SSRIs, but effects behavior with other mechanisms that should be investigated further.
- | fluoxetine / Generic mfg.
Journal: The impact of chronic fluoxetine treatment in adolescence or adulthood on context fear memory and perineuronal nets. (Pubmed Central) - May 29, 2024
Contrary to previous reports, fluoxetine did not shift the percentage of PNNs toward non-PV cells in either the BLA or CA1 in the adults, or adolescents. These findings demonstrate that fluoxetine differentially affects fear memory in adolescent and adult rats but does not appear to have age-specific effects on PNNs.
- | fluoxetine / Generic mfg.
Journal: Fluoxetine Successfully Treats Intracranial Enterovirus E18 Infection in a Patient with CD79a Deficiency Arising from Segmental Uniparental Disomy of Chromosome 19. (Pubmed Central) - May 28, 2024
Another key outcome of this study is the effective management of long-term chronic enteroviral meningitis using a combination of intravenous immunoglobulin (IVIG) and fluoxetine. This approach offers compelling evidence of fluoxetine's utility in treating enteroviral meningitis, particularly in immunocompromised patients.
- | escitalopram / Generic mfg.
Journal: Elucidation of escitalopram oxalate and related antidepressants as putative inhibitors of PTP4A3/PRL-3 protein in hepatocellular carcinoma: A multi-computational investigation. (Pubmed Central) - May 26, 2024
Therefore, in the current communication, an in-silico drug repurposing approach has been employed to target the function of PTP4A3/PRL-3 protein in HCC using antidepressants: Fluoxetine hydrochloride, Citalopram, Amitriptyline, Imipramine, and Escitalopram oxalate as the desired ligands...Escitalopram oxalate exhibited a comparatively significant docking score (-7.4?kcal/mol) compared to the control JMS-053 (-6.8?kcal/mol) against the PRL-3 protein...The docked complexes were subjected to MD studies (100?ns) showing stable interactions. Considering all the findings, it can be concluded that Escitalopram oxalate and related therapeutics can act as potential pharmacological candidates for targeting the activity of PTP4A3/PRL-3 in HCC.
- | citalopram / Generic mfg., fluoxetine / Generic mfg., tianeptine / Generic mfg.
Journal: The atypical antidepressant tianeptine confers neuroprotection against oxygen-glucose deprivation. (Pubmed Central) - May 25, 2024
Here, we studied the effects of 24-h pretreatment with serotonin (5-HT), citalopram (CIT), fluoxetine (FLU), and tianeptine (TIA) on primary mouse cortical neurons subjected to transient OGD. Finally, deep RNA sequencing of primary neurons subjected to OGD
- | fluoxetine / Generic mfg.
Journal: Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior. (Pubmed Central) - May 25, 2024
Furthermore, we show that suppression of indirect pathway activity using optogenetics or treatment with the first-line OCD pharmacotherapy fluoxetine is associated with reduced grooming in Sapap3-knockouts. Together, these findings highlight the striatal indirect pathway as a potential treatment target for compulsive behavior.
- | fluoxetine / Generic mfg.
Journal: Ecotoxicological effects of ketoprofen and fluoxetine and their mixture in an aquatic microcosm. (Pubmed Central) - May 19, 2024
The structure of micro-eukaryotic communities was altered in the fluoxetine-containing systems, whereas the structure of bacterial communities was affected to a greater extent by the mixture. The disruptions to the equilibrium of the microcosm demonstrate the ecological risk these compounds pose to aquatic ecosystems.
- | fluoxetine / Generic mfg.
Journal, Surgery: Evaluation of safety of fluoxetine for cerebellar mutism syndrome in children after posterior fossa surgery. (Pubmed Central) - May 17, 2024
It does not answer the question of whether the treatment is effective for this indication. A randomized controlled trial based on a syndrome severity scale should be conducted to provide a more reliable assessment of the efficacy and safety of fluoxetine.
- | Retrospective data, Journal: Antipsychotic medications associated with increased length of hospital stay in autoimmune encephalitis and multiple sclerosis: A retrospective study. (Pubmed Central) - May 16, 2024
There was a statistically significant increase in LOS associated with APM use in non-infectious encephalitis and MS, as well as with SSRI use in MS. These data reflect the importance of these medications in these neuroinflammatory disorders and suggest that further investigation into their risks and benefits would be warranted.
- | fluoxetine / Generic mfg.
Journal: Delivering biochemicals with precision using bioelectronic devices enhanced with feedback control. (Pubmed Central) - May 15, 2024
These experiments showcased consistent performance across diverse input signals, maintaining the current value near the reference with a relative error of less than 7% in all trials. Our findings underscore the potential of the developed controller to address challenges in bioelectronic device implementation, offering reliable precision in drug delivery strategies within the realm of precision medicine.
- | Visken (pindolol) / Novartis
Preclinical, Journal: Evaluation of multitarget drugs on the expression of cocaine-induced locomotor sensitization in male rats: A comparative study. (Pubmed Central) - May 10, 2024
Our findings underscore the potential of the developed controller to address challenges in bioelectronic device implementation, offering reliable precision in drug delivery strategies within the realm of precision medicine. Here we compare the efficacy of mirtazapine (MIR), pindolol (PIN), fluoxetine (FLX), risperidone (RIS), trazodone (TRZ), ziprasidone (ZPR), ondansetron (OND), yohimbine (YOH), or prazosin (PRZ), to reduce long-term cocaine-induced locomotor activity and the expression of cocaine-induced locomotor sensitization in rats...After each administration, locomotor activity for each animal was recorded for 30
- | fluoxetine / Generic mfg.
Journal: Parietal-Frontal Pathway Controls Relapse of Fear Memory in a Novel Context. (Pubmed Central) - May 10, 2024
In addition, we found that parvalbumin-expressing interneurons controlled novel context-dependent fear renewal, which was blocked by the chronic administration of fluoxetine. Our findings highlight the PPC-to-ACC pathway in mediating the relapse of extinguished fear in novel contexts, thereby contributing significant insights into the intricate neural mechanisms that govern fear renewal.