fluoxetine / Generic mfg. 
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  • ||||||||||  atomoxetine / Generic mfg., dextroamphetamine immediate release / Generic mfg.
    Journal:  The Effects of Drugs on Behavior Maintained by Social Contact: Role of Monoamines in Social Reinforcement. (Pubmed Central) -  Mar 11, 2022   
    These data indicate that increases in extracellular dopamine, but not extracellular norepinephrine or serotonin, increases the positive reinforcing effects of social contact in both male and female rats. These data also provide support for the hypothesis that some drugs with high abuse liability increase the motivation to establish and maintain contact with social peers.
  • ||||||||||  sertraline / Generic mfg., duloxetine / Generic mfg.
    Antidepressant Use and Psychiatric Rehospitalization in Patients with Schizophrenia () -  Mar 11, 2022 - Abstract #SIRS2022SIRS_934;    
    Altogether 49.3% (N=30,508) of the study cohort used antidepressants during the follow-up (median 14.8 years, IQR 7.5-22.0), with citalopram and mirtazapine being the most used antidepressants. The risk of psychiatric rehospitalization was lower during antidepressant use as compared to non-use (aHR 0.93, 95% CI 0.92-0.95).
  • ||||||||||  palmatine / LKT Labs
    Journal:  The effect and mechanism of Jiao-tai-wan in the treatment of diabetes mellitus with depression based on network pharmacology and experimental analysis. (Pubmed Central) -  Mar 9, 2022   
    JTW plays a role in reducing blood glucose level and antidepressant mainly through active compounds such as quercetin, styrene, cinnamic acid, ethyl cinnamate, (R)-Canadine, palmatine and berberine, etc., the key targets of its therapeutic effect include INS, AKT1, IL-6, VEGF-A, TNF and so on, mainly involved in HIF-1 signal pathway, pathways in cancer, Hepatitis B, TNF signal pathway, PI3K-Akt signal pathway and MAPK signaling pathway, etc. Our experimental study showed that JTW has hypoglycemic and antidepressant effects. The possible mechanism was explored by network pharmacology, reflecting the characteristics of multi-component, multi-target and multi-pathway, which provides a theoretical basis for the experimental research and clinical application of JTW in the future.
  • ||||||||||  fluoxetine / Generic mfg.
    Fluoxetine inhibit osteosarcoma progression via RANK/RANKL signaling pathway (E-Poster Website) -  Mar 9, 2022 - Abstract #AACR2022AACR_6863;    
    Moreover, the inhibition of tumour angiogenesis by fluoxetine has also proven by using aorta ring assay. Further in vivo experiment may need to be performed to identify anti-tumor efficacy of fluoxetine.In sum, fluoxetine can be used anti-tumour adjuvant of OS therapy and the detailed mechanism or further combination strategy may be worth exploring.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  Sex differences in long-term behavioral alterations, especially anxiety, following prenatal fluoxetine exposure in C57BL/6 mice. (Pubmed Central) -  Mar 8, 2022   
    Prenatal fluoxetine exposure did not affect other adult behaviors including social preference, self-grooming, passive avoidance and open field activity. These findings suggest males are more sensitive than females to disruptions in serotonin balance during prenatal development and highlight the need for additional systematic and mechanistic studies to evaluate the impact of fluoxetine exposure during other periods of gestation.
  • ||||||||||  Rexulti (brexpiprazole) / Lundbeck, Otsuka
    Economic Evaluation of Brexpiprazole As Adjunctive Treatment of Major Depressive Disorder in the Mexican National Health System (In-person & Virtual) -  Mar 8, 2022 - Abstract #ISPOR2022ISPOR_1746;    
    Brexpiprazole, when used as adjunctive treatment presented statistically significant differences vs ADT monotherapy in remission rate (RR: 1.28; 95% CI: 1.01 – 1.62; p: 0.04). The BIA showed inclusion of brexpiprazole as adjunctive treatment in adults with MDD from the MNHS perspective has an annual mean budget impact in a 5-year horizon of MXN $21,543,663, representing 0.0124% of their pharmacotherapy budget for all conditions.
  • ||||||||||  sertraline / Generic mfg., fluoxetine / Generic mfg., escitalopram / Generic mfg.
    Comparative Effectiveness of Sertraline, Fluoxetine Vs Escitalopram Among Adults with Depression in the United States (In-person & Virtual) -  Mar 8, 2022 - Abstract #ISPOR2022ISPOR_1383;    
    While Sertraline and Escitalopram were less likely to improve psychological distress than Fluoxetine, result was statistically insignificant possibly because of smaller sample size. Further study is needed to assess the comparative effectiveness and health-care utilization of these medications.
  • ||||||||||  sertraline / Generic mfg., paroxetine / Generic mfg., fluoxetine / Generic mfg.
    Trends of Second-Generation Antidepressants Utilization Among Adults with Depression in the United States (In-person & Virtual) -  Mar 8, 2022 - Abstract #ISPOR2022ISPOR_942;    
    Monotherapy second-generation antidepressants’ utilization trends varied significantly based on patients’ characteristics such as age, gender, and race. Sertraline was utilized more than other antidepressants and was associated with less utilization of mental health services, which is consistent with the clinical findings that it is well-tolerated and have better patient-reported outcomes.
  • ||||||||||  fluoxetine / Generic mfg.
    Predictive Factors for Depressive Symptoms in the Stroke Recovery Follow-Up Period (Poster Hall) -  Mar 6, 2022 - Abstract #AAN2022AAN_2800;    
    History of depression and a positive inpatient PHQ-9 appear to be most strongly associated with long-term PSD. Initiating SSRIs only in those individuals at higest risk for PSD may help reduce the burden of stroke recovery in this targeted population.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  Baihe Extracts Reduce the Activation and Apoptosis of Microglia in the Hippocampus of Mice with Depression-like Behaviors by Downregulating MYC. (Pubmed Central) -  Mar 5, 2022   
    Network meta-analysis was applied for the synthesis of efficacy outcomes of fluoxetine and three traditional Chinese medicine Baihe prescriptions in depression...Serum containing Baihe extracts could inhibit the activation of microglia and the release of inflammatory mediators by downregulating MYC. In summary, Baihe extracts were found to diminish MYC expression to reduce microglial activation and inflammatory factor release, thereby exerting antidepressant effects.
  • ||||||||||  calcitonin/benzyl alcohol/phenyl ethyl alcohol/aqueous buffer / Generic mfg., ketamine / Generic mfg.
    Journal:  Salmon Calcitonin Exerts an Antidepressant Effect by Activating Amylin Receptors. (Pubmed Central) -  Mar 4, 2022   
    Taken together, our data revealed that sCT could ameliorate a depressive-like phenotype probably via the amylin signaling pathway. sCT should be considered as a potential therapeutic candidate for depressive disorder in the future.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Light Therapy Improved Depression-Like Behavior Induced by Chronic Unpredictable Mild Stress in Mongolian Gerbils. (Pubmed Central) -  Feb 26, 2022   
    Interestingly, we also found that light therapy improved anhedonic behavior more effectively than fluoxetine after two weeks of treatment. In summary, our study is the first to use diurnal Mongolian gerbils, which have the same circadian rhythm as humans, to establish an effective, economical, and practical animal model of depression and confirmed that light therapy could improve depression-like behavior more effectively than fluoxetine to some extent in diurnal Mongolian gerbils, which establishes a good foundation for clarifying the neural mechanism of light therapy for depression.
  • ||||||||||  sertraline / Generic mfg.
    Clinical, Journal:  Antidepressant medication to prevent depression relapse in primary care: the ANTLER RCT. (Pubmed Central) -  Feb 26, 2022   
    P4
    The participants may not have been representative of all people on long-term maintenance treatment and we could study only a restricted range of antidepressants and doses. Identifying patients who will not relapse if they discontinued antidepressants would be clinically important.
  • ||||||||||  citalopram / Generic mfg., paroxetine / Generic mfg., fluoxetine / Generic mfg.
    Journal:  Sodium Binding Stabilizes the Outward-Open State of SERT by Limiting Bundle Domain Motions. (Pubmed Central) -  Feb 26, 2022   
    Importantly, the binding of NaCl reduced the dynamics of the hSERT by decreasing the internal fluctuations of the bundle domain as well as the movement of the bundle domain relative to the scaffold domain. In contrast, the presence of only the bound chloride ion did not reduce the high domain mobility of the apo state.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  Carrier-mediated serotonin efflux induced by pharmacological anoxia in the rat heart in vivo. (Pubmed Central) -  Feb 25, 2022   
    Fluoxetine, a selective serotonin reuptake inhibitor raised the baseline level of 5-HT, and neither sodium cyanide nor the combination of ouabain and reserpine induced further increase in 5-HT in the presence of fluoxetine. The results indicate that reverse transport of 5-HT via SERT, which is caused by an impaired ion gradient contributes to the rise in interstitial level of 5-HT during ischaemia suggesting carrier-mediated 5-HT efflux occurs in the heart in vivo.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Fluoxetine acts concomitantly on dorsal and ventral hippocampus to Trk-dependently modulate the extinction of fear memory. (Pubmed Central) -  Feb 25, 2022   
    The results indicate that reverse transport of 5-HT via SERT, which is caused by an impaired ion gradient contributes to the rise in interstitial level of 5-HT during ischaemia suggesting carrier-mediated 5-HT efflux occurs in the heart in vivo. Both dHC and vHC are essential for the Trk-dependent effect of FLX on extinction memory, although a discrepancy in the fear response was observed with the infusion of BDNF into the dHC or vHC.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  Effect of fluoxetine treatment on neurotoxicity induced by lysolecithin in male rats. (Pubmed Central) -  Feb 25, 2022   
    Fluoxetine has increased the expression level of myelination and neurotrophic genes such as myelin basic protein (MBP), oligodendrocyte transcription factor 2 (OLIG2), and brain-derived neurotrophic factor (BDNF). The outcomes demonstrated that fluoxetine reduces inflammation and strengthens the endogenous myelination in the LPC-induced demyelination model; however, supplementary studies are required for specifying the details of its mechanisms.
  • ||||||||||  diazepam / Generic mfg., fluoxetine / Generic mfg.
    Preclinical, Journal:  Anxiolytic and antidepressant-like activities of aqueous extract of Azadirachta indica A. Juss. flower in the stressed rats. (Pubmed Central) -  Feb 25, 2022   
    Additionally, the stressed rats treated with either positive control medications or A. indica flower extract exhibited significantly higher brain dopamine (DA) and serotonin (5-HT) levels, but lower blood cortisol levels as compared to the stressed rats treated with vehicle. Moreover, A. indica flower extract had no harmful effect on the stressed rats' liver tissue.
  • ||||||||||  fluoxetine / Generic mfg.
    Clinical, Journal:  Efficacy of Fluoxetine for Post-Ischemic Stroke Depression in Tanzania. (Pubmed Central) -  Feb 24, 2022   
    Our findings parallel results from trials from higher income settings that fluoxetine does not significantly improve post-ischemic stroke depression, although our sample size was small. More work is needed to depict the longitudinal nature and treatment of post-stroke depression in Sub-Saharan Africa.
  • ||||||||||  gabapentin / Generic mfg., celecoxib oral / Generic mfg.
    Clinical, Review, Journal:  Spinal cord stimulation in the approach to chronic pelvic pain: A case report and literature review. (Pubmed Central) -  Feb 24, 2022   
    Additionally, both EuroQOL-5D and visual analogue scale scores improved after the intervention. Through the combination of spinal cord stimulation Spectra Wavewriter and 3D programming technology, both lumbar and leg pain and CPP were successfully relieved, along with an improvement in the quality of life of the patient.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Oral fluoxetine treatment changes serotonergic sympatho-regulation in experimental type 1 diabetes. (Pubmed Central) -  Feb 22, 2022   
    Low-dose fluoxetine administered in the premenstrual phase deserves further attention for management of panic disorders in women. Our findings suggest that fluoxetine improves metabolic and renal profiles, changes the vasopressor responses, and 5-HT receptors modulating sympathetic activity in diabetic rats: 5-HT are involved in the sympatho-inhibition, while 5-HT is implicated in the sympatho-potentiation, being both effects pre and/or postjunctional in nature.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Postpartum corticosterone and fluoxetine shift the tryptophan-kynurenine pathway in dams. (Pubmed Central) -  Feb 19, 2022   
    Moreover, maternal FLX treatment showed limited efficacy to influence TKP metabolites, which may correspond to its limited efficacy to treat depressive-like endophenotypes in the postpartum. Overall suggesting changes in TKP may be used as a biomarker of de novo PPD and antidepressant efficacy and targeting this pathway may serve as a potential therapeutic target.