doxycycline / Generic mfg. 
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  • ||||||||||  doxycycline / Generic mfg.
    Preclinical, Journal:  Dual TGFβ and Wnt inhibition promotes Mesp1-mediated mouse pluripotent stem cell differentiation into functional cardiomyocytes. (Pubmed Central) -  Aug 21, 2021   
    Here, we utilize a doxycycline-inducible Mesp1-expressing mouse embryonic stem cell system to develop an efficient differentiation protocol to generate functional cardiomyocytes...Moreover, cardiomyocytes thus derived are functional, displaying intrinsic contractile capacity and contraction in response to electric stimulus. Derivation of mouse cardiomyocytes without the use of growth factors or other costly supplementation provides an accessible cell source for future applications.
  • ||||||||||  vancomycin / Generic mfg., ceftriaxone / Generic mfg., ampicillin / Generic mfg.
    Journal:  Molecular detection of vancomycin and methicillin resistance in Staphylococcus aureus isolated from food processing environments. (Pubmed Central) -  Aug 20, 2021   
    All S. aureus isolates obtained from non-hotel samples were susceptible to chloramphenicol, ceftriaxone, ciprofloxacin, doxycycline, meropenem, and vancomycin; however, 40% of isolates were resistant to novobiocin...The presence of methicillin-resistant S. aureus (MRSA) which is also vancomycin-resistant in food processing environments is a threat to public health. This is the first report on the molecular detection of methicillin and vancomycin-resistant S. aureus isolated from food processing environments in Bangladesh.
  • ||||||||||  doxycycline / Generic mfg.
    Clinical, Journal:  An AIDS Patient with Recurrent Multiple Skin Crusted Ulcerations. (Pubmed Central) -  Aug 20, 2021   
    Malignant syphilis is a rare form of secondary syphilis, but tends to occur in acquired immune deficiency syndrome patients because of poor immunity. Although the clinical manifestations of malignant syphilis are severe, the response to the therapy of penicillin and doxycycline are excellent, even with repeated infection.
  • ||||||||||  doxycycline / Generic mfg.
    Preclinical, Journal:  Murine Typhus Presenting With Mucosal Involvement. (Pubmed Central) -  Aug 20, 2021   
    Laboratory abnormalities may include elevated C-reactive protein, elevated erythrocyte sedimentation rate, hypoalbuminemia, elevated transaminases, elevated neutrophil band count, and thrombocytopenia. The treatment of choice for R. typhi is doxycycline.
  • ||||||||||  doxycycline / Generic mfg., azithromycin / Generic mfg.
    Trial completion date, Trial primary completion date:  Treatment of Macrolide-resistant Mycoplasma Pneumoniae (clinicaltrials.gov) -  Aug 18, 2021   
    P=N/A,  N=100, Recruiting, 
    Trial completion date: Mar 2024 --> Dec 2023 | Trial primary completion date: Mar 2023 --> Dec 2023 Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2020 --> Dec 2021
  • ||||||||||  Xolair (omalizumab) / Roche, Novartis, Rituxan (rituximab) / Roche
    Trial completion date, Trial primary completion date:  Efficacy and Safety of Rituximab Combined With Omalizumab in Patients With Bullous Pemphigoid (clinicaltrials.gov) -  Aug 18, 2021   
    P3,  N=15, Not yet recruiting, 
    N=60 --> 20 | Recruiting --> Terminated; COVID-19 Trial completion date: Nov 2021 --> Nov 2023 | Trial primary completion date: May 2021 --> May 2023
  • ||||||||||  doxycycline / Generic mfg.
    Trial completion date:  Lipidome and Microbiome Profile of the Eye in Rosacea (clinicaltrials.gov) -  Aug 18, 2021   
    P1,  N=30, Active, not recruiting, 
    Trial completion date: Nov 2021 --> Nov 2023 | Trial primary completion date: May 2021 --> May 2023 Trial completion date: Aug 2021 --> Nov 2021
  • ||||||||||  remdesivir / Generic mfg., ivermectin oral / Generic mfg.
    Preclinical, Journal:  Combination Treatment With Remdesivir and Ivermectin Exerts Highly Synergistic and Potent Antiviral Activity Against Murine Coronavirus Infection. (Pubmed Central) -  Aug 17, 2021   
    Using an in vitro model of MHV infection of RAW264.7 macrophages, the safety and efficacy of monotherapy of remdesivir, chloroquine, ivermectin, and doxycycline were investigated...The next best synergistic combination was remdesivir with doxycycline, which decreased levels of live virus by ~3-log and viral RNA by ~1.5-log. These results warrant further studies to explore the mechanisms of action of the combination therapy, as well as future in vivo experiments and clinical trials for the treatment of SARS-CoV-2 infection.
  • ||||||||||  clarithromycin / Generic mfg., amoxicillin / Generic mfg.
    Journal:  Different antibiotic profiles in wild and farmed Chilean salmonids. Which is the main source for antibiotic in fish? (Pubmed Central) -  Aug 15, 2021   
    All farmed salmon samples were associated with ofloxacin, tetracycline, cephalexin, erythromycin, azithromycin, roxithromycin, sulfabenzamide, sulfamethazine, sulfapyridine, sulfisomidin, and sulfaguanidine...Further research is necessary for linking the ABs profile in wild fish with the anthropic source. However, to our knowledge, this is the first report showing differences in the ABs profile between wild and aquaculture salmonids, which could have both environmental and health consequences.
  • ||||||||||  rifampicin / Generic mfg.
    Journal:  Systemic Bartonellosis Manifesting With Endocarditis and Membranoproliferative Glomerulonephritis. (Pubmed Central) -  Aug 15, 2021   
    Repeat echocardiogram in 4 months demonstrated a resolution of valvular vegetations; however, the left eye blindness was permanent. In the present case the correct diagnosis of systemic bartonellosis allowed institution of appropriate antibiotic therapy and to also achieve a partial recovery of renal function and to discontinue hemodialysis.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Granulocytic anaplasmosis in captive ring-tailed lemur (Lemur catta) in Poland. (Pubmed Central) -  Aug 15, 2021   
    Thus, miR-494-3p might modulate MYH2 expression and fast oxidative myotube formation by directly regulating p300 levels during skeletal myogenesis in MyoD-hiPSCs and murine skeletal muscle tissues. This is the first report on granulocytic anaplasmosis in a ring-tailed lemur in Europe, indicating that A. phagocytophilum infection must also be considered in differential diagnosis in this animal species, especially in individuals with thrombocytopenia associated with Ixodes ricinus parasitism.
  • ||||||||||  doxycycline / Generic mfg.
    Preclinical, Journal:  Downregulation of miR-142a Contributes to the Enhanced Anti-Apoptotic Ability of Murine Chronic Myelogenous Leukemia Cells. (Pubmed Central) -  Aug 14, 2021   
    Scl/tTA and TRE-BA transgenic mice were crossed in the presence of doxycycline to get double transgenic mice...Moreover, miR-142a overexpression could partially rescue the abnormal anti-apoptotic phenotype and attenuate CML progression. Taken together, this study explored the miRNA-mRNA regulatory networks in murine CML LSKs and demonstrated that ERK-miR-142a-Ciapin1 axis played an essential role in CML pathogenesis.
  • ||||||||||  moxidectin / Generic mfg., doxycycline / Generic mfg.
    Clinical, Review, Journal:  An Accessible Alternative to Melarsomine: "Moxi-Doxy" for Treatment of Adult Heartworm Infection in Dogs. (Pubmed Central) -  Aug 14, 2021   
    In moxi-doxy protocols, doxycycline should be repeated annually until NAD. This review summarizes the safety and efficacy of moxi-doxy, addresses controversies surrounding this treatment approach, and provides detailed recommendations for treatment regimens and post-treatment testing.
  • ||||||||||  ampicillin / Generic mfg., rifampicin / Generic mfg., amoxicillin / Generic mfg.
    Journal:  Occurrence and antibiogram signatures of some Vibrio species recovered from selected rivers in South West Nigeria. (Pubmed Central) -  Aug 14, 2021   
    Antibiotic resistance by all Vibrio species was mostly observed against doxycycline (71-89%), erythromycin (86-100%), tetracycline (71-89%), rifampicin (86-100%), and sulfamethoxazole (87-100%), though susceptibility to meropenem (86-100%), cephalothin (60-100%), norfloxacin (93-100%), ciprofloxacin (88-100%), amikacin (64-100%), gentamicin (57-74%), and trimethoprim/sulfamethoxazole (57-81%) was equally observed in all species...High resistance against ampicillin (57%) and amoxicillin (50%) was exhibited by V. cholerae and V. mimicus respectively...This study reveals high prevalence of Vibrio species in the selected rivers as well as elevated resistance against some first-line antibiotics, which suggests possible inappropriate antimicrobial usage around study communities. We conclude that the freshwater resources investigated are unfit for domestic, industrial, and recreational uses without treatment prior to use and are potential reservoirs of antibiotic-resistant Vibrio species in this environment.
  • ||||||||||  doxycycline / Generic mfg., azithromycin / Generic mfg.
    [VIRTUAL] Organic and medicinal chemistry meeting biophysics: Solving microbiological problems (Room: Zoom Room 18) -  Aug 13, 2021 - Abstract #ACSFall2021ACS_Fall_6155;    
    Our results indicate that pyridine-based molecules are a promising scaffold to develop drugs that are selective for CT. In addition, we have solved the structure of a CT cylindrical protease subunit, which will be key to developing molecules that are selective for this promising target.
  • ||||||||||  doxycycline / Generic mfg.
    Preclinical, Journal:  A novel Axin2 knock-in mouse model for visualization and lineage tracing of WNT/CTNNB1 responsive cells. (Pubmed Central) -  Aug 13, 2021   
    The resulting knock-in allele expresses a bright fluorescent reporter (3xNLS-SGFP2) and a doxycycline-inducible driver for lineage tracing (rtTA3)...It faithfully reports the subtle and dynamic changes in physiological WNT/CTNNB1 signaling activity that occur in vivo. We expect this mouse strain to be a useful resource for biologists who want to track and trace the location and developmental fate of WNT/CTNNB1 responsive stem cells in different contexts.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Increased nuclear but not cytoplasmic activities of CELF1 protein leads to muscle wasting. (Pubmed Central) -  Aug 11, 2021   
    To understand the contribution of nuclear and cytoplasmic CELF1 activity to normal and pathogenic skeletal muscle biology, we generated transgenic mice for doxycycline-inducible and skeletal muscle-specific expression of active CELF1 mutants engineered to be localized predominantly to either the nucleus or the cytoplasm...RNA-sequencing revealed extensive gene expression and AS changes in mice overexpressing nuclear and naturally-localized CELF1 protein, with affected genes involved in cytoskeleton dynamics, membrane dynamics, RNA processing, and zinc ion binding. These results support a stronger role for nuclear CELF1 functions as compared to cytoplasmic CELF1 functions in skeletal muscle wasting.