fluoxetine / Generic mfg. 
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  • ||||||||||  fluoxetine / generics
    Preclinical, Journal:  Mice exposed to bisphenol A exhibit depressive-like behavior with neurotransmitter and neuroactive steroid dysfunction. (Pubmed Central) -  Apr 28, 2019   
    Finally, high resolution mass spectrometry revealed reduced circulating levels of the neuroactive steroid dehydroepiandrosterone in BPA-exposed males, suggesting another potential mechanism underlying the depressive-like phenotype. Thus, behavioral changes associated with early life BPA exposure may be mediated by sex-specific disruptions in the serotonergic system and/or sex steroid biogenesis in male offspring.
  • ||||||||||  sertraline / generics, paroxetine / generics, fluoxetine / generics
    Journal:  Exploring the clinical characters of Shugan Jieyu capsule through text mining (Pubmed Central) -  Apr 26, 2019   
    Syndrome of malnutrition of heart spirit was the potential Chinese medical pattern of Shugan Jieyu capsule. Primary comorbid anxiety and depression, concomitant comorbid anxiety and depression followed by physical diseases, and postpartum depression were potential diseases treated by Shugan Jieyu capsule.For combination treatment, Shugan Jieyu capsule was most commonly used with paroxetine, sertraline and fluoxetine.
  • ||||||||||  fluoxetine / Generic mfg.
    Trial completion date, Trial primary completion date:  Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus (DM) (clinicaltrials.gov) -  Apr 20, 2019   
    P1,  N=64, Recruiting, 
    However, these changes varied according to pre-existing metabolic and functional conditions in the rodents and humans. Trial completion date: Dec 2019 --> Dec 2020 | Trial primary completion date: Dec 2019 --> Dec 2020
  • ||||||||||  fluoxetine / generics
    Preclinical, Journal:  Antidepressant-like effects of paeoniflorin on post-stroke depression in a rat model. (Pubmed Central) -  Apr 19, 2019   
    The failure of initial pharmacological therapy might not be a reason to abandon a pharmacological treatment strategy. Observed results suggested that paeoniflorin could ameliorate the symptoms and improve the functional capability of PSD rats, similar to the effect of fluoxetine.
  • ||||||||||  desvenlafaxine extended release / generics, fluoxetine / generics
    Clinical, Journal:  Desvenlafaxine Versus Placebo in a Fluoxetine-Referenced Study of Children and Adolescents with Major Depressive Disorder. (Pubmed Central) -  Apr 19, 2019   
    Because neither desvenlafaxine nor the reference medication, fluoxetine, demonstrated a statistically significant difference from placebo on the primary endpoint, this was considered a failed trial and no efficacy conclusions can be drawn. Desvenlafaxine 25-50 mg/d was generally safe and well tolerated in children and adolescents in this study.
  • ||||||||||  Biomarker, Journal:  Pharmacogenetic evaluation of a DISP1 gene variant in antidepressant treatment of obsessive-compulsive disorder. (Pubmed Central) -  Apr 19, 2019   
    These results indicate that an association exists between prenatal letrozole treatment, same sex preference and immobility in the FST. This replication study did not support the role of DISP1 in predicting SRI response in OCD; however, methodological differences between the original GWAS and our study, as well as limited power and low minor allele frequency, may have hindered replication.
  • ||||||||||  fluoxetine / generics
    Preclinical, Journal:  Fluoxetine affects differentiation of midbrain dopaminergic neurons in vitro. (Pubmed Central) -  Apr 18, 2019   
    Further investigations using ERβ knock-out (BERKO) mDPCs showed that FLX had no or even opposite effects on several of the genes analyzed, and that FLX may putatively bind directly to the ERs. These findings suggest that FLX affects differentiation of the dopaminergic system by increasing production of dopaminergic precursors, yet decreasing their maturation, partly via interference with the estrogen system.
  • ||||||||||  fluoxetine / generics
    Preclinical, Journal:  Kamiuntanto increases prefrontal extracellular serotonin levels and ameliorates depression-like behaviors in mice. (Pubmed Central) -  Apr 18, 2019   
    ...KUT (1000 mg/kg) reversed encounter-induced hyperactivity and increased immobility in the forced swim test in isolation-reared mice, as also found for an antidepressant, fluoxetine (30 mg/kg)...Furthermore, the antidepressant-like effect of KUT in the forced swim test was prevented by pretreatment with GR127935, a 5-HT antagonist. These findings suggest that KUT may ameliorate depressive symptoms via 5-HTergic systems, and that BC plays an important role in the antidepressant-like effects of KUT.
  • ||||||||||  Retrospective data, Review, Journal:  Maternal drug use and the risk of anorectal malformations: systematic review and meta-analysis. (Pubmed Central) -  Apr 17, 2019   
    Nevertheless, the few available studies indicate any anti-asthma medication, and hypnotics and benzodiazepine to be associated with increased risks. Further, ideally large-scale multicenter and register-based studies are needed to clarify the role of maternal drug intake for the development of ARM.
  • ||||||||||  fluoxetine / generics
    Preclinical, Journal:  Antidepressant effects of creatine on amyloid β-treated mice: The role of GSK-3β/Nrf pathway. (Pubmed Central) -  Apr 17, 2019   
    ...These impairments were attenuated by creatine (0.01 and 10 mg/kg, p.o.) and fluoxetine (10 mg/kg, p.o., positive control)...This study provides the first evidence of the antidepressive-like effects of creatine in Aß-treated mice, which were accompanied by hippocampal inhibition of GSK-3β and modulation of antioxidant defenses. These findings indicate the potential of creatine for the treatment of depression associated with AD.
  • ||||||||||  fluoxetine / generics
    Preclinical, Journal:  SMIP004: a compound with antidepressant-like activities in mouse models. (Pubmed Central) -  Apr 17, 2019   
    ...Combined SMIP004-fluoxetine administration was found to induce coordinated antidepressant-like effects in naïve mice in the TST and FST...Further, long-term SMIP004 treatment at the dosage of 2 but not 1mg/kg reversed CUS-induced increase in immobility time in the TST and FST as well as CUS-induced decrease in sucrose preference in the SPT, suggesting that SMIP004 can produce antidepressant-like activities at stressed conditions. These results show that SMIP004 displays obvious antidepressant-like activities in all conducted tests, and suggest that SMIP004 might be a novel antidepressant.
  • ||||||||||  fluoxetine / Generic mfg.
    Enrollment open:  Poststroke Depression in Hemorrhagic Stroke (clinicaltrials.gov) -  Apr 16, 2019   
    P1,  N=224, Recruiting, 
    SNS treatment may perform antidepressant effects on young and adult MS rats through the BDNF/PKA/CREB pathway. Not yet recruiting --> Recruiting
  • ||||||||||  fluoxetine / generics
    Journal:  A novel 5HT3 receptor-IGF1 mechanism distinct from SSRI-induced antidepressant effects. (Pubmed Central) -  Apr 7, 2019   
    Furthermore, our in vivo microdialysis analysis shows that 5HT3R regulates hippocampal extracellular IGF1 levels, and we also show that 5HT3R-dependent hippocampal neurogenesis is mediated by increased IGF1 levels. Altogether, our findings suggest a novel 5HT3R-IGF1 mechanism that is distinct from fluoxetine-induced responses and that provides a new therapeutic target for depression, especially bringing significant benefits for SSRI-resistant depressed patients.Molecular Psychiatry advance online publication, 25 April 2017; doi:10.1038/mp.2017.87.
  • ||||||||||  fluoxetine / generics
    Preclinical, Journal:  In vivo Characterization of a Selective, Orally Available, and Brain Penetrant Small Molecule GPR139 Agonist. (Pubmed Central) -  Apr 6, 2019   
    In the marble burying test, the agonist (10 mg/kg p.o.) produced a small anxiolytic-like effect, with no interaction with fluoxetine, and no effect in elevated plus maze (EPM)...It did not alter catecholamine/serotonin levels and had a mostly silent signal in in vivo models commonly associated with these pathways. The physiological function of GPR139 remains elusive.
  • ||||||||||  fluoxetine / generics
    Preclinical, Journal:  Acupuncture Alleviated Depressive-like Behavior by Down-regulating NF-κB, iNOS and NO Levels in Prefrontal Cortex of Depression Rats (Pubmed Central) -  Apr 5, 2019   
    Acupuncture intervention plays a positive role in anti-depression in rats, which may be related to its effects in regulating the expression of GFAP in the hippocampal and prefrontal astrocytes, and in increasing the content of serum anti-inflammatory cytokine IL-10. Acupuncture treatment can improve the depressive-like behavior of depression rats, which is closely related to its effects in down-regulating the levels of NF-κB protein, iNOS and NO in the prefrontal cortex to reduce brain inflammatory damage.
  • ||||||||||  fluoxetine / generics
    Journal:  R-Fluoxetine Increases Melanin Synthesis Through a 5-HT1A/2A Receptor and p38 MAPK Signaling Pathways. (Pubmed Central) -  Apr 5, 2019   
    Furthermore, r-fluoxetine increased the phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), without affecting the phosphorylation of extracellularly responsive kinase (ERK1/2) and c-Jun N-terminal kinase (JNK). These data suggest that r-fluoxetine may be used as a drug for skin hypopigmentation disorders.
  • ||||||||||  fluoxetine / Generic mfg.
    Trial completion date, Trial initiation date, Trial primary completion date:  RECONISE: Serotonin Selective Reuptake Inhibitor (SSRI) Effects on Cerebral Connectivity in Acute Ischemic Stroke (clinicaltrials.gov) -  Apr 3, 2019   
    P4,  N=60, Recruiting, 
    These findings provide a new insight into the influence of environmental conditions on the interactions between nanomaterials and pollutants in organisms. Trial completion date: Dec 2018 --> Apr 2020 | Initiation date: Jan 2016 --> Feb 2017 | Trial primary completion date: Dec 2018 --> Feb 2020
  • ||||||||||  risperidone / Generic mfg., Egis, fluoxetine / Generic mfg.
    Two Cases of Brief Affective Psychosis Induced by Diet Aids (Regency S-V) -  Apr 3, 2019 - Abstract #SIRS2019SIRS_89;    
    Her symptoms disappreared in 3 days with risperidone 2mg/day after admission...He has prescribed diet medicines at the local diet clinic with Phentermine, fluoxetine, topiramate and caffeine for about 3 years...Detailed informations and cautions regarding the side effects of diet medicines must be established for customers to know about safety, efficacy and effects of diet therapy. 2
  • ||||||||||  fluconazole / generics, paroxetine / generics, fluoxetine / generics
    Journal:  A further insight on the metabolic profile of the nuclear receptor Rev-erb agonist, SR9009. (Pubmed Central) -  Apr 3, 2019   
    Concerning the effects of gender, genetic polymorphism and drug-drug interactions on the metabolic profile of SR9009, our observation have shown the following: (i) no significant alterations were measured between female and male; (ii) significant differences were registered using either the CYP2D6 or CYP2C19 allelic variants, and finally (iii) significant alterations were registered in the presence of ketoconazole, miconazole, fluoxetine, nefazodone and paroxetine; moderate variation were instead registered with fluconazole, itraconazole, gestodene and levonorgestrel. The above observation put in evidence the importance to take into account both genetic polymorphism and drug-drug interaction to select the most appropriate marker(s) of use in doping analysis.