- |||||||||| doxycycline / generics
Journal: Pyoderma gangrenosum: a presenting sign of myelodysplastic syndrome in undiagnosed Fanconi anemia. (Pubmed Central) - May 24, 2019
...He was treated with systemic, intralesional, and topical steroids, as well as doxycycline...Fanconi anemia is a rare genetic hematologic disorder with congenital defects leading to bone marrow failure and malignancy in long-standing disease. In our patient, we consider his development of PG a paraneoplastic sign associated with the onset of his hypocellular myelodysplastic syndrome.
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Biomarker, Journal: Translational Research in Alzheimer's and Prion Diseases. (Pubmed Central) - May 22, 2019
During the last few decades, translational research provided a framework for advancing development of new diagnostic devices and promising disease-modifying therapies for patients with prion encephalopathies and AD. In this review, we provide present evidence of how supportive can be the translational approach to the study of dementias and show some results of our preclinical studies which have been translated to the clinical application following the 'bed-to-bench-and-back' research model.
- |||||||||| ciprofloxacin / generics, rifampicin / generics, doxycycline / generics
Journal: Rifampicin: not always an innocent drug. (Pubmed Central) - May 22, 2019
Due to subsequent appearance of myositis, ciprofloxacin and rifampicin were added for treatment of localised brucellosis...Drug withdrawal in conjunction with intravenous immune globulin and prednisolone resulted in resolution of haemolysis and no relapse in the ensuing 1-year period. Our case highlights the importance of recognising commonly administrative drugs as cause of haemolytic anaemia, that can often be life threatening.
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Journal: Syphilis: what's new? (Pubmed Central) - May 21, 2019
Treatment normally relies on intramuscular benzathine penicillin or oral doxycycline. The effectiveness of the treatment is judged on the decrease of the quantitative VDRL.
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Journal: Molecular characterization and antimicrobial resistance profile of fecal contaminants and spoilage bacteria that emerge in rainbow trout (Oncorhynchus mykiss) farms. (Pubmed Central) - May 21, 2019
All isolates were found to be phenotypically resistant to sulfamethoxazole, and some isolates were resistant to tetracycline, florfenicol, amoxicillin, and doxycycline; the resistance genes of these isolates included floR, tetC, tetD, and tetE. We showed that fecal coliforms, spoilage bacteria, and antimicrobial resistant bacteria were present in farmed rainbow trout, and they pose a threat for human health and must be controlled in the farming stage of fish production.
- |||||||||| rifampicin / generics, doxycycline / generics
Journal: Disseminate recurrent folliculitis as the presenting picture of hidradenitis suppurativa. (Pubmed Central) - May 17, 2019
We showed that fecal coliforms, spoilage bacteria, and antimicrobial resistant bacteria were present in farmed rainbow trout, and they pose a threat for human health and must be controlled in the farming stage of fish production. Disseminate recurrent folliculitis constitutes part of the clinical picture of HS; if it is isolated, screening should be performed for personal or familial signs of HS.
- |||||||||| doxycycline / generics
Journal: Metastable Reprogramming State of Single Transcription Factor-Derived Induced Hepatocyte-Like Cells. (Pubmed Central) - May 16, 2019
...Here, we describe the generation of transgene-independent iHeps by inducing the ectopic expression of Hnf1a using both an episomal vector and a doxycycline-inducible lentivirus...Taken together, our data indicates that the reprogramming state of single factor Hnf1a-derived iHeps is metastable and that the hepatic identity of these cells could be maintained only by the continuous supply of either small molecules or the master hepatic factor Hnf1a. Our findings emphasize the importance of a factor screening strategy for inducing specific cellular identities with a stable reprogramming state in order to eventually translate direct conversion technology to the clinic.
- |||||||||| doxycycline / Generic mfg.
Enrollment open: FATB: Fever After Tick Bite Study (clinicaltrials.gov) - May 15, 2019
P=N/A, N=310, Recruiting,
Our findings emphasize the importance of a factor screening strategy for inducing specific cellular identities with a stable reprogramming state in order to eventually translate direct conversion technology to the clinic. Not yet recruiting --> Recruiting
- |||||||||| metformin / generics, doxycycline / generics
Review, Journal, Cancer stem cells: Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti-cancer therapies. (Pubmed Central) - May 15, 2019
This review highlights the intriguing aspects of mitochondrial biology that may have a crucial role in cancer initiation, progression, and resistance and which might facilitate pharmacological targeting. Indeed, understanding of mitochondrial function in the regulation of CSCs will promote the development of novel CSC-targeted therapeutic strategies, which could significantly improve the long-term survival of cancer patients.
- |||||||||| doxycycline / generics
Journal, IO Biomarker: The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription. (Pubmed Central) - May 15, 2019
...Here we performed a systematic and comparative analysis of cells where the CCR4-NOT subunits CNOT1, CNOT2 or CNOT3 were individually downregulated using doxycycline-inducible shRNAs...CNOT2 downregulation resulted in an increased de novo transcription of mRNAs whereas tethering of CNOT2 to a regulatory region governing MHC II expression resulted in diminished transcription. These results expand the known repertoire of CCR4-NOT members for immune regulation and identify CNOT proteins as a novel group of corepressors restricting class II expression.
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Journal: Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy. (Pubmed Central) - May 15, 2019
...A pair of doxycycline (Dox)-inducible cell lines that specifically report on the ability of an inhibitor to induce apoptosis by targeting either the Mcl-1 arm or the Bcl-2/Bcl-xL/Bcl-w arm were used...Validation studies identified unique combinations that synergistically inhibited growth and induced apoptosis in a panel of cancer cell lines. Since these inhibitors have been or are currently in clinical trials as single agents, the combinations can be rapidly translated to the clinics.
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Journal: Illustration of sexual differentiation to undergraduates with a conditional gene expression system. (Pubmed Central) - May 15, 2019
Allogeneic stem cell transplantation can be used in selected patients. ...The Tet-on system allows conditional control of gene expression, when doxycycline is applied...The laboratory practice is inexpensive and straightforward, while allowing students to understand well how molecular biology technology can change biological processes, including development.
- |||||||||| doxycycline / generics, ibuprofen / generics
Review, Journal: Inflammatory arthritis: a unique presentation of human anaplasmosis. (Pubmed Central) - May 14, 2019
Because of an Anaplasma phagocytophilum IgM of 1:320 (normal < 1:20; IgG < 1:64; normal < 1:64) that returned few weeks after presentation, he was prescribed 4 weeks of doxycycline...HGA presents acutely with a spectrum of manifestations ranging from a flu-like illness to severe complications such as respiratory failure. Myalgias and arthralgias are common, but an inflammatory arthritis has not been described.
- |||||||||| vancomycin / generics, doxycycline / generics, amoxicillin / generics
Clinical, Journal: Evaluation of the clinical relevance of vancomycin for the treatment of Lyme disease. (Pubmed Central) - May 12, 2019
It is concluded that vancomycin is a much less attractive option for the treatment of patients with early Lyme disease (or any other manifestation of Lyme disease), compared with the antimicrobials currently being used. Based on available evidence, clinical studies to evaluate the safety and efficacy of vancomycin for Lyme disease cannot be recommended.
- |||||||||| doxycycline / generics
Journal: Aeromonas induced polyostotic osteomyelitis in a juvenile loggerhead sea turtle Caretta caretta. (Pubmed Central) - May 11, 2019
...Bacterial cultures and antibiotic susceptibility testing led to the isolation of Aeromonas hydrophila responsive to amikacin and doxycycline...The turtle was released 17 mo after admission, upon resolution of clinical signs. The documentation of this case provides a treatment approach that may improve the outcome of Aeromonas-associated osteomyelitis, especially in endangered wildlife species.
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Journal: Suppression of Conditional TDP-43 Transgene Expression Differentially Affects Early Cognitive and Social Phenotypes in TDP-43 Mice. (Pubmed Central) - May 10, 2019
...Suppression of TG expression with doxycycline (Dox) at this time point prevented the development of cognitive deficits previously observed at 1 month post-induction, as revealed by the performance of the 1 month (sup) group...Moreover, all motor tests (open field, accelerated rotarod, limb clasping, hanging wire grip) showed identical responses in both control and bigenic animals in the suppressed group, demonstrating that this protocol and treatment do not cause non-specific effects in motor behavior, which could potentially mask the phenotypes in other domains. Our results show that TDP-43-WT mice have a phenotype that qualifies them as a useful model of FTD and provide valuable information for susceptibility windows in therapeutic strategies for TDP-43 proteinopathies.
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Journal: Fibroblast Growth Factor 2 Regulates Activity and Gene Expression of Human Postmitotic Excitatory Neurons. (Pubmed Central) - May 9, 2019
...Upon induction of NEUROG2 with doxycycline, the vast majority of cells are post-mitotic, and the gene expression profile recapitulates that of excitatory neurons within 6 days...Novel neuron specific genes were also identified that may mediate FGF2-dependent increases in synaptic efficacy including NRXN3, SYT2, and GALR1. Since several of these genes have been implicated in MDD previously, these results will provide the basis for more mechanistic studies of the role of FGF2 in MDD.
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Journal: Improved reactive nanoparticles to treat dentin hypersensitivity. (Pubmed Central) - May 9, 2019
...Four experimental nanoparticle solutions based on zinc, calcium or doxycycline-loaded polymeric nanoparticles (NPs) were applied on citric acid etched dentin, to facilitate the occlusion and the reduction of the fluid flow at the dentinal tubules...Zinc-based nanogels are, therefore, proposed for effective dentin remineralization and tubular occlusion. Further research to finally prove for clinical benefits in patients with dentin hypersensitivity using Zn-doped nanogels is encouraged.
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Preclinical, Journal: Microbiological and SEM-EDS Evaluation of Titanium Surfaces Exposed to Periodontal Gel: In Vitro Study. (Pubmed Central) - May 8, 2019
...Among several methods proposed for the decontamination of titanium surfaces, the administration of topical 14% doxycycline gel seems to be a reliable option...However, the SEM observations revealed the permanence of the gel on the titanium surfaces due to the physical composition of the gel. This permanence needs to be further investigated in vivo and a final polishing protocol on the titanium surface is recommended.
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Preclinical, Journal: Protective effect of RIPK1-inhibitory compound in in vivo models for retinal degenerative disease. (Pubmed Central) - May 7, 2019
Moreover, the in vivo protective effects of RIC were superior to those of ACU-4429 and doxycycline, which are other medications investigated in clinical trials for the treatment of dry AMD, and RIC did not induce retinal toxicity following topical administration in rats. Collectively, RIC displayed excellent retinal penetration and prevented retinal degeneration in the pathogenesis of dry AMD with a high in vivo efficacy.
- |||||||||| doxycycline / generics
Journal: O-GlcNAcylation regulates integrin-mediated cell adhesion and migrationvia formation of focal adhesion complexes. (Pubmed Central) - May 7, 2019
...Here, we used the doxycycline-inducible short hairpin RNA (shRNA) system to establish an OGT knockdown (KD) HeLa cell line and found that O-GlcNAcylation is a key regulator for cell adhesion, migration, and focal adhesion (FA) complex formation...Consistently, levels of active integrin β1 were significantly enhanced in KD cells, while they were decreased in cells overexpressing OGT. The data suggest a novel regulatory mechanism for O-GlcNAcylation during FA complex formation, which thereby affects integrin activation and integrin-mediated functions such as cell adhesion and migration.
- |||||||||| doxycycline / generics
Journal: Manure and Doxycycline Affect the Bacterial Community and Its Resistome in Lettuce Rhizosphere and Bulk Soil. (Pubmed Central) - May 7, 2019
Thus, the gene tetA(P) might be a suitable marker of soil contamination by ARB, ARGs, and antibiotics of manure origin. These findings illustrate that the effects of manure and doxycycline on ARGs and MGEs differ between rhizosphere and bulk soil, which needs to be considered when assessing risks for human health connected to the spread of ARGs in the environment.
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