doxycycline / Generic mfg. 
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 114 Diseases   151 Trials   151 Trials   5480 News 


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  • ||||||||||  Journal:  Atypical Presentation of Severe Bullous Pemphigoid: A Case Report. (Pubmed Central) -  Sep 23, 2024   
    With no clinical improvement, tissue biopsy was performed that confirmed bullous pemphigoid and treatment with steroid taper, doxycycline, and triamcinolone acetonide 0.1% cream was started. The aim of this case report is to present an atypical presentation of BP and to highlight maintaining a high index of suspicion of BP in patients presenting with disseminated significantly pruritic lesions.
  • ||||||||||  Journal:  Antibiotic-resistant bacteria and resistance-genes in drinking water source in north Shoa zone, Amhara region, Ethiopia. (Pubmed Central) -  Sep 23, 2024   
    However, a low resistance was observed for early introduced antibiotics such as ciprofloxacin and recently introduced antibiotics such as cefotaxime, ceftazidime, imipenem, and meropenem...Various ES?L resistance genes have also been detected. Therefore, regular sanitary inspection and bacteriological analysis should be mandatory to protect drinking water sources from contamination and the persistence of resistant bacteria.
  • ||||||||||  Journal:  Osteomyelitis in the Nonunion of a Patellar Fracture. (Pubmed Central) -  Sep 23, 2024   
    Surgical debridement was not necessary, and the patient was able to resume her daily activities with the pain resolved. The possibility of patients only having to undergo antibiotic treatment for patellar osteomyelitis improves their chances of a full recovery and reduces the risks associated with undergoing surgical debridement.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Enhancing terminal erythroid differentiation in human embryonic stem cells through TRIB3 overexpression. (Pubmed Central) -  Sep 23, 2024   
    Then, we analyzed hemoglobin expression, condensed chromosomes, organelle clearance, and enucleation with or without doxycycline treatment...Our results showed that TRIB3 overexpression during terminal erythropoiesis may promote the maturation of erythroid cells. Therefore, our study delineates the role of TRIB3 in terminal erythropoiesis, and reveals TRIB3 as a key regulator of UPS and downstream mitophagy by ensuring appropriate mitochondrial clearance during the compaction of chromatin.
  • ||||||||||  ceftriaxone / Generic mfg., doxycycline / Generic mfg.
    Enrollment closed, Trial completion date, Trial primary completion date:  Treatment Responses of Early Syphilis to Ceftriaxone Plus Doxycycline (clinicaltrials.gov) -  Sep 23, 2024   
    P4,  N=300, Active, not recruiting, 
    Consequently, pneumococcal vaccines should be included in the national immunization schedule to prevent disease spread. Recruiting --> Active, not recruiting | Trial completion date: Mar 2025 --> Aug 2026 | Trial primary completion date: Mar 2025 --> Aug 2025
  • ||||||||||  doxycycline / Generic mfg.
    Preclinical, Journal:  Chitosan-coated PLGA microemulsion loaded with tannic acid against Escherichia coli in vitro and in vivo. (Pubmed Central) -  Sep 21, 2024   
    Compared to the model group, TPC treatment elevated serum glutathione peroxidase activities and lowered myeloperoxidase and lactate dehydrogenase levels, offering antioxidant protection that was slightly better than that of doxycycline hydrochlorid group. In summary, we prepared a novel TA antimicrobial preparation with significant antioxidant potential and inhibitory effect against E. coli both in vitro and in vivo.
  • ||||||||||  doxycycline / Generic mfg.
    Preclinical, Journal:  Generation of SOX2ZsGreen reporter authentic porcine induced pluripotent stem cells. (Pubmed Central) -  Sep 21, 2024   
    To enhance the utility of these piPSCs, we used a CRISPR/Cas9-based homology-directed repair (HDR) system to introduce a nls-zsGreen reporter in-frame and before the stop codon of the SOX2 coding sequence. The incorporation of the zsGreen reporter offers a novel opportunity for real-time monitoring of SOX2 expression and aiding in the characterization of piPSC lines.
  • ||||||||||  doxycycline / Generic mfg.
    Preclinical, Journal:  Impaired learning and memory in male mice induced by sodium arsenite was associated with MMP-2/MMP-9-mediated blood-brain barrier disruption and neuronal apoptosis. (Pubmed Central) -  Sep 20, 2024   
    Ninety male mice were given 0, 25, and 50?mg/L NaAsO2 in drinking water and 30?mg/kg doxycycline hyclate (DOX, an inhibitor of MMPs) gavage for 12 weeks to observe the alterations in learning and memory of mice, the morphology of hippocampal neurons, as well as the BBB permeability and ultrastructure, the localization and expression of tight junction proteins, MMP-2, and MMP-9...Our research demonstrates that cognitive disfunction in mice induced by arsenic exposure is associated with MMP-2 and MMP-9-mediated BBB destruction and neuronal apoptosis. The current investigation provides new insights into mechanisms of arsenic neurotoxicity and suggests that MMP-2 and MMP-9 may serve as potential therapeutic targets for treating arsenic-induced cognitive dysfunction in the future.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Exposure to doxycycline increases risk of carrying a broad range of enteric antimicrobial resistance determinants in an elderly cohort. (Pubmed Central) -  Sep 20, 2024   
    As a critical antibiotic in medical practice, a comprehensive understanding of the impact of doxycycline exposure on the gut resistome is paramount for informed antibiotic use, particularly in an evolving landscape of prophylactic applications. Near-universal asymptomatic carriage of clinically critical resistance determinants is highly concerning and reinforces the urgent need for improved management of antibiotic use in long-term aged care.
  • ||||||||||  doxycycline / Generic mfg.
    Preclinical, Journal:  Cytoplasmic aggregation of TDP43 and topographic correlation with tau and ?-synuclein accumulation in the rTg4510 mouse model of tauopathy. (Pubmed Central) -  Sep 20, 2024   
    Suppression of the human mutant tau (P301L) expression by doxycycline treatment reduces the accumulation of p-TDP43, hp-tau, and p-?Syn...These results indicate that the accumulation of mouse p-TDP43 is associated with the accumulation of human mutant tau (P301L) in rTg4510 mouse brains. The accumulation of hp-tau and p-?Syn may promote sarkosyl-insoluble p-TDP43 aggregates that are resistant to proteinase K. The synergistic effects of tau, TDP43, and ?Syn may be involved in the pathology of proteinopathies, leading to the accumulation of multiple abnormal proteins.
  • ||||||||||  trimethoprim/sulfamethoxazole / Generic mfg., doxycycline / Generic mfg.
    Journal:  Case Report: Acute large bowel obstruction with actinomycosis of the sigmoid colon mimicking neoplasm. (Pubmed Central) -  Sep 19, 2024   
    It can be mistaken for malignancy, leading to unnecessary surgery in non-complicated cases, since it is effectively treated by antibiotics. In complicated cases, a combined approach involving both surgery and antibiotic therapy is necessary until the infection is completely eradicated.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Role of mitochondrial and cytosolic folylpolyglutamate synthetase in one-carbon metabolism and antitumor efficacy of mitochondrial-targeted antifolates. (Pubmed Central) -  Sep 17, 2024   
    MIA PaCa-2 pancreatic cancer cells with CRISPR knockout of FPGS were engineered to express doxycycline-inducible FPGS exclusively in the cytosol (cFPGS) or in both the cytosol and mitochondria (mFPGS)...AGF347 accumulation increases with folylpolyglutamate synthetase (FPGS) levels in both the cytosol and mitochondria. Increased mitochondrial FPGS stimulated one-carbon metabolic fluxes in the cytosol and mitochondria and substantially enhanced in vitro inhibition of pancreatic cancer cells by AGF347 Mitochondrial FPGS levels play important roles in determining the anti-tumor efficacies of pyrrolo[3,2-d]pyrimidine antifolates for pancreatic cancer.
  • ||||||||||  doxycycline / Generic mfg., acetylcysteine solution / Generic mfg.
    Journal:  acetylcysteine promotes doxycycline resistance in the bacterial pathogen edwardsiella tarda. (Pubmed Central) -  Sep 17, 2024   
    We also propose that NAC promotes protein aggregation, thus contributing to antibiotic resistance. Our study describes the mechanism underlying E. tarda resistance to doxycycline and cautions against the indiscriminate use of metabolite adjuvants.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Cat-Scratch Disease Mimicking Neoplastic Etiology in a Complex Clinical Presentation: A Case Report. (Pubmed Central) -  Sep 17, 2024   
    Empirical doxycycline therapy was initiated, resulting in the complete resolution of symptoms. This case underscores the importance of considering CSD in the differential diagnosis of lymphadenopathy, particularly in people living with HIV regardless of immunocompetency, and highlights the challenges of diagnosis and management in complex patients.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Protracted Course of Staphylococcus lugdunensis Septic Arthritis in Native Knee Joint. (Pubmed Central) -  Sep 17, 2024   
    Few cases of native joint infections with S. lugdunensis have been documented, and to our knowledge, the impact of treatment noncompliance on the sequelae of septic arthritis with this organism has not been reported. Socioeconomic factors and comorbidities have been shown to increase a patient's risk for an extended joint infection with S. lugdunensis.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Bacteremia Due to Lactococcus lactis cremoris Following Food Poisoning: A Case Report. (Pubmed Central) -  Sep 17, 2024   
    The patient gave a history of travel to a local pilgrimage and consumption of unpasteurized dairy products for a week leading up to the incident. The patient was treated with intravenous doxycycline and recovered after seven days of treatment with sterile blood cultures on follow-up.
  • ||||||||||  ivermectin topical / Generic mfg.
    Review, Journal:  Efficacy of Treatments in Reducing Inflammatory Lesion Count in Rosacea: A Systematic Review. (Pubmed Central) -  Sep 15, 2024   
    Several topical and systemic therapies have demonstrated efficacy in reducing inflammatory lesion count in rosacea patients, with mechanisms of action centred around suppressing inflammation and killing Demodex folliculorum mites. Additional research is required to determine effective combination therapies in rosacea.
  • ||||||||||  Journal:  Tuberculosis or Nontuberculosis? A Case of Mycobacterial Skin Infection. (Pubmed Central) -  Sep 15, 2024   
    Antibiotics such as quinolones, trimethoprim-sulfamethoxazole, linezolid, doxycycline, clarithromycin, azithromycin, imipenem, tigecycline, linezolid, and amikacin are recommended at least in dual combination therapy. In this case presentation, the diagnosis and treatment of a 2-year skin soft-tissue infection with M. fortuitum growth in culture will be discussed.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Learning from Classic: DNA-Based Conditional Equilibrium Constant To Regulate Affinity "On-the-Fly" for Bioassays. (Pubmed Central) -  Sep 15, 2024   
    The proof of concept of affinity programming also allows improved discrimination of single-nucleotide variants as well as assaying ribonuclease and doxycycline in a homogeneous solution. Therefore, the theory of DNA-based conditional equilibrium constant (K'DNA) will enable to engineer versatile DNA switches with programmable affinity in assays and bionanotechnology.
  • ||||||||||  ambroxol oral / Generic mfg., doxycycline / Generic mfg.
    Journal:  An Inducible Luminescent System to Explore Parkinson's Disease-Associated Genes. (Pubmed Central) -  Sep 14, 2024   
    Moreover, the GCase chaperone ambroxol elicited an increase in the luminescence signal in HiBiT-tagged GBA1 cells, correlating with an increase in the levels of GCase in dopaminergic cells. Taken together, we have developed and validated a Doxycycline-inducible luminescence system to serve as a sensitive assay for the quantification, localization, and activity of HiBiT-tagged PD-associated proteins with reliable sensitivity and efficiency.
  • ||||||||||  doxycycline / Generic mfg.
    Journal, Machine learning:  Systems Biology and Machine Learning Identify Genetic Overlaps Between Lung Cancer and Gastroesophageal Reflux Disease. (Pubmed Central) -  Sep 13, 2024   
    The present study is the first of its kind that combines in silico and machine learning algorithms to identify the gene signatures that relate to both LC and GERD and promising drug candidates that warrant further research in relation to therapeutic innovation in LC and GERD. Finally, this study also suggests upstream regulators, including microRNAs and transcription factors, that can inform future mechanistic research on LC and GERD.
  • ||||||||||  doxycycline / Generic mfg., isotretinoin / Generic mfg.
    Review, Journal:  Acne and the cutaneous microbiome: A systematic review of mechanisms and implications for treatments. (Pubmed Central) -  Sep 13, 2024   
    Despite the heterogeneity of study types and microbiome classifications limiting the analysis, this review underscores the complexity of microbial involvement in acne pathogenesis. It delineates the effects of acne therapeutics on microbial diversity, abundance and composition, emphasizing the necessity for personalized approaches in acne management based on microbiome modulation.
  • ||||||||||  Journal:  Emergency department utilization in Veterans with spinal cord injuries & disorders. (Pubmed Central) -  Sep 11, 2024   
    Overall, more than half of Veterans with SCI/D required an ED visit during the five-year study period and over one third of Veterans in each fiscal year required an ED visit. Interventions to target prevention of ED visits and subsequent hospitalizations could focus on these areas.
  • ||||||||||  doxycycline / Generic mfg.
    Preclinical, Journal:  A novel mouse model for hepatocyte-specific apoptosis-induced myeloid cell-dominant sterile liver injury and repair. (Pubmed Central) -  Sep 11, 2024   
    After subcutaneous administration of a single dose of doxycycline (5 mg/kg, Dox) to 3xTg-iHAP mice, we observed a complete histological spectrum of sterile liver wound-healing responses: asymptomatic hepatocyte apoptosis at 8 h, necrotic liver injury and sterile inflammation at 48 h, followed by hepatocyte mitosis and regeneration within 7 days...Together, we established a novel mouse model of injury and regeneration induced by hepatocyte apoptosis. This tool provides a robust in vivo platform for studying the pathophysiology of sterile liver inflammation, regeneration, and new therapeutic interventions for liver diseases.