- |||||||||| Journal: Using filled prescription sequences to rank antidepressants: A nationwide replication study. (Pubmed Central) - Jan 2, 2023
Escitalopram again was the most acceptable option, and the five following antidepressants were the same as in the replication sample of the proof-of-concept study, in order Fluoxetine, Paroxetine, Sertraline, Citalopram and Venlafaxine with aOR (95% CI) for continuation ranging from 0.79 (0.77-0.81) to 0.66 (0.64-0.67). The present study provides evidence that filled prescription sequences is a widely available, robust and reproductible tool to rank antidepressant treatments in real life settings.
- |||||||||| venlafaxine / Generic mfg., fluoxetine / Generic mfg.
Journal: BDNF exon IV promoter methylation and antidepressant action: a complex interplay. (Pubmed Central) - Dec 27, 2022
The study strengthens the previously reported association between antidepressant treatment and BDNF exon IV promoter methylation as well as hints toward the mechanism of action. We argue that potential CpG methylation biomarkers display a complex synergy with the molecular changes at the neighboring CpG positions, thus highlighting the importance of epiallele analyses.
- |||||||||| fluoxetine / Generic mfg.
Journal: Fluoxetine increased adult neurogenesis is mediated by 5-HT3 receptor. (Pubmed Central) - Dec 26, 2022
By contrast, co-treatment with ondansetron blocked the increase in proliferation and neurogenesis. This study demonstrates that the activation of 5-HT3 receptors is necessary for the increase of adult neurogenesis induced by fluoxetine.
- |||||||||| fluoxetine / Generic mfg.
Journal: Chemical component analysis of the traditional Chinese medicine Guipi Tang and its effects on major depressive disorder at molecular level. (Pubmed Central) - Dec 21, 2022
Male Sprague-Dawley rats were subjected to a chronic unpredictable mild stress (CUMS) procedure and treated with various doses of GPT, with fluoxetine treatment as a positive control...GPT had anti-depressive activity as indicated by the amelioration of depression-like behaviour and the inhibition of hippocampal neuronal apoptosis in CUMS rats. This inhibition was mediated partly by modulating the PI3K/Akt and/or BDNF/TrkB/CREB pathway, in which, glycosides, the main components of GPT, might be involved.
- |||||||||| venlafaxine / Generic mfg., fluoxetine / Generic mfg.
Journal: Fluoxetine or Venlafaxine for Early Post Stroke Depression. (Pubmed Central) - Dec 21, 2022
Venlafaxine has got a better outcome and adverse event profile compared to fluoxetine in this group of patients. However, larger multicenter studies will provide more helpful data in this area.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Baicalin improves the energy levels in the prefrontal cortex of mice exposed to chronic unpredictable mild stress. (Pubmed Central) - Dec 20, 2022
Following a 6-week exposure to CUMS, mice were treated with baicalin (10 mg/kg) or fluoxetine (10 mg/kg) for 4 weeks by oral gavage...Furthermore, baicalin increased the activity of the respiratory chain complexes I and V as well as the mitochondrial membrane potential. In conclusion, baicalin may exert its antidepressant effect partly by upregulating the expression of some genes coding for enzymes involved in the glycolysis and the tricarboxylic acid cycle, and improving the mitochondrial function to enhance the ATP level in the brain.
- |||||||||| fluvoxamine / Generic mfg., sertraline / Generic mfg., fluoxetine / Generic mfg.
Review, Journal: Selective serotonin reuptake inhibitors: New hope in the fight against COVID-19. (Pubmed Central) - Dec 20, 2022
SSRIs' low cost and availability make them potentially eligible for COVID-19 repurposing. This review summarizes current achievements and literature about the connection between SSRIs administration and COVID-19 prognosis.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Uptake and Metabolization of Serotonin by Granulosa Cells Form a Functional Barrier in the Mouse Ovary. (Pubmed Central) - Dec 12, 2022
Moreover, the accumulation of serotonin is more effective in the denuded oocytes and occurs at lower concentrations than in the oocytes within the follicles. This confirms that the activity of SERT and MAO in the granulosa cells surrounding the oocytes impedes the accumulation of serotonin in the oocytes and forms a functional barrier to serotonin.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Fluoxetine Enhances Synaptic Vesicle Trafficking and Energy Metabolism in the Hippocampus of Socially Isolated Rats. (Pubmed Central) - Dec 12, 2022
Flx treatment of CSIS rats predominantly increased expression of proteins involved in synaptic vesicle trafficking (exocytosis and endocytosis), and energy metabolism (glycolytic and mitochondrial respiration). Overall, these Flx-regulated changes in synaptic and mitochondrial proteins of CSIS rats might be critical targets for new therapeutic development for the treatment of MDD.
- |||||||||| hydroxyzine hydrochloride / Generic mfg., sertraline / Generic mfg., fluoxetine / Generic mfg.
An Assessment of Mental Health Needs in Pediatric Patients With Inflammatory Bowel Disease (IBD) During the COVID-19 Pandemic () - Dec 9, 2022 - Abstract #AIBD2022AIBD_277;
Most individuals were diagnosed with Crohn’s disease (81%), and a smaller percentage were classified as having ulcerative colitis (19%). Approximately 43% of the pediatric IBD population had at least 1 mental health concern over this time period, and the most common psychiatric diagnoses were depression alone (67%), anxiety alone (3%), or both depression and anxiety (30%).
- |||||||||| Review, Journal: Noradrenergic Modulation of Stress Resilience. (Pubmed Central) - Dec 9, 2022
It has attracted increasing attention over the past decades with the revolution of modern neuroscience technologies. In this review article, we first briefly go over resilience-related concepts and introduce rodent paradigms for segregation of susceptibility and resilience, then highlight recent literature that identifies the neuronal and molecular substrates of active resilience in the locus coeruleus, and discuss possible future directions for resilience investigations.
- |||||||||| fluoxetine / Generic mfg.
Phase classification, Trial completion date, Trial primary completion date: Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD (clinicaltrials.gov) - Dec 7, 2022
P1/2, N=100, Recruiting,
In this review article, we first briefly go over resilience-related concepts and introduce rodent paradigms for segregation of susceptibility and resilience, then highlight recent literature that identifies the neuronal and molecular substrates of active resilience in the locus coeruleus, and discuss possible future directions for resilience investigations. Phase classification: P1 --> P1/2 | Trial completion date: Jun 2024 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Jun 2024
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Baicalin ameliorates CUMS-induced depression-like behaviors through activating AMPK/PGC-1α pathway and enhancing NIX-mediated mitophagy in mice. (Pubmed Central) - Dec 5, 2022
After exposure to CUMS for 6 weeks, mice were given baicalin (20 mg/kg) or fluoxetine (20 mg/kg) by oral gavage for 4 weeks, and HT22 cells were injured by corticosterone (CORT) in vitro...Treatment with Phorbol 12-Myristate 13-acetate demonstrated that up-regulation of NIX ameliorated CORT-induced mitochondrial dysfunction in HT22 cells. In conclusion, the present study suggested that the antidepressant effect of baicalin may be related to the enhancement of NIX-mediated mitophagy through activating the AMPK/PGC-1α pathway by directly binding to AMPK.
- |||||||||| methylphenidate tablet / Generic mfg., fluoxetine / Generic mfg.
Preclinical, Journal: Combined methylphenidate and fluoxetine treatment in adolescent rats significantly impairs weight gain with minimal effects on skeletal development. (Pubmed Central) - Dec 4, 2022
We conclude that while the adverse microstructural and biomechanical effects of MP + FLX seen via direct comparison are predominantly attributable to reductions in body weight rather than direct effects on bone, MP and FLX, particularly in combination show detrimental effects on growth plate structure and chondrocyte morphology. These findings warrant further research into the effect of these drugs on weight gain, skeletal development and growth plate morphology, as well as consideration by physicians treating children and adolescents with ADHD.
- |||||||||| fluoxetine / Generic mfg.
Journal: Relationship of obstructive sleep apnea with major depressive disorder and development of metabolic syndrome. (Pubmed Central) - Dec 3, 2022
Among all clinical variables, antidepressant exposure in terms of total fluoxetine units, duration of treatment, and risk of developing OSA was found to be significantly more in patients with MS...The increased risk of MS is contributed by an increased risk of developing OSA among patients with MDD. Cross-sectional design and limited generalizability are the major limitations of this study.
- |||||||||| fluoxetine / Generic mfg.
Enrollment open, Trial initiation date: Fluoxetine Treatment of Depression in Down Syndrome (clinicaltrials.gov) - Dec 2, 2022
P4, N=25, Recruiting,
Cross-sectional design and limited generalizability are the major limitations of this study. Not yet recruiting --> Recruiting | Initiation date: Aug 2022 --> Dec 2022
- |||||||||| fluoxetine / Generic mfg., reboxetine / Generic mfg., duloxetine / Generic mfg.
Preclinical, Journal: Monoaminergic mediation of hyperalgesic and analgesic descending control of nociception in mice. (Pubmed Central) - Dec 1, 2022
Thus, hyperalgesic DCN seems to be the neurochemical opposite to analgesic DCN. These data further validate and help elucidate a preclinical paradigm that mimics dysfunctional CPM and thus may form the basis of translational experiments that aim to reveal preventative pharmacological strategies for individuals predisposed to persistent pain.
- |||||||||| Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie
PK/PD data, Journal: Practical Psychopharmacology: Using a Knowledge of Pharmacokinetics to More Rapidly Stabilize Patients at Lower Drug Doses. (Pubmed Central) - Dec 1, 2022
From a knowledge of pharmacokinetics, it can be shown that stopping a drug for just 1 half-life and then resuming it at half the dose results in the immediate achievement of steady state; that is, there is no need to wait for 4 additional half-lives as with the usual strategy of dose reduction without dosing interruption. A limitation of this pharmacokinetically driven dosing strategy, however, is that it would work well in the average patient but not in those with outlying pharmacokinetic parameters.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: A repeated measures cognitive affective bias test in rats: comparison with forced swim test. (Pubmed Central) - Dec 1, 2022
Instability in the CRS-no treatment group precluded interpretation of the impact of fluoxetine on CAB post-CRS. Our results suggest that behaviour in the FST does not reflect or alter affective state and support the use of CAB tests as part of the behavioural testing repertoire for preclinical animal models of affective disorders.
- |||||||||| gabapentin / Generic mfg., fluoxetine / Generic mfg.
Journal: Unlicensed Transdermal Medications in Feline Patients: Three Case Reports. (Pubmed Central) - Nov 30, 2022
In cases 2 and 3, two cats were prescribed fluoxetine 40-mg/g topical Lipoderm, to be applied once a day, in order to manage the inappropriate behavior (urination and defecation)...Permeation-enhancing (transdermal) medications are a promising dosage form in veterinary pharmacotherapy. The benefits and versatility of these alternative, customized treatment options are worth considering in current therapeutics.
- |||||||||| progesterone / Generic mfg., fluoxetine / Generic mfg.
Preclinical, Journal: Resident intruder paradigm-induced PMDD rat model of premenstrual irritability: behavioral phenotypes, drug intervention, and biomarkers. (Pubmed Central) - Nov 29, 2022
Premenstrual irritability rat model of PMDD demonstrates a behavioral phenotype consistent with the clinical symptoms of PMDD and micro index. The increased levels of 5-HT, NE, and expression of GABRA4, as well as the decrease of GABA, P, and ALLO levels, may be critical biomarkers of the abnormal changes that occur during the pathogenesis of PMDD.
- |||||||||| methylphenidate tablet / Generic mfg., sertraline / Generic mfg., fluoxetine / Generic mfg.
Journal: Rates of psychotropic medicine prescribing in paediatric populations in Australian general practice from 2000-2016. (Pubmed Central) - Nov 27, 2022
Sertraline was the most common psychotropic medicine prescribed, followed by fluoxetine and methylphenidate. Future studies involving data from other prescribers, e.g. paediatricians and psychiatrists, and studies linking prescribed medicines to their indications may widen our understanding of psychotropic medicine prescribing in Australian paediatric patients.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Acute and long-lasting effects of adolescent fluoxetine exposure on feeding behavior in Sprague-Dawley rats. (Pubmed Central) - Nov 26, 2022
Likewise, no differences in meal pattern parameters to a palatable diet (45% fat, 17% sucrose) presented from PND74 to PND88, even after CVS, were observed. Our findings indicate that juvenile FLX reduces body weight gain acutely via reduced meal size intake; however, no long-term changes in ad libitum feeding behavior or binge access to a palatable stimulus are evident.
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