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Review, Journal: Natural products and their derivatives: Promising modulators of tumor immunotherapy. (Pubmed Central) - Dec 16, 2020
Here, we performed a deep generalization, analysis, and summarization of the previous achievements, recent progress, and the bottlenecks in the development of natural products as tumor immunotherapy. We expect this review to provide some insight for guiding future research.
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[VIRTUAL] A Case of Shiitake Mushroom Dermatitis in a 21-Year-Old Female () - Dec 2, 2020 - Abstract #ASDP2020ASDP_327;
She noted improvement at 2 week phone follow-up with use of triamcinolone 0.1% cream and shiitake mushroom avoidance. This case highlights the importance of detailed history taking and describes rarely reported histologic findings of shiitake mushroom dermatitis.
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Journal: Plant-derived compounds: A potential source of drugs against Tobacco mosaic virus. (Pubmed Central) - Aug 30, 2020
The results demonstrated that the antiviral effects of UA and 4-methoxycoumarin were as effective as those of the commercial agent lentinan, in either the protective effect, inactivation effect or curative effect...Meanwhile, electrolyte leakage and malondialdehyde experiments indicated that these effects did not result in phytotoxicity or damage to the leaf plasma membrane of tobacco plants. Collectively, the results demonstrate that UA and 4-methoxycoumarin have potential as eco-friendly and safe strategies to control TMV in the future.
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Preclinical, Journal: The protective effect and mechanism of lentinan on acute kidney injury in septic rats. (Pubmed Central) - Aug 15, 2020
Compared with the BS group, the protein expression levels of NF-κB, iNOS, and ICAM-1 along with the levels of pro-inflammatory factors TNF-α and IL-6 in serum were significantly decreased, while the levels of anti-inflammatory factors IL-4 and IL-10 were obviously increased in the LNT group with different concentrations.. LNT has a certain protective effect on AKI in septic rats, and its mechanism may involve inhibiting the activation of NF-κB, which suppresses the expression of proinflammatory factors in turn, thus promoting the release of anti-inflammatory factors.
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Preclinical, Journal: Effects of lentinan on NF-κB activity in the liver of burn rats with sepsis. (Pubmed Central) - Aug 9, 2020
Most importantly, treatment with lentinan was able to reverse the increased concentration of IL-4, IL-6, IL-10 and TNF-α in plasma which was induced by LPS. Lentinan treatment can significantly decrease the expression of NF-κB in the liver of burn rats with sepsis.
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Journal: Transcriptome analysis of the edible mushroom Lentinula edodes in response to blue light. (Pubmed Central) - Jul 1, 2020
Lentinula edodes is one of the most popular edible mushrooms worldwide and contains important medicinal components such as lentinan, ergosterol, and eritadenine...We identified 8 upregulated genes under blue light condition, such as DDR48-heat shock protein, Fasciclin-domain-containing protein and carbohydrate esterase family 4 protein, FAD NAD-binding domain-containing protein that are involved in morphological development of primordium and embryonic muscle development, cell adhesion and affect the structure of cellulosic and non-cellulosic cell walls of fruit body development, and photoreceptor of blue light signaling for fruit body and pigment development, respectively. This study provides valuable insights into the molecular mechanisms underlying the role of blue light in mushroom growth and development and can thus contribute to breeding programs to improve mushroom cultivation.
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Journal: Not a fungi to be with: Shiitake mushroom flagellate dermatitis. (Pubmed Central) - Jun 28, 2020
Shiitake dermatitis is thought to be either a toxic or hypersensitivity reaction to lentinan, a heat-inactivated polysaccharide found in the cell walls of shiitake mushrooms. Although this mushroom is widely consumed in Eastern Asia, with the increasing globalisation of cuisine and travel, cases are likely to become more common in the Western world.
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Journal, IO Biomarker: Therapeutic effects of lentinan on inflammatory bowel disease and colitis-associated cancer. (Pubmed Central) - Jun 20, 2020
In addition, lentinan restored the intestinal bacterial microbiotal community structure in IBD model mice. Thus, it shows therapeutic potential in IBD and CAC model mice possibly by inhibiting TLR4/NF-κB signalling-mediated inflammatory responses and disruption of the intestinal microbiotal structure.
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Review, Journal: Review of Bioactive Molecules Production, Biomass, and Basidiomata of Shiitake Culinary-Medicinal Mushrooms, Lentinus edodes (Agaricomycetes). (Pubmed Central) - Jun 18, 2020
It has a low lipid content, high fiber content, and a considerable amount of proteins; it also contains B vitamins and minerals in addition to a wide range of functional metabolites including polysaccharides, polysaccharopeptides, lectins, and secondary metabolites with bioactivity, e.g., lentinan, a β-(1-3)-glucan with immunomodulatory activity, among others...However, it is necessary to perform in vivo studies to determine the appropriate doses, side effects, and action spectrum of different bioactive compounds and fractions as well as to improve their production in liquid media and to potentiate their activity. We present an updated review of existing studies on the production of biomass and bioactive compounds of L. edodes in liquid culture and on solid fermentation for obtaining secondary mycelia and basidiomata.
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Journal, IO Biomarker: The Effects of Lentinan on the Expression Patterns of β-Catenin, Bcl-2, and Bax in Murine Bone Marrow Cells Are Associated with Enhancing Dectin-1. (Pubmed Central) - Jun 18, 2020
Furthermore, the expression profiles of β-catenin, Bcl-2, and Bax reversed with the administration of laminarin (P < 0.05). Taken together, our results identified that the changing expression profiles of β-catenin, Bcl-2, and Bax in murine BMCs are associated with enhancing dectin-1.
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Journal: Naturally potential antiviral agent polysaccharide from Dendrobium nobile Lindl. (Pubmed Central) - Jun 18, 2020
Bioactivity assays indicated that DNPE6(11) possessed outstanding curative and inactivating activities against cucumber mosaic virus, which were superior to chitosan oligosaccharide and lentinan...Furthermore, the preliminary mechanism study found that DNPE6(11) cannot accumulate salicylic acid to induce systemic acquired resistance, but had a strong binding capacity for cucumber mosaic virus coat protein. Therefore, DNPE6(11) could be considered as a promising antiviral agent to study in the future.
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Journal: Different activities of antitumor immunomodulators to induce neutrophil adherence response. (Pubmed Central) - May 13, 2020
Several bacterial immunomodulators (OK-432, Corynebacterium parvum, B.C.G.) and components of bacteria cell walls (lipopolysaccharide (LPS), lipid A, lipoteicoic acid, N-cell wall skelton (N-CWS), muramyl dipeptide (MDP)) and fungal polysaccharides (lentinan, zymosan A, etc.) were tested...Although purified polysaccharides mainly prepared from fungi did not induce the adherent response, not only bacterial bodies and their components but also tumor necrosis factor-α (TNF-α) clearly induced it. On the base of these results, functional classification and typing of immunomodulators by different activities in neutrophil adherence was discussed.
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Clinical, Journal: Mushroom polysaccharide lentinan for treating different types of cancers: A review of 12 years clinical studies in China. (Pubmed Central) - Feb 22, 2020
The 9474 reported lentinan-associated cancer treatment cases include lung cancer (3469 cases), gastric cancer (3039 cases), colorectal cancer (1646 cases), ovarian cancer (183 cases), cervical cancer (130 cases), Non-Hodgkin lymphoma (70 cases), pancreatic cancer (15 cases), cardiac cancer (15 cases), nasopharyngeal cancer (14 cases), duodenal cancer (1 case) and 110 cancer cases with no classifying patient information. Overall clinical data show solid effect of lentinan on improving the quality of life and on promoting the efficacy of chemotherapy and radiation therapy during cancer treatment.
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Journal, IO Biomarker: Lentinan protects cardiomyocytes against hypoxia-induced injury by regulation of microRNA-22/Sirt1. (Pubmed Central) - Feb 21, 2020
In conclusion, LEN relieved hypoxia-induced cellular injuries evidenced by increasing viability and decreasing apoptosis via down-regulation of miR-22, which was accompanied by activation of PI3K/AKT and β-catenin pathways. Highlights Lentinan alleviates hypoxia-induced injuries of PNCM and H9c2 cells; microRNA-22 expression is decreased by lentinan; Lentinan reduces hypoxia-induced injury by microRNA-22 downregulation; Lentinan regulates PI3K/AKT and Wnt/β-catenin by regulation of microRNA-22/Sirt1.
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Journal: Selenium-containing polysaccharides from Lentinula edodes-Biological activity. (Pubmed Central) - Feb 8, 2020
To verify this hypothesis, we obtained by biotechnological methods a Se-enriched analog of Japanese anticancer drug lentinan and, as a reference, the non-Se-enriched fraction...However, we observed no effect of the polysaccharide fractions on the production of reactive oxygen species by granulocytes in vitro. The selenium content increased the biological activity of the tested polysaccharide fractions.
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Preclinical, Journal: Effect of Lentinan on Peyer's patch structure and function in an immunosuppressed mouse model. (Pubmed Central) - Jan 15, 2020
Furthermore, the number of M-like cells, which were differentiated from intestinal epithelial cells, and their antigen transfer ability were enhanced. These results indicate that orally administered LNT can improve the immune status of the intestinal mucosa in immunosuppressed mice.
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Preclinical, Journal: Supplementation with compound polysaccharides contributes to the development and metabolic activity of young rat intestinal microbiota. (Pubmed Central) - Jan 4, 2020
This study was conducted to investigate the health effects of supplementation with dietary compound polysaccharides (Lycium barbarum polysaccharides (LBP), Poria cocos polysaccharides (PCPs) and Lentinan, 1 : 1 : 1) on the intestinal microecosystem and metabolism of young rats...Meanwhile, dietary compound polysaccharide treatment promoted the functional maturation of the gut bacterial community, characterised by increased basic metabolism (amino acid metabolism and energy metabolism), short chain fatty acid (SCFA)-related metabolism and nucleotide metabolism. These findings suggest that compound polysaccharides may help to promote the colonisation and functional maturation of infant intestinal microbiota and maintain the health of the intestinal microecosystem.
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Review, Journal: Role of edible mushroom as a potent therapeutics for the diabetes and obesity. (Pubmed Central) - Dec 15, 2019
Here, in this review, we have discussed the potential role of edible mushrooms and its biochemicals in control of diabetes and obesity. Using Bioinformatics, we can find the specific targets of theses biochemicals, so that these can be more effective.
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Journal: A dual-action pesticide carrier that continuously induces plant resistance enhances plant anti-TMV activity of plant and promotes plant growth. (Pubmed Central) - Oct 29, 2019
We produced an alginate-lentinan-amino-oligosaccharide hydrogel (ALA-hydrogel) by coating the surface of an alginate-lentinan drug-loaded hydrogel (AL-hydrogel) with amino-oligosaccharide using electrostatic action...Our findings provide an alternative to the traditional approach of applying pesticide for controlling plant viral diseases. In the future, this hydrogel with the simple synthesis method, green synthetic materials, and its efficiency in the induction of plant resistance will attract increasing attention and have a good potential to be employed in the plant protection and agricultural production.
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Journal: Identification of genes underlying the enhancement of immunity by a formula of lentinan, pachymaran and tremelia polysaccharides in immunosuppressive mice. (Pubmed Central) - Oct 13, 2019
Consequently, polysaccharide formula treatment helped to recover the expression of immune-related genes, including CADM1, CCR2, IGLL1, LIGP1, and FCGR3, FCGR2 in B cells, as well as S100A8, S100A9, ChIL3, MMP8 and IFITM3 in T cells. These results suggest that treatment with polysaccharides improves the immunity of immunosuppressive mice by regulating genes associated with T and B cell functions.
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Journal: Reflectance confocal microscopy in Shiitake dermatitis (Pubmed Central) - Oct 11, 2019
It is caused by lentinan, a polysaccharide component of the cell walls of shiitake mushrooms...The results of reflectance confocal microscopy (RCM) correlated with the histopathological investigations. Therefore, RCM can be used for non-invasive diagnostic confirmation of Shiitake dermatitis in the future.
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Journal: Bioactive mushroom polysaccharides as antitumor: an overview. (Pubmed Central) - Sep 22, 2019
Mushrooms are well known for their bioactive compounds such as chizophyllan, lentinan, grifolan, PSP (polysaccharide-peptide complex) and PSK (polysaccharide-protein complex) which are considered as medicines against melignancy...Mushroom polysaccharides have promising future for treatment of cancers due to their mode of action and efficacy. Also there are some hurdles during this treatment, but it will start a new era of safer and effective medicine based on mushroom polysaccharides.
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Journal: Lentinan administration relieves gut barrier dysfunction induced by rotavirus in a weaned piglet model. (Pubmed Central) - Aug 22, 2019
Supplementation also further alleviated the effects of RV infection on diarrhea, intestinal morphology, permeability, antioxidant capacity, microbiota and apoptosis of jejunal epithelial cells in piglets (P < 0.05). Thus, these results suggest that LNT administration relieved RV-induced diarrhea in piglets, which could be due to the increase in antioxidant capacity, reduction in apoptosis and improvement of the microbiota-increased gut barrier.
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Preclinical, Journal: Evaluation of lentinan effects on cytochrome P450 activity in rats by a cocktail method. (Pubmed Central) - Jun 4, 2019
We found that various concentrations of lentinan increased the activity of rat CYP1A2, CYP3A4, CYP2D6, and CYP2C19 but not CYP2C9. These findings suggest that clinical application of lentinan combination with CYP3A4, CYP1A2, CYP2C19, or CYP2D6 should be given careful consideration as this may lead to herb-drug interactions and hence treatment failure.
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Clinical, Journal: A Case of P0CY1 Gastric Cancer without Recurrence for 13 Years Postoperatively (Pubmed Central) - Apr 13, 2019
Myelosuppression was prolonged even after stopping the chemothera- py; hence, we administered S-1/Lentinan(S-1 80mg/bodyweight , Lentinan 2mg/time)combined chemotherapy. At present, no signs of recurrence were observed for 13 years postoperatively.
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Journal: Conformation-Dependent Manipulation of Human Islet Amyloid Polypeptide Fibrillation by Shiitake-Derived Lentinan. (Pubmed Central) - Mar 29, 2019
Further investigation shows that the interaction between triple-helical lentinan and monomeric hIAPP is more favorable than the inter-molecular binding of hIAPP, which redirects hIAPP aggregates to discrete nontoxic nanocomposites. To the best of our knowledge, this is the first time to report a conformation-dependent inhibition of hIAPP aggregation, which will provide new insights for our understanding of the manipulation mechanisms on hIAPP by natural polysaccharides, and open a new avenue for designing and screening potential amyloid inhibitors against type 2 diabetes.
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