fluoxetine / Generic mfg. 
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  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Syntheses of Benzo[d]Thiazol-2(3H)-One Derivatives and Their Antidepressant and Anticonvulsant Effects. (Pubmed Central) -  Jan 8, 2020   
    In the maximal electroshock seizure test, 3n and 3q showed the highest anticonvulsant effect, with ED values of 46.1 and 64.3 mg kg, and protective indices of 6.34 and 4.11, respectively, which were similar to those of phenobarbital or valproate. We also found that the mechanism for the antidepressant activity of 2c and 2d may be via increasing the concentrations of serotonin and norepinephrine.
  • ||||||||||  fluoxetine / Generic mfg.
    Developmental delay and psychiatric issues in an under-stimulated deaf child (Chapman #4) -  Jan 4, 2020 - Abstract #WSMRF2020WSMRF_293;    
    The patient was placed on Fluoxetine (40 mg) for long-term management of depression...Furthermore, the support community for deaf people should be connected with the mental health community. These individuals have unique needs and life experiences that deserve careful attention in all healthcare settings.
  • ||||||||||  fluoxetine / Generic mfg.
    Trial completion date, Trial primary completion date:  The Effect of G-DBT on the Patients With BN : A Multicenter Randomized Controlled Study (clinicaltrials.gov) -  Jan 3, 2020   
    P=N/A,  N=300, Recruiting, 
    Recruiting --> Completed | N=60 --> 78 Trial completion date: Nov 2019 --> Dec 2020 | Trial primary completion date: Nov 2019 --> Dec 2020
  • ||||||||||  fluoxetine / Generic mfg.
    Clinical, Journal:  Loss of adult 5-HT1A autoreceptors results in a paradoxical anxiogenic response to antidepressant treatment. (Pubmed Central) -  Jan 1, 2020   
    Tamoxifen-induced recombination in adult 1AcKO mice specifically reduced 5-HT1A autoreceptor levels...Subchronic fluoxetine (FLX) treatment induced an unexpected anxiogenic effect in 1AcKO mice in the novelty suppressed feeding and elevated plus maze tests, as did escitalopram in the novelty suppressed feeding test...Here we show that rather than enhancing SSRI benefits, adulthood knockout of the 5-HT1A autoreceptor, a critical negative regulator of 5-HT activity, results in an SSRI-induced anxiety effect that appears to involve a hyper-activation of the 5-HT system in certain brain areas. Thus, subjects with very low levels of 5-HT1A autoreceptors, such as during childhood or adolescence, may be at risk for an SSRI-induced anxiety response.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  Nutraceuticals to promote neuronal plasticity in response to corticosterone-induced stress in human neuroblastoma cells. (Pubmed Central) -  Dec 29, 2019   
    vesiculosus) and β-carotene in restoring neuronal plasticity. Abbreviation: TrKB, tropomyosin receptor kinase B; P-ERK, phosphorylated extracellular signal-related kinase; PI3K, phosphatidylinositol 3-kinase; Akt, protein kinase B; Ca++/CaMK, calcium/calmodulin-dependent protein kinase; pCREB, phosphorylated cAMP response element-binding protein; CRE, cAMP response elements, CORT, corticosterone; and BDNF; brain-derived neurotrophic factor.
  • ||||||||||  fluoxetine / Generic mfg.
    Biomarker, Preclinical, Journal:  N-Palmitoylethanolamide exerts antidepressant-like effects in rats: involvement of PPAR-alpha pathway in the hippocampus. (Pubmed Central) -  Dec 28, 2019   
    In this study, rats were subjected to 35 days of CUMS and treated with drugs such as PEA (2.5, 5.0, or 10 mg/kg, by mouth), fluoxetine (10 mg/kg, by mouth), or the combination of PEA and MK886 (1-[(4-chlorophenyl) methyl]-3-[(1,1-dimethylethyl) thio]-α,α-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid)...However, the aforementioned effects of PEA were completely or partially abolished by MK886, a selective PPAR-alpha antagonist. Based on these findings, the PPAR-alpha pathway in the hippocampus is a possible target of the antidepressant effects of PEA, and the maintenance of a stable hypothalamic-pituitary-adrenal axis, the antioxidant defenses and normalization of neurotrophic factor levels in the hippocampus are involved in this process.
  • ||||||||||  Potiga (retigabine) / Bausch Health, GSK, ezogabine (pediatric formulation of potiga) / Xenon, fluoxetine / Generic mfg.
    Journal:  Reversal of a Treatment-Resistant, Depression-Related Brain State with the Kv7 Channel Opener Retigabine. (Pubmed Central) -  Dec 26, 2019   
    By contrast, retigabine (also known as ezogabine) normalized neural excitability and I currents recorded from slices of HFD-treated animals and significantly ameliorated most of the behavioral impairments, without effects in control diet exposed animals. Thus, treatment resistant depressive-like brain states that are associated with chronic neuroinflammation may involve hyperexcitability of pyramidal neurons and may be effectively treated by retigabine.
  • ||||||||||  Ritalin (methylphenidate tablet) / Generic mfg., fluoxetine / Generic mfg.
    Preclinical, Journal:  Serotonin transporter inhibition and 5-HT receptor activation drive loss of cocaine-induced locomotor activation in DAT Val559 mice. (Pubmed Central) -  Dec 23, 2019   
    Furthermore, genetic elimination of high-affinity cocaine interactions at SERT in DAT Val559 mice, or specific inhibition of 5-HT receptors in these animals, restored cocaine-induced locomotion, but did not restore cocaine-induced elevations of extracellular DA. Our findings reveal a significant serotonergic plasticity arising in the DAT Val559 model that involves enhanced 5-HT signaling, acting independently of striatal DA release, capable of suppressing the activity of cocaine-sensitive motor circuits.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Behavioral and synaptic alterations relevant to obsessive-compulsive disorder in mice with increased EAAT3 expression. (Pubmed Central) -  Dec 23, 2019   
    Electrophysiological and biochemical analyses at corticostriatal synapses of EAAT3/CMKII mice revealed changes in NMDA receptor subunit composition and altered NMDA-dependent synaptic plasticity. By recapitulating relevant behavioral, neurophysiological, and psychopharmacological aspects, our results provide support for the glutamatergic hypothesis of OCD, particularly for the increased EAAT3 function, and provide a valuable animal model that may open novel therapeutic approaches to treat this devastating disorder.
  • ||||||||||  Clinical, Journal:  Comparative Cardiac Safety of Selective Serotonin Reuptake Inhibitors among Individuals Receiving Maintenance Hemodialysis. (Pubmed Central) -  Dec 23, 2019   
    By recapitulating relevant behavioral, neurophysiological, and psychopharmacological aspects, our results provide support for the glutamatergic hypothesis of OCD, particularly for the increased EAAT3 function, and provide a valuable animal model that may open novel therapeutic approaches to treat this devastating disorder. The heterogeneous QT-prolonging potential of SSRIs may differentially affect cardiac outcomes in the hemodialysis population.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  Helicid Ameliorates Learning and Cognitive Ability and Activities cAMP/PKA/CREB Signaling in Chronic Unpredictable Mild Stress Rats. (Pubmed Central) -  Dec 23, 2019   
    Sprague-Dawley rats were randomly assigned to six groups (n = 10): control; CUMS; CUMS + fluoxetine (5 mg/kg) and CUMS + helicid at 8, 16 and 32 mg/kg...In addition, CUMS resulted in a significant reduction in the expression of cAMP, PKA C-α and p-CREB, each of which were partially attenuated by helicid administration. These results indicated that helicid could improve depressive behaviors, learning and cognitive deficits and increase hippocampal neurogenesis, which may be mediated by the regulation of SERTs, activation of the cAMP/PKA/CREB signaling pathway and upregulation of p-CREB levels in hippocampal.
  • ||||||||||  ondansetron / Generic mfg., fluoxetine / Generic mfg.
    Journal:  The Use of Antidepressants for Physical and Psychological Symptoms in Cancer. (Pubmed Central) -  Dec 21, 2019   
    While fluoxetine was found to be associated to the reduction of antiemetic property in ondansetron, mirtazapine was identified to be a good alternative in treating nausea and cachexia among cancer patients. More research studies with adequate statistical power are warranted to validate the use of antidepressants among cancer patients in treating these physical and psychological symptoms.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Divergent action of fluoxetine in zebrafish according to responsivity to novelty. (Pubmed Central) -  Dec 21, 2019   
    Our results have important implications for behavioral data analysis since such behavioral differences can potentially increase individual response variability and interfere with the outcomes obtained from various behavioral tasks. Our data reinforce the validity of personality determination in zebrafish since we show clear differences in behavior in response to fluoxetine.
  • ||||||||||  oxybutynin / Generic mfg., Allergan, Orion, fluoxetine / Generic mfg.
    Recreational Drug Use and Arterial Ischemic Stroke in a Pediatric Cohort (Hall H) -  Dec 21, 2019 - Abstract #ISC2020ISC_2125;    
    We are unable to comment on the incidence of AIS related to drug use from our cohort. However, our data highlights a need for public health strategies that acknowledge AIS as a potential consequence of recreational drug use in adolescents.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  The three-spined stickleback as a model for behavioural neuroscience. (Pubmed Central) -  Dec 20, 2019   
    We show that behaviour of three-spined sticklebacks in these standard tests is remarkably similar to that of zebrafish and other species and can be altered by fluoxetine and buspirone. These findings highlight the potential of using three-spined sticklebacks for cross-species and translational studies.
  • ||||||||||  sertraline / Generic mfg., paclitaxel / Generic mfg., fluoxetine / Generic mfg.
    Preclinical, Journal:  An In Vitro Study of Aromatic Stacking of Drug Molecules. (Pubmed Central) -  Dec 20, 2019   
    Molecular modeling illustrates that differences in the stability of the NCXs are likely due to the distance between the aromatic rings present in both the paclitaxel and antidepressant medications. Graphical Abstract.
  • ||||||||||  fluoxetine / Generic mfg.
    Clinical, Journal:  Could Treatment Matching Patients' Beliefs About Depression Improve Outcomes? (Pubmed Central) -  Dec 20, 2019   
    Moreover, responders who received continuation treatment better matched to their biological beliefs (i.e., responders with weaker biological beliefs about depression who received continuation CT, or responders with stronger biological beliefs about depression who received continuation fluoxetine) had fewer depressive symptoms and less relapse/recurrence by 32 months after acute-phase CT than did responders who received mismatched continuation treatment. Specific screening and/or intervention targeting patients' biological beliefs about depression could increase CT efficacy.
  • ||||||||||  venlafaxine / Generic mfg., fluoxetine / Generic mfg.
    Journal:  Ancestral fluoxetine exposure sensitizes zebrafish to venlafaxine-induced reductions in cortisol and spawning. (Pubmed Central) -  Dec 19, 2019   
    The VEN treatment further suppresses cortisol production in females and decreases spawning rates in adult pairs. This is an important demonstration that in an animal model, a brief ancestral exposure of great-great-grandparents to the selective serotonin reuptake inhibitor FLX shapes the physiological responses of future generations to the serotonin and norepinephrine reuptake inhibitor VEN.
  • ||||||||||  Evomate (raloxifene hydrochloride) / Shreya Life Sciences, fluoxetine / Generic mfg.
    Preclinical, Journal:  Is there any potential anticancer effect of raloxifene and fluoxetine on DMBA-induced rat breast cancer? (Pubmed Central) -  Dec 19, 2019   
    However, TIMP-1 levels were higher in the whole therapeutic groups rather than the DMBA group and the most effective increase was observed in group IV. Results of the present study suggest that combined therapy of RAL with FLX might lead to a better outcome targeting breast tumor.