- |||||||||| pregabalin / Generic mfg., trazodone ER / Generic mfg., gabapentin / Generic mfg.
Clinical, Journal: Challenges in the Treatment of Restless Legs Syndrome: A Case Report. (Pubmed Central) - Jun 26, 2021 Over the course of nearly 4 years, treatment interventions for this patient's RLS included: cognitive behavioral therapy for insomnia, discontinuation of exacerbating medications, switching dopamine agonists, use of pregabalin and iron supplement. This report demonstrates a challenging case of RLS in the setting of psychiatric comorbidities, development of augmentation, and polypharmacy.
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Journal: A Key Role for Prefrontocortical Small Conductance Calcium-Activated Potassium Channels in Stress Adaptation and Rapid Antidepressant Response. (Pubmed Central) - Jun 22, 2021 This antidepressant-like effect was mediated via a muscarinic M1 receptor-SKC pathway because it was mimicked by intra-medial prefrontal cortex (intra-mPFC) infusions of scopolamine, of the M1 antagonist pirenzepine or of the SKC antagonist apamin, but not by the selective serotonin reuptake inhibitor (SSRI) antidepressant fluoxetine...Scopolamine also induced a slow-onset activation of raphe serotonergic neurons, which in turn was dependent on mPFC-induced neuroplasticity or excitatory input, since mPFC transection abolished this effect. These early behavioral and mPFC activational effects of scopolamine did not appear to depend on prefrontocortical brain-derived neurotrophic factor and serotonin-1A activity, classically linked to SSRIs, and suggest a novel mechanism associated with antidepressant response onset through SKC-mediated regulation of activity-dependent plasticity.
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Preclinical, Journal: Third-party prosocial behavior in adult female rats is impaired after perinatal fluoxetine exposure. (Pubmed Central) - Jun 22, 2021 We conclude that female rats are able to show prosocial behavior, possibly in the form of consolation behavior. In addition, the negative effects of perinatal fluoxetine exposure on prosocial behavior could provide additional evidence that SSRI treatment during pregnancy could contribute to the risk for social impairments in the offspring.
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Clinical, Journal: Whole blood and oral fluid microsampling for the monitoring of patients under treatment with antidepressant drugs. (Pubmed Central) - Jun 22, 2021 Method validation results were satisfactory (extraction yield >84%, precision RSD 85.0% after 3 months). Application to blood and oral fluid VAMS from patients treated with four possible different antidepressants (sertraline, fluoxetine, citalopram and vortioxetine) provided results always in good agreement with those obtained from the corresponding fluid matrices, including the levels of drug metabolites.
- |||||||||| Fintepla (low-dose fenfluramine) / Zogenix
Preclinical, Journal: Acute D-fenfluramine, but not fluoxetine decreases sweet intake in BALB/c, C57BL/6 and SWR inbred mouse strains. (Pubmed Central) - Jun 22, 2021 Fluoxetine marginally altered sucrose intake in all strains. D-fenfluramine significantly, but quite similarly reduced (ID) sucrose and saccharin intake in BALB/c (5.7 vs. 5.8 mg/kg), C57BL/6 (4.4 vs. 4.3 mg/kg) and SWR (4.6 vs. 5.6 mg/kg) mice, suggesting serotonin-induced inhibition of orosensory mechanisms in all three inbred mouse strains.
- |||||||||| Fycompa (perampanel) / Eisai
Preclinical, Journal: Impact of extensive plasma protein binding on the in situ hepatic uptake and clearance of perampanel and fluoxetine in Sprague Dawley rats. (Pubmed Central) - Jun 22, 2021 As for FLU, the parameters were V= 65.5, 18.83, 34.5 and 15.3 (nmol/min/g liver) and K= 1.5, 2.4, 0.69 and 6.31 (μM) in all four scenarios, respectively. In conclusion, a protein-mediated hepatic uptake likely occurred only at low free concentrations for both drugs (i.e., therapeutic concentrations) in the presence of plasma proteins (except for the scenario of PER with AGP).
- |||||||||| imipramine / Generic mfg., fluoxetine / Generic mfg.
Preclinical, Journal: Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice. (Pubmed Central) - Jun 22, 2021 Integrative gene expression analysis specifically links changes in amygdaloid intracellular signaling activity to the behavioral treatment response in Brd1 mice. Collectively, our study highlights the importance of BRD1 as a modulator of affective pathology and adds to our understanding of the molecular mechanisms underlying affective disorders and their treatment response.
- |||||||||| fluoxetine / Generic mfg., citicoline / Generic mfg.
Review, Journal: An update on pharmacological treatment options for amblyopia. (Pubmed Central) - Jun 22, 2021 For these reasons, new treatment options are being studied, in order to extend the "treatment window" beyond the critical period also in older patients. In this review, we will discuss all the most promising novel pharmacological agents in the management of amblyopia.
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Journal: Developing a data-driven algorithm for guiding selection between cognitive behavioral therapy, fluoxetine, and combination treatment for adolescent depression. (Pubmed Central) - Jun 22, 2021 Physical illness and disability were identified as overall predictors of response to treatment, regardless of treatment type, whereas baseline CDRS-R, psychosomatic symptoms, school missed, view of self, treatment expectations, and attention problems determined the patients' response to specific treatments. The model developed in this study provides a critical starting point for personalized treatment planning for adolescent depression.
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Journal: Dentate gyrus activin signaling mediates the antidepressant response. (Pubmed Central) - Jun 22, 2021 Enhancement of Activin signaling in the DG converted behavioral non-responders into responders to fluoxetine treatment more effectively than commonly used second-line antidepressant treatments, while inhibition of Activin signaling in the DG converted responders into non-responders. Taken together, these results demonstrate that the behavioral response to fluoxetine can be bidirectionally modified via targeted manipulations of the DG and suggest that molecular- and neural circuit-based modulations of DG may provide a new therapeutic avenue for more effective antidepressant treatments.
- |||||||||| fluoxetine / Generic mfg.
Journal: Corticosterone-induced Hippocampal 5-HT Responses were Muted in Depressive-like State. (Pubmed Central) - Jun 22, 2021 Basal dialysate 5-HT, true extracellular 5-HT, 5-HT reuptake efficiency, and time courses of dialysate 5-HT following CORT injections at 10, 20, and 40 mg/kg were determined at baseline, depressive-like state and after subsequent fluoxetine (FLX) treatment using in vivo microdialysis in male C57BL/6 mice...Increased 5-HT reuptake efficiency was one of the underlying mechanisms, with target effectors remaining to be explored. The findings in the FLX nonresponsive mice suggest distinct neuromechanisms, which might be genetically predetermined.
- |||||||||| fluoxetine / Generic mfg.
Journal: Cell cycle abnormality is a cellular phenotype in OCD. (Pubmed Central) - Jun 22, 2021 We also evaluated the effect of in vitro fluoxetine, commonly used serotonin reuptake inhibitor (SRI) in OCD patients, on cell cycle regulation...The findings suggest that cell cycle dysregulation could be peripheral cellular phenotype for OCD. Among cases, all of whom had been systematically characterized for SRI treatment response, LCLs from non-responders to SRI treatment had a lower proportion of cells in G2/M phase than responders.
- |||||||||| Humira (adalimumab) / Eisai, AbbVie
Journal, Adverse events: Leveraging digital media data for pharmacovigilance. (Pubmed Central) - Jun 22, 2021 Moreover, we manually validated some of the under-reported side effect predicted by our model using literature search. Common known and under-reported side effects can be found at https://github.com/cbrl-nuces/Leveraging-digital-media-data-for-pharmacovigilance.
- |||||||||| sertraline / Generic mfg., duloxetine / Generic mfg.
Retrospective data, Review, Journal: New generation antidepressants for depression in children and adolescents: a network meta-analysis. (Pubmed Central) - Jun 22, 2021 If an antidepressant is being considered for an individual, this should be done in consultation with the child/adolescent and their family/caregivers and it remains critical to ensure close monitoring of treatment effects and suicide-related outcomes (combined suicidal ideation and suicide attempt) in those treated with newer generation antidepressants, given findings that some of these medications may be associated with greater odds of these events. Consideration of psychotherapy, particularly cognitive behavioural therapy, as per guideline recommendations, remains important.
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Preclinical, Journal: The Effect of Lactobacillus casei Consumption in Improvement of Obsessive-Compulsive Disorder: an Animal Study. (Pubmed Central) - Jun 12, 2021 They were fed with L. casei Shirota (10 CF/g, daily for 4 weeks) (group 1), fluoxetine (10 mg/kg, daily for 4 weeks) (group 2), combination of L. casei Shirota and fluoxetine (group 3), and normal saline (positive control group)...The current study showed the effectiveness of L. casei Shirota in the treatment of OCD in a rat model. The beneficial effects of this probiotic are possibly exerted through the modulation of serotonin-related genes expression.
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Journal: More evidence that fluoxetine does not improve functional recovery from stroke. (Pubmed Central) - Jun 10, 2021 Every month, DTB scans sources of information on treatments, disease management and other healthcare topics for key items to bring to our readers' attention and help them keep up to date. To do this, we produce succinct, contextualised summaries of the information concerned.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Effect of fluoxetine on seizures in rats with high susceptibility to audiogenic stress. (Pubmed Central) - Jun 10, 2021 Decreased manifestation of seizures in the experimental SS rats under acute administration of fluoxetine may be explained by highly distinctive repertoire and spatial distribution of 5-HT receptors in their brain structures in comparison to the ST rats. The study of the monoaminergic mechanisms of seizure generation is of practical importance due to the existence of pharmacological agents, which selectively affect the activity of the monoaminergic systems of the brain, as well as the metabolism of the monoamines synthesized by them.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Fluoxetine Protects against Dendritic Spine Loss in Middle-aged APPswe/PSEN1dE9 Double Transgenic Alzheimer's Disease Mice. (Pubmed Central) - Jun 8, 2021 Meanwhile, FLX effectively attenuated hyperphosphorylation of tau at Ser396 and elevated protein levels of postsynaptic density 95 (PSD-95) and synapsin-1 (SYN-1) in the hippocampus. These results indicated that the enhanced learning ability observed in FLX-treated middle-aged APP/PS1 mice might be associated with remarkable mitigation of hippocampal dendritic spine pathology by FLX and suggested that FLX might be explored as a new strategy for therapy of AD in the middle-to-late stage.
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