- |||||||||| doxycycline / Generic mfg.
Journal: Dermatoscopic Features of Early Erythema Chronicum Migrans. (Pubmed Central) - Nov 30, 2023
The rash was diagnosed as erythema chronicum migrans (ECM), and the patient was started on doxycycline 100 mg BID...However, as emphasized by Errichetti, dermatoscopic examination in non-neoplastic diseases should be regarded as the second step of a "2-step procedure", with differential diagnoses established first by history and clinical examination (3). A systematic investigation of early and late, typical and atypical lesions would improve the reliability and utility of this method.
- |||||||||| doxycycline / Generic mfg.
Journal: Brucella-infected abdominal aortic aneurysm: management strategies for an uncommon aneurysm. (Pubmed Central) - Nov 29, 2023
The prompt initiation of targeted antibiotic therapy is recommended, and the selection of appropriate surgical strategies should be guided by considerations including aneurysm dimensions and morphological attributes. The timely identification and intervention carry utmost significance in retarding disease advancement and ameliorating unfavorable clinical outcomes.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: Acute expression of human APOBEC3B in mice results in RNA editing and lethality. (Pubmed Central) - Nov 29, 2023
The timely identification and intervention carry utmost significance in retarding disease advancement and ameliorating unfavorable clinical outcomes. This work identifies, for the first time, a new deaminase-dependent function for APOBEC3B in RNA editing and presents a preclinical tool to help understand the emerging role of APOBEC3B as a driver of carcinogenesis.
- |||||||||| doxycycline / Generic mfg.
Trial completion date, Trial primary completion date: Tick-borne Encephalitis and Borrelial Antibodies in Serum (clinicaltrials.gov) - Nov 29, 2023
P=N/A, N=80, Recruiting,
This work identifies, for the first time, a new deaminase-dependent function for APOBEC3B in RNA editing and presents a preclinical tool to help understand the emerging role of APOBEC3B as a driver of carcinogenesis. Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Dec 2024
- |||||||||| doxycycline / Generic mfg.
Trial completion date, Trial primary completion date: Duration of Doxycycline Treatment in MEM Patients (clinicaltrials.gov) - Nov 29, 2023
P=N/A, N=200, Recruiting,
Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Dec 2024 Trial completion date: Jan 2024 --> Dec 2024 | Trial primary completion date: Jan 2024 --> Dec 2024
- |||||||||| doxycycline / Generic mfg.
Trial completion date, Trial primary completion date: Patient's Pretreatment Expectations About Post-Lyme Symptoms (clinicaltrials.gov) - Nov 29, 2023
P=N/A, N=200, Recruiting,
Trial completion date: Jan 2024 --> Dec 2024 | Trial primary completion date: Jan 2024 --> Dec 2024 Trial completion date: Jun 2023 --> Dec 2024 | Trial primary completion date: Jun 2023 --> Dec 2024
- |||||||||| Journal: BACTERIAL PROFILE, ANTIMICROBIAL RESISTANCE, AND FACTORS ASSOCIATED WITH URINARY TRACT INFECTION AMONG PREGNANT WOMEN AT HOSANNA TOWN HEALTH FACILITIES, CENTRAL ETHIOPIA. (Pubmed Central) - Nov 27, 2023
The gram-positive bacteria were susceptible to gentamicin (86.4%), erythromycin (81.8%), and nitrofurantoin (77.3%): whereas they showed a high level of resistance to penicillin (72.7%), doxycycline (54.5%), trimethoprim-sulfamethoxazole (52.9%), and cefoxitin (52.9%)...Therefore, regularly, culture-based bacterial identification and antibiotic susceptibility testing should be performed. Alternatively, empiric antibiotic therapy should consider the prevalence of antibiotic-resistant uropathogens and the factor that may increase the urinary tract infection occurrence due to multi-drug resistant uropathogens.
- |||||||||| doxycycline / Generic mfg., tetracycline / Generic mfg.
Journal: A novel method for predicting the emergence of toxicity interaction in ternary mixtures. (Pubmed Central) - Nov 27, 2023
Doxycycline hyclate (DH), bromoacetic acid (BAA) and iodoacetic acid (IAA) were used as target pollutants...TIPM could predict the emergence of DH-MAA-IAA toxicity interactions well based on the relationship. Due the model is only related to the toxicity interactions and p value of a mixture, so it can be suggested to predict toxicity interaction within the more complex multicomponent mixtures, which provides a novel approach for the environmental risk assessment and prediction of hazardous substances.
- |||||||||| doxycycline / Generic mfg., amoxicillin / Generic mfg.
Journal: Doxycycline for the Treatment of Lyme Disease in Young Children. (Pubmed Central) - Nov 27, 2023
Prospective, observational studies with long-term assessment of dental staining and clinical outcomes are needed. Alternative antibiotics, principally amoxicillin, remain the preferred treatment of non-neurological Lyme disease manifestations in young children, but doxycycline is likely a safe and effective alternative when needed.
- |||||||||| doxycycline / Generic mfg.
Journal: Chlamydia psittaci-Induced Reactive Infectious Mucocutaneous Eruption With Ocular Involvement. (Pubmed Central) - Nov 27, 2023
RIME is a rare parainfectious inflammatory condition with sequelae frequently involving the periocular mucosa. Although systemic and nonocular adverse outcomes in this condition tend to be self-limited, the impact on the ocular surface may be severe, and the consequences to vision may be ongoing, especially if not treated aggressively at the outset.
- |||||||||| doxycycline / Generic mfg., erythromycin / Generic mfg.
Journal: Preliminary SAR of Novel Pleuromutilin-Polyamine Conjugates. (Pubmed Central) - Nov 25, 2023
Furthermore, this series displayed moderate to low antibiotic potentiation of legacy antibiotics doxycycline and erythromycin, with three conjugates enhancing the activity four-fold in combination with doxycycline. In comparison to pleuromutilin (1) and tiamulin (2), one of the conjugates exhibited an expanded spectrum of activity, including Gram-negative bacteria and fungi, making it a promising option for combating microbial infections.
- |||||||||| Journal: Pathotypes and Phenotypic Resistance to Antimicrobials of Escherichia coli Isolates from One-Day-Old Chickens. (Pubmed Central) - Nov 25, 2023
On the other hand, 20.5% of the isolates were identified as multidrug-resistant (8.7% of isolates were resistant to three antimicrobials, 7.3% to four antimicrobials, 3.6% to five antimicrobials and 0.9% to six antimicrobials). Monitoring pathogenic strains of E. coli in different animals and in the environment makes it possible to understand their spread in animal and human populations and, at the same time, reveal the sources of virulence and resistance genes.
- |||||||||| Cytovene (ganciclovir) / Roche
Preclinical, Review, Journal: From Animal Models to Clinical Trials: The Potential of Antimicrobials in Multiple Sclerosis Treatment. (Pubmed Central) - Nov 25, 2023
Antivirals included acyclovir, valacyclovir, and ganciclovir...While the effect of antimicrobials in animal models was promising, only minocycline and hydroxychloroquine improved outcome measures in pwMS...The number and size of clinical trials testing antimicrobials have been limited. Large, multicenter, well-designed studies are needed to further evaluate the effect of antimicrobials in MS.
- |||||||||| VE-821 / EMD Serono, Vertex
Journal: Depletion of Labile Iron Induces Replication Stress and Enhances Responses to Chemoradiation in Non-Small-Cell Lung Cancer. (Pubmed Central) - Nov 25, 2023
Depletion of the LIP in non-small-cell lung cancer cell lines using the doxycycline-inducible overexpression of the ferritin heavy chain (Ft-H) (H1299 and H292), or treatment with deferoxamine (DFO) (H1299 and A549), inhibited cell growth and decreased clonogenic survival...The Ft-H and DFO treatment also sensitized H1299 to VE-821, an inhibitor of ataxia telangiectasis and Rad2-related (ATR) kinase, highlighting the potential of LIP depletion, combined with DNA damage response modifiers, to alter lung cancer cell responses...Importantly, the Ft-H and DFO sensitized both H1299 and A549 to chemoradiation in vitro, and Ft-H overexpression increased the efficacy of chemoradiation in vivo in H1299. These results support the hypothesis that the depletion of the LIP can induce genomic instability, cell death, and potentiate therapeutic responses to chemoradiation in NSCLC.
- |||||||||| doxycycline / Generic mfg.
Journal, BRCA Biomarker: The oncogenic fusion protein TAZ::CAMTA1 promotes genomic instability and senescence through hypertranscription. (Pubmed Central) - Nov 23, 2023
To study the oncogenic mechanism leading to EHE initiation, we developed a model system whereby TAZ::CAMTA1 expression is induced by doxycycline in primary endothelial cells...Knockout of Cdkn2a, the most common secondary mutation found in EHE, allows senescence bypass and uncontrolled growth. Together, this provides a mechanistic explanation for the clinical course of EHE and offers novel insight into therapeutic options.
- |||||||||| Oral Postoperative Antibiotic Prophylaxis Patterns for Outpatient Total Hip and Knee Arthroplasty (OrthoLive, West Hall) - Nov 22, 2023 - Abstract #AAOS2024AAOS_165;
Variation was additionally noted in the odds of receiving oral prophylactic antibiotics which were found to be higher in THA patients, ambulatory surgery centers, and surgeries in 2020/2021. Follow-up research will evaluate how antibiotic prophylaxis patterns have evolved as outpatient THA and TKA have increased as well as the efficacy of these antibiotic regimens in prosthetic joint infection prevention.
- |||||||||| doxycycline / Generic mfg.
Journal, Synthetic lethality: Mitoribosomal synthetic lethality overcomes multidrug resistance in MYC-driven neuroblastoma. (Pubmed Central) - Nov 21, 2023
Notably, neuroblastoma cells failed to develop significant resistance to the mitoribosomal inhibitor doxycycline over a long-term repeated (pulsed) selection. Collectively, we identify mitochondrial translation machinery as a novel synthetic lethality target for multidrug-resistant MYC-driven tumors.
- |||||||||| doxycycline / Generic mfg.
Journal: Transient knockdown of p53 during focal limb irradiation increases the development of sarcomas. (Pubmed Central) - Nov 20, 2023
We utilized mice that express a doxycycline-inducible p53 shRNA to reduce p53 expression temporarily during irradiation...Comparison of the transcriptomes of human and mouse sarcomas that arose in irradiated tissues revealed regulation of common gene programs, including elevated EMT pathway gene expression. These results suggest that blocking p53 during radiotherapy could minimize acute toxicity while exacerbating late effects including second cancers.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: Urinary VOCs as biomarkers of early stage lung tumour development in mice. (Pubmed Central) - Nov 19, 2023
These results suggest that blocking p53 during radiotherapy could minimize acute toxicity while exacerbating late effects including second cancers. The analysis of mice urinary VOCs have shown that cancer can induce changes in odour profiles at an early stage of cancer development, opening a promising avenue for early diagnosis of lung cancer in other models.
- |||||||||| tetracycline / Generic mfg.
Journal: One Pot Synthesis of Nanofiber-Coated Magnetic Composites as Magnetic Dispersive Solid-Phase Extraction Adsorbents for Rapid Determination of Tetracyclines in Aquatic Food Products. (Pubmed Central) - Nov 18, 2023
Finally, MSPE based on C-nanofiber-coated magnetic nanoparticles was successfully applied to TC analysis in real aquatic products (grass carp, large yellow croaker, snakehead, mandarin fish, Penaeus vannamei, swimming crab, etc.). Compared with traditional extraction methods, the proposed method for TC analysis in aquatic products is more sensitive, effective, recyclable, and environmentally friendly.
- |||||||||| doxycycline / Generic mfg.
Review, Journal: Bartonella quintana endocarditis: A systematic review of individual cases. (Pubmed Central) - Nov 17, 2023
quintana endocarditis has a global distribution, and long delays between symptom onset and presentation frequently occur. Improved clinician education and diagnostic capacity are needed to screen at-risk populations and identify infection before endocarditis develops.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: Antimicrobial susceptibility of U.S. porcine Brachyspira isolates and genetic diversity of B. hyodysenteriae by multilocus sequence typing. (Pubmed Central) - Nov 16, 2023
We evaluated the antimicrobial susceptibility profiles of U.S. Brachyspira isolates recovered between 2013 and 2022 to tiamulin, tylvalosin, lincomycin, doxycycline, bacitracin, and tylosin...Our findings indicate an overall low prevalence of resistance to clinically important antimicrobials other than tylosin and bacitracin, and high genetic diversity among the clinical Brachyspira isolates from pigs in the United States during the past decade. Further molecular, epidemiologic, and surveillance studies are needed to better understand the infection dynamics of Brachyspira on swine farms and to help develop effective control measures.
- |||||||||| baclofen / Generic mfg.
Back to Baclofen: An Unusual Presentation of Fluid Collection in the Back of a Patient with Stiff Person Syndrome () - Nov 16, 2023 - Abstract #AAPMR2023AAPMR_874;
This case illustrates a disease of unknown etiology leading to significant changes in motor strength, mobility, and ability to perform ADLs. If a surgical complication related to a baclofen pump arises in a patient with SPS, withdrawal symptoms can be monitored and managed with medications that would suppress the adrenergic response such as clonidine, tizanidine, or dexmedetomidine offered in conjunction with baclofen and benzodiazepines.
- |||||||||| doxycycline / Generic mfg.
Acute Rehabilitation Course of a Patient with Lyme Disease Presenting as Guillain () - Nov 16, 2023 - Abstract #AAPMR2023AAPMR_722;
Due to this circumstance, she was treated with both a course of IVIG to cover GBS, and oral doxycycline which she continued throughout her rehab stay... Acute Rehabilitation in the setting of patient with Lyme Disease Presenting as Guillain
- |||||||||| doxycycline / Generic mfg.
Acute Motor Axonopathy Associated with Lyme Disease: A Case Report () - Nov 16, 2023 - Abstract #AAPMR2023AAPMR_489;
Lyme related motor-only neuropathy and polyradiculopathy are rare, but previously reported. As symptoms can be reversed with adequate antibiotic treatment, early recognition and treatment are necessary to limit axonal loss and disability.
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