| escitalopram / Generic mfg. |
| Recruiting | 4 | 2688 | | | Brain Resource, Brain Resource | Major Depressive Disorder (MDD) | | | | |
2005-001991-11: Effekte von Escitalopram auf Aufmerksamkeit und kognitive Funktionen bei gesunden Probanden |
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| Not yet recruiting | 4 | 100 | Europe | escitalopram, Tablet, Cipralex 10mg | University of Aachen | 50 gesunde Probanden erhalten randomisiert, doppelt blind einmalig 10 mg Escitalopram oder Placebo im "cross over"-Design.50 weitere gesunde Probanden erhalten randomisiert, doppelt blind sieben Tage lang täglich 10 mg Escitalopram oder Placebo im "cross over"-Design.Nach der Medikamenteneinnahme erfolgt eine testpsychologische Untersuchung und eine fMRI-Untersuchung. | | | | |
2006-002880-19: Comparación de dos estrategias de intervención para el tratamiento de los trastornos depresivos en pacientes oncológicos |
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| Ongoing | 4 | 200 | Europe | cipralex, Capsule*, Cipralex | Servicio de psiquiatria. Hospital Universitario La Paz | Major depressive Disorder, one episode or several episodes.ICD: 296.2x, 296.3x | | | | |
2009-016953-16: Depressions-Spektrums-Störung und differenzielle Effekte neuerer Antidepressiva auf die Verkehrssicherheit |
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| Ongoing | 4 | 120 | Europe | Cipralex, Solvex, Remergil, Elontril, Valdoxan, Tablet, Cipralex, Solvex, Remergil, Elontril, Valdoxan | Inn-Salzach-Klinikum gGmbH | Spectrum of depressive diseases, ICD-10: F32.x, F33.x | | | | |
ChiCTR-TNRC-10001112: The study on clinical and biological characters of bipolar depression and the treatment scheme optimizing |
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| Completed | 4 | 640 | | Lithium, Sodium valproate, Lamotrigine, MECT, Sertraline, Citalopram, Escitalopram, venlafaxine, Quetiapine, Olanzapine, Risperidone, sulpiride | Guangzhou Scientific and Technological Bureau, Guangzhou Board of Health; Guangzhou first people's hospital, The Tackling Key Problems of Guangzhou Scientific and Technological Project | bipolar depressive disorder | | | | |
2010-023007-10: A neuroscience perspective on anxiety proneness - Sex differences, monoaminergic pathways and treatment response |
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| Ongoing | 4 | 48 | Europe | Cipralex, Capsule, Cipralex | Uppsala university | Men and women diagnosed with DSM-IV social phobia (social anxiety disorder) | | | | |
| Ongoing | 4 | 165 | Europe | escitalopram or nortriptyline, Capsule, Escitalopram 5mg (RVG 30494) Nortriptyline 10mg (RVG 03285) and 25mg (RVG 03286) | University Medical Center Groningen, ZonMW, Lundbeck BV | Major Depressive Disorder, Depression, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
| Ongoing | 4 | 90 | Europe | Tablet, Escitalopram Actavis | University of Helsinki - Erkki Isometsä | Major Depressive disorder | | | | |
2013-003370-27: Functional changes in the brain after application of antidepressants and their clinical impact, their relation to the stress hormone system and to the enterobacteria Bildgebung des Kopfes nach Behandlung mit Antidepressiva sowie der Zusammenhang zum klinischen Verlauf, zum Stresshormonsystem und zu den Darmbakterien |
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| Ongoing | 4 | 80 | Europe | Coated tablet, Mirtazapin-CT, Cipralex, Valdoxan | Rainer Rupprecht, Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Regensburg am Bezirksklinikum, Universität(sklinikum) Regensburg, Bundesministerium für Bildung und Forschung | Major Depressive Disorder is a chronic stress related disorder characterized by depressed mood and by vegetative and cognitive symptoms. Moreover, genetic, neuroendocrine and neurochemical biomarkers may predict impaired processing and regulation of emotions related to major depression as well as antidepressant treatment response in general. There is evidence, that the gut microbiome may influence stress, anxiety and depression-related behavior via effects on the host´s neuroendocrine system. Depression ist eine stressassoziierte Störung, charakterisiert durch gedrückte Stimmung, vegetative und kognitive Symptome. Außerdem könnten genetische, neuroendokrine, -chemische Biomarker Vorhersagen treffen über gestörte Verarbeitung/Regulation von Emotionen in Zusammenhang mit Depression sowie über das Ansprechen auf antidepressive Therapie. Es gibt Anhaltspunkte, dass das Dickdarm-Mikrobiom womöglich Einfluss hat auf Stress und Angst durch Effekte auf das neuroendokrine System des Wirtes., Disease characterized by depressed mood and by vegetative Symptoms (e.g. sleep disturbance, dimished appetite) and cognitive symptoms (e.g. reduced attention) Krankheitsbild charakterisiert durch gedrückte Stimmung, vegetative (z.B. Schlafstörungen, Appetitlosigkeit) und kognitive Symptome (z.B. Aufmerksamkeitsstörungen)., Diseases [C] - Nervous System Diseases [C10] | | | | |
2005-002655-41: IMPACTO DE UN PROGRAMA DE TRATAMIENTO PSIQUIÁTRICO COMBINADO SOBRE LA SINTOMATOLOGÍA ANSIOSA Y DEPRESIVA DE UN GRUPO DE PACIENTES ONCOLÓGICOS Y SUS CUIDADORES PRNCIPALES |
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| Ongoing | 4 | 100 | Europe | Cipralex, Cipralex, Cipralex | Hospital Universitario La Paz | Trastorno adaptativo con sintomatología ansiosa, depresiva o mixta | | | | |
| Ongoing | 4 | 12 | Europe | Azilect, Cipralex, Azilect, Cipralex, Azilect, Cipralex | Oy Lundbeck | terveet vapaaehtoiset | | | | |
2006-002411-27: Evaluation of the effect of escitalopram on cognitive and fine motor function in depressed elderly patients. |
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| Ongoing | 4 | 40 | Europe | Sipralexa, Sipralexa | Universitair Psychiatrisch Centrum KU Leuven | Elderly depressed patients, MDD, DSM IV-TR, single episode or recurrent | | | | |
2006-005394-22: ESCITALOPRAM MONOTHERAPY COMPARED TO COMBINATION OF ESCITALOPRAM AND RISPERIDONE IN THE TREATMENT OF ACUTE PSYCHOTIC DEPRESSION |
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| Ongoing | 4 | 50 | Europe | Cipralex, Risperdal, Cipralex, Risperdal, Cipralex, Risperdal | Turku university hospital | ICD-10 diagnosis F32.3; psykoottinen masennus, F 33.3; toistuva psykoottinen masennus. | | | | |
2005-006195-35: Estudio clínico con Escitalopram para el tratamiento de la depresión, la ansiedad y el craving, asociados al alcoholismo. |
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| Ongoing | 4 | 60 | Europe | Escitalopram, Escitalopram 2006, CIPRALEX 10 mg CIPRALEX 20 mg, CIPRALEX 10 mg CIPRALEX 20 mg | Institut de Recerca / Hospital de Sant Pau | Tratamiento de la depresión, la ansiedad y el craving, asociados al alcoholismo. | | | | |
2007-000516-93: “Eficacia analgésica del escitalopram vs. amitriptilina en la neuropatía periférica dolorosa asociada a la infección por el VIH”. |
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| Ongoing | 4 | 40 | Europe | Tryptizol®, Escitalopram. Cipralex, Tryptizol®, Escitalopram. Cipralex | CESAR MARGARIT FERRI | Neuropatía dolorosa | | | | |
2008-000370-20: Evaluation of pharmacokinetic and pharmacodynamic interactions between escitalopram and drugs used for the treatment of bipolar disorders. |
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| Ongoing | 4 | 24 | Europe | Lamotrigine, Gabapentin, Carbamazepine, Oxcarbazepine, Levetiracetam, Valproic acid, CIPRALEX, LITIO CARBONATO, CIPRALEX, LITIO CARBONATO | AZIENDA OSPEDALIERA PISANA | bipolar disorders | | | | |
2009-016443-19: Etude prospective du rôle prédictif du polymorphisme fonctionnel 5-HTTLPR sur la réponse au traitement par l’escitalopram des patients souffrant d’un trouble obsessionnel compulsif |
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| Ongoing | 4 | 150 | Europe | SEROPLEX, DEROXAT, SEROPLEX 10mg et 20mg, DEROXAT 20mg, SEROPLEX 10mg et 20mg, DEROXAT 20mg | CHU de Poitiers | obsessive compulsive disorder | | | | |
| Ongoing | 4 | 50 | Europe | Paroxetine, Amitriptyline, Clomipramine, Imipramine, Nortriptyline, escitalopram, Citalopram, Fluoxetine, Fluvoxamine, Sertraline, Duloxetine, venlafaxine, EU/1/04/296/002, Seroxat, Tryptizol, Anafranil, Imipramine, Nortrilen, Lexapro, Cipramil, prozac, Fevarin, Zoloft, Cymbalta, Efexor, Seroxat, Tryptizol, Anafranil, Imipramine, Nortrilen, Lexapro, Cipramil, prozac, Fevarin, Zoloft, Cymbalta, Efexor | Isala Klinieken | Pregnant women with psychiatric morbidity and an strong indication for using antidepressants | | | | |
2010-019423-61: GENRAS(GENetics of Response to Agomelatine vs. EScitalopram) |
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| Ongoing | 4 | 400 | Europe | CIPRALEX - Filmtabletten 10 mg, VALDOXAN 25 mg - Filmtabletten, CIPRALEX - Filmtabletten 10 mg, VALDOXAN 25 mg - Filmtabletten, CIPRALEX - Filmtabletten 10 mg, VALDOXAN 25 mg - Filmtabletten | Medizinische Universität Wien,Univ.Klinik f.Psychiatrie und Psychotherapie | depressive disorder | | | | |
2010-023446-70: Neural, Genetic, and Peripheral Correlates of SSRI Pharmaco-Response |
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| Ongoing | 4 | 20 | Europe | Cipralex, Cipralex | Med. Univ. Wien, Univ. Klinik für Psychiatrie und Psychotherapie | Major Depressive Disorder (MDD) remains to be under-recognized and under-treated, though it is amongst the leading causes of disease burden worldwide. Despite the proven efficacy of modern antidepressants, response rates are still unsatisfying, since a substantial number of patients shows only limited response or fails to respond at all and high risk of relapse remains even when remission is achieved. | | | | |
2011-002727-18: The effects of switching antidepressants on endoxifen exposure |
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| Ongoing | 4 | 13 | Europe | Tamoxifen, Paroxetine, Escitalopram, Venlafaxine, RVG 09592, RVG 14668, RVG 30494, RVG 31854, Nolvadex, Seroxat, Lexapro, Efexor, Nolvadex, Seroxat, Lexapro, Efexor | | Breast cancer | | | | |
2011-005001-78: Factors influencing Antidepressant (SSRI) Drug Response: Impact of Stress-related Genes Einflussfaktoren des Ansprechens auf eine Therapie mit Antidepressiva (selektive Serotoninwiederaufnahmehemmer): Einflussnahme stressbezogener Gene |
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| Ongoing | 4 | 30 | Europe | CIPRALEX, CIPRALEX | Medizinische Universität Wien, Universitätsklinik für Psychiatrie u. Psychotherapie, Abteil. für biologische Psychiatrie, FWF | Major Depressive Disorder Depressive Störung | | | | |
2014-001550-42: Combined molecular and functional brain imaging (PET/MR) to predict treatment response to neuropharmacological treatment Kombinierte molekulare und funktionelle Bildgebung des Gehirns (PET/MR) zur Vorhersage des Therapieerfolgs von Neuropharmaka |
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| Ongoing | 4 | 80 | Europe | Seropram, Cymbalta, Efectin, Cipralex, Seropram, Cymbalta, Efectin, Cipralex, Seropram, Cymbalta, Efectin | Medizinische Universität Wien, Medizinische Universität Wien | Major depressive disorder Depression | | | | |
2014-005366-30: RESOLVING THE NEUROBIOLOGICAL MECHANISMS OF ANXIETY DISORDERS – BRAIN IMAGING SUB-STUDY |
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| Ongoing | 4 | 70 | Europe | Escitalopram, Tablet | University of Helsinki, Jane and Aatos Erkko Foundation | Social Anxiety disorder, Social Anxiety disorder, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2016-001217-25: Emotion, Serotonin and Premenstrual Dysphoric Disorder (EmSeP) |
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| Not yet recruiting | 4 | 50 | Europe | Cipralex, N06AB10, Tablet, Cipralex - Escitalopram (Lundbeck) | Uppsala University, Swedish Research Council | Premenstrual Dysphoric Disorder, Mood disorder with onset of mood and physical symptoms in the luteal phase of the menstrual cycle, a decline in symptom severity after onset of menstruation., Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2016-003325-41: PREemptive Pharmacogenomic testing for Preventing Adverse drug REactions (PREPARE) |
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| Ongoing | 4 | 450 | Europe | Syrup, Tablet, Capsule, hard, Powder for injection, Capsule, Solution for injection, Concentrate for solution for infusion, Powder for solution for infusion, Codeine, Acenocoumarol, Amitriptyline, Aripiprazole, Atomoxetine, Atorvastatine, Azathioprine, Capecitabine, Carbamazepine, Citalopram, Clomipramine, Clopidogrel, Clozapine, Efavirenz, Escitalopram, Flecainide, Flucloxacillin, Fluorouracil, Haloperidol, Irinotecan, Mercaptopurine, Metoprolol, Oxycodone, Paroxetine, Phenprocoumon, Phenytoin, ORAP 1 mg Tabletten, Propafenone, Sertraline, Simvastatin, Tacrolimus, Tamoxifen, Tegafur, Tioguanine, Tramadol, Venlafaxine, Voriconazole, Zuclopenthixol, Ethinylestradiol, ORAP 4 mg Tabletten | Leiden University Medical Center, Leiden University Medical Center | Adverse drug reactions, Side-effects, Not possible to specify | | | | |
| Completed | 4 | 40 | Europe | Escitalopram 20 mg, Placebo | Odense University Hospital | Polycystic Ovary Syndrome | 10/17 | 10/17 | | |
2012-002817-20: Etude sur l’effet de la stimulation magnétique et des antidépresseurs sur l’expression des gènes C-FOS et DUSP1 des patients traités pour un état dépressif |
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| Not yet recruiting | 4 | 60 | Europe | Capsule, Tablet, ZOLOFT, SEROPLEX | CHU Dijon, DIRC Est | troubles dépressifs majeurs, dépression, Psychiatry and Psychology [F] - Psychological processes [F02] | | | | |
2017-000990-35: Effects of the antidepressive therapy with Agomelatin and Escitalopram in people with depression and epilepsy Effetti della terapia antidepressiva utilizzando Agomelatina ed Escitalopram in persone con depressione ed epilessia |
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| Ongoing | 4 | 208 | Europe | Agomelatina, Escitalopram, n.a., Film-coated tablet, VALDOXAN - 25 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (ALU/PVC) 7 COMPRESSE, ESCITALOPRAM ACCORD - " 10 MG COMPRESSE RIVESTITE CON FILM " 98 COMPRESSE IN BLISTER AL/AL | DIP. MEDICINA DEI SISTEMI UNIVERSITÃ DEGLI STUDI DI ROMA TOR VERGATA | Depression in patients affected by epilepsy Depressione in pazienti affetti da epilessia, Depression in person with epilepsy Depressione in persone con epilessia, Diseases [C] - Nervous System Diseases [C10] | | | | |
ChiCTR1800019366: Escitalopram in 8-week open-label treatment of post-stroke depression: the efficacy, safety and the effect on regional brain function |
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| Recruiting | 4 | 48 | | escitalopram | Beijing Tiantan Hospital, Capital Medical University; Beijing Stroke Association(BSA), Lundbeck, Denmark | post-stroke depression | | | | |
2019-002232-82: Downstream targets of SSRI effect in treatment of Major Depressive Disorder |
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| Ongoing | 4 | 20 | Europe | [11C]AZ10419369, Escitalopram, Solution for injection, Tablet | Karolinska Institutet, Soderstrom-Konig foundation, Thurings foundation | Major depressive disorder (MDD), Depression, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
ChiCTR2100051241: Effectiveness of Escitalopram-Tandospirone Citrate in Patients with Vascular Depression Accompanied by Mild Cognitive Decline: A Pilot Randomized Controlled Trial at a Single-Center in China |
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| Completed | 4 | 116 | | Escitalopram 10 mg once daily, and 5 mg of Tandospirone Citrate three times per day in Week 1; from Week 2, Tandospirone Citrate was increased to 10 mg per time and administered three times per day. ;Escitalopram 10 mg once daily. | Fujian Medical University Union Hospital; Fujian Medical University Union Hospital, Sumitomo Pharmaceuticals (Suzhou) Co., Ltd | Vascular depression | | | | |
ChiCTR1900024858: Comparison of the efficacy and safety of vortioxetine and escitalopram in depression and the corresponding changes in Brain-Gut axis |
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| Recruiting | 4 | 130 | | vortioxetine ;escitalopram | The First Affiliated Hospital, College of Medicine, Zhejiang University; The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang key research and development project funding: 1 million yuan (2015C03040) | Major Depressive Disorder | | | | |
2019-004018-33: Prefrontal brain networks for cognitive flexibility in cognitive task for humans. |
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| Ongoing | 4 | 40 | Europe | Seropram, Film-coated tablet, Concentrate for solution for infusion, Cipralex, Seropram | Department of Psychiatry and Psychotherapy, Medical University of Vienna, Medical University of Vienna | Major depressive disorder, Depression, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2020-000160-28: Investigation of changes in the structure and function of the brain in musicians using magentic resonance tomography |
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| Ongoing | 4 | 80 | Europe | Tablet, Cipralex | Medical University of Vienna, Medical University of Vienna | Focal dystonia in musicians Musikerdystonie, Musician´s cramp Musikerkrampf, Psychiatry and Psychology [F] - Behaviours [F01] | | | | |
ChiCTR1800017338: Intervening in compliance and efficacy of anxiety/depression in the treatment of chronic obstructive pulmonary disease (COPD) |
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| Recruiting | 4 | 220 | | EscitalopramOxalateTablets | Xinqiao Hospital; Xinqiao Hospital, State key project | COPD | | | | |
ChiCTR1900028541: Effect of aripiprazole combined with antidepressants on cognitive function of patients with depressive disorder and clinical efficacy evaluation |
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| Not yet recruiting | 4 | 60 | | Treat with the escitalopram ;Treat with aripiprazole and escitalopram | Shandong Mental Health Center; Shandong Mental Health Center, Self financing | Major Depressive Disorder | | | | |
ChiCTR2000041328: Analysis of the efficacy and safety of SSRIs combined with Shugan Jieyu in the treatment of depression: a multicenter randomized, controlled, double-blind, prospective study |
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| Recruiting | 4 | 180 | | Shugan Jieyu and Escitalopram placebo Oral ;Shugan Jieyu placebo and Escitalopram Oral ; Shugan Jieyu and Escitalopram Oral | Shandong Mental Health Center; Shandong Mental Health Center, Shandong Province Integrated Traditional Chinese and Western Medicine Depression Prevention Project | Depression | | | | |
ChiCTR2100042981: Efficacy, safety and compliance of integrated traditional Chinese and Western medicine in patients with depression in the community: a multi-center, randomized controlled study |
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| Not yet recruiting | 4 | 300 | | Use escitalopram or duloxetine ;Use Shu-Gan Jie-Yu capsule ;Use Shu-Gan Jie-Yu capsule combined with escitalopram or duloxetine | Shandong Mental Health Center; Shandong Mental Health Center, Shandong Province Integrated Traditional Chinese and Western Medicine Depression Prevention Project | Major depressive disorder | | | | |
ChiCTR2300069946: The application of esketamine with subclinical anesthesia dose in intravenous adjuvant in epidural anesthesia for cesarean section |
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| Completed | 4 | 60 | | Cut the peritoneal immediate intravenous escitalopram ketamine 0.15 mg/kg (diluted saline to 5 ml) ;Cut the peritoneal immediate intravenous equal volume normal saline | Wenzhou People's Hospital; Wenzhou People's Hospital, self-funded | postpartum depression | | | | |
| Completed | 4 | 119 | US | Escitalopram + Celecoxib, Escitalopram + Placebo | University of Pennsylvania | Depression, Inflammation | 07/22 | 07/22 | | |
NCT05145270: A Comparative Study on Efficacy and Safety of add-on Sulforaphane or rTMS to Escitalopram for Major Depressive Disorder With Poor Response to Initial Treatment |
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| Recruiting | 4 | 180 | RoW | Escitalopram+Sulforaphane, Escitalopram+rTMS, Escitalopram | Shanghai Mental Health Center | Major Depressive Disorder | 11/22 | 11/22 | | |
ChiCTR2000032518: Efficacy and safety of agomelatine combined with SSRIs in depressive disorder: a randomized controlled trial |
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| Recruiting | 4 | 120 | | Treat with the combination of SSRIs (sertraline or escitalopram) in the first 6 weeks.Those whose efficacy is well in the first stage of treatment will continue to receive the original drug and the same dose.Others who did not respond to the treatment will be given a combination of sertraline or esc ;Treat with Agomelatine in the first 6 weeks.Those whose efficacy is well in the first stage of treatment will continue to receive the original drug and the same dose.Others who did not respond to the treatment will be given a combination of sertraline or escitalopram with agomelatine. | Shandong Mental Health Center; Shandong Mental Health Center, Teachers' Scientific Research Support Fund of Jining Medical College | Major Depressive Disorder | | | | |
2019-004880-33: Reward-specific changes of the chemical messenger dopamine in the brain of healthy and depressed people Veränderungen in der Menge des Botenstoffs Dopamin durch Belohnungsreize bei Aufgaben, gemessen im Gehirn gesunder und depressiver Personen |
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| Not yet recruiting | 4 | 100 | Europe | Tablet, Cipralex® 10 mg - Filmtabletten, Wellbutrin XR 150 mg - Retardtabletten | Medical University of Vienna, University Department of Psychiatry and Psychotherapy, Medical University of Vienna, University Department of Psychiatry and Psychotherapy | Major Depression Depressive Episode, Depression, a disease characterized by lowering of mood, reduction of energy, and decrease in activity. Capacity for enjoyment, interest, and concentration is reduced. Depression. Betroffene Patienten unter einer gedrückten Stimmung und einer Verminderung von Antrieb und Aktivität. Die Fähigkeit zu Freude, das Interesse und die Konzentration sind vermindert., Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
| Completed | 4 | 362 | Europe | Vortioxetine, Brintellix, Trintellix, Sertraline, Zoloft, citalopram, Elopram, Escitalopram, Entact, Paroxetine, Daparox, Fluoxetine, Prozac, Fluvoxamine | Azienda Ospedaliera Universitaria Integrata Verona, University of Catania | Major Depressive Disorder | 02/23 | 02/23 | | |
2022-003279-41: Investigating the neuroreceptor NMDA in the brain of healthy and depressed people Untersuchung des Neurorezeptors NMDA im Gehirn gesunder und depressiver Personen |
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| Not yet recruiting | 4 | 60 | Europe | Tablet, Cipralex® 10 mg - Filmtabletten | Medical University of Vienna, University Department of Psychiatry and Psychotherapy, Medical University of Vienna, University Department of Psychiatry and Psychotherapy | Major Depression Depressive Episode, Depression, a disease characterized by lowering of mood, reduction ofenergy, and decrease in activity. Capacity for enjoyment, interest, andconcentration is reduced. Depression. Betroffene Patienten unter einer gedrückten Stimmung undeiner Verminderung von Antrieb und Aktivität. Die Fähigkeit zu Freude,das Interesse und die Konzentration sind vermindert., Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
NCT04352101: Bupropion Versus Escitalopram on Reward Circuitry and Motivational Deficits |
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| Completed | 4 | 18 | US | Bupropion XL, Wellbutrin, Escitalopram, Lexapro | Emory University, National Institute of Mental Health (NIMH) | Major Depression | 07/22 | 07/22 | | |
ChiCTR2100048741: Sodium valproate and escitalopram in the treatment of severe depression patients with mixed characteristics of acute phase: an open randomized controlled trial |
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| Not yet recruiting | 4 | 100 | | Antidepressant ;Mood stabilizer | Beijing Anding Hospital, Capital Medical University; Beijing Anding Hospital, Capital Medical University, Research and cultivation program of Beijing Municipal Hospital | Depression | | | | |
NEMO, NCT03128021: Neural Mechanisms of Monoaminergic Engagement in Late-life Depression Treatment Response |
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| Completed | 4 | 57 | US | Escitalopram Pill, Lexapro, Placebo, Levomilnacipran Pill, Fetzima | Howard Aizenstein, Weill Cornell Institute of Geriatric Psychiatry, National Institute of Mental Health (NIMH) | Major Depressive Disorder | 06/23 | 08/23 | | |
ChiCTR2300071665: A multicenter, randomized controlled trial of Xiangshao Granules enhancing SSRIs in the treatment of depression in women |
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| Recruiting | 4 | 180 | | Xiangshao Granules + any SSRI; On the basis of control group, Xiangshao granules, Xiangshao granules, 1 bag/time, 4 g/bag, 3 times/d, 30 min after meals, continuous treatment for 8 weeks. ;Any of the SSris (e.g., Escitalopram, citalopram, fluoxetine, paroxetine, Sertraline, fluvoxamine); Escitalopram, once daily, 10-20 mg daily; Or citalopram, once daily, 20-60 mg daily; Fluoxetine, once daily, 20 mg daily; Or paroxetine, once daily, 20-50 mg daily; Or Sertraline, once daily, 50-200 mg daily; Or fluvoxamine, once daily, 50-300 mg daily; Treatment course: Continuous treatment for 8 weeks. | The Second Xiangya Hospital of Central South University; The Second Xiangya Hospital of Central South University, Yangzijiang Pharmaceutical Group Sichuan Hairong Pharmaceutical Co., LTD. | Female depression | | | | |
| Recruiting | 4 | 60 | US | Duloxetine, Cymbalta, Irenka, Escitalopram, Lexapro | University of Cincinnati | Anxiety, Depressive Symptoms | 07/24 | 08/24 | | |
| Recruiting | 4 | 84 | US | Escitalopram, Lexapro, Duloxetine, Cymbalta | University of Cincinnati | Anxious Depression, Depression | 07/24 | 12/24 | | |
NCT04336228: The Role of Serotonin in Compulsive Behavior in Humans: Underlying Brain Mechanisms |
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| Recruiting | 4 | 48 | Europe | Escitalopram, Escitalopram STADA, Placebo oral tablet, calcium tables | Rigshospitalet, Denmark, University of Cambridge, Lundbeck Foundation | Obsessive-Compulsive Disorder/High Compulsive Individuals, Healthy Individuals | 08/24 | 08/24 | | |
NCT04239339: Serotonergic Modulation of Cognition, Emotion and Brain Activation in Healthy Volunteers |
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| Completed | 4 | 66 | Europe | Escitalopram 20 mg, Placebo | Rigshospitalet, Denmark, University of Cambridge, Lundbeck Foundation | Healthy | 10/22 | 10/22 | | |
| Not yet recruiting | 4 | 2726 | Canada, US | Cariprazine, Vraylar, Aripiprazole/Escitalopram combination, Abilify/ Lexapro, Quetiapine, Seroquel, Lurasidone, Latuda | Massachusetts General Hospital, Patient-Centered Outcomes Research Institute | Bipolar I Disorder, Depression | 02/30 | 02/30 | | |
ChiCTR2300073617: Escitalopram and Gui-Fu-Di-Huang pills combination in the treatment of hypodynamic symptoms in depressed patients with Yang deficiency constitution: a randomized controlled study |
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| Not yet recruiting | 4 | 94 | | Escitalopram and Gui-Fu-Di-Huang pills combination in the treatment ;Escitalopram | Beijing Anding Hospital affiliated to Capital Medical University; Beijing Anding Hospital affiliated to Capital Medical University, Beijing university of Chinese medicine dicipline funding, Beijing Anding Hospital dicipline funding | depression | | | | |
PrEcISE, NCT04623099: Pharmacogenetically-guided Escitalopram Treatment for Pediatric Anxiety: Aiming to Improve Safety and Efficacy |
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| Recruiting | 4 | 132 | US | Escitalopram, Lexapro | University of Cincinnati, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Anxiety | 06/25 | 12/25 | | |
ChiCTR2300075407: The mechanism of Escitalopram combined with tandospirone on sleep disorder and cognitive impairment in patients with vascular depression |
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| Not yet recruiting | 4 | 180 | | Escitalopram 10mg once daily, plus tandospirone citrate 5mg 3 times a day for the first week, increased to 10mg 3 times a day from the second week. ;In the monotherapy group, Escitalopram 10mg, once a day, plus a placebo preparation with the same size, shape and smell as tandospirone citrate 5mg, 3 times a day in the first week, increased to 10mg, 3 times a day from the second week. ;No drugs that may affect 5-HT metabolism, and only preventive treatment of common diseases in the elderly. | Fujian Medical University Union Hospital; Fujian Medical University Union Hospital, Fujian Provincial Department of Science and Technology Department of Social Development | Vascular depression | | | | |
| Recruiting | 4 | 90 | US | Escitalopram Oxalate, Lexapro, ESC, Placebo, PBO | NYU Langone Health, National Institute on Aging (NIA) | Alzheimer Disease, Major Depressive Disorder | 04/26 | 06/26 | | |
NCT05737511: Efficacy of Hydroxyzine for Patients With Panic Disorder |
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| Not yet recruiting | 4 | 80 | NA | Hydroxyzine, Atarax, Vistaril, Escitalopram Oxalate, citalopram, fluoxetine, fluvoxamine, paroxetine, paroxetine CR, sertraline, venlafaxine XR,, Alprazolam, clomipramine, clonazepam, diazepam, imipramine, lorazepam, mirtazapine, reboxetine, Bupropion SR, divalproex, duloxetine, gabapentin, levetiracetam, milnacipran, moclobemide, olanzapine, phenelzine, quetiapine, risperidone, tranylcypromine | Sultan Qaboos University | Panic Disorder | 12/26 | 12/26 | | |
| Recruiting | 4 | 400 | Canada | Escitalopram, Cipralex, Brexpiprazole, Rexulti | Nova Scotia Health Authority, Unity Health Toronto, Centre for Addiction and Mental Health, McMaster University, Queen's University, University of Ottawa, University of British Columbia, University of Calgary, McGill University, Dalhousie University, University of Michigan, Simon Fraser University | Major Depressive Disorder | 12/28 | 04/29 | | |
ACTRN12623000227695: The SAD-AF trial: a study of escitalopram (a selective serotonin reuptake inhibitor, SSRI) antidepressant vs placebo in patients with atrial fibrillation (AF) and depression, on AF-related quality of life |
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| Not yet recruiting | 3 | 154 | | | Melbourne Health, Melbourne Health | atrial fibrillation, major depressive disorder | | | | |
2006-001491-21: Studies on Permeability of the Blood-Brain-Barrier for Escitaloprame related to various Genotypes of the ABCB1-Gene: Effects on Sleep and Motoric Learning |
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| Ongoing | 3 | 58 | Europe | Film-coated tablet, Cipralex 10 mg Filmtabletten | Max Planck Institute of Psychiatry | Effects on sleep electroencephalogram and motoric learning in healthy volunteers related to the permeability of the blood-brain-barrier related to genotypes of the ABCB 1 gene | | | | |
2008-004182-26: Antidepressive efficacy, safety, tolerability and genetic response predictors of lithium augmentation in Escitalopram-treated patients with major depression |
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| Ongoing | 3 | 50 | Europe | Escitalopram, Lithiumcarbonat, Capsule, hard | Charité - Universitätsmedizin Berlin | 30-40% of depressed patients do not respond to the first course of drug treatment chosen. Over 50% of nonresponders to the first treatment also do not respond to a second, different treatment . Of those who do respond to the initial antidepressant, up to 50% do not reach full remission but rather display residual symptoms. Therefore, treatment optimization strategies should be considered at critical decision points early in the treatment progress to avoid prolonged treatment-resistant courses. | | | | |
2011-005320-17: Effects of agomelatine on emotional experiences in depressed adults patients as compared to escitalopram |
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| Ongoing | 3 | 500 | Europe | S20098, S20098, Capsule, VALDOXAN, SEROPLEX, CIPRALEX | Institut de Recherches Internationales Servier, SRDL, Servier Research and Develpment | Major Depressive Disorder, Major Depressive Disorder, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2006-006540-54: Efficacy of agomelatine (25 to 50 mg/day) given orally on improvement of subjective sleep in patients with Major Depressive Disorder.A randomised, double-blind, flexible-dose international multicentre study with parallel groups versus escitalopram (10 to 20mg/day).Twelve-week treatment plus double-blind extension for 12 weeks. |
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| Ongoing | 3 | 100 | Europe | S20098, S20098, CIPRALEX, CIPRALEX | Institut de Recherches Internationales Servier, Servier Research and Development Limited | Major Depressive Disorder | | | | |
2012-005612-26: Efficacy and safety of tianeptine oral administration (25 to 50 mg/day) in elderly patients suffering from Major Depressive Disorder. A 8-week, randomized, double-blind, flexible-dose, parallel groups, placebo-controlled, international, multicentre study with escitalopram as active control, followed by an optional double-blind extension treatment period of 16 weeks. |
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| Ongoing | 3 | 60 | Europe | S01574, S01574, Stablon, Seroplex, Cipralex, Stablon, Seroplex, Cipralex | Institut de Recherches Internationales Servier, ADIR | Major Depressive Disorder | | | | |
2013-004881-33: Multicentre trial in to investigate the usage of antidepressant and antipsychotics (with / without approval) in patients at the age of children and adolescents Groß an gelegte, einfache offene klinische Studie mit mehreren teilnehmenden Prüfzentren zur Anwendung von Antidepressiva und Neuroleptika (mit /ohne Zulassung) |
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| Ongoing | 3 | 1000 | Europe | Tablet, Abilify, Zyprexa, Leponex, Seroquel, Risperdal, Zeldox, Melneurin, Dipiperon, Saroten, Cipramil, Anafranil, Aponal, Cymbalta, Cipralex, Fluctin, Fevarin, Tofranil, Ludiomil, Remergil, Nortrilen, Paroxat, Zoloft, Stangyl, Trevilor | Universitätsklinikum Würzburg, Kompetenznetz TDM-KJP e.V., BfArM | therapeutic use in clinical practise Therapeutische Anwendung im klinischen Alltag, therapeutic use in clinical practise Therapeutische Anwendung im klinischen Alltag, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
| Terminated | 3 | 1 | Europe | Mirtazapine, Escitalopram | Hospices Civils de Lyon | Cancer, Neoplasms, Neoplasm Metastasis | 12/21 | 12/21 | | |
NCT03538691 / 2018-000601-22: A Trial to Evaluate the Efficacy, Safety & Tolerability of Brexpiprazole in the Maintenance Treatment of Adults With Major Depressive Disorder |
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| Completed | 3 | 1149 | US | Brexpiprazole, OPC-34712, Rexulti, Antidepressant therapy | Otsuka Pharmaceutical Development & Commercialization, Inc. | Major Depressive Disorder | 07/22 | 07/22 | | |
NCT05950061: Sertraline Versus Escitalopram in South Asian Participants With Moderate to Severe Major Depressive Disorder |
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| Completed | 3 | 744 | RoW | Sertraline, Sertraline pill, Escitalopram, Escitalopram pill | KRL Hospital, Islamabad, Khyber Medical College, Peshawar, Quaid-e-Azam Medical College, Dow University of Health Sciences | Major Depressive Disorder | 10/22 | 02/23 | | |
NCT04162522: Canadian Biomarker Integration Network for Depression (CAN-BIND) - Validation Study |
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| Completed | 3 | 1 | Canada | Escitalopram, Cipralex, Brexpiprazole, Rexulti | University Health Network, Toronto, Unity Health Toronto, Baycrest, Centre for Addiction and Mental Health, McMaster University, Queen's University, University of Ottawa, University of British Columbia, University of Calgary, McGill University, Dalhousie University, University of Michigan, Simon Fraser University | Major Depressive Disorder | 12/22 | 12/22 | | |
| Completed | 3 | 52 | Europe | Nortriptyline, Nortriptyline 25mg, Escitalopram, Escitalopram 5mg, Placebo, Placebo oral tablet | University College, London, London North West Healthcare NHS Trust, King's College London, University Hospital Plymouth NHS Trust, NHS Lothian | Depression, Parkinson Disease | 01/23 | 04/23 | | |
NCT05480878: Role of Nitazoxanide and Escitalopram in Patients With Rheumatoid Arthritis |
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| Completed | 3 | 90 | RoW | Placebo, Nitazoxanide 500Mg Oral Tablet, Escitalopram 10mg | Tanta University | Rheumatoid Arthritis | 03/23 | 04/23 | | |
NCT06025474: Comparison of Vortioxetine Versus Other Antidepressants With Pregabalin Augmentation in Burning Mouth Syndrome |
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| Recruiting | 3 | 203 | Europe | Vortioxetine 20Mg Tab, Brintellix, Paroxetine 20 Mg Oral Tablet, Sertraline 50 MG, Citalopram 20mg, Escitalopram 10mg, Duloxetine 60 MG, Pregabalin 75mg | Federico II University | Burning Mouth Syndrome | 10/23 | 07/24 | | |
IPT, NCT04973930: Feasibility Trial of Tele- and Tele-Pharmacotherapy for Patients With Depression and Non-Metastatic Breast Cancer |
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| Recruiting | 3 | 20 | US | Interpersonal Psychotherapy, IPT, Venlafaxine HCl ER, Escitalopram Oral Tablet | New York State Psychiatric Institute, Columbia University | Major Depressive Disorder, Breast Cancer, Venlafaxine | 12/24 | 12/24 | | |
| Active, not recruiting | 3 | 187 | Canada, US | Escitalopram, Lexapro, Placebo, non-applicable | JHSPH Center for Clinical Trials, National Institute on Aging (NIA) | Dementia | 03/24 | 05/25 | | |
INTENSIFY BD, NCT05973786: The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. |
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| Recruiting | 3 | 418 | Europe | Escitalopram, ATC code: N06AB10, Sertraline, ATC code: N06AB06, Venlafaxine, ATC code: N06AX16, Lithium, ATC code: N05AN01, Valproate acid, ATC code: N03AG01, Quetiapine, ATC code: N05AH04 | Dr. Inge Winter, Universität Münster | Bipolar Depression | 06/26 | 06/26 | | |
INTENSIFY, NCT05603104: Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure |
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| Not yet recruiting | 3 | 1254 | RoW | Clozapine, ATC code: N05AH02, Esketamine Nasal Product, ATC code: N06AB10, Escitalopram, Sertraline, ATC code: N06AB06, Venlafaxine, ATC code: N06AX16, Lithium, ATC code: N05AN01, Valproate acid, ATC code: N03AG01, Quetiapine, ATC code: N05AH04, Second-line Antidepressants, Second-line Antipsychotics, Ketamine Hydrochloride, N01AX03, Esketamine hydrochloride, N015X14 | Dr. Inge Winter, Universität Münster | Schizophrenia and Related Disorders, Major Depressive Disorder, Bipolar Depression | 06/26 | 06/26 | | |
TECAS, NCT03909217: Treating Depression With Transcutaneous Electrical Cranial-auricular Acupoint Stimulation (). |
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| Completed | 2/3 | 470 | RoW | TECAS Procedure, TECAS, Escitalopram, Escitalopram Oxalate Tablets, Insomnia medication, Benzo | The University of Hong Kong, Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing First Hospital of integrated Chinese and Western Medicine, The First Hospital of Hebei Medical University, Southwest Medical University, Hospital of Traditional Chinese Medicine | Mild-to-moderate Depression | 07/21 | 12/21 | | |
| Recruiting | 2/3 | 160 | US | TEA, Transcutaneous Electrical Acustimulation, Lexapro, escitalopram | University of Michigan, National Institute of Neurological Disorders and Stroke (NINDS), National Center for Complementary and Integrative Health (NCCIH) | Irritable Bowel Syndrome With Constipation | 09/25 | 09/25 | | |
| Recruiting | 2/3 | 330 | US | Antidepressant, AD: aripiprazole, bupropion, duloxetine, escitalopram, mirtazapine, sertraline, venlafaxine, Enhanced Fear Avoidance Rehabilitation, EFAR | Ajay Wasan, MD, Msc, National Institutes of Health (NIH), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Brigham and Women's Hospital, Mayo Clinic | Chronic Low Back Pain, Negative Affectivity | 12/25 | 04/26 | | |
| Ongoing | 2 | 95 | Europe | escitalopram, Lexapro, Lundbeck BV, Lundbeck BV | Academic Medical Center | Dystonia | | | | |
2010-020906-14: Investigation on the efficacy of treatment of patients with functional abdominal pain and anxiety disorder with escitalopram, compared to placebo. |
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| Ongoing | 2 | 80 | Europe | Escitalopram, NL/H/0984/001, escitalopram, escitalopram | MUMC, MUMC | IBS and panic disorder | | | | |
2018-002947-27: Simvastatin add-on to Escitalopram in patients with obesity and depression Simvastatin als Zusatztherapie zur antidepressiven Medikation mit Escitalopram bei Patienten mit Depression und Adipositas |
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| Not yet recruiting | 2 | 160 | Europe | SimvaHEXAL®, ESCITALOPRAM, Capsule, hard, Film-coated tablet, SimvaHEXAL® | Charité – Universitätsmedizin Berlin, Charité – Universitätsmedizin Berlin | Patients with comorbid obesity (body mass index ≥ 30) and major depression Patienten mit komorbider Adipositas (body mass index ≥ 30) und Major Depression, Patients with obesity and depression Patienten mit starkem Übergewicht und Depression, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
NCT05289830: Escitalopram to Placebo in Patients With Localized Pancreatic Cancer |
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| Terminated | 2 | 4 | US | Escitalopram, Placebo | Case Comprehensive Cancer Center | Pancreatic Ductal Adenocarcinoma, Periampullary Cancer | 08/23 | 08/23 | | |
JUNIPER, NCT05536414: Trial of Centanafadine Efficacy and Safety as Monotherapy or as Adjunct to SSRI in Adults With Major Depressive Disorder |
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| Recruiting | 2 | 336 | US | Centanafadine, Escitalopram, Placebo | Otsuka Pharmaceutical Development & Commercialization, Inc. | Major Depressive Disorder | 01/25 | 01/25 | | |
NCT03728673: A Study Utilizing Escitalopram in Glioma Patients |
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| Recruiting | 2 | 20 | US | Escitalopram Oral Capsules, escitalopram 10mg, Lexapro | University of Nebraska | Glioma of Brain, Glioma | 12/24 | 08/25 | | |
NCT06216535: Escitalopram in Asthma Patients With Frequent Exacerbation |
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| Not yet recruiting | 2 | 105 | US | Escitalopram, Placebo | University of Texas Southwestern Medical Center | Asthma | 12/28 | 06/29 | | |
SIMCODE, NCT04301271: Simvastatin add-on Treatment to Standard Antidepressant Therapy in Patients With Comorbid Obesity and Major Depression |
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| Active, not recruiting | 2 | 161 | Europe | Simvastatin 40mg, Zocor, C10AA01, Placebo oral tablet | Charite University, Berlin, Germany, NeuroCure Clinical Research Center, Charite, Berlin, University Medical Center Goettingen | Depressive Disorder, Major, Obesity | 02/25 | 02/25 | | |
| Recruiting | 2 | 88 | US | Escitalopram 10mg, Lexapro, Placebo, Placebo (for Escitalopram), Computer-delivered naming treatment, Computer-delivered naming treatment (CoDeNT) | Johns Hopkins University, University of South Carolina, Medical University of South Carolina, University of California, Irvine, National Institute on Deafness and Other Communication Disorders (NIDCD) | Aphasia, Stroke | 09/25 | 01/26 | | |
NCT03527043: Impact of Escitalopram on Sperm DNA Fragmentation |
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| Recruiting | 2 | 70 | US | Escitalopram, Placebo | Weill Medical College of Cornell University | Sperm DNA Fragmentation, Infertility, Male | 12/28 | 02/29 | | |
NCT04410341: The DPP-4 Inhibitor Vildagliptin as Adjunct in Major Depressive Disorder Patients |
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| Active, not recruiting | 1/2 | 100 | RoW | Vildagliptin 50 MG, Escitalopram 20 mg | Sadat City University | Major Depressive Disorder | 12/24 | 12/24 | | |
ChiCTR-TRC-13003179: The different effects of agomelatine and escitalopram on the circadian rhythmic system in the first episode depressive patients |
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| Completed | 1 | 90 | | agomelatine 25-50mg per day before sleep ;escitalopram 10-20mg per day after breakfast ;No intervention | National Institute on Drug Dependence, Peking University; Level of the institution：, Natural Science Foundation of China | Depression | | | | |
| Not yet recruiting | 1 | 200 | | Genotyping | Institute of Clinical Pharmacology, Central South University; Changsha Central Hospital, raise independently | healthy subjects | | | | |
NCT03623711: A Prediction Study of Multiple Indexes of the Effect of Different Mechanisms of Antidepressants Treatment on Depression |
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| Recruiting | 1 | 200 | RoW | Escitalopram, Lexapro, Duloxetine, cymbalta, Bupropion, bupropion hydrochloride tablets, Healthy control, placebo tablets | Yuqi Cheng | Major Depressive Disorder, Depression, Unipolar | 12/22 | 12/22 | | |
ChiCTR2300071340: Study on Individual and Group Intervention Models of Yishu Psychodrama Technology in the Treatment and Rehabilitation of Outpatient Depression |
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| Completed | 1 | 50 | | Yi Shu psychodrama treatment ;first-line antidepressant (escitalopram oxalate) treatment | The First Affiliated Hospital of Chongqing Medical University; The First Affiliated Hospital of Chongqing Medical University, Chongqing Technology Innovation and Application Demonstration Project | Depression | | | | |
NCT05470465: Effect of Selective Serotonin Reuptake Inhibitors (SSRIs) and an Opioid on Ventilation |
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| Completed | 1 | 27 | US | Placebo and Oxycodone, Paroxetine and Oxycodone, Escitalopram and Oxycodone | Food and Drug Administration (FDA), Spaulding Clinical Research LLC, Leiden University | Hypercapnia, Ventilatory Depression | 09/23 | 09/23 | | |
NCT06476509: A Study to Assess Serotonin Transporter Occupancy of Healthy Adults Using 11C-DASB PET |
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| Not yet recruiting | 1 | 8 | NA | LV232 40mg, LV232, Escitalopram 20 mg, Escitalopram | Vigonvita Life Sciences | Major Depressive Disorder | 09/24 | 10/24 | | |
ChiCTR2300070230: Evaluation of psychosocial factors in patients with functional gastroenterology and prediction of efficacy of escitalopram |
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| Not yet recruiting | 1 | 218 | | no ;no | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, National Natural Science Foundation of China (No. 82090034) | functional gastroenterology | | | | |
