fluoxetine / Generic mfg. 
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  • ||||||||||  hypidone hydrochloride (HHT101) / Zhejiang Huahai Pharma, Viibryd (vilazodone) / AbbVie
    Preclinical, Journal:  A critical step in antidepressants onset: Excitation of glutamatergic pyramidal neurons in rodents' medial prefrontal cortex. (Pubmed Central) -  Jan 15, 2024   
    Furthermore, a significant reduction was observed in the firing activity of pyramidal neurons in the mPFC of CRS-exposed mice, which was reversed by antidepressants. Taken together, our findings suggested that five pharmacologically distinct classes of antidepressants share the common ability to increase the firing activity of pyramidal neurons, which contributes to the body of knowledge of the mechanisms underlying antidepressant effects and paves the way for developing rapid-acting antidepressants.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Pharmaceutical pollution alters the cost of bacterial infection and its relationship to pathogen load. (Pubmed Central) -  Jan 14, 2024   
    Instead, fluoxetine modified the relationship between the degree of pathogen proliferation and its virulence, with both the strength of this trade-off and the component of host fitness most affected varying by fluoxetine concentration and host genotype. Our study underscores the potential for pharmaceutical pollution to modify the virulence of an invading pathogen, as well as the fundamental trade-off between host and pathogen fitness, even at the trace amounts increasingly found in natural waterways.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Altered task-related decoupling of the rostral anterior cingulate cortex in depression. (Pubmed Central) -  Jan 14, 2024   
    We enrolled 81 15- to 25-year-old young people with moderate-to-severe major depressive disorder (MDD) before they commenced a 12-week clinical trial that assessed the effectiveness of cognitive behavioral therapy plus either fluoxetine or placebo...Further, we found MDD participants showed significant increased coupling with the anterior insula cortex during task engagement. Our findings indicate that aberrant task-related rACC suppression is associated with disruptions in adaptive neural communication and dynamic switching between internal and external cognitive modes that may underpin maladaptive cognitions and biased emotional processing in depression.
  • ||||||||||  fluoxetine / Generic mfg., duloxetine / Generic mfg.
    Journal:  The integrated stress response-related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability. (Pubmed Central) -  Jan 13, 2024   
    Our findings indicate that aberrant task-related rACC suppression is associated with disruptions in adaptive neural communication and dynamic switching between internal and external cognitive modes that may underpin maladaptive cognitions and biased emotional processing in depression. Together, the results suggest that early pre-clinical screening for CHOP expression could indicate liability of mitochondrial toxicity in the context of DILI, and, therefore, could serve as an important warning signal to consider during decision-making in drug development.
  • ||||||||||  Genetically-determined variants lead to to neuronal hyperexcitability and clinical psychosis/catatonia: case series. (MTCC - Exhibit Halls DE) -  Jan 10, 2024 - Abstract #ACMG2024ACMG_585;    
    Catatonia is not a common phenomenon in psychosis and can have significant morbidity and mortality, usually signaling a profound deficit in neuronal homeostasis resulting in neuronal hyperexcitability and neurotoxicity. In this report, three individuals with psychosis/catatonia harbored genetic variants which are plausibly directly linked to neuronal hyperexcitability (KCNQ1, ADCY8; due to prolonged repolarization) or psychosis-high risk neurodevelopmental changes (CNTN4/GPR29/LYPD1).
  • ||||||||||  SCH-23390 / Boehringer Ingelheim
    Preclinical, Journal:  Water-soluble Moringa oleifera Seed Lectin Exhibits Monoaminergic Pathway-linked Anti-depressive-like Effects in Mice. (Pubmed Central) -  Jan 8, 2024   
    In this report, three individuals with psychosis/catatonia harbored genetic variants which are plausibly directly linked to neuronal hyperexcitability (KCNQ1, ADCY8; due to prolonged repolarization) or psychosis-high risk neurodevelopmental changes (CNTN4/GPR29/LYPD1). WSMoL elicits an anti-depressant-like effect that is dependent on monoaminergic signaling.
  • ||||||||||  fluoxetine / Generic mfg., haloperidol / Generic mfg., methadone / Generic mfg.
    Journal, Metastases:  Polypharmacy and Reversible Drug Induced QT Prolongation in a Patient with Advanced Cancer: Case Report. (Pubmed Central) -  Jan 5, 2024   
    Herein we present the case of a patient with advanced cancer under anti-tumor treatment with radical intention that developed a reversible drug-induced QT prolongation when simultaneously treated with methadone, haloperidol and fluoxetine that presented with chest pain and bradycardia. An approach to cancer patients at risk for drug-induced QT prolongation is discussed highlighting the need of a thorough medication review with a special focus in the patient with polypharmacy.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Drugs for depressionr. (Pubmed Central) -  Dec 26, 2023   
    The findings suggest that paroxetine prevents pathological cardiac remodeling by inhibiting the GRK2-mediated I?B?/NF-?B signaling pathway. No abstract available
  • ||||||||||  Preclinical, Journal:  Risk Assessment of Psychotropic Drugs on Mitochondrial Function Using In Vitro Assays. (Pubmed Central) -  Dec 23, 2023   
    The acute extracellular flux assay identified inhibitors of the electron transport chain (ETC), i.e., aripiprazole, phenytoin, and fluoxetine, an uncoupler (reserpine), substrate inhibitors (quetiapine, carbamazepine, buspirone, and tianeptine), and cytotoxic compounds (chlorpromazine and valproic acid) in HepG2 cells. Assessing complex-II-linked respiration in isolated rat liver mitochondria revealed haloperidol is an ETC inhibitor, chlorpromazine is an uncoupler in basal respiration and an ETC inhibitor under uncoupled respiration (IC = 135
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Treatment guesses in the Treatment for Adolescents with Depression Study: Accuracy, unblinding and influence on outcomes. (Pubmed Central) -  Dec 21, 2023   
    P3
    Treatment for Adolescents with Depression Study trialled fluoxetine, placebo, cognitive behaviour therapy or their combination, in treating adolescents with major depressive disorder...For Treatment for Adolescents with Depression Study, treatment guesses strongly predicted outcomes and may have led to the exaggeration of drug effectiveness in the absence of actual effects. The integrity of double-blinding in trials should be routinely assessed and reported.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Fluoxetine-Associated Enuresis in a Pediatric Patient. (Pubmed Central) -  Dec 19, 2023   
    If anything, there was a slight fall in prescribing of the main antidepressants prescribed, which given prevailing circumstances at the time, suggests that access to services may have restricted access to timely assessment. No abstract available
  • ||||||||||  Retrospective data, Journal:  Use of Psychotropic Drugs during the COVID-19 pandemic in Minas Gerais, Brazil. (Pubmed Central) -  Dec 17, 2023   
    This study suggests that fluoxetine, by upregulating Cx43 levels, could strengthen the Antitumor effect of OEC-TK/GCV gene therapy on GBM cells. The change in the psychotropic drug dispensation profile during the COVID-19 pandemic highlights the need to produce more studies to complete, confirm or rule out this profile and monitor the use of psychotropic drugs by the population in the post-pandemic context.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Engeletin alleviates depression-like phenotype by increasing synaptic plasticity via the BDNF-TrkB-mTORC1 signalling pathway. (Pubmed Central) -  Dec 17, 2023   
    Engeletin was also investigated in the chronic restraint stress (CRS) mouse model of depression with fluoxetine (FLX) as the positive control...Moreover, it enhanced the BDNF-TrkB-mTORC1 pathway in the PFC during CRS and altered the reduction in dendritic spine density and levels of synaptic plasticity-linked protein induced by CRS. In conclusion, engeletin has antidepressant activity via activation of the BDNF-TrkB-mTORC1 signalling pathway and upregulation of PFC synaptic plasticity.
  • ||||||||||  fluoxetine / Generic mfg., nitazoxanide / Generic mfg.
    Journal:  Combined Treatment of Progressive Encephalitis in an X-linked Agammaglobulinemia Patient. (Pubmed Central) -  Dec 12, 2023   
    In most of the cases the evolution of the progressive encephalitis is complicated and catastrophic. Based on our experience and the review of the literature, we propose the use of this combined treatment to control this devastating complication.
  • ||||||||||  selenomethionine (SLM) / University of Iowa, Holden Comprehensive Cancer Center
    Journal:  Comparing Transcriptomic Responses to Chemicals Across Six Species using the EcoToxChip RNASeq database. (Pubmed Central) -  Dec 12, 2023   
    The most common enriched pathways were metabolic pathways, biosynthesis of cofactors and biosynthesis of secondary metabolites, and chemical carcinogenesis, drug metabolism and metabolism of xenobiotics by Cytochrome P450. The RNA-sequencing database presented here may be used by the research community for multiple purposes, including for example, cross-species investigations, in depth analyses of a particular test compound, and transcriptomic meta-analyses.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  The antidepressant fluoxetine (Prozac (Pubmed Central) -  Dec 10, 2023   
    Infants exposed to SSRIs have increased risks of delayed adaptation in a type and dose-dependent relationship, pointing toward a causal relationship. The steroids cortisol and progesterone were not altered by fluoxetine treatment whereas estradiol was decreased after the onset of treatment (12.4?
  • ||||||||||  fluoxetine / Generic mfg.
    Review, Journal:  Unlocking Therapeutic Synergy: Tailoring Drugs for Comorbidities such as Depression and Diabetes through Identical Molecular Targets in Different Cell Types. (Pubmed Central) -  Dec 9, 2023   
    To this end, we firstly remind readers of the close link existing between depression and diabetes and secondly address the potential benefit of the pleiotropic actions of two major active molecules used to treat central and peripheral disorders, first a serotonin reuptake inhibitor (Prozac ) and then GLP-1R agonists. In the second part, by discussing the therapeutic potential of new experimental antidepressant molecules, we will support the concept that a better understanding of the intracellular signaling pathways targeted by pharmacological agents could lead to future synergistic treatments targeting solely positive effects for comorbidities.
  • ||||||||||  imipramine / Generic mfg., fluoxetine / Generic mfg.
    Journal:  A comparative analysis of depressive-like behavior: Exploring sex-related differences and insights. (Pubmed Central) -  Dec 3, 2023   
    The inherent stress of the FST and TST tasks appears to influence [CORT] as well as depressant and antidepressant effects. These comparisons provide valuable insights for further behavioral phenotyping, model sensitivity assessment, and deepen our neurobiological understanding of depression in the context of drug screening.
  • ||||||||||  fluoxetine / Generic mfg.
    Trial completion, Phase classification, Enrollment change, Trial completion date, Trial primary completion date:  Clinical Trial of Fluoxetine in Anxiety and Depression in Children, and Associated Changes in the Brain (clinicaltrials.gov) -  Nov 28, 2023   
    P2,  N=2290, Completed, 
    These comparisons provide valuable insights for further behavioral phenotyping, model sensitivity assessment, and deepen our neurobiological understanding of depression in the context of drug screening. Recruiting --> Completed | Phase classification: PN/A --> P2 | N=120 --> 2290 | Trial completion date: Dec 2024 --> Sep 2023 | Trial primary completion date: Dec 2024 --> Sep 2023
  • ||||||||||  Trintellix (vortioxetine) / Lundbeck, Takeda
    Clinical, Journal:  PHARMACOLOGY OF POST-TRAUMATIC STRESS DISORDER. (Pubmed Central) -  Nov 27, 2023   
    Antidepressants (SSRI SNRIs) are primarily considered as first-line drugs, but only sertraline, paroxetine, and fluoxetine are approved by the FDA...Vortioxetine becomes a very promising option...In insomnia the use of prazosin and trazodone is recommended...Currently, there are no unified approaches to the pharmacotherapy of posttraumatic stress disorder. Further randomized clinical trials are necessary for developing effective treatment of posttraumatic stress disorder.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  Effects of in utero exposure to fluoxetine on the gastrointestinal tract of rat offspring. (Pubmed Central) -  Nov 27, 2023   
    In utero exposure to fluoxetine was not found to increase susceptibility to dextran sulfate sodium-induced acute colitis at 6 months. These findings suggest that fluoxetine-exposure during development can lead to changes in serotonergic neurons at the peak of exposure with sex-specific changes in 5-HT signaling and colonic motility in adulthood.
  • ||||||||||  Trintellix (vortioxetine) / Lundbeck, Takeda
    Journal, Adverse events:  Drugs and bruxism: a study in the World Health Organization's pharmacovigilance database. (Pubmed Central) -  Nov 27, 2023   
    A signal was also described for oxybate sodium and metoclopramide. For antidepressants, a negative association was found between ROR values and NET (norepinephrine transporter) but not SERT (serotonin transporter) pKi values, suggesting this ADR is more closely linked to norepinephrine than serotonin reuptake inhibition.
  • ||||||||||  lisdexamfetamine / Generic mfg., fluoxetine / Generic mfg.
    Review, Journal:  Eating Disorders. (Pubmed Central) -  Nov 22, 2023   
    Careful examination for and documentation of dental erosions, posterior oropharyngeal bruising, Russel's sign, and salivary and parotid gland inflammation are clues to the purging behavior. Treatment for AN should include cognitive behavioral therapy with concomitant efforts to treat any psychiatric comorbidities, whereas BN and BED have been successfully treated with fluoxetine and lisdexamfetamine, respectively.