doxycycline / Generic mfg. 
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 114 Diseases   151 Trials   151 Trials   5480 News 


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  • ||||||||||  doxycycline / Generic mfg., gentamicin sulfate / Generic mfg.
    Clinical data, Review, Journal:  Tularemia treatment: experimental and clinical data. (Pubmed Central) -  Feb 1, 2024   
    However, we have attempted to summarize current knowledge through proposals for improving tularemia treatment which will have to be discussed by a group of experts. A major factor in improving the prognosis of patients with tularemia is the early administration of appropriate treatment, which requires better medical knowledge and diagnostic strategy of this disease.
  • ||||||||||  Epsolay (microencapsulated benzoyl peroxide cream 5%) - Sol / Gel, Mirvaso (brimonidine tartrate) / Galderma
    Journal:  Drugs for rosacea. (Pubmed Central) -  Jan 31, 2024   
    A major factor in improving the prognosis of patients with tularemia is the early administration of appropriate treatment, which requires better medical knowledge and diagnostic strategy of this disease. No abstract available
  • ||||||||||  Mycobutin (rifabutin) / Pfizer, Lupin
    Retrospective data, Review, Journal:  Prevalence of antibiotic resistance in clinical isolates of M. kansasii: a systematic review and meta-analysis. (Pubmed Central) -  Jan 31, 2024   
    The rates of resistance of M. kansasii to various antibiotics were as follows: clarithromycin (0%), rifampin (1%), amikacin (0%), ciprofloxacin (14%), linezolid (0%), moxifloxacin (0%), rifabutin (1%), doxycycline (96%), and SXT (49%). Our findings underscore the importance of managing and monitoring the use of these antibiotics, as well as the need for further studies to elucidate the exact mechanism of M. kansasii resistance to these antibiotics.
  • ||||||||||  Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J, Humira (adalimumab) / AbbVie, Orkambi (lumacaftor/ivacaftor) / Vertex
    Review, Journal:  Assessing the Labeling Information on Drugs Associated With Suicide Risk: Systematic Review. (Pubmed Central) -  Jan 30, 2024   
    We found several case reports involving drugs without suicide risk information on the drug label. Our findings might provide valuable insights into drugs that may cause suicidal ADRs.
  • ||||||||||  Pneumosil (10-valent pneumococcal conjugate vaccine) / Serum Institute of India
    Journal:  Strain features of pneumococcal isolates in the pre- and post-PCV10 era in Pakistan. (Pubmed Central) -  Jan 29, 2024   
    Owing to the diversity of serotypes observed during the post-vaccine period, the suggested inclusion of serotype in future vaccine formulations will require investigations with larger data sets with an extended temporal window. This article contains data hosted by Microreact.
  • ||||||||||  ivermectin oral / Generic mfg., doxycycline / Generic mfg.
    Review, Journal:  Filarial disease in the Brazilian Amazon and emerging opportunities for treatment and control. (Pubmed Central) -  Jan 29, 2024   
    While the long treatment courses required for doxycycline-based mansonellosis therapies preclude their use in control programmes, new fast-acting filarial drug treatments are likely to soon become available for the treatment of both onchocerciasis and mansonellosis in the Amazon region. Filarial disease management in the Brazilian Amazon is thus likely to become dramatically more viable at a time when the public health importance of these diseases is increasingly being recognized.
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Time-dependent effects of BRAF-V600E on cell cycling, metabolism, and function in engineered myocardium. (Pubmed Central) -  Jan 28, 2024   
    Transient, doxycycline-controlled caBRAF expression revealed that the induction of CM cycling is rapid and precedes functional decline, and the effects are reversible only with short-lived ERK activation. Together, direct activation of the BRAF kinase is sufficient to modulate CM cycling and functional phenotype, offering mechanistic insights into roles of ERK signaling in the context of cardiac development and regeneration.
  • ||||||||||  doxycycline / Generic mfg., azithromycin / Generic mfg.
    Journal:  Spontaneous splenic rupture associated with scrub typhus: a case report. (Pubmed Central) -  Jan 27, 2024   
    Clinicians should consider the possibility of splenic rupture in patients with scrub typhus who display sudden-onset abdominal pain and unstable vital signs. In addition, splenic capsular rupture and extra-capsular hemorrhage are thought to be caused by splenomegaly and capsular distention resulting from red blood cell congestion in the red pulp destroying the splenic sinus.
  • ||||||||||  tetracycline / Generic mfg., isotretinoin / Generic mfg.
    New P1 trial:  Weekly Isotretinoin vs Tetracycline for Moderate Acne (clinicaltrials.gov) -  Jan 26, 2024   
    P1,  N=50, Not yet recruiting, 
  • ||||||||||  ceftriaxone / Generic mfg., doxycycline / Generic mfg.
    THE LYME IN THE COCAINE-NUT: AN INTERESTING CASE OF LYME CARDITIS (Hall B4-5) -  Jan 26, 2024 - Abstract #ACC2024ACC_7267;    
    Timely recognition and treatment may avoid unnecessary interventions. Clinicians should be cognizant of the possibility of Lyme carditis in non-endemic areas.
  • ||||||||||  ceftriaxone / Generic mfg., doxycycline / Generic mfg.
    BUGGING THE TICKER: A CASE OF ANAPLASMA MYOCARDITIS PRESENTING AS STEMI (Hall B4-5) -  Jan 26, 2024 - Abstract #ACC2024ACC_5391;    
    It is crucial to consider HGA in the differential for patients with myopericarditis, especially in tick-endemic regions. HGA is responsive to antibiotics and prompt administration can reduce cardiovascular morbidity and mortality.
  • ||||||||||  doxycycline / Generic mfg.
    TICK OR TRICK? (Hall B4-5) -  Jan 26, 2024 - Abstract #ACC2024ACC_4913;    
    Prompt recognition of Lyme myocarditis is crucial given favorable prognosis with antibiotics. Patient education and insect repellents are key.
  • ||||||||||  prednisone / Generic mfg., doxycycline / Generic mfg.
    A CASE OF MASSIVE LIPOMATOUS HYPERTROPHY OF THE INTERATRIAL SEPTUM ENCASING THE SUPERIOR VENA CAVA (Hall B4-5) -  Jan 26, 2024 - Abstract #ACC2024ACC_4260;    
    However, prior to proceeding with surgical interventions, often an under-recognized mass of LASH should be considered using cardiac imaging. LASH does not require further treatment, however in cases where there is severe SVC obstruction, surgical excision with reconstruction of the IAS may be warranted.
  • ||||||||||  hydroxychloroquine / Generic mfg., doxycycline / Generic mfg.
    UNUSUAL PRESENTATION OF COXIELLA BURNETII ENDOCARDITIS (Hall B4-5) -  Jan 26, 2024 - Abstract #ACC2024ACC_4078;    
    Timely identification of the offending microorganism is important for initiation of appropriate antibiotics. Coxiella Burnetii should be strongly considered as part of the differential diagnosis in culture-negative endocarditis.
  • ||||||||||  rifampicin / Generic mfg., doxycycline / Generic mfg.
    BLOOD CULTURE NEGATIVE ENDOCARDITIS SECONDARY TO BARTONELLA HENSELAE INFECTION (Hall B4-5) -  Jan 26, 2024 - Abstract #ACC2024ACC_523;    
    Though rare, Bartonella endocarditis should remain high on the differential in patients with underlying valvular disease and exposure to felines. In clinical scenarios where culture negative endocarditis is suspected, prompt antimicrobial treatment should be initiated followed by confirmatory testing and multidisciplinary management.
  • ||||||||||  ceftriaxone / Generic mfg., doxycycline / Generic mfg.
    INFARCTION OR INFECTION (Hall B4-5) -  Jan 26, 2024 - Abstract #ACC2024ACC_257;    
    This is likely due to Lyme's myocardial inflammation increasing metabolic demand and generating instability in the atherosclerotic plaque causing ACS. Usually LM presents as heart block, but our patient oddly presented as VT.
  • ||||||||||  ceftriaxone / Generic mfg., doxycycline / Generic mfg.
    A DANCE OF HEARTS RHYTHM-UNVEILING LYME CARDITIS (Hall B4-5) -  Jan 26, 2024 - Abstract #ACC2024ACC_255;    
    In rare LC cases, timely intervention is crucial. A pacemaker may be required if antibiotics prove ineffective, supporting patients with ongoing sinus pauses until the block is resolved.
  • ||||||||||  doxycycline / Generic mfg., tetracycline / Generic mfg., erythromycin / Generic mfg.
    Preclinical, Journal:  In Vitro Activity of Allium cepa Organosulfur Derivatives against Canine Multidrug-Resistant Strains of Staphylococcus spp. and Enterobacteriaceae. (Pubmed Central) -  Jan 22, 2024   
    In addition, 50% of S. pseudintermedius strains resistant to erythromycin, ibofloxacin, difloxacin and orbifloxacin and 50% of Enterobacteriaceae strains resistant to tetracycline and doxycycline were sensitive to PTS and PTSO. Although studies are needed to verify their efficacy in vivo, the combined use of PTS and PTSO exhibits promise in enhancing bacterial sensitivity against S. pseudintermedius and Enterobacteriaceae infections, providing a first insight into the potential of both compounds in veterinary practice.
  • ||||||||||  Ganovo (danoprevir) / Roche, Ascletis, Pfizer
    Journal:  A Standardized Set of MoClo-Compatible Inducible Promoter Systems for Tunable Gene Expression in Yeast. (Pubmed Central) -  Jan 22, 2024   
    Furthermore, each of the five classes of systems could be induced at least 60-fold after a 6 h induction and the highest fold change observed was approximately 300. Thus, yTEST provides a reliable, diverse, and customizable set of inducible promoters to modulate gene expression in yeast for applications in synthetic biology, metabolic engineering, and basic research.
  • ||||||||||  doxycycline / Generic mfg., isotretinoin / Generic mfg., cyclosporine ophthalmic emulsion / Generic mfg.
    Review, Journal:  Treatment of ocular rosacea: a systematic review. (Pubmed Central) -  Jan 20, 2024   
    Thus, yTEST provides a reliable, diverse, and customizable set of inducible promoters to modulate gene expression in yeast for applications in synthetic biology, metabolic engineering, and basic research. Treatment options for ocular rosacea include lid hygiene, topical and oral antibiotics, cyclosporine ophthalmic emulsion, oral vitamin
  • ||||||||||  doxycycline / Generic mfg.
    Trial completion:  Intra-articular Doxycycline: A Novel Treatment of Adhesive Capsulitis (clinicaltrials.gov) -  Jan 18, 2024   
    P4,  N=1, Completed, 
    Variations in intestinal collagen dynamics are relevant since they may represent changes in the environmental dispersion of S. mansoni eggs, bringing repercussions for schistosomiasis propagation. Terminated --> Completed
  • ||||||||||  cephalexin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., doxycycline / Generic mfg.
    Trial completion date, Trial primary completion date:  Effects of Treatments on Atopic Dermatitis (clinicaltrials.gov) -  Jan 17, 2024   
    P2,  N=130, Recruiting, 
    Terminated --> Completed Trial completion date: Jan 2024 --> Jan 2025 | Trial primary completion date: Jan 2024 --> Jan 2025
  • ||||||||||  doxycycline / Generic mfg., oseltamivir / Generic mfg.
    Journal:  Infectious diseases: what's new in 2023 (Pubmed Central) -  Jan 17, 2024   
    Administration of doxycycline post-exposure prophylaxis reduced the risk of bacterial sexually transmitted infections at the risk of resistance selection...A meta-analysis concludes that oseltamivir does not significantly reduce the risk of hospitalisation for influenza...Several studies have led to the introduction of RSV (Respiratory Syncytial Virus (RSV) vaccination. 2023 also saw the resurgence of invasive Group A Streptococcal infections, of which clinicians must be wary.
  • ||||||||||  ciprofloxacin oral / Generic mfg., doxycycline / Generic mfg.
    Journal:  Exogenous methionine contributes to reversing the resistance of Streptococcus suis to macrolides. (Pubmed Central) -  Jan 17, 2024   
    We investigated the mechanism of action of exogenous methionine supplementation in restoring macrolides in Streptococcus suis and the role of the methionine cycle pathway on methylation levels, efflux pump genes, oxidative stress, and metal starvation in Streptococcus suis. It provides a theoretical basis for the rational use of macrolides in clinical practice and also identifies a possible target for restoring drug resistance in Streptococcus suis.