escitalopram / Generic mfg. 
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  • ||||||||||  citalopram / Generic mfg., fluoxetine / Generic mfg., escitalopram / Generic mfg.
    Preclinical, Journal:  Effects of Three Serotonin Reuptake Inhibitors on Sign-Tracking in Male Sprague-Dawley Rats. (Pubmed Central) -  May 13, 2023   
    In each study, it was found that measures of sign-tracking were reduced, although effects on goal-tracking were different between drugs. This study provides evidence that administration of serotonergic antidepressants is effective in reducing sign-tracking and may have some efficacy in preventing cue-triggered relapse.
  • ||||||||||  hydrocortisone / Generic mfg., escitalopram / Generic mfg.
    Can Selective Serotonin Reuptake Inhibitors Unmask Underlying Polyglandular Autoimmune Syndrome Type II? (ENDOExpo) -  May 11, 2023 - Abstract #ENDO2023ENDO_1987;    
    Hyponatremia is one of the manifestations of adrenal insufficiency which can be inevitably missed or misdiagnosed with syndrome of inappropriate antidiuretic hormone (SIADH) as both can manifest as euvolemic hyponatremia and inappropriate urinary Na concentration. This case demonstrates the importance of thorough investigation of underlying etiologies of patients with symptomatic hyponatremia who are also at risk SIADH secondary to SSRIs use.
  • ||||||||||  nortriptyline / Generic mfg., escitalopram / Generic mfg.
    Trial completion, Enrollment change:  ADepT-PD: Antidepressants Trial in Parkinson's Disease (clinicaltrials.gov) -  May 6, 2023   
    P3,  N=52, Completed, 
    No abstract available Recruiting --> Completed | N=408 --> 52
  • ||||||||||  quetiapine / Generic mfg., escitalopram / Generic mfg.
    Effects of Anti-Depressant Treatment on Interleukin-8 in Major Depressive Disorder (Sapphire AB) -  Apr 29, 2023 - Abstract #SOBP2023SOBP_831;    
    The absence of change in IL-8 levels at week 12, in spite of significant change in depression and anxiety scores, probably indicates that immune system homeostasis lags behind mood normalization. Exploration of the time interval for normalization of inflammation biomarkers is needed.
  • ||||||||||  sertraline / Generic mfg., venlafaxine extended release / Generic mfg., escitalopram / Generic mfg.
    A Cognitive Biotype of Depression Linking Symptoms, Behavior Measures, Neural Circuits, and Treatment Outcomes (Aqua D) -  Apr 29, 2023 - Abstract #SOBP2023SOBP_34;    
    Lack of treatment-related amelioration of cognitive impairment mediated the relationship between pretreatment binary cognitive status (impaired or not) and poorer antidepressant response (a*b=-0.24, 95% CI, -0.49 to -0.02) as well as poorer psychosocial functioning (a*b=0.70, 95% CI, 0.28 to 1.23). Conclusions Findings suggest the presence of a cognitive dyscontrol biotype of depression with a distinct clinical profile, neural correlates, and treatment response which may benefit from therapies specifically targeting cognitive dysfunction and its underlying neurocircuitry.
  • ||||||||||  agomelatine / Generic mfg.
    Journal:  Evidence-Based Pharmacotherapy of Anxiety Symptoms in Patients with Major Depressive Disorder: Focus on Agomelatine. (Pubmed Central) -  Apr 28, 2023   
    Irrespective of the pharmacotherapy used in patients with depression, the likelihoods of response and remission are increased when pharmacotherapy is combined with psychotherapy, with this approach being more effective than either pharmacotherapy or psychotherapy alone. Persistence with treatment is important, and clinicians should therefore encourage patients to keep trying to obtain relief.
  • ||||||||||  nitazoxanide / Generic mfg., escitalopram / Generic mfg.
    Trial completion, Trial completion date:  Role of Nitazoxanide and Escitalopram in Patients With Rheumatoid Arthritis (clinicaltrials.gov) -  Apr 25, 2023   
    P3,  N=90, Completed, 
    This high rate of response is likely due to dual serotonin and norepinephrine reuptake inhibition achieved at 150 mg dosing. Not yet recruiting --> Completed | Trial completion date: Aug 2023 --> Apr 2023
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma
    Progressive Bronchiolitis Obliterans in Toxic Epidermal Necrolysis in an adult patient associated with Mycoplasma pneumoniae infection: a case report (Level 3 - Room 320) -  Apr 24, 2023 - Abstract #WCD2023WCD_3231;    
    OBSERVATION: A 28-year-old female was taking escitalopram and quetiapine for depression, suddenly developed cough, sore throat and conjunctivitis last June 17, 2019...Lymphocyte activation test is reactive to ciprofloxacin, tazocin, bupropion, lamotrigine and quetiapine...KEY MESSAGE: Chronic pulmonary complications in SJS/TEN are rare but may cause high morbidity and potential fatality. The development of BO in SJS/TEN may be multifactorial, including antecedent infection and severity of cutaneous involvement, but its pathogenesis is still unknown
  • ||||||||||  escitalopram / Generic mfg.
    Trial completion date, Trial primary completion date:  Impact of Escitalopram on Sperm DNA Fragmentation (clinicaltrials.gov) -  Apr 19, 2023   
    P2,  N=70, Recruiting, 
    ClinicalTrials.gov Identifier: NCT03924323. Trial completion date: Dec 2023 --> Dec 2027 | Trial primary completion date: Dec 2022 --> Dec 2027
  • ||||||||||  venlafaxine extended release / Generic mfg., escitalopram / Generic mfg.
    Trial completion date, Trial primary completion date, Metastases:  Feasibility Trial of Tele-IPT and Tele-Pharmacotherapy for Patients With Depression and Non-Metastatic Breast Cancer (clinicaltrials.gov) -  Mar 28, 2023   
    P3,  N=20, Recruiting, 
    Trial completion date: Aug 2023 --> Apr 2024 | Trial primary completion date: Jul 2023 --> Apr 2024 Trial completion date: Feb 2023 --> Aug 2023 | Trial primary completion date: Feb 2023 --> Aug 2023
  • ||||||||||  masupirdine (SUVN-502) / Suven Life Sci, Rexulti (brexpiprazole) / Lundbeck, Otsuka
    Journal:  A 2023 update on the advancements in the treatment of agitation in Alzheimer's disease. (Pubmed Central) -  Mar 25, 2023   
    Clinical trials remain underway utilizing both novel and repurposed agents to address symptoms of agitation in AD. With increasing understanding of the neurobiological mechanisms that fuel the development of agitation in AD, the use of enhanced trial design and conduct, advanced statistical approaches, and accelerated pathways for regulatory approval, we are advancing closer to having safe and efficacious treatment options for agitation in AD.
  • ||||||||||  Journal, Bariatric surgery:  The Influence of a Roux-en-Y Gastric Bypass on Plasma Concentrations of Antidepressants. (Pubmed Central) -  Mar 25, 2023   
    TDM before and after RYGB, in addition to close monitoring of psychiatric symptomatology, may help optimize antidepressant treatment after bariatric surgery. These results also highlight the need for prospective studies assessing the clinical evidence available through TDM in these patients.
  • ||||||||||  escitalopram / Generic mfg.
    Retrospective data, Journal:  Low Escitalopram Concentrations in Patients with Depression predict Treatment Failure: A Naturalistic Retrospective Study. (Pubmed Central) -  Mar 25, 2023   
    Of note, treatment discontinuation is not always a cause of insufficient response but may also be related to other factors such as medication side effects. TDM might not only be useful in addressing these issues but titrating drug concentrations into the currently recommended reference range for escitalopram will also increase response in non-responders and avoid treatment failure in underdosed patients.
  • ||||||||||  baclofen / Generic mfg.
    Brain Dead or Not: A Case of Baclofen Overdose (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) -  Mar 25, 2023 - Abstract #ATS2023ATS_7946;    
    In regards to our patient who initially presented with an acute kidney injury, supportive management without hemodialysis was adequate in treatment, although recovery time was prolonged about 24-48 hours in comparison to use of intermittent hemodialysis. It is prudent to recognize various clinical presentations and management strategies for baclofen overdose to optimally treat it and limit psychologic burden on caretakers.
  • ||||||||||  When Fevers and Chills Aren (Walter E. Washington Convention Center, Area I, Hall C (Lower Level)) -  Mar 25, 2023 - Abstract #ATS2023ATS_6611;    
    It is prudent to recognize various clinical presentations and management strategies for baclofen overdose to optimally treat it and limit psychologic burden on caretakers. We present a case of a patient initially presenting with acute encephalopathy and respiratory distress requiring intubation for airway protection eventually found to have serotonin syndrome.Case Presentation: A 69-year-old female with history of chronic back pain, anxiety, depression on venlafaxine plus escitalopram developed change in mental status, gait instability, a fall with head injury but without loss of consciousness, and irregular breathing pattern prompting urgent evaluation...Additional history provided by patient
  • ||||||||||  Intralipids for Refractory Shock in a Case of Unknown Toxin (Walter E. Washington Convention Center, Area I, Hall C (Lower Level)) -  Mar 25, 2023 - Abstract #ATS2023ATS_6609;    
    He was obtunded with blood pressure of 54/28 despite high doses of norepinephrine, vasopressin, angiotensin II, and epinephrine...He then informed us he had also take escitalopram and subsequently was discharged with no permanent deficit or organ damage. Intralipid is a therapy for refractory shock due to toxic ingestion...We empirically gave intralipid that ultimately saved our patient
  • ||||||||||  ketamine / Generic mfg., bupropion / Generic mfg., escitalopram / Generic mfg.
    Journal:  Conditioned anti-immobility by ketamine: A comparison to escitalopram and bupropion. (Pubmed Central) -  Mar 24, 2023   
    Moreover, no group differences were observed in the place-conditioning test, indicating that the anti-immobility effect of the KET CS + was likely not influenced by a conditioned incentive or aversive state. Together, these data suggest that a KET-paired context can elicit a conditioned antidepressant-like response, which may be a mechanism involved in its sustained antidepressant clinical action.
  • ||||||||||  rofecoxib (TRM-201) / Tremeau Pharma
    Biomarker, Journal:  Genetic polymorphisms of pharmacogenomic VIP variants in the Hui population from Ningxia Province of China. (Pubmed Central) -  Mar 24, 2023   
    Our study indicated that the loci of PTGS2 (rs20417), NAT2 (rs1801280 and rs1208), ACE (rs4291), and CYP2D6 (rs1065852) in the Hui population were obviously different from those in the other 26 populations, which provides reliable information for predicting drug efficacy. Besides, it supplements the pharmacogenomic knowledge of the Hui population and lays the foundation for the individualized treatment for the Hui population.
  • ||||||||||  escitalopram / Generic mfg.
    Journal:  Predicting Antidepressant Treatment Response Using Functional Brain Controllability Analysis. (Pubmed Central) -  Mar 21, 2023   
    While the interventions had comparable effects on mental health, running therapy outperformed antidepressants on physical health, due to both larger improvements in the running therapy group as well as larger deterioration in the antidepressant group. Our results suggest that the functional brain network controllability measures may be utilized as novel biomarkers to predict antidepressant response on depression and provide theoretical support to employ neuromodulation for treating antidepressant non-responders.
  • ||||||||||  escitalopram / Generic mfg.
    Journal:  De-Novo Depression, Prophylactic Antidepressant, and Survival in Patients With Head and Neck Cancer. (Pubmed Central) -  Mar 16, 2023   
    There was no significant association between OS and development of moderate or greater depression in patients being treated for stages II-IV HNC, or between OS and use of prophylactic antidepressant escitalopram. Prophylactic antidepressant may be considered in patients with HNC for prevention of clinically significant depression and may offer improved quality of life outcomes.
  • ||||||||||  escitalopram / Generic mfg.
    Preclinical, Journal:  Sex differences in serotonergic control of rat social behaviour. (Pubmed Central) -  Mar 14, 2023   
    Prophylactic antidepressant may be considered in patients with HNC for prevention of clinically significant depression and may offer improved quality of life outcomes. These data suggest that females may respond differently to serotonergic pharmacotherapy with respect to enhancement of beneficial effects of social support, especially in stress-related situations.