- |||||||||| doxycycline / Generic mfg.
Journal: Doxycycline promotes proteasome fitness in the central nervous system. (Pubmed Central) - Nov 4, 2021
Our results suggest that the UPR initiates a conserved mitochondria-to-cytosol stress signal, resulting in proteasome activation, and that this signal has adapted during evolution, in a sex and tissue specific-manner. Therefore, while our results support the use of doxycycline in the prevention of proteopathic diseases, they also indicate that sex is an important variable to consider in the design of future clinical trials using doxycycline.
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg.
Clinical, Journal: Prospective Study to Assess the Response to Therapy and Its Predictors in Children with Scrub Typhus. (Pubmed Central) - Nov 4, 2021
The logistic regression analysis revealed that the presence of splenomegaly (Adjusted Odds Ratio (AOR) 2.60; 95% Confidence interval (CI) = 1.49-4.53; p = 0.001) and lung crepts (AOR 2.02; 95% CI = 1.06-3.85; p = 0.032) in azithromycin-treated group and presence of meningeal signs (AOR 16.11; 95% CI = 5.47-47.45; p 48 h). Doxycycline is superior to azithromycin in defervescing fever, reducing hospital stay and preventing severity in pediatric ST.
- |||||||||| doxycycline / Generic mfg.
TREATING COVID-19 PNEUMONIA WITH DOXYCYCLINE DOES NOT IMPROVE MORTALITY (Hall B (1st Floor); Monitor 12) - Nov 2, 2021 - Abstract #ACAAI2021ACAAI_987;
In a further logistic regression model containing every risk factor, adjusted odds ratio of death was 0.99 (95% CI [0.91, 1.07], p =0.722). Conclusion Treating COVID-19 pneumonia with doxycycline did not improve mortality.
- |||||||||| Humira (adalimumab) / Eisai, AbbVie
BLEPHAROCHALASIS: A HEREDITARY ANGIOEDEMA-MASQUERADER. RECURRENT ANGIOEDEMA IN A 12 YEAR-OLD AFRICAN AMERICAN MALE (Hall B (1st Floor); Monitor 03) - Nov 2, 2021 - Abstract #ACAAI2021ACAAI_761;
He was trialed on antibiotics, antihistamines, prednisone, and ecallantide...Subsequent intramuscular epinephrine and adalimumab also failed...Ophthalmology ultimately diagnosed blepharochalasis and trialed doxycycline, with surgical repair now considered...Orbital pseudotumor, idiopathic angioedema, granulomatous lymphangitis (Melkersson-Rosenthal syndrome), and IgE-mediated processes were considered and ruled out. Treatment for blepharochalasis involves reducing inflammation during attacks, but is ultimately surgical, requiring resection of inflamed tissue.
- |||||||||| Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
UNDER THE MASQUERADE OF ANGIOEDEMA, CHEILITIS GRANULOMATOSA AN IMPORTANT CLINICAL CONSIDERATION (Hall B (1st Floor); Monitor 03) - Nov 2, 2021 - Abstract #ACAAI2021ACAAI_751;
She did not improve with diphenhydramine, prednisone, or tofacitinib discontinuation...Concurrent medications including ciprofloxacin and rifaximin were discontinued with no difference in swelling...Empiric treatment of CG with doxycycline and topical tacrolimus was initiated...Discussion An atypical pattern of symptom development and treatment response should prompt consideration of alternative etiologies of lip swelling. Early diagnosis of CG allows for targeted therapies and avoids unnecessary labeling of hypersensitivities that may negatively impact patient comorbidities.
- |||||||||| Dupixent (dupilumab) / Sanofi, Regeneron
NEW-ONSET ROSACEA IN A PATIENT ON DUPILUMAB TREATMENT FOR NASAL POLYPOSIS (Hall B (1st Floor); Monitor 01) - Nov 2, 2021 - Abstract #ACAAI2021ACAAI_677;
The mechanisms underpinning these adverse effects should be explored to better enable physician recognition and treatment. Providers should be aware of these reactions when counseling patients, particularly those with a history of rosacea.
- |||||||||| doxycycline / Generic mfg.
[VIRTUAL] Doxycycline Sclerodesis of a Large Morel-Lavallée Lesion: A Case Report () - Nov 1, 2021 - Abstract #AAPMR2021AAPMR_380;
The treatment of Morel-Lavallée lesions has evolved over time to favor conservative options such as doxycycline sclerotherapy. Further investigation is needed to clarify the recommended size/volume cutoffs for surgical versus conservative management for Morel-Lavallée lesions.
- |||||||||| doxycycline / Generic mfg.
Journal: 20-HETE Interferes with Insulin Signaling and Contributes to Obesity-Driven Insulin Resistance. (Pubmed Central) - Oct 31, 2021
Mice in which Cyp4a12 was induced by doxycycline (DOX) at the onset of HFD feeding gained weight at a greater rate and extent than corresponding DOX-untreated Cyp4a12 mice...Additional studies in 3T3-1 differentiated adipocytes confirmed that 20-HETE impairs insulin signaling and that its effect may require activation of its receptor GPR75. Taken together, these results provide strong evidence that 20-HETE interferes with insulin function and contributed to diet-driven insulin resistance.
- |||||||||| ceftriaxone / Generic mfg.
Clinical, Journal: Changes in Antibiotic Treatment for Children With Lyme Meningitis 2015-2020. (Pubmed Central) - Oct 31, 2021
Parenteral antibiotic treatment of children with Lyme meningitis has been on the decline in advance of the published clinical guideline. Carefully designed comparative effectiveness studies are needed to examine the effect of oral versus parenteral treatment regimens on clinical outcomes.
- |||||||||| doxycycline / Generic mfg.
Clinical, Review, Journal: Acute transverse myelitis following scrub typhus: A case report and review of the literature. (Pubmed Central) - Oct 30, 2021
Doxycycline, the standard treatment for scrub typhus, was administered...Conclusions Orientia tsutsugamushi causes scrub typhus, which can affect not only the brain, but also the spinal cord. Although acute transverse myelitis develops rarely from scrub typhus, this should be considered as differential diagnosis in patients of fever with neurological deficit in endemic areas.
- |||||||||| Sulonex (sulodexide) / Alfasigma, Defitelio (defibrotide) / IRCCS San Raffaele Hospital, Jazz
Review, Journal: A Literature Review of Pharmacological Agents to Improve Venous Leg Ulcer Healing. (Pubmed Central) - Oct 30, 2021
Venous leg ulcer pharmacological treatment options were searched in the English language from February 2020 to March 2020 using numerous databases and sites, such as PubMed. Drugs used adjunctively with compression therapy that facilitate healing in long-standing or large VLUs include micronized purified flavonoid fraction, pentoxifylline, sulodexide, and mesoglycan.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: In vivo proton magnetic resonance spectroscopy detection of metabolite abnormalities in aged Tat-transgenic mouse brain. (Pubmed Central) - Oct 30, 2021
Tat-transgenic (Tat-tg) mice are used to study Tat's effects, typically after transgene induction with doxycycline...However, additional studies in controls not expressing Tat are needed to confirm this point and to deconvolve individual effects of age and Tat expression. Sex steroid hormone supplements, which counter climacteric effects, increase taurine levels, and reduce inflammation and oxidative stress, could attenuate some of the brain abnormalities we identified in aged Tat-tg mice.
- |||||||||| isotretinoin oral / Generic mfg.
Journal: Rosacea: An Update in Diagnosis, Classification and Management. (Pubmed Central) - Oct 30, 2021
Topical metronidazole, topical ivermectin, and topical azelaic acid are appropriate for maintenance therapy. In conclusion, the updated phenotype approach, based on presenting clinical features, is the foundation for current diagnosis, classification, and treatment of rosacea.
- |||||||||| doxycycline / Generic mfg.
Journal: Mutation-specific effects of NRAS oncogenes in colorectal cancer cells. (Pubmed Central) - Oct 29, 2021
To elucidate specific functions of NRAS mutations in CRC, we expressed doxycycline-inducible G12D and Q61K mutations in the CRC cell line Caco-2...In addition, RNA sequencing results indicated activation of the IL1-, JAK/STAT-, NFκB- and TNFα signalling pathways. These results form the basis for an NRAS-driven inflammatory phenotype in CRC.
- |||||||||| doxycycline / Generic mfg.
Review, Journal: Mediterranean Spotted Fever: Current Knowledge and Recent Advances. (Pubmed Central) - Oct 28, 2021
Doxycycline remains the treatment of choice, while preventive measures are focused on modification of human behavior and vector control strategies. The purpose of this review is to summarize the current knowledge on the epidemiology, pathogenesis, clinical features, diagnosis, and treatment of MSF.
- |||||||||| doxycycline / Generic mfg.
Journal: DNA REPAIR PATHWAYS ARE ALTERED IN NEURAL CELL MODELS OF FRATAXIN DEFICIENCY. (Pubmed Central) - Oct 28, 2021
As part of the overall efforts to understand the molecular basis of neurodegeneration in FRDA, a new human neural cell line with doxycycline-induced FXN knockdown was established...These results suggest that the deficiency of FXN leads to a down-regulation of DNA repair pathways that synergizes with oxidative stress to provoke DNA damage, which may be involved in the pathogenesis of FRDA. Thus, a failure in DNA repair may be considered a shared common molecular mechanism contributing to neurodegeneration in a number of hereditary ataxias including FRDA.
- |||||||||| Xolair (omalizumab) / Roche, Novartis
Journal: State of the Art in Cystic Fibrosis Pharmacology Optimization of anti-microbials in the treatment of Cystic Fibrosis Pulmonary Exacerbations: III. Executive Summary. (Pubmed Central) - Oct 28, 2021
aureus) antibiotics include ceftaroline, clindamycin, fluoroquinolone derivatives (ciprofloxacin, levofloxacin), glycopeptide derivatives (telavancin, vancomycin), linezolid, rifampin, sulfamethoxazole/trimethoprim, and tetracycline derivatives (doxycycline, minocycline, tigecycline). Medications used for ABPA include corticosteroids, amphotericin B, azole anti-fungals (isavuconazole, itraconazole, posaconazole, and voriconazole), and a monoclonal antibody, omalizumab.
- |||||||||| Xeljanz (tofacitinib) / Pfizer
Journal: Granulomatous rosacea-like dermatitis under therapy with tofacitinib (Pubmed Central) - Oct 28, 2021
It is well known that the class of JAK inhibitors can cause infectious and allergic cutaneous side effects. However, sterile papulopustular dermatitis as a side-effect has rarely been reported to date.
- |||||||||| doxycycline / Generic mfg.
Journal: Induction of apically mistrafficked epiregulin disrupts epithelial polarity via aberrant EGFR signaling. (Pubmed Central) - Oct 28, 2021
Using a doxycycline-inducible system in 3D Matrigel cultures, we now show that induction of Y156A EREG in fully formed MDCK cysts results in direct and complete delivery of mutant EREG to the apical cell surface...Moreover, the most frequent EREG mutation in human cancer (R147stop) results in its apical mistrafficking in engineered MDCK cells. Thus, induction of EREG apical mistrafficking is sufficient to disrupt selective aspects of polarity of a preformed polarized epithelium.
- |||||||||| doxycycline / Generic mfg., tetracycline / Generic mfg.
Review, Journal: Treatment Options for Lower Eyelid Festoons. (Pubmed Central) - Oct 27, 2021
Fortunately, a variety of treatment options exist that can benefit each patient and be tailored to their specific needs. Knowledge of the underlying anatomy, clinical characteristics, and clinical evaluation will better equip the treating physician to manage festoons.
- |||||||||| doxycycline / Generic mfg.
Journal, IO biomarker: Proteolysis-Targeting Chimeras Enhance T Cell Bispecific Antibody-Driven T Cell Activation and Effector Function through Increased MHC Class I Antigen Presentation in Cancer Cells. (Pubmed Central) - Oct 27, 2021
T cell-mediated response directed against cancer cells was tested on treatment with a TCR-like TCB, which was able to bridge human T cells to a WT1 peptide displayed on MHC I. FKBP12 degrader treatment increased the expression of early and late activation markers (CD69, CD25) in T cells; the secretion of granzyme β, IFN-γ, and TNF-α; and cancer cell killing in a tumor-T cell coculture model. This study supports harnessing targeted protein degradation in tumor cells, for modulation of T cell effector function, by investigating for the first time, to our knowledge, the potential of combining a degrader and a TCB in a cancer immunotherapy setting.
- |||||||||| ciprofloxacin oral / Generic mfg., doxycycline / Generic mfg.
Journal: Hypermetabolic pulmonary lesions on FDG-PET/CT: tularemia or neoplasia? (Pubmed Central) - Oct 27, 2021
This study supports harnessing targeted protein degradation in tumor cells, for modulation of T cell effector function, by investigating for the first time, to our knowledge, the potential of combining a degrader and a TCB in a cancer immunotherapy setting. Depending on the epidemiological setting, pulmonary tularemia may be considered an alternative diagnosis to lung cancer, lymphoma, or tuberculosis, in the presence of infectious symptoms and hypermetabolic pulmonary lesions and mediastinal lymphadenopathies on PET/CT.
- |||||||||| ceftriaxone / Generic mfg., clarithromycin / Generic mfg., rifampicin / Generic mfg.
Journal: Antimicrobial resistance spectrum conferred by pRErm46 of emerging macrolide (multidrug)-resistant Rhodococcus equi. (Pubmed Central) - Oct 27, 2021
pRErm46 variants with spontaneous deletions in the class 1 integron (C1I) region, observed in ≈30% of erm(46)-positive isolates, indicated that the newly identified resistances were attributable to C1I's sulfonamide (sul1) and aminoglycoside (aaA9) resistance cassettes and adjacent tetRA(33) determinant. Most MDR isolates carried the rpoB mutation of the 2287 clone, while different rpoB mutations (S531L, S531Y) detected in two cases suggest the emergence of novel MDR R. equi strains.
- |||||||||| Journal: Emerging presence of urethritis and balanitis by Pasteurella bettyae. (Pubmed Central) - Oct 27, 2021
This novel finding highlights the need for complete microbiological screening in adequate samples to detect possible infectious agents in these cases, not limited to conventional agents. These rare microorganisms can be detected by the application of Maldi-Tof in colonies grown in culture media.
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