fluoxetine / Generic mfg. 
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  • ||||||||||  fluoxetine / Generic mfg.
    A case of drug-induced bullous pemphigoid associated with fluoxetine (e-Poster Hall) -  Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_39;    
    which is unusual compared to the data in the literature (less than 6 weeks). That unusual delay can be explained by the complex pathogenesis of DIBP which is possibly linked to the interaction between various precipitating factors or triggers such as drugs in our case, that could induce or exacerbate BP disease in the context of several predisposing factors include genetics, comorbidities, and aging.
  • ||||||||||  ketamine / Generic mfg., fluoxetine / Generic mfg.
    Preclinical, Journal:  Exploring pharmacological options for adolescent depression: a preclinical evaluation with a sex perspective. (Pubmed Central) -  Jun 11, 2022   
    Moreover, when rats were re-exposed in adulthood to the same drug regimens as in adolescence, a drop in efficacy was observed. These findings may have translational ramifications in that ketamine or cannabidiol could be moved forward as antidepressants for the adolescent depressed population, but not before further characterizing their potential long-term safety and/or beneficial vs. harmful effects for both sexes.
  • ||||||||||  ketamine / Generic mfg., fluoxetine / Generic mfg.
    Journal:  Rapid-Onset Antidepressant-Like Effect of Nelumbinis semen in Social Hierarchy Stress Model of Depression. (Pubmed Central) -  Jun 10, 2022   
    The antidepressant-like effect of NS was related to enhanced phosphorylation of mTOR in the prefrontal cortex and dephosphorylation of GluR1 S845 in the hippocampus. Since NS has shown antidepressant-like potential in a preclinical model, it may be considered as a candidate for the development of antidepressants in the future.
  • ||||||||||  verapamil / Generic mfg., probenecid / Generic mfg., fluoxetine / Generic mfg.
    Journal:  Establishment of ion channel and ABC transporter assays in 3D-cultured ReNcell VM on a 384-pillar plate for neurotoxicity potential. (Pubmed Central) -  Jun 8, 2022   
    Activities of major efflux transporters, MDR1, MRP1, and BCRP, were assessed using their respective blockers, verapamil, probenecid, and novobiocin. From this study, we demonstrated that 3D-cultured ReNcell VM on the 384-pillar plate could be a good alternative to rapidly identify environmental chemicals and therapeutic compounds for their role in modulating the activity of ion channels and efflux transporters, potentially leading to neurotoxicity.
  • ||||||||||  Wakix (pitolisant) / Ferrer International, Paragon Biosci
    LONGITUDINAL MANAGEMENT OF NARCOLEPSY WITH ATYPICAL PRESENTATION OF CATAPLEXY (UNILATERAL WITH SYMPTOMS ONLY ON THE RIGHT SIDE FOR THE PAST 13 YEARS) () -  Jun 6, 2022 - Abstract #SLEEP2022SLEEP_1284;    
    Eventually did not control EDS fully, methylphenidate (2014) was added...After cognitive impairment, patient stopped refilling it in 2014 and subsequently slept better without the venlafaxine...She had many episodes of unilateral cataplexy mainly with laughing or excitement so was started on Fluoxetine 20 mg and eventually up titrated to 40 mg. Management of Narcolepsy with atypical unilateral cataplexy is challenging and requires use of multiple medications with different sites of action.
  • ||||||||||  Wakix (pitolisant) / Ferrer International, Paragon Biosci
    LATE ONSET NARCOLEPSY WITH CATAPLEXY () -  Jun 6, 2022 - Abstract #SLEEP2022SLEEP_1244;    
    Cataplexy in geriatric populations is associated with falls and fractures. Medication for treatment of cataplexy comes with its own risks.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Fluoxetine and Nutrients Removal from Aqueous Solutions by Phycoremediation. (Pubmed Central) -  Jun 5, 2022   
    In both experiments, fluoxetine was completely removed within six days. The total phosphorus (TP) and total nitrogen (TN) removal efficiencies achieved for free and immobilized cells were, null and 65.0 ± 0.1%, and 86.2 ± 0.1% and 81.8 ± 3.1, respectively.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  Fluoxetine Treatment Decreases Cardiac Vagal Input and Alters the Serotonergic Modulation of the Parasympathetic Outflow in Diabetic Rats. (Pubmed Central) -  Jun 5, 2022   
    Enhancement of the electrical-induced bradycardia by 5-CT (10 μg/kg) was abolished by pretreatment with SB269970 (5-HT receptor antagonist). Thus, oral fluoxetine treatment originates a decrease in cardiac cholinergic activity and changes 5-HT modulation of bradycardic responses in diabetes: prejunctional 5-HT receptors augment cholinergic-evoked bradycardic responses, whereas prejunctional 5-HT receptors inhibit vagally-induced bradycardia.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Cav3.1-driven bursting firing in ventromedial hypothalamic neurons exerts dual control of anxiety-like behavior and energy expenditure. (Pubmed Central) -  Jun 4, 2022   
    Interestingly, we found that fluoxetine (anxiolytics) could block the increase of Cav3.1 expression to inhibit the burst firing, and then rescued the anxiety-like behaviors and energy expenditure changes. Collectively, our study first revealed an important role of Cav3.1-driven bursting firing of dmVMH neurons in the control of anxiety-like behavior and energy expenditure, and provided potential therapeutic targets for treating the chronic stress-induced emotional malfunction and metabolism disorders.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  In vitro electrochemical measurement of serotonin release in the human jejunum mucosa using a diamond microelectrode. (Pubmed Central) -  Jun 4, 2022   
    The nominal reciprocal slope, |slope|, of the ln current vs. distance plots increased from 270 ± 25 μm in Krebs buffer (N = 3) to 471 ± 65 μm during fluoxetine addition (N = 3), reflective of a reduced rate of reuptake in the presence of the SERT antagonist. The paper reports on the characterization of the diamond microelectrodes and the in vitro electrochemical measurement data.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  Antidepressant-like Activity of Patchouli Oil var. Tapak Tuan (Pogostemon cablin Benth) via Elevated Dopamine Level: A Study Using Rat Model. (Pubmed Central) -  May 30, 2022   
    The TST results revealed that POF-3 had the best antidepressant-like effect and was second only to the fluoxetine-based antidepressant, Kalxetin, where both groups had significant reductions of immobility time post-treatment (p < 0.0001)...Brain dopamine levels increased significantly in the group treated with POF-3 (p < 0.05 as compared with the control group), suggesting its primary anti-depressant mechanism. These findings suggest the potential of vacuum-distilled patchouli oil in reducing depression via dopamine elevation.
  • ||||||||||  Review, Journal:  Repurposing Autophagy Regulators in Brain Tumors. (Pubmed Central) -  May 29, 2022   
    Sertraline and desipramine, depending on the neoplastic context, were demonstrated to either induce or inhibit autophagy. Collectively, these medications were associated with favorable therapeutic outcomes in a variety of cancer cell models, including brain tumors.
  • ||||||||||  fluoxetine / Generic mfg.
    S01 - Mechanisms of Stress Response at the Single Cell Resolution () -  May 27, 2022 - Abstract #CINP2022CINP_17;    
    Michael Meaney, from the Singapore Institute for Clinical Sciences, will discuss recent findings from his lab investigating single-cell transcriptomic changes in the dorsal and ventral dentate gyrus of an non-human primate model of stress (Cynomolgus monkey) and the changes that occur with fluoxetine- and vehicle-treatment...Laser captured microdissection (LCM) was used to isolate prefrontal pyramidal neurons and RNA sequencing was conducted at a depth of ~40M reads per subject. Weighted Gene Co-Expression Network Analysis uncovered a network of celltype specific changes associated with a history of early-life stress.
  • ||||||||||  PK/PD data, Journal:  Pharmacokinetic Interactions Between Antiseizure and Psychiatric Medications. (Pubmed Central) -  May 26, 2022   
    As a general rule, these interactions can be managed by careful evaluation of clinical response and, when indicated, individualized dosage adjustments guided by measurement of drugs serum concentrations, especially if pharmacokinetic interactions may cause any change in seizure control, or signs of toxicity. Further studies are required to improve predictions of pharmacokinetic interactions between antiseizure medications and drugs for psychiatric diseases providing practical helps for clinicians in the clinical setting.
  • ||||||||||  chlorpromazine / Generic mfg., fluoxetine / Generic mfg.
    Journal:  Treatment aspects of youth depression with attenuated schizophrenic symptoms (Pubmed Central) -  May 26, 2022   
    The study represents a cost-effective, faster and environmentally friendly approach to the discovery of promising SARI antidepressants for further translational study. The results show that a combination treatment and the implementation of measures, increasing the degree of compliance are required to increase the efficacy of treatment in patients with youth depression and ASS.
  • ||||||||||  Marplan (isocarboxazid) / Validus
    Clinical, Review, Journal:  A review on post-traumatic stress disorder (PTSD): "Symptoms, Therapies and Recent Case Studies". (Pubmed Central) -  May 26, 2022   
    Various drugs which are used for the treatment of PTSD include selective serotonin reuptake inhibitors (SSRIs) (citalopram, fluvoxamine, fluoxetine, etc.); tricyclic antidepressants (amitriptyline and isocarboxazid); mood stabilizers (Divalproex and lamotrigine); atypical antipsychotics (aripiprazole and quetiapine), etc. In this review, we have covered the different risk factors, case studies related to various treatment options with different age group peoples in PTSD and their effects on them. We have also covered the symptoms and associated disorders which can play a key role in the development of PTSD.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Fluoxetine-induced neurotoxicity at environmentally relevant concentrations in adult zebrafish Danio rerio. (Pubmed Central) -  May 26, 2022   
    Moreover, as FLX-exposed fish showed a significant increase in the levels of oxidative damage biomarkers, we suggest this AChE disruption is associated with the oxidative stress response fish exhibited. Based on our findings, we believe the environmentally relevant concentration of FLX alters the redox status of the brain, impairing this way the behavior of fish and making them more vulnerable to predation.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Brief Developmental Exposure to Fluoxetine Causes Life-Long Alteration of the Brain Transcriptome in Zebrafish. (Pubmed Central) -  May 24, 2022   
    We report life-long disruptive effects of FLX on pathways associated with neuroendocrine signaling, stress response and the circadian rhythm, and all of which are implicated in the development of depressive disorders in humans. Our results raise concern for the persistent endocrine-disrupting potential of brief antidepressant exposure during embryonic development.
  • ||||||||||  tianeptine / Generic mfg.
    Journal:  Mu opioid receptors on hippocampal GABAergic interneurons are critical for the antidepressant effects of tianeptine. (Pubmed Central) -  May 22, 2022   
    Moreover, we show a dissociation between the antidepressant-like phenotype and other opioid-like phenotypes resulting from acute tianeptine administration such as analgesia, conditioned place preference, and hyperlocomotion. Taken together, these results suggest a novel entry point for understanding what circuit dysregulations may occur in depression, as well as possible targets for the development of new classes of antidepressant drugs.