fluoxetine / Generic mfg. 
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  • ||||||||||  fluoxetine / Generic mfg.
    Behavioral effects of long-term SSRI exposure in mice (WCC Halls A-C) -  Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_2866;    
    Supported By Psychology Dept Endowment FundSelective Serotonin Reuptake Inhibitors (SSRIs), including fluoxetine, are the most commonly prescribed and studied antidepressants, though most preclinical work has not involved treatment periods of more than a month or two...Our findings suggest that long-term chronic SSRI exposure, beginning in adolescence, may result in effects contrary to those seen with short term drug treatment. Future research on supra-chronic SSRI use, especially relating to anxiety, is needed to determine the mechanisms and generality of our findings.
  • ||||||||||  fluoxetine / Generic mfg.
    Dichotomous role of serotonin during different developmental epochs. (WCC Halls A-C) -  Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_2813;    
    To modulate levels of serotonin we used a Selective Serotonin Reuptake Inhibitor (SSRI), Fluoxetine...We observed a significant increase in the levels of ATP and alleviation of the pro-depressive effects observed with PNFlx. Our findings highlight two distinct windows of early life in which SSRI exposure evokes starkly differing effects on behavior, gene regulation, and bioenergetics while establishing a link between bioenergetics and despair-like behavior.
  • ||||||||||  fluoxetine / Generic mfg.
    Selective serotonin reuptake inhibitors attenuate the cognitive deficits in the 5xFAD Alzheimer (WCC Halls A-C) -  Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_2257;    
    We daily administeredsertraline (SER) and fluoxetine (FLX) into 5xFAD AD model mice for 4 weeks (10mg/kg, i. p. )...We also found the significantlydecreased level of mRNA expression of inflammatory markers including IL-1 beta,IL-10 in AD model. These results suggest that chronic SSRI treatment attenuatesthe cognitive impairment and neuroinflammation in AD pathology.
  • ||||||||||  fluoxetine / Generic mfg.
    Serotonergic dysregulation and social dysfunction following early life stress (WCC 152A) -  Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_1524;    
    Our findings suggest that there are separate changes in social behavior between adolescence and adulthood that may be affected by fluoxetine administration, and these behavioral data coincide with alterations in electrophysiological properties of DRN serotonergic neurons, likely driven by synaptic inputs. Our ongoing experiments aim to shed light on the relationship between these electrophysiological and behavioral findings.
  • ||||||||||  amitriptyline / Generic mfg., fluoxetine / Generic mfg.
    Recipient Platelet-Derived Extracellular Vesicles (PEV) Suppress Antibody-Mediated Transfusion-Related Acute Lung Injury (TRALI) (SDCC - Halls G-H) -  Nov 3, 2023 - Abstract #ASH2023ASH_5454;    
    To determine the role of in vivo generated PEV in antibody-mediated TRALI, mice were first administered amitriptyline (AMI), a potent inhibitor of PEV formation...Prozac-treated mice had normal levels of PEV after 34-12s administration and TRALI induction was not affected...Further studies are underway to determine the mechanism(s) of PEV-mediated TRALI suppression. Thus, modulating PEV formation in recipients may be an effective therapy for reducing TRALI reactions.
  • ||||||||||  Bystolic (nebivolol) / Menarini, AbbVie
    PK/PD data, Review, Journal:  Clinical pharmacokinetics of nebivolol: a systematic review. (Pubmed Central) -  Oct 30, 2023   
    Nebivolol showed higher C, AUC and half-life (t) when co-administered with bupropion, duloxetine, fluvoxamine, paroxetine, lansoprazole, and fluoxetine. This concise review of nebivolol would be advantageous in assessing all PK parameters, which may be crucial for clinicians to avoid drug-drug interactions, prevent adverse drug events and optimize the dosage regimen in diseased patients diagnosed with hypertension and cardiovascular disorders.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal, Metabolomic study:  Metabolomic identification of biochemical changes induced by fluoxetine in an insulinoma cell line (MIN6). (Pubmed Central) -  Oct 16, 2023   
    Sixty-six metabolites that had been differentially expressed between the control and fluoxetine-treated groups demonstrated that the citric acid cycle is mainly perturbed by fluoxetine treatment. The current study provides insights into the molecular mechanisms of fluoxetine effects in MIN6 cells.
  • ||||||||||  sulphadiazine / Generic mfg., fluoxetine / Generic mfg.
    Journal:  A SERS Responsive DGT Sensing Device for On-Site Determination of Organic Contaminants Underwater. (Pubmed Central) -  Oct 9, 2023   
    The platform proves to be versatile by extending the method to the monitoring of rhodamine 6G, metronidazole, fluoxetine, and enrofloxacin. In this article, SERS-DGT Sensor, a platform for directly on-site sensing of organic DGT, holds great potential for in situ sampling and on-site sensing for a wide range of organics and provides a new idea for environmental monitoring.
  • ||||||||||  sirolimus / Generic mfg., fluoxetine / Generic mfg.
    Journal:  Organic cation transporter 2 contributes to SSRI antidepressant efficacy by controlling tryptophan availability in the brain. (Pubmed Central) -  Oct 4, 2023   
    (GSK3?) and mammalian/mechanistic target of rapamycin (mTOR) intracellular signaling was impaired in OCT2 mutant mice brain after corticosterone and fluoxetine treatment and, conversely, tryptophan supplementation recruited selectively the mTOR protein complex 2. This study provides the first evidence of the physiological relevance of OCT2-mediated tryptophan transport, and its biological consequences on serotonin homeostasis in the brain and SSRI efficacy.
  • ||||||||||  fluoxetine / Generic mfg.
    Creativity Camp: An Intervention for Adolescents With Depression (Riverside Ballroom (Sheraton New York Times Square Hotel); In-person) -  Sep 30, 2023 - Abstract #AACAP2023AACAP_1070;    
    Creativity Camp is a novel intervention that shows promise in reducing depression symptoms and enhancing well-being in teenagers with depression. Parent-report of improvement in their children
  • ||||||||||  fluoxetine / Generic mfg.
    Sex Differences in a Sequential Treatment Strategy on Residual Symptoms in Youth With MDD (Americas Hall II (New York Hilton Midtown); In-person) -  Sep 30, 2023 - Abstract #AACAP2023AACAP_944;    
    We examined sex differences in response to MM and MM+CBT on residual symptoms after the acute phase, 6 week s of fluoxetine treatment in adolescents and children with MDD...Conclusions Residual symptoms are similarly present between females and males following short-term acute medication treatment. Continuation-phase MM+CBT treatment appears to reduce the number and severity of residual symptoms significantly more in females than in males by week 30.
  • ||||||||||  Adequacy of Antidepressant Trials in Youth in Care (Americas Hall II (New York Hilton Midtown); In-person) -  Sep 30, 2023 - Abstract #AACAP2023AACAP_941;    
    Longitudinally, it is possible that these medications would have been effective with an adequate trial. Unfortunately, patients will likely recall these trials as failed, resulting in a potentially useful medication being avoided in the future in the case of relapse.
  • ||||||||||  sertraline / Generic mfg., fluoxetine / Generic mfg.
    The Effects of Fluoxetine and Sertraline on Height and Weight During Puberty (Americas Hall II (New York Hilton Midtown); In-person) -  Sep 30, 2023 - Abstract #AACAP2023AACAP_939;    
    Conclusions The use of SSRIs, particularly sertraline, is associated with failure to grow in height, likely mediated by a suppression of growth hormone signaling. Future studies should examine whether adult height and body composition are impacted.
  • ||||||||||  Trintellix (vortioxetine) / Lundbeck, Takeda
    Pharmacogenetic Guideline Updates and Resources to Support Evidence-Based Implementation (Trianon Ballroom (New York Hilton Midtown); In-person) -  Sep 30, 2023 - Abstract #AACAP2023AACAP_724;    
    Results The CPIC recommends genotype-based guidance, if a patient has genotype data available, for es/citalopram ( CYP2C19 ), fluvoxamine ( CYP2D6 ), paroxetine ( CYP2D6 ), sertraline ( CYP2C19 and CYP2B6 ), venlafaxine ( CYP2D6 ), and vortioxetine ( CYP2D6 )...Evidence did not support PGx guidance of fluoxetine or duloxetine...Conclusions CPIC and FDA evidence evaluations are helpful resources for identifying evidence-based pharmacogenetic information for commonly used antidepressants. PharmGKB and Sequence2Script support access to foundational literature and the clinical implementation of PGx results.
  • ||||||||||  Association Between SSRIs and Delayed Puberty in Children (Americas Hall II (New York Hilton Midtown); In-person) -  Sep 30, 2023 - Abstract #AACAP2023AACAP_604;    
    These findings could be related to the impacts of SSRIs on the hypothalamic-pituitary-gonadal (HPG) axis, resulting in lower levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and sex hormones, as described by one study evaluating the HPG axis in adults on SSRIs. Further research is warranted to explore the underlying mechanisms and long-term effects of SSRIs on pubertal development in children.
  • ||||||||||  sertraline / Generic mfg., mirtazapine / Generic mfg., fluoxetine / Generic mfg.
    Journal:  Patterns in Medication Use for Treatment of Depression in Autistic Spectrum Disorder. (Pubmed Central) -  Sep 26, 2023   
    This study raises concern that standard of care pharmacological treatments for depression in individuals with ASD may be less effective than in neurotypical populations. There remains a need to develop effective interventions for depression specifically tailored to the needs of individuals with ASD.
  • ||||||||||  duloxetine / Generic mfg.
    Journal:  Status Cataplecticus Induced by an Abrupt Duloxetine Withdrawal-A Case Report. (Pubmed Central) -  Sep 25, 2023   
    We review the pathophysiology of antidepressant withdrawal-induced status cataplecticus. In persons with narcolepsy type 1, physicians discontinuing any antidepressant should counsel on adverse effects of antidepressant withdrawal and reduce the dose in tapering manner.
  • ||||||||||  paroxetine / Generic mfg., fluoxetine / Generic mfg.
    Journal:  Peripartum Depression: Detection and Treatment. (Pubmed Central) -  Sep 23, 2023   
    Cognitive behavior therapy and interpersonal psychotherapy are the mainstay of treatment for peripartum depression; physicians should consider selective serotonin reuptake inhibitors for those with moderate to severe depression. The benefits of selective serotonin reuptake inhibitors generally outweigh the risks; however, fluoxetine and paroxetine should be avoided during pregnancy because they can cause an increased risk of birth defects.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal, IO biomarker:  Icariin prevents depression-like behaviors in chronic unpredictable mild stress-induced rats through Bax/cytoplasm C/caspase-3 axis to alleviate neuronal apoptosis. (Pubmed Central) -  Sep 20, 2023   
    Forty male rats were randomly divided into control, CUMS, CUMS-fluoxetine (Flx) (10 mg/kg), and CUMS-ICA (20 mg/kg) groups...Additionally, ICA significantly inhibited mitochondrial translocation of GR, reduced mitochondrial outer membrane permeabilization (MOMP) to suppress the release of cytochrome C, and then inhibit the activation of caspase-3. In conclusion, our research provides new evidence to understand the anti-depressant activity of ICA, which relates to its inhibition of neuronal apoptosis in the hippocampus through the mitochondrial apoptotic pathway.
  • ||||||||||  Nuplazid (pimavanserin) / Acadia Pharma
    Preclinical, Journal:  Pimavanserin treatment increases plasma brain-derived neurotrophic factor levels in rats. (Pubmed Central) -  Sep 15, 2023   
    No significant changes in mBDNF levels were found in the prefrontal cortex or hippocampus following Pimavanserin or Fluoxetine treatment. These findings suggest that increase in mBDNF levels could be a contributing mechanism for the neuroprotective potential of Pimavanserin.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Fluoxetine promotes longevity via reactive oxygen species in Caenorhabditis elegans. (Pubmed Central) -  Sep 14, 2023   
    Additionally, fluoxetine extended lifespan through the daf-2-sod-3 pathway in daf-16-dependent and -independent manners, and fluoxetine-induced lifespan extension was abolished in C. elegans sod-3, daf-2, and daf-16 mutants. In conclusion, these findings suggest that fluoxetine can promote health and longevity in C. elegans via the interaction of ROS and insulin signaling.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  A system for bioelectronic delivery of treatment directed toward wound healing. (Pubmed Central) -  Sep 11, 2023   
    To demonstrate the functionality of the platform, the devices are used to deliver H[Formula: see text] in vivo using mouse models and fluoxetine ex vivo using a simulated wound environment. Immunohistochemistry staining shows an improvement of 35.86% in the M1/M2 ratio of H[Formula: see text]-treated wounds compared with control wounds, indicating the potential of the platform to improve wound healing.
  • ||||||||||  ketamine / Generic mfg., fluoxetine / Generic mfg.
    Journal:  Methodological approach: using a within-subjects design in the marble burying assay. (Pubmed Central) -  Sep 7, 2023   
    The positive controls buspirone (3.2-10?mg/kg) ketamine (32?mg/kg), and fluoxetine (10?mg/kg) decreased the number of marbles buried using the within-subjects design. These data suggest that a within-subjects design is optimal for the marble burying assay as it will reduce the number of animals and increase statistical power.