- |||||||||| doxycycline / Generic mfg.
Morphological and electrophysiological characterization of STXBP1 patient iPSC-derived cortical-like pyramidal neurons () - Dec 12, 2021 - Abstract #AES2021AES_883;
Whole cell patch-clamp recordings showed significant reductions in both sEPSC frequency (0.33 ± 0.07 Hz, n=15) and amplitudes (8.84 ± 1.26 pA, n=15) in STXBP1 patient neurons compared to controls (4.49 ± 0.88 Hz and 30.54 ± 3.66 pA, respectively, n=13, p< 0.001), suggesting that spontaneous neurotransmitter release from presynaptic terminals is significantly impaired. Consistent with this result, the patient neurons had significantly higher threshold potentials for action potential initiation, higher sensitivity to depolarization-induced block, slower maximum rise rates, and lower firing frequency (P< 0.001, n=29) compared to controls (n=21).
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: Generation of AAVS1 integrated doxycycline-inducible CRISPR-Prime Editor human induced pluripotent stem cell line. (Pubmed Central) - Dec 10, 2021
Prime editing of iPSCs resulted in precise insertion of three nucleotides in HEK3 locus with high efficiency, demonstrating the utility of this approach. This engineered cell line can be used to edit a single or multiple genomic loci by introducing a target-specific pegRNA for precise and effective genome editing to facilitate disease modeling and functional genetics studies.
- |||||||||| doxycycline / Generic mfg.
SEXUALLY TRANSMITTED INFECTIONS PROPHYLAXIS, IS THIS THE ANSWER? ([VIRTUAL]) - Dec 9, 2021 - Abstract #CROI2022CROI_26;
STI antimicrobial prophylaxis has been explored in several studies and concerns are still raised around possible resistance to current antimicrobial agents as has been noted particularly with GC. The presentation will explore the options of prophylaxis of STI’s management s and also suggest mechanisms for programmatic and research implications by drawing on research done globally with a focus on doxycycline for STI prophylaxis.
- |||||||||| tetracycline / Generic mfg.
Observational data, Journal: Multivalent cations interactions with fluoroquinolones or tetracyclines: A cross-sectional study. (Pubmed Central) - Dec 7, 2021
Despite being a very known contraindicated DDI, the prevalence of simultaneous co-administration of oral fluoroquinolones or tetracyclines with polyvalent cations was extremely high in a hospital with handwritten MARs. Antimicrobial stewardship programs should target this DDI, and future studies should evaluate the impact of different practical solutions to this problem in different clinical settings.
- |||||||||| doxycycline / Generic mfg.
Clinical, Journal: Human granulocytic anaplasmosis combined with rhabdomyolysis: a case report. (Pubmed Central) - Dec 6, 2021
HGA can lead to serious complications in patients with associated risk factors. Therefore, in patients with HGA accompanied by rhabdomyolysis, management with antibiotics and hydration should be initiated immediately, and not delayed until diagnostic confirmation.
- |||||||||| doxycycline / Generic mfg., tetracycline / Generic mfg.
Journal: Lentivirus-mediated Conditional Gene Expression. (Pubmed Central) - Dec 5, 2021
This flexible lentiviral expression platform may be used for stable and robust induction of a gene of interest in a range of cells for multiple applications. Graphic abstract: Schematic overview of lentiviral transduction of THP-1 cells.
- |||||||||| doxycycline / Generic mfg.
Journal: Acute disseminated encephalomyelitis due to Rickettsia conorii infection. (Pubmed Central) - Dec 2, 2021
To our knowledge this is the first case of ADEM associated with Mediterranean spotted fever - we found a previous report of ADEM in a child with Rocky Mountain spotted fever, whose diagnosis of rickettsial infection was also delayed. We hypothesise that delayed diagnosis of spotted fever group rickettsial infections could rarely result in ADEM.
- |||||||||| doxycycline / Generic mfg.
Journal: Facile fabrication of robust, versatile, and recyclable biochar-graphene oxide composite monoliths for efficient removal of different contaminants in water. (Pubmed Central) - Dec 2, 2021
Characterization results indicated the BC-GO composite monolith had abundant microchannels, nanopores, and a large specific surface area, thereby exhibiting a high adsorption capacity of 796.8 mg g to doxycycline in water, which was superior to conventional adsorbents...In addition, both BC-GO composite monoliths were highly stable and could be reused for a number of cycles of pollutants removal. The simplicity, environmental friendliness, and effectiveness of our approach to building BC-GO composite monoliths may pave the way for their future applications in the field of water purification.
- |||||||||| Humira (adalimumab) / Eisai, AbbVie
Clinical, Journal, HEOR: Economic analysis of the costs associated with Hidradenitis suppurativa at a German University Hospital. (Pubmed Central) - Dec 1, 2021
However, the primary goal of physicians is not and should not be to save costs regarding their patients`treatment, but rather the premise to utilize the existing resources as efficient as possible. Reducing the use of costly therapeutics and inpatient stays therefore requires more effective therapy options with an improved cost-benefit profile.
- |||||||||| losartan potassium / Generic mfg., doxycycline / Generic mfg.
Journal: Connective Tissue Disorders and Cardiovascular Complications: The Indomitable Role of Transforming Growth Factor-β Signaling. (Pubmed Central) - Dec 1, 2021
With overwhelming evidence of the involvement of aberrant Transforming Growth Factor-beta (TGF-β) signaling in MFS and LDS, this signaling pathway may represent the common link in the relationship between connective tissue disorders and their associated cardiovascular complications. To further explore this hypothetical link, this chapter will review the TGF-β signaling pathway, the heritable connective tissue syndromes related to aberrant TGF-β signaling, and will discuss the pathogenic contribution of TGF-β to these syndromes with a primary focus on the cardiovascular system.
- |||||||||| tetracycline / Generic mfg.
Clinical, Review, Journal: Nonantibiotic Properties of Tetracyclines in Rosacea and Their Clinical Implications. (Pubmed Central) - Nov 30, 2021
This includes reviewing the inflammatory aspects of rosacea that correlate with the known nonantibiotic properties of tetracyclines and providing the most up-to-date clinical evidence supporting the use of tetracyclines to treat rosacea. Given the evolving and multifactorial nature of pathophysiology, this review offers clinicians a unified picture that includes research on the links between rosacea pathophysiology and clinical presentation, the nonantibiotic properties of tetracyclines that relate to pathophysiologic pathways in rosacea, and the potential for clinical application of tetracyclines in rosacea therapy.
- |||||||||| rifampicin / Generic mfg.
Clinical, Journal: Comprehensive Approach to Reduce Surgical Site Infections in Patients Undergoing Neurosurgical Procedures. (Pubmed Central) - Nov 29, 2021
Those identified as colonized received a 10-day decolonization protocol that consisted of: oral doxycycline 100 mg twice daily or oral trimethoprim-sulfamethoxazole (TMP-SMX) DS twice daily; oral rifampin 600 mg daily; daily bathing with chlorhexidine; and twice daily use of mupirocin ointment in each nostril and under the fingernails. In addition to cefazolin (weight-based dosing), vancomycin (weight-based dosing) was recommended for perioperative prophylaxis in known MRSA carriers and patients undergoing surgical procedures involving hardware implantation irrespective of colonization status...The overall rate of neurosurgical site infections can be reduced through a bundled approach of MRSA decolonization and change in perioperative antibiotic prophylaxis to include vancomycin for procedures involving hardware implantation irrespective of MRSA carriage state.
- |||||||||| doxycycline / Generic mfg., moxifloxacin intravenous / Generic mfg.
Clinical, Journal: Mycobacterium septicum associated peritonitis: A case report. (Pubmed Central) - Nov 29, 2021
Antibiotics were adjusted due to sensitivities profile and side effects, and he completed 4 months of antibiotic treatment with decreasing cell counts and negative PD fluid cultures. This case highlights the growing list of organisms responsible for NTM peritonitis and complexity of care in the patient with NTM peritonitis.
- |||||||||| ceftriaxone / Generic mfg., amoxicillin / Generic mfg.
Journal: Stages of Lyme Arthritis. (Pubmed Central) - Nov 29, 2021
Lyme arthritis provides unique insights into the complex interplay between microbes and host immunity. The progression from localized erythema migrans to early disseminated disease and late Lyme arthritis allows insight into arthritis initiation, and the study of postinfectious Lyme arthritis allows further insight into mechanisms of arthritis persistence.
- |||||||||| doxycycline / Generic mfg.
PK/PD data, Journal: Pharmacokinetics of doxycycline after oral administration of multiple doses in dogs. (Pubmed Central) - Nov 29, 2021
Doxycycline was used against numerous localized infections in different organs and tissues. For the strains with MIC < 1 μg/mL, PTA was close to 100%, even for the most demanding ones, specifically 94.98% for an index of 40% and 99.9% for an index of 25.
- |||||||||| doxycycline / Generic mfg.
Clinical, Journal: Doxycycline-induced idiopathic intracranial hypertension in a patient with Lyme disease. (Pubmed Central) - Nov 29, 2021
Idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri, is a rare but serious adverse reaction to this medication. This article reviews the pathophysiology, presentation, diagnosis, and treatment of a patient with disseminated Lyme disease complicated by doxycycline-induced IIH.
- |||||||||| doxycycline / Generic mfg.
Clinical, Journal: Case Report: Management of Refractory Filamentary Keratitis with N-acetylcysteine. (Pubmed Central) - Nov 29, 2021
N-acetylcysteine is not commercially available in an ophthalmic solution and must be compounded by a local pharmacist for patient use. Because filamentary keratitis can be challenging to manage because of frequent recurrences, addition of N-acetylcysteine to the treatment regimen should be considered a viable option in refractory cases when other therapies have failed to provide sustained symptomatic relief and resolution of filaments.
- |||||||||| Preclinical, Journal: A stable cell line inducibly expressing hERG1a/1b heteromeric channels. (Pubmed Central) - Nov 29, 2021
Here we report a new cell line stably expressing hERG1a, with hERG1b reliably controlled by an inducible promoter sensitive to doxycycline...Differences in pharmacological sensitivity between homomeric and heteromeric channels were observed for dofetilide and ebastine, but not fluoxetine, as evaluated by their IC values...The hERG1a/1b cell line thus represents an advanced model for contemporary drug safety screening assays such as CiPA that employ IC values to estimate risk of proarrhythmia in computational models of ventricular cardiomyocytes. This novel technology fulfills an unmet need to enhance specificity and foster a safe yet expanded drug development pipeline.
- |||||||||| doxycycline / Generic mfg.
Clinical, Journal: Small joint polyarthritis - An unusual presentation of scrub typhus in a child. (Pubmed Central) - Nov 29, 2021
We discuss a five-year-old boy who presented with fever, small joint polyarthritis, hepatosplenomegaly and pathognomonic eschar with positive scrub IgM ELISA. Arthritis resolved completely with doxycycline therapy without any deformity.
- |||||||||| tetracycline / Generic mfg., midazolam hydrochloride / Generic mfg.
Journal: Generation of tetracycline-controllable CYP3A4-expressing Caco-2 cells by the piggyBac transposon system. (Pubmed Central) - Nov 29, 2021
The CYP3A4-Caco-2 cells had enough ability to metabolize midazolam, a substrate of CYP3A4...Thus, we succeeded in establishing Caco-2 cells with CYP3A4 metabolizing activity comparable to in vivo human intestinal tissue. This cell line would be useful in pharmaceutical studies as a model that can simultaneously evaluate drug absorption and metabolism.
- |||||||||| doxycycline / Generic mfg., tetracycline / Generic mfg.
Journal, IO biomarker: Activation of the integrated stress response confers vulnerability to mitoribosome-targeting antibiotics in melanoma. (Pubmed Central) - Nov 29, 2021
Moreover, a melanoma patient exposed to doxycycline experienced complete and long-lasting response of a treatment-resistant lesion. Our study indicates that the repurposing of mitoribosome-targeting antibiotics offers a rational salvage strategy for targeted therapy in BRAF mutant melanoma and a therapeutic option for NRAS-driven and immunotherapy-resistant tumors.
- |||||||||| doxycycline / Generic mfg.
PK/PD data, Journal: Doxycycline pharmacokinetics in geese. (Pubmed Central) - Nov 29, 2021
The multiple-dose simulations showed a low accumulation index. A dosage of 10 mg/kg/day for 5 days seemed to be adequate for a good therapeutic efficacy without reaching unnecessarily high plasma concentrations.
- |||||||||| dexamethasone / Generic mfg.
Journal: Determination of veterinary drugs in microalgae biomass from photobioreactors fed with piggery wastewater. (Pubmed Central) - Nov 29, 2021
Some critical operation parameters of the QuEChERS procedure were optimized by an experimental design but tetracycline, oxytetracycline, doxycycline, marbofloxacin and ciprofloxacin were not detected by the QuEChERS sample preparation...Nine drugs were detected in the samples at relatively low concentration and a proportional relationship between the found concentrations and the octanol/water partition coefficients of the drugs has been outlined. Moreover, a linear ratio between the concentrations measured in biomass and effluent has been observed for most of the drugs.
- |||||||||| doxycycline / Generic mfg.
Journal: Mesoporous silica nanoparticles prepared by different methods for biomedical applications: Comparative study. (Pubmed Central) - Nov 29, 2021
The preparation method effect was evaluated on the drug release behaviour using doxycycline hyclate as a model drug...However, the release behaviour of S3 was satisfied for treatments which require long period with relatively highest release rate. The preparation method influenced the cell viability as S1 and S2 showed acceptable cell cytotoxicity compared with S3.
- |||||||||| doxycycline / Generic mfg.
Clinical, Journal: Absorption of N-acetylcysteine in Healthy and Mycoplasma gallisepticum-Infected Chickens. (Pubmed Central) - Nov 29, 2021
In healthy chickens treated solely with NAC, maximum plasma concentrations of 2.26 ± 0.91 µg mL were achieved at 2.47 ± 0.45 h after dosing. The value of absorption half-life was 1.04 ± 0.53 h. The population pharmacokinetic analysis showed that dose adjustment of NAC is not required in M. gallisepticum-infected broilers or when it is combined with doxycycline.
- |||||||||| amoxicillin / Generic mfg.
Review, Journal: Local/Topical Antibiotics for Peri-Implantitis Treatment: A Systematic Review. (Pubmed Central) - Nov 29, 2021
Overall, local antibiotic use can be considered a valid approach in the treatment of peri-implantitis. Therefore, future long-term clinical trials with standardised protocols and antibiotics with similar biological activity profiles should be tested to achieve a valid and definitive conclusion.
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