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0 Diseases |  |
3 Trials |
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3 Trials |  |
33 News |  |
- ||||||| Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Trial completion: Efficacy and Safety of Lidocaine and Tetracaine Cream for Facial Laser Aesthetics in Chinese Adults (clinicaltrials.gov) - Nov 12, 2024
P3, N=286, Completed, Sponsor: Cutia Therapeutics?Wuxi?Co.,Ltd
Not yet recruiting --> Completed
- | Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Trial completion date, Trial primary completion date: The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) - Mar 14, 2024
P=N/A, N=48, Active, not recruiting, Sponsor: Northwestern University
Not yet recruiting --> Completed Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Dec 2024
- | lidocaine topical / Generic mfg.
Journal, PD(L)-1 Biomarker, IO biomarker: Topical application of local anesthetics to melanoma increases the efficacy of anti-PD-1 therapy. (Pubmed Central) - Jul 27, 2023
Our data suggest that Pliaglis reduces melanoma growth through a direct effect on melanoma cells as well as through modulation of the immune response. The involvement of nervous system-related signaling in the inhibitory effect of Pliaglis on melanoma is inconclusive from our data.
- |||||||||| Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
New P3 trial: Efficacy and Safety of Lidocaine and Tetracaine Cream for Facial Laser Aesthetics in Chinese Adults (clinicaltrials.gov) - Mar 31, 2023
P3, N=286, Not yet recruiting, Sponsor: Cutia Therapeutics?Wuxi?Co.,Ltd
- | Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Trial completion date, Trial primary completion date: The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) - Feb 21, 2023
P=N/A, N=48, Active, not recruiting, Sponsor: Northwestern University
The involvement of nervous system-related signaling in the inhibitory effect of Pliaglis on melanoma is inconclusive from our data. Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Dec 2022 --> Dec 2023
- || lidocaine topical / Generic mfg.
Clinical, Journal: Real-life experience of a lidocaine/tetracaine self-occluding topical anesthetic for dermatological procedures. (Pubmed Central) - Jul 23, 2022
Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Dec 2022 --> Dec 2023 Pliaglis is an effective topical anesthetic for several dermatological procedures, with an excellent safety and tolerability profile.
- | Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Trial completion date, Trial primary completion date: The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) - Mar 4, 2022
P=N/A, N=48, Active, not recruiting, Sponsor: Northwestern University
Pliaglis is an effective topical anesthetic for several dermatological procedures, with an excellent safety and tolerability profile. Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Dec 2021 --> Dec 2022
- | Emla-cream / Akorn, AstraZeneca, Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Journal: Transdermal Application of Anesthetic Preparations Is Effective in Increasing Mechanical Nociceptive Threshold at Perineural Injection Sites in Horses. (Pubmed Central) - Aug 8, 2021
Furthermore, no significant difference of MNT values at sites distal to treatment was recorded between the two time points, both in the treated limb and control limbs. Both formulations are effective to obtain superficial skin desensitization.
- || lidocaine topical / Generic mfg.
Clinical, Journal: Efficacy of lidocaine 7%, tetracaine 7% self-occlusive cream in reducing MAL-cPDT-associated pain in subjects with actinic keratosis: A randomized, single-blind, vehicle-controlled trial (The "3P-Trial"). (Pubmed Central) - Apr 15, 2021
Both formulations are effective to obtain superficial skin desensitization. The 3P-trial has demonstrated that the preventive application of the self-occlusive lidocaine 7%-tetracaine 7% cream is very effective in reducing the procedure-associated pain during MAL-cPDT for the treatment of AK lesions.
- | Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Trial completion date, Trial primary completion date: The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) - May 8, 2020
P=N/A, N=48, Active, not recruiting, Sponsor: Northwestern University
The 3P-trial has demonstrated that the preventive application of the self-occlusive lidocaine 7%-tetracaine 7% cream is very effective in reducing the procedure-associated pain during MAL-cPDT for the treatment of AK lesions. Trial completion date: Dec 2019 --> Dec 2021 | Trial primary completion date: Dec 2019 --> Dec 2021
- | Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Trial completion date, Trial primary completion date: The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) - Apr 26, 2019
P=N/A, N=48, Active, not recruiting, Sponsor: Northwestern University
Trial completion date: Dec 2019 --> Dec 2021 | Trial primary completion date: Dec 2019 --> Dec 2021 Trial completion date: Dec 2018 --> Dec 2019 | Trial primary completion date: Dec 2018 --> Dec 2019
- | Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Trial completion date, Trial primary completion date: The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) - Apr 26, 2018
P=N/A, N=48, Active, not recruiting, Sponsor: Northwestern University
Trial completion date: Dec 2018 --> Dec 2019 | Trial primary completion date: Dec 2018 --> Dec 2019 Trial completion date: Mar 2018 --> Dec 2018 | Trial primary completion date: Mar 2018 --> Dec 2018
- | Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Trial completion date, Trial primary completion date: The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) - Mar 3, 2018
P=N/A, N=48, Active, not recruiting, Sponsor: Northwestern University
Trial completion date: Mar 2018 --> Dec 2018 | Trial primary completion date: Mar 2018 --> Dec 2018 Trial completion date: Jan 2018 --> Mar 2018 | Trial primary completion date: Jan 2018 --> Mar 2018
- | Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Trial primary completion date: The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) - Oct 18, 2017
P=N/A, N=48, Active, not recruiting, Sponsor: Northwestern University
Trial completion date: Jan 2018 --> Mar 2018 | Trial primary completion date: Jan 2018 --> Mar 2018 Trial primary completion date: Sep 2017 --> Jan 2018
- | New P4 trial: Fractional Laser Assisted Delivery of Anesthetics IIIb (clinicaltrials.gov) - Sep 11, 2017
P4, N=15, Completed, Sponsor: Netherlands Institute for Pigment Disorders
- Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Trial primary completion date: The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) - Dec 6, 2016
P=N/A, N=48, Active, not recruiting, Sponsor: Northwestern University
Trial primary completion date: Sep 2017 --> Jan 2018 Trial primary completion date: Sep 2016 --> Sep 2017
- Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Enrollment closed: The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) - May 13, 2016
P=N/A, N=48, Active, not recruiting, Sponsor: Northwestern University
Trial primary completion date: Sep 2016 --> Sep 2017 Recruiting --> Active, not recruiting
- Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Trial completion: OPTICA: 7% Lidocaine/7% Tetracaine Cream Versus 2,5% Lidocaine / 2,5% Prilocaine Cream (clinicaltrials.gov) - Jan 20, 2016
P4, N=30, Completed, Sponsor: Erasmus Medical Center
Recruiting --> Active, not recruiting Recruiting --> Completed
- Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Trial primary completion date: The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) - Oct 22, 2015
P=N/A, N=48, Recruiting, Sponsor: Northwestern University
Recruiting --> Completed Trial primary completion date: Sep 2015 --> Sep 2016
- Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Trial primary completion date: OPTICA: 7% Lidocaine/7% Tetracaine Cream Versus 2,5% Lidocaine / 2,5% Prilocaine Cream (clinicaltrials.gov) - Aug 21, 2015
P4, N=30, Recruiting, Sponsor: Erasmus Medical Center
Trial primary completion date: Sep 2015 --> Sep 2016 Trial primary completion date: May 2015 --> Oct 2015
- Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
New trial: The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) - Apr 28, 2015
P=N/A, N=48, Recruiting, Sponsor: Northwestern University
- ||| Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Trial completion: A Non-interventional Study to Evaluate the Use of Pliaglis in Daily Practice (clinicaltrials.gov) - Mar 3, 2015
P=N/A, N=582, Completed, Sponsor: Q-Med AB
Trial primary completion date: May 2015 --> Oct 2015 Recruiting --> Completed
- Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
New P4 trial: OPTICA: 7% Lidocaine/7% Tetracaine Cream Versus 2,5% Lidocaine / 2,5% Prilocaine Cream (clinicaltrials.gov) - Feb 26, 2015
P4, N=30, Recruiting, Sponsor: Erasmus Medical Center
- ||||||| Trial completion: S-Caine (clinicaltrials.gov) - Feb 22, 2014
P3, N=81, Completed, Sponsor: ZARS Pharma Inc.
Recruiting --> Completed Recruiting --> Completed
- ||||||| Trial completion: S-Caine (clinicaltrials.gov) - Feb 22, 2014
P3, N=80, Completed, Sponsor: ZARS Pharma Inc.
Recruiting --> Completed Recruiting --> Completed
- ||||||| Trial completion: S-Caine (clinicaltrials.gov) - Feb 22, 2014
P3, N=70, Completed, Sponsor: ZARS Pharma Inc.
Recruiting --> Completed Recruiting --> Completed
- ||||||| Trial completion: S-Caine (clinicaltrials.gov) - Feb 22, 2014
P3, N=54, Completed, Sponsor: ZARS Pharma Inc.
Recruiting --> Completed Recruiting --> Completed
- ||||||| Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Trial completion: S-Caine (clinicaltrials.gov) - Feb 22, 2014
P3, N=60, Completed, Sponsor: ZARS Pharma Inc.
Recruiting --> Completed Recruiting --> Completed
- || Trial completion: Duration of Skin Numbing Effect Created by the S-Caine (clinicaltrials.gov) - Feb 22, 2014
P3, N=40, Completed, Sponsor: ZARS Pharma Inc.
Recruiting --> Completed No longer recruiting --> Completed
- ||||||| Trial completion: Safety Study of S-Caine Peel (Skin Numbing Cream) Before a Painful Dermatologic Procedure in Adults (clinicaltrials.gov) - Feb 22, 2014
P3, N=408, Completed, Sponsor: ZARS Pharma Inc.
No longer recruiting --> Completed Recruiting --> Completed
- ||||||| Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Trial completion: Safety Study of S-Caine Peel (Skin Numbing Cream) Before a Painful Dermatologic Procedure in Children (clinicaltrials.gov) - Feb 22, 2014
P3, N=80, Completed, Sponsor: ZARS Pharma Inc.
Recruiting --> Completed Recruiting --> Completed
- Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Enrollment open: Comparison of Two Topical Anesthetics: Benzocaine Versus Pliaglis (clinicaltrials.gov) - Sep 23, 2013
P4, N=64, Recruiting, Sponsor: University of Michigan
Recruiting --> Completed Not yet recruiting --> Recruiting
- | Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
New P4 trial: Comparison of Two Topical Anesthetics: Benzocaine Versus Pliaglis (clinicaltrials.gov) - Aug 21, 2013
P4, N=64, Recruiting, Sponsor: University of Michigan
- ||| Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Clinical: A Non-interventional Study to Evaluate the Use of Pliaglis in Daily Practice (clinicaltrials.gov) - Feb 25, 2013
P=N/A, N=700, Recruiting, Sponsor: Q-Med AB
- | Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Trial completion: Anesthetic Effect Duration Assessment (clinicaltrials.gov) - Jun 13, 2012
P4, N=30, Completed, Sponsor: Galderma
Not yet recruiting --> Recruiting Recruiting --> Completed
- | Enrollment change: Lidocaine and Tetracaine Cream to Treat Postherpetic Neuralgia (PHN) (clinicaltrials.gov) - Mar 13, 2012
P2, N=23, Completed, Sponsor: ZARS Pharma Inc.
Recruiting --> Completed N=18 --> 23
- | Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
New P4 trial: Anesthetic Effect Duration Assessment (clinicaltrials.gov) - Mar 5, 2012
P4, N=30, Completed, Sponsor: Galderma