- |||||||||| doxycycline / Generic Mfg.
METASTATIC THYROID CARCINOMA MANIFESTING AS LEFT SIDED PLEURAL EFFUSION (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 4) - Sep 25, 2019 - Abstract #CHEST2019CHEST_2567;
We report the case of a symptomatic unilateral malignant pleural effusion arising from metastatic papillary thyroid carcinoma effectively palliated with chemical pleurodesis using doxycycline without short-term recurrence.Case Presentation:An 89-year-old female with a past medical history of locally invasive papillary carcinoma which initially presented with vocal cord paralysis without distal disease, subsequently underwent total thyroidectomy and radioactive iodine ablation...Malignant pleural effusion is rare and portends a poor prognosis in patients with papillary thyroid carcinoma. Chemical pleurodesis offers a viable palliative option in related pleural effusions that are not highly responsive to systemic therapy.
- |||||||||| doxycycline / Generic Mfg.
FIXING A RARE CASE OF PERSISTENT PULMONARY AIR LEAK (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 4) - Sep 25, 2019 - Abstract #CHEST2019CHEST_2560;
Chemical pleurodesis offers a viable palliative option in related pleural effusions that are not highly responsive to systemic therapy. Hence this time a doxycycline pleurodeses was attempted for almost two hours...This case illustrates the need for larger studies to better understand the management of PALs in patients with minimal risk factors and prevent life-threatening complications associated with it.
- |||||||||| doxycycline / Generic Mfg., Herceptin (trastuzumab) / Roche, paclitaxel / Generic Mfg.
TRASTUZUMAB-INDUCED INTERSTITIAL PNEUMONITIS: DIAGNOSTIC AWARENESS (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 1) - Sep 25, 2019 - Abstract #CHEST2019CHEST_2504;
She was treated initially with 4 cycles of neoadjuvant paclitaxel, trastuzumab, and pertuzumab followed by local radiation, lumpectomy, and maintenance chemotherapy with trastuzumab and pertuzumab...She was initiated on empiric antibiotics including vancomycin, cefepime, and doxycycline...Drug-related interstitial pneumonitis can be a challenging diagnosis. It requires a high index of suspicion and ruling out infectious etiology, withdrawal of causative agent, and consideration of steroids in an appropriate clinical setting.
- |||||||||| doxycycline / Generic Mfg.
SEVERE PNEUMONITIS AND PULMONARY FIBROSIS RELATED TO A COMMON CHEMOTHERAPY AGENT (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 4) - Sep 25, 2019 - Abstract #CHEST2019CHEST_2415;
It requires a high index of suspicion and ruling out infectious etiology, withdrawal of causative agent, and consideration of steroids in an appropriate clinical setting. She was recently diagnosed with metastatic sigmoid colorectal cancer and received FOLFOX chemotherapy (Folinic acid, 5-Fluorouracil and Oxaliplatin)...She was initially treated with vancomycin, levofloxacin and doxycycline for presumed pneumonia...Hence, she was started on methylprednisolone...Most cases of oxaliplatin associated pulmonary fibrosis reported in literature have a rapid and fatal course similar to our patient.
- |||||||||| ciprofloxacin / Generic Mfg., doxycycline / Generic Mfg.
A RARE CAUSE OF INFECTIVE ENDOCARDITIS IN A LUNG TRANSPLANT PATIENT (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 4) - Sep 25, 2019 - Abstract #CHEST2019CHEST_2363;
feeleii is an extremely rare cause of infection in immunocompromised hosts. Its relatively high mortality rate warrants prompt diagnosis and appropriate management, but accurate diagnosis may be challenging because PCR testing is not routinely available.
- |||||||||| ceftriaxone / Generic Mfg., doxycycline / Generic Mfg., Pulmozyme (dornase alfa) / Roche
INTRAPULMONARY TERATOMA: A CAUSE OF SHORTNESS OF BREATH IN A YOUNG WOMAN (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 3) - Sep 25, 2019 - Abstract #CHEST2019CHEST_2359;
IPTs are a rare entity and may present with non-specific symptoms. Radiographic imaging often assists in diagnosis and surgery is the mainstay of treatment.
- |||||||||| doxycycline / Generic Mfg.
A RARE PRESENTATION OF PRIMARY PULMONARY EXTRANODAL DIFFUSE LARGE B CELL LYMPHOMA (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 1) - Sep 25, 2019 - Abstract #CHEST2019CHEST_1790;
Given the non-specific clinical presentation, non-specific radiologic findings, and overall rarity, initial diagnosis is difficult, making prompt treatment a challenge. Further research is warranted to better diagnose and prognosticate primary DLBL of the lung.
- |||||||||| Flagyl (metronidazole) / SLA, doxycycline / Generic Mfg.
ASPIRATION-INDUCED LUNG ABSCESS IN A PATIENT WITH PSEUDOACHALASIA SYNDROME POST GASTRIC BANDING (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 2) - Sep 25, 2019 - Abstract #CHEST2019CHEST_1704;
Based on current literature review, our case demonstrates a rare complication of gastric banding surgery and a rare cause of a lung abscess. However, given the increasing number of gastric banding procedures being performed, we expect this problem to become more common and recommend careful monitoring of patients' food and alcohol consumption patterns post surgery.
- |||||||||| doxycycline / Generic Mfg.
BLAST THE STEROIDS (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 2) - Sep 25, 2019 - Abstract #CHEST2019CHEST_1703;
This case highlights that good outcomes can be achieved without the combination. More studies are required on this going forward.
- |||||||||| doxycycline / Generic Mfg.
PRESENTATION OF MYCOBACTERIUM ABSCESSUS INFECTION FOLLOWING A SARCOIDOSIS DIAGNOSIS: A CASE REPORT (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 2) - Sep 25, 2019 - Abstract #CHEST2019CHEST_1683;
She received Doxycycline with complete resolution of her symptoms.Although the patient's clinical and CT findings were not typical for sarcoidosis, the histopathology and improvement with steroids supported the diagnosis. Mycobacterial infection should be investigated in all patients with sarcoidosis as it could be a causative agent an infection that evaded detection.
- |||||||||| doxycycline / Generic Mfg.
A Rational Combination Therapy Approach with Radiation Therapy in Ewing Sarcoma (ASTRO Innovation Hub) - Sep 24, 2019 - Abstract #ASTRO2019ASTRO_3407;
P1
At physiologically-relevant concentrations of the PARPi talazoparib (TAL), the combination of RT+TAL showed the highest synergist effect and combined efficacy compared to the other PARPis and SOC chemotherapeutics in human EWS cell lines... Taking together, our work suggested the combination of TAL and IRN may be a useful therapeutic strategy when RT is used in the progressive disease setting.
- |||||||||| doxycycline / Generic Mfg.
Clinical, Journal: Doxycycline treatment efficacy in dogs with naturally occurring Anaplasma phagocytophilum infection. (Pubmed Central) - Sep 22, 2019
The results of this study support the efficacy of doxycycline therapy for clinical treatment of dogs naturally infected with A. phagocytophilum in the USA. This study did not find clinical, haematological or microbiological indicators that supported the persistence of A. phagocytophilum infection in naturally infected dogs following treatment with doxycycline for 28 days.
- |||||||||| doxycycline / Generic Mfg.
Journal: Cardiac c-Kit Biology Revealed by Inducible Transgenesis. (Pubmed Central) - Sep 22, 2019
For creation of the mouse model, the cloned mouse c-Kit promoter drives Histone2B-EGFP (enhanced green fluorescent protein; H2BEGFP) expression in a doxycycline-inducible transgenic reporter line...Both cardiac stem cells and a subpopulation of cardiomyocytes express c-Kit in uninjured adult heart, upregulating c-Kit expression in response to pathologic stress. c-Kit myocardial biology is more complex and varied than previously appreciated or documented, demonstrating validity in multiple points of coexisting yet heretofore seemingly irreconcilable published findings.
- |||||||||| doxycycline / Generic Mfg.
Preclinical, Journal: CRISPR/Cas9 Immunoengineering of Hoxb8-Immortalized Progenitor Cells for Revealing CCR7-Mediated Dendritic Cell Signaling and Migration Mechanisms in vivo. (Pubmed Central) - Sep 22, 2019
Hematopoietic progenitor cells from the bone marrow of Cas9-transgenic mice were conditionally immortalized by lentiviral transduction introducing a doxycycline-regulated form of the transcription factor Hoxb8 (Cas9-Hoxb8 cells)...Finally, we used two-photon microscopy and imaged Cas9-Hoxb8 DCs that expressed the genetic Ca sensor GCaMP6S to visualize in real-time chemokine-induced Ca signaling of lymph-derived DCs entering the LN parenchyma. Altogether, our study not only allows mechanistic insights in DC migration in vivo, but also provides a platform for the immunoengineering of DCs that, in combination with two-photon imaging, can be exploited to further dissect DC dynamics in vivo.
- |||||||||| doxycycline / Generic Mfg.
Journal: Timed GDNF gene therapy using an immune-evasive gene switch promotes long distance axon regeneration. (Pubmed Central) - Sep 22, 2019
We report that time-restricted GDNF expression (1 month) using an immune-evasive doxycycline-inducible gene switch attenuated local axon entrapment in avulsed reimplanted ventral spinal roots, was sufficient to promote long-term motor neuron survival (24 weeks) and facilitated the recovery of compound muscle action potentials by 8 weeks...These findings demonstrate that timed expression can resolve the deleterious effect of uncontrolled growth factor delivery and shows that inducible growth factor gene therapy can be employed to enhance the efficacy of axon regeneration after neurosurgical repair of a proximal nerve lesion in rats. This preclinical study is an important step in the ongoing development of a neurotrophic factor gene therapy for patients with severe proximal nerve lesions.
- |||||||||| doxycycline / Generic Mfg.
Clinical, Journal: Femoral mononeuropathy in Lyme disease: a case report. (Pubmed Central) - Sep 21, 2019
Positive serological test results led to the administration of oral doxycycline therapy at a dosage of 100 mg twice daily...Eventually, he recovered, and he was able to return to work. We firmly believe that the femoral neuropathy and Lyme disease seen in this patient were causally related.
- |||||||||| doxycycline / Generic Mfg.
Preclinical, Journal: Regulatable Lentiviral Hematopoietic Stem Cell Gene Therapy in a Mouse Model of Parkinson's Disease. (Pubmed Central) - Sep 20, 2019
Here, we introduced a regulatable lentiviral vector (LV-MSP-Tet-Off-hGDNF) to allow the expression of human GDNF (hGDNF) to be adjusted or stopped by oral administration of doxycycline (Dox)...Neuroprotection by therapeutic GDNF expression was further evidenced by significant amelioration of nigral tyrosine hydroxylase loss after both the first and second MPTP treatment cycles. These data suggest that neurotrophic factor expression can be upregulated to achieve efficacy or downregulated in case of off-target effects or adverse events, a feature that may eventually increase the acceptance of this potentially neuroprotective/disease-modifying PD therapy.
- |||||||||| doxycycline / Generic Mfg.
Journal: A Raf-competitive K-Ras binder can fail to functionally antagonize signaling. (Pubmed Central) - Sep 20, 2019
Through lentiviral transduction, we generated cell lines that constitutively or through induction with doxycycline express R11.1.6 or a control protein YW1 and show specific binding by R11.1.6 to endogenous Ras through microscopy and co-immunoprecipitation experiments...To understand this lack of signaling inhibition, we quantified the number of molecules of R11.1.6 expressed by the inducible cell lines and developed a simple mathematical model describing the competitive binding of Ras by R11.1.6 and Raf. This model supports a potential mechanism for the lack of biological effects that we observed, suggesting stoichiometric and thermodynamic barriers that should be overcome in pharmacological efforts to directly compete with downstream effector proteins localized to membranes at very high effective concentrations.
- |||||||||| doxycycline / Generic Mfg., ceftazidime / Generic Mfg., Garamycin (gentamicin sulfate) / Generic Mfg.
Journal: Isolation and Antibiotic Resistant Research of Tetragenococcus halophilus from Xuanwei Ham, A China High-Salt-Fermented Meat Products. (Pubmed Central) - Sep 19, 2019
The antibiotic resistance phenotype was detected by the Bauer-Kirby (K-B) method and the results showed that 49 isolates can be considered completely susceptible to penicillin, ampicillin, amoxicillin, cefradine, cefotaxime, tetracyclines, minocycline, doxycycline, and vancomycin, but resistant to gentamicin, streptomycin, neomycin, polymyxinB, cotrimoxazole...A total of 32 isolates were resistant to ofloxacin, 4 isolates were resistant to ciprofloxacin and chloramphenicol, and 2 isolates were resistant to ceftazidime and ticarcillin...Among the 26 antibiotic resistance genes, 5 varieties of antibiotic resistance genes, including acrB, blaTEM, AAda1, SulII, and GyrB were detected and the detection rates were 89.79%, 47.7%, 16.33%, 77.55%, and 75.51%, respectively. The potential acquisition of transmissible determinants for antibiotic resistance and antibiotic resistance genes identified in this study necessitate the need for a thorough antibiotic resistance safety assessment of T. halophilus before it can be considered for use in food fermentation processes.
- |||||||||| ceftriaxone / Generic Mfg., doxycycline / Generic Mfg.
Journal: Extended-spectrum beta-lactamase and Class 1 integrons in multidrug-resistant Escherichia coli isolated from turkeys. (Pubmed Central) - Sep 19, 2019
Double disk synergy test showed that 6/18 (33.3%), 8/18 (44.4%), and 13/18 (72.2%) of isolates demonstrated the phenotypic pattern of ESBL producers with cefepime, cefotaxime, and ceftriaxone, respectively...The results revealed that 18/18 (100%) of E. coli isolates demonstrated MDR against three or more antibiotic groups, 9/18 (50%) of isolates showed extensive resistance against the nine tested chemotherapeutic agents from seven antibiotic groups. It is recommended to monitor the circulation of MDR and ESBL-producing pathogens in poultry production in a one health approach, as a preventive measure to mitigate the risk imposed on public health.
- |||||||||| doxycycline / Generic Mfg.
Journal: Doxycycline Prophylaxis for Bacterial Sexually Transmitted Infections: Promises and Perils. (Pubmed Central) - Sep 18, 2019
A recent report among MSM showed that the use of postexposure prophylaxis with doxycycline could dramatically reduce the incidence of chlamydia and syphilis but not of gonorrhea. The long-term consequences of this strategy are yet unknown, especially the risk of selection and dissemination of syphilis and chlamydia strains with doxycycline resistance, which has not been reported yet.
- |||||||||| ceftriaxone / Generic Mfg., doxycycline / Generic Mfg.
Journal: In vitro antimicrobial susceptibility of clinical isolates of Borrelia miyamotoi. (Pubmed Central) - Sep 18, 2019
In contrast to the MIC of the tested B. burgdorferi sl strains and in line with our previous findings, the MICs for amoxicillin (range 8-32mg/L) of all RF Borrelia -- including B. miyamotoi clinical isolates -- were above the clinical breakpoint for resistance (≤4 mg/L). Clinical isolates of B. miyamotoi are highly susceptible to doxycycline, azithromycin and ceftriaxone in vitro Interestingly, as earlier described for tick isolates, amoxicillin shows poor in vitro activity against clinical B. miyamotoi isolates.
- |||||||||| doxycycline / Generic Mfg.
Journal: Antibodies to PfsEGXP, An Early Gametocyte Enriched Phosphoprotein, Predict Decreased Plasmodium falciparum Gametocyte Density In Humans. (Pubmed Central) - Sep 18, 2019
At the start of the high-transmission season, 144 males (12-35 years) were enrolled and treated with quinine and doxycycline, peripheral venous blood samples were obtained, volunteers were observed, and weekly blood films were obtained for 18 weeks to quantify gametocytemia...When analyzed dichotomously, anti-PfsEGXP responders had 31% lower gametocyte density over 18 weeks of follow-up, compared to non-responders (P = 0.04). PfsEGXP is one of the first reported gametocyte-specific target of antibodies that predict decreased gametocyte density in humans and supports our novel TBV antigen discovery platform.
- |||||||||| doxycycline / Generic Mfg.
SEVERE CATAPLEXY IN A MOUSE MODEL OF CHILDHOOD NARCOLEPSY (Board #165 - Exhibition) - Sep 17, 2019 - Abstract #WSS2019WSS_2126;
Orexin neuron loss in young mice results in severe cataplexy, whereas orexin neuron loss during adulthood increases REM sleep in the active period but produces only mild cataplexy. This difference parallels the pattern seen in children and adults with narcolepsy and provides opportunities to study the underlying mechanisms.
- |||||||||| trimethoprim/sulfamethoxazole / Generic mfg., doxycycline / Generic mfg.
Enrollment closed, Trial completion date, Trial primary completion date: CleanUp-IPF: CleanUP IPF for the Pulmonary Trials Cooperative (clinicaltrials.gov) - Sep 17, 2019
P3, N=509, Active, not recruiting,
This difference parallels the pattern seen in children and adults with narcolepsy and provides opportunities to study the underlying mechanisms. Recruiting --> Active, not recruiting | Trial completion date: Jul 2019 --> Jul 2020 | Trial primary completion date: Jul 2019 --> Jul 2020
- |||||||||| doxycycline / Generic Mfg.
Clinical, Journal: Case Report: Concurrent Sympatric Scrub Typhus and Japanese Spotted Fever in Japan. (Pubmed Central) - Sep 16, 2019
A significant > 4-fold increase in IgG and IgM titers against multiple serotypes of Orientia tsutsugamushi and Rickettsia japonica were revealed by indirect immunoperoxidase assays. These clinical and serological data, even in the absence of molecular or isolation evidence, provided grade II evidence that this was a concurrent infection of sympatric scrub typhus and Japanese spotted fever.
- |||||||||| doxycycline / Generic Mfg., carbamazepine / Generic Mfg.
Journal: New Insights into Dose- and Time-Dependent Response of Five Typical PPCPs on Soil Microbial Respiration. (Pubmed Central) - Sep 16, 2019
At high concentrations (25 and 50 mg/kg) CIP and SMZ showed an inhibitory effect (- 69.13%, - 80.86% for 25 and 50 mg/kg, respectively), while TCC and CBZ exhibited stimulatory effect (38.07%, 9.64% and 4.06%, 12.18% at 25 and 50 mg/kg, respectively) at 1 day of incubation. Our findings indicate that the effect of tested PPCPs on soil microbial respiration had an inhibitory or stimulatory effect based on the dose and extent of time.
- |||||||||| Journal: Antimicrobial susceptibility pattern of oral isolates of Aggregatibacter actinomycetemcomitans. (Pubmed Central) - Sep 15, 2019
All isolates were resistant to metronidazole...Development of resistance against tetracycline also appears to be significant. Variable resistance among the different members of the cephalosporin group is a factor to be investigated further since susceptibility profile against these antibiotics and interpretative criteria for oral bacteria are not available.
- |||||||||| doxycycline / Generic Mfg.
Journal: The putative role of insulin-like growth factor (IGF)-binding protein 5 independent of IGF in the maintenance of pulpal homeostasis in mice. (Pubmed Central) - Sep 15, 2019
This study aimed to elucidate the role of IGFBP5 in maintaining pulpal homeostasis during tooth development and pulpal healing after tooth injury in doxycycline-inducible TetOP-histone 2B (H2B)-green fluorescent protein (GFP) transgenic mice (GFP expression was induced at E14.5 or E15.5) by using TUNEL assay, RT-PCR, in situ hybridization for Igfbp5, and immunohistochemistry for IGFBP5, Nestin, and GFP...In situ hybridization and RT-PCR analyses confirmed the expression of Igfbp5 in the dental pulp. These findings suggest that IGFBP5 play a pivotal role in regulating the survival and apoptosis of DPSCs during both tooth development and pulpal healing following tooth injury.
- |||||||||| doxycycline / Generic Mfg.
Journal: Concurrent primary chancre and ocular syphilis in an HIV-negative man. (Pubmed Central) - Sep 14, 2019
We believe this to be the first report of co-existing PCR-confirmed primary genital and ocular syphilis in a patient with penicillin allergy treated with doxycycline. The case examines the use of non-penicillin and corticosteroid treatment of ocular syphilis and highlights the risk of eye involvement early in the disease process.
- |||||||||| doxycycline / Generic Mfg.
Journal: ¿Azitromicina como tratamiento contra Chlamydia trachomatis? (Pubmed Central) - Sep 14, 2019
With the new diagnostic methods and tests of cure, a difference has been demonstrated in favor of doxycycline in the treatment of rectal chlamydiasis Antimicrobial resistance has not played a relevant role since no treatment-resistant strains have been found in vivo. Nevertheless, azithromycin remains a first-choice drug, since it can be administered as a single dose, which favors therapeutic adherence.
- |||||||||| doxycycline / Generic Mfg.
Effect of Outpatient Antibiotic Ordering Restrictions on Antibiotic Prescribing Patterns at a State-Wide VA Health Care System (147 AB) - Sep 12, 2019 - Abstract #IDWeek2019IDWeek_788;
Conclusion : Removal of AZM restriction led to significant decrease in FQ Rx, with greater effect in shorter duration and urban clinics, and an increase in AZM Rx, with greater effect in shorter duration, but no difference in clinic setting. Disparity of rural prescribers needs further exploration, as do other interventions outside of restrictive ordering, which needs periodic evaluation of risk and benefit if implemented.
- |||||||||| Sivextro (tedizolid) / Merck (MSD), Nabriva Therap
Enrollment closed: TEDIZOAM: Tedizolid Prolonged Treatment for Prosthetic Joint Infections (clinicaltrials.gov) - Sep 11, 2019
P=N/A, N=35, Active, not recruiting,
Thus, there is considerable uncertainty in effects observed and the effects of different prophylactic antibiotics requires further research. Recruiting --> Active, not recruiting
|
