- |||||||||| rifampicin / Generic mfg., doxycycline / Generic mfg.
Retrospective data, Journal, Real-world evidence, Real-world: Clinical Characteristics, Treatment, and Prognosis of Osteoarticular Brucellosis: A Retrospective Real-World Study in Shenyang, China, 2014-2019. (Pubmed Central) - Apr 12, 2024
P=N/A
In summary, our study provided important insights into the clinical characteristics, treatment, and outcomes of osteoarticular brucellosis. Clinical Trial Registration number: NCT04020536.
- |||||||||| Retrospective data, Review, Journal: Syphilis Treatment: Systematic Review and Meta-Analysis Investigating Nonpenicillin Therapeutic Strategies. (Pubmed Central) - Apr 10, 2024
The studies were considerably homogeneous, and stratified analyses considering each alternative treatment separately revealed that penicillin monotherapy did not outperform ceftriaxone (pooled odds ratio, 1.66 [95% confidence interval, .97-2.84]; I2 = 0%), azithromycin (0.92; [.73-1.18]; I2 = 0%), or doxycycline (0.82 [.61-1.10]; I2 = 1%) monotherapies with respect to serological conversion. Alternative treatment strategies have serological cure rates equivalent to penicillin, potentially reducing global dependence on this antibiotic.
- |||||||||| Journal: Antimicrobial resistance of avian pathogenic Escherichia coli isolated from broiler, layer, and breeder chickens. (Pubmed Central) - Apr 10, 2024
Similarly, a significant phenotype-genotype correlation (p < 0.001) was observed between chloramphenicol and the tetB, and colistin with blaTEM and resistance gene of quinolone (qnrA)...We deciphered the complex nature of AMR in APEC populations. This information of molecular surveillance is useful to combat AMR in APEC and to contribute to manage APEC associated diseases and develop policies and guidelines to enhance the commercial chicken production.
- |||||||||| doxycycline / Generic mfg.
Journal: Generation of Connexin-Expressing Stable Cell Pools. (Pubmed Central) - Apr 9, 2024
Taking advantage of the ability of lentivirus (LV) to promote transgene delivery, and genomic integration and expression in both dividing and nondividing cells, a doxycycline-inducible transfer vector expressing a bicistronic transgene was developed to study the function of connexins in HeLa DH cells...We further present step-by-step immunolabeling protocols to characterize the transgene protein expression by confocal microscopy using an antibody that targets an extracellular domain epitope of Cx32 in living cells, and in fixed permeabilized cells using high affinity anti-Cx32 antibodies. Using common molecular biology laboratory techniques, this protocol can be adapted to generate stable pools expressing any transgene of interest, for both in vitro and in vivo functional assays, including molecular, immune, and optical assays.
- |||||||||| metronidazole oral / Generic mfg., doxycycline / Generic mfg.
Clinical, P2 data, Journal: A randomized, double-blind, positive-controlled, Phase-II clinical trial to evaluate efficacy and safety of Fuke Qianjin capsule in Pakistani patients with pelvic inflammatory disease. (Pubmed Central) - Apr 8, 2024
P2
The results of this trial indicate that the test drug (Fuke Qianjin capsule) is non-inferior to the control drug (doxycycline hyclate tablet) in treating mild-to-moderate PID patients with comparable efficacy, safety, and tolerability to the control drug. Clinical Trial Registration: www.clinicaltrials.gov, identifier NCT04723069.
- |||||||||| doxycycline / Generic mfg.
Journal: Elucidating doxycycline biotransformation mechanism by Chryseobacterium sp. WX1: Multi-omics insights. (Pubmed Central) - Apr 8, 2024
The elucidated degradation pathway encompassed several key biological processes, such as the microbial transmembrane transport of DOX and its intermediates, the orchestration of enzyme synthesis for transformation, energy metabolism, and other gene-regulated biological directives. This study provides the first insight into the adaptive biotransformation strategies of Chryseobacterium under DOX-induced stress, highlighting the potential applications of this strain to augment DOX removal in wastewater treatment systems containing high concentrations of DOX.
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg.
Retrospective data, Journal: A Retrospective Study of Covid-19 Patients: A Real-Life Experience in a Secondary Care Hospital, Jashore, Bangladesh. (Pubmed Central) - Apr 5, 2024
Therefore, we can conclude that the disease was well managed with highly satisfactory outcomes even in the low resource health care setting in the early stage of Covid-19 pandemic era. Hence, the early case detection, identification of the high-risk groups and proper management may mitigate to develop complications and fatalities of Covid-19.
- |||||||||| doxycycline / Generic mfg.
Trial completion date, Trial primary completion date: MED-hATTR: Monitoring of Early Disease Progression in Hereditary Transthyretin Amyloidosis (clinicaltrials.gov) - Apr 4, 2024
P=N/A, N=30, Active, not recruiting,
Hence, the early case detection, identification of the high-risk groups and proper management may mitigate to develop complications and fatalities of Covid-19. Trial completion date: Feb 2024 --> Dec 2026 | Trial primary completion date: Feb 2024 --> Sep 2026
- |||||||||| doxycycline / Generic mfg.
Journal: Glioblastoma U-87 (Pubmed Central) - Apr 4, 2024
Our results demonstrated that an antibiotic at a non-toxic concentration could suppress the enhanced cell migration accelerated by EF of physiological strength. This finding may be applied as an anti-metastatic treatment for cancers.
- |||||||||| Journal: Prevalence and antimicrobial resistance of Enterobacteriaceae in the north of Kazakhstan. (Pubmed Central) - Apr 2, 2024
The most common genes encoding antimicrobial resistance were as follows: BlaTEM and OXA in 41 and 28 isolates, respectively, encoding resistance to beta-lactams; StrA and StrB in 45 and 48 isolates encoding aminoglycosides; and tetA and tetB in 43 and 28 isolates encoding tetracyclines. Obtained data demonstrate that uncontrolled and frequent use of beta-lactam and tetracycline antibacterials, in cats and dogs, results in the spread of genotypic resistance among micro-organisms of the family Enterobacteriaceae.
- |||||||||| doxycycline / Generic mfg., erythromycin / Generic mfg.
Journal: Antimicrobial Indole-3-Carboxamido-Polyamine Conjugates Target Bacterial Membranes and Are Antibiotic Potentiators. (Pubmed Central) - Apr 1, 2024
The same analogue also restored the action of doxycycline toward P. aeruginosa with a 21-fold enhancement, while the corresponding 5-bromo-indole-3-carboxamide-PA3-7-3 analogue was able to enhance the action of both doxycycline and erythromycin toward P. aeruginosa and Escherichia coli, respectively. The analogue 13b was capable of disrupting the bacterial membrane of both S. aureus and methicillin-resistant S. aureus (MRSA) and the outer membrane of P. aeruginosa, suggesting that membrane perturbation could be a mechanism of action of both intrinsic antimicrobial activities and antibiotic potentiation.
- |||||||||| doxycycline / Generic mfg.
Journal: Outcome of complicated osteoarticular brucellosis in a tertiary care center in Saudi Arabia. (Pubmed Central) - Mar 31, 2024
The analogue 13b was capable of disrupting the bacterial membrane of both S. aureus and methicillin-resistant S. aureus (MRSA) and the outer membrane of P. aeruginosa, suggesting that membrane perturbation could be a mechanism of action of both intrinsic antimicrobial activities and antibiotic potentiation. Unfavorable outcomes have been noticed to be minimal in our cohort of patients with osteoarticular brucellosis, treated mainly with a three-drug regimen and a longer duration of therapy.
- |||||||||| doxycycline / Generic mfg.
Intricate mechanisms trigger scattered crypt IEC apoptosis mediated necrotizing enterocolitis pathogenesis in neonatal mice (Exhibit Hall F1; Poster Board Number: B216) - Mar 29, 2024 - Abstract #IMMUNOLOGY2024IMMUNOLOGY_1859;
We developed a novel triple-transgenic mouse model, namely, 3xTg-iAPcIEC (inducible apoptosis phenotype in crypt-IEC) using doxycycline (Dox)-inducible tetO-rtTA system and vil-cre technology, for inducing tissue-specific overexpression of Fasl in IECs...Notably, we observed that blocking any of these events protects NEC development in 3xTg-iAPcIEC mouse pups, underlining their central roles in the NEC pathogenesis. Our findings may advance knowledge in preventing or treating this devastating disorder in humans.
- |||||||||| doxycycline / Generic mfg.
Lumbar spinal cord expression of Tollip, a Toll-like receptor pathway regulator in HIV Tat-associated sensory neuropathy (Exhibit Hall F1; Poster Board Number: B642) - Mar 29, 2024 - Abstract #IMMUNOLOGY2024IMMUNOLOGY_1120;
Using doxycycline inducible HIV-1 Tat transgenic (iTat) mice, we and others have shown that Tat induction is associated with HIV-sensory neuropathy (SN)-like behaviors...Time course study showed consistent changes in Tollip expression at the protein level to that at the RNA level. Future work will identify potential sex-dependent Tollip expression and investigate the role of Tollip in Tat-associated HIV-SN.
- |||||||||| hydroxychloroquine / Generic mfg., doxycycline / Generic mfg.
IgA VASCULITIS REVEALING WHIPPLE'S DISEASE: FIRST DESCRIPTION (Poster View) - Mar 29, 2024 - Abstract #EULAR2024EULAR_2593;
Learning points for clinical practice: Whipple's disease is a very rare disease with often a significant delay in diagnosis. Persistent arthritis and biological inflammatory parameters in other condition with articular involvement, such as typical rheumatoid purpura, should lead clinicians to consider Whipple's disease and perform PCR in saliva and stool.
- |||||||||| Review, Journal, Surgery: Prophylactic Antibiotics before Gynecologic Surgery: A Comprehensive Review of Guidelines. (Pubmed Central) - Mar 28, 2024
Conversely, procedures such as intrauterine device insertion, hysteroscopy, and laparoscopy typically do not necessitate antibiotic prophylaxis. For several other procedures, the evidence is inconclusive, while considering dose, timing, and indications can mitigate infectious complications and provide benefits for the healthcare system.
- |||||||||| doxycycline / Generic mfg.
Preclinical, Journal: In Vivo Study on Doxycycline Protective Mechanisms during Myocardial Ischemia Injury in Rats. (Pubmed Central) - Mar 28, 2024
For several other procedures, the evidence is inconclusive, while considering dose, timing, and indications can mitigate infectious complications and provide benefits for the healthcare system. Inhibition of MMPs by doxycycline, in vivo, may serve as a protective agent in future therapy.
- |||||||||| doxycycline / Generic mfg.
Review, Journal: Preventive and Sexual Health in LGBTQ+ Older Adults. (Pubmed Central) - Mar 27, 2024
Inhibition of MMPs by doxycycline, in vivo, may serve as a protective agent in future therapy. In this review, we discuss approaches to engaging LGBTQ
- |||||||||| metformin / Generic mfg.
Journal: Modulating the antibacterial effect of the existing antibiotics along with repurposing drug metformin. (Pubmed Central) - Mar 27, 2024
Further, molecular dynamics simulation revealed that the docked complexes were relatively stable during the 100 ns simulation period. This study suggest Metformin and other experimented drugs can be used as adjuvants boost up antibiosis but further study is needed to find out the safety and efficacy of this non-antibiotic drug as potent antibiotic adjuvant.
- |||||||||| Reimbursement, US reimbursement, Journal, Medicaid: Decreases and Pronounced Geographic Variability in Antibiotic Prescribing in Medicaid. (Pubmed Central) - Mar 25, 2024
This study identified sizable disparities by geography in the prescribing rates of eight antibiotics with over three-fold state-level differences. Areas with high prescribing rates, particularly for outpatients, may benefit from stewardship programs to reduce potentially unnecessary prescribing.
- |||||||||| doxycycline / Generic mfg.
Journal: Community pharmacist intervention in doxycycline self-medication for acne among pregnant women in Saudi Arabia. (Pubmed Central) - Mar 25, 2024
However, further improvement is needed, particularly in terms of in-depth inquiry about pregnancy status and potential risks associated with specific medications. Collaborative efforts between the Ministry of Health (MOH), Saudi Food and Drug Administration (SFDA), and pharmacy education programs are crucial to minimize inappropriate dispensing practices and ensure optimal patient safety.
- |||||||||| doxycycline / Generic mfg.
Observational data, Journal, Adherence: Adherence to doxycycline for uncomplicated genitourinary chlamydia: A prospective observational study. (Pubmed Central) - Mar 25, 2024
The CDC recommendation to consider azithromycin when nonadherence is a "substantial concern" should be applied broadly in these settings by routinely discussing barriers to adherence when selecting the optimal antimicrobial regimen. The benefit of dispensing the doxycycline regimen on-site compared to prescribing it could not be determined given differences in baseline characteristics between the two groups.
- |||||||||| Preclinical, Journal: Impaired neuronal macroautophagy in the prelimbic cortex contributes to comorbid anxiety-like behaviors in rats with chronic neuropathic pain. (Pubmed Central) - Mar 24, 2024
Taken together, our work identifies causal linkage between PrL neuronal macroautophagy dysfunction and comorbid anxiety in neuropathic pain and provides novel insights into the role of PrL by differentiating its contribution in pain-induced comorbid anxiety from its modulation over general anxiety-like behaviors.Abbreviation: AAV: adeno-associated viruses; ACC: anterior cingulate cortex; ATG5: autophagy related 5; ATG7: autophagy related 7; ATG12: autophagy related 12; CAMK2/CaMKII: calcium/calmodulin-dependent protein kinase II; CNO: clozapine-N-oxide; CQ: chloroquine; DIA: data independent acquisition; DIO: double floxed inverse orf; DLG4/PSD-95: discs large MAGUK scaffold protein 4; Dox: doxycycline; GABA: ?-aminobutyric acid; GFP: green fluorescent protein; GO: gene ontology; Gi: inhibitory guanine nucleotide-binding proteins; HsCHRM4/M4D: human cholinergic receptor muscarinic 4; HsSYN: human synapsin; KEGG: Kyoto encyclopedia of genes and genomes; LAMP1: lysosomal-associated membrane protein 1; LC3-II: PE conjugated microtubule-associated protein 1 light chain3; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; mPFC: medial prefrontal cortex; P2A: 2A self-cleaving peptide; PPI: protein-protein interaction networks; PrL: prelimbic cortex; RBFOX3/NeuN: RNA binding protein, fox-1 homolog (C. elegans) 3; rtTA: reverse tetracycline-transactivator; SDS-PAGE: sodium dodecylsulfate-polyacrylamide gel electrophoresis; SHANK3: SH3 and multiple ankyrin repeat domains 3; SLC1A1/EAAC1: solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, systemXag), member 1; SNAP23: synaptosomal-associated protein 23; SNI:spared nerve injury; SQSTM1/p62: sequestosome 1; SYT3: synaptotagmin 3; TRE: tetracycline-responsive element; TRE3G: third-generation tetracycline-responsive element.
- |||||||||| Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi
Unraveling Powassan Encephalitis After a Kidney-Pancreas Transplant: Case Report and Implication () - Mar 23, 2024 - Abstract #NKFSCM2024NKF_SCM_925;
No definitive management guidelines exist, with corticosteroids and IVIG showing limited efficacy. This case of Powassan encephalitis underlines the need for increased awareness and research into treatment for this potentially fatal disease in immunocompromised patients , particularly those who have undergone organ transplants.
- |||||||||| doxycycline / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
C3 glomerulopathy mimic induced by mycoplasma infection. () - Mar 23, 2024 - Abstract #NKFSCM2024NKF_SCM_842;
Mycoplasma can induce a systemic autoimmune reaction which can produce multiple antibodies including nephritic factors leading to C3GN mimic. The recovery of complement level indicates a transient disease, favoring infection related glomerulonephritis.
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