doxycycline / Generic mfg. 
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  • ||||||||||  doxycycline / Generic mfg., tetracycline / Generic mfg.
    Preclinical, Journal:  Poor Decision Making and Sociability Impairment Following Central Serotonin Reduction in Inducible TPH2-Knockdown Rats. (Pubmed Central) -  May 11, 2024   
    Using a novel rat model of inducible serotonin depletion via the genetic knockdown of tryptophan hydroxylase 2 (TPH2), we achieved a 20% decrease in serotonin levels in the hypothalamus after three weeks of non-invasive oral doxycycline administration...This study highlights the great opportunity the Tph2-kd rat model offers to study inter-individual susceptibilities to develop cognitive impairment following mild variations of brain serotonin in otherwise healthy individuals. These transgenic and differential approaches together could be critical for the identification of translational markers and vulnerabilities in the development of mental disorders.
  • ||||||||||  Clinical data, Retrospective data, Journal:  Neurobrucellosis: laboratory features, clinical characteristics, antibiotic treatment, and clinical outcomes of 21 patients. (Pubmed Central) -  May 11, 2024   
    When patients with unexplained neurological symptoms accompanied by fever, fatigue, and other systemic manifestations in a brucellosis epidemic area or with a history of contact with cattle, sheep, animals, or raw food are encountered in clinical practice, the possibility of NB should be considered. Treatment is based on the principles of an early, combined, and long course of treatment, and the general prognosis is good.
  • ||||||||||  rifampicin / Generic mfg., doxycycline / Generic mfg.
    Journal:  Cat-scratch disease: a rare cause of osteomyelitis. (Pubmed Central) -  May 11, 2024   
    Cat-scratch disease was diagnosed, and complete recovery achieved after treatment with doxycycline and rifampicin.Cat-scratch disease is a challenging diagnosis in the absence of typical features. However, B. henselae must be investigated if common pathogens are ruled out and response to therapy is poor.
  • ||||||||||  doxycycline / Generic mfg., gefitinib / Generic mfg.
    Journal:  CD133 Stimulates Cell Proliferation via the Upregulation of Amphiregulin in Melanoma. (Pubmed Central) -  May 10, 2024   
    Treatment with the EGFR inhibitor gefitinib blocked CD133-induced cell growth increase and MAPK pathway activation. Importantly, siRNA knockdown of AREG reversed the stimulatory effects of CD133 on cell growth, indicating that AREG mediates the effects of CD133 on cell proliferation, thus serving as an attractive target for novel combinatorial therapeutics in melanoma and cancers with overexpression of both CD133 and AREG.
  • ||||||||||  Dupixent (dupilumab) / Sanofi, Regeneron, Xolair (omalizumab) / Roche, Novartis
    Review, Journal:  A systematic review of the management of eosinophilic dermatosis of hematological malignancy. (Pubmed Central) -  May 10, 2024   
    Targeted therapies, including dupilumab and omalizumab, showed promise, as did other modalities such as montelukast, dapsone, doxycycline, and phototherapy. Higher-quality studies should be conducted to facilitate higher-quality management recommendations for EDHM.
  • ||||||||||  tetracycline / Generic mfg.
    Journal:  Aluminium-doped Carbon Dots for the Simultaneous Selective Detection of Five Tetracycline Antibiotics. (Pubmed Central) -  May 8, 2024   
    In this paper, the aluminium-doped carbon dots (Al-CDs) were developed for simultaneous selective detection of five tetracycline antibiotics (TCs), including minocycline (MC), tetracycline (TC), oxytetracycline (OTC), doxycycline (DOC) and chlortetracycline (CTC). A good linear relationship was achieved for five TCs in the range of 0-100
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Minimum inhibitory concentration of doxycycline for Vibrio parahaemolyticus. (Pubmed Central) -  May 6, 2024   
    These findings add to a growing body of evidence that allosteric modulation of DAT could provide a promising therapeutic intervention for patients with comorbid HIV-1 and cocaine use disorder (CUD). No abstract available
  • ||||||||||  doxycycline / Generic mfg.
    A Tale of Two Lungs: Donor Derived Legionnaires Disease Following Lung Transplantation (Poster Hall, Exhibit Hall A, Level 2) -  May 6, 2024 - Abstract #ATC2024ATC_2356;    
    Legionnaires disease following lung transplantation is a rare infectious disease, and its impact on both short-term and long-term allograft outcomes remains uncertain. The presented cases offer distinct presentations on disease severity and graft function following Legionella infection from a shared donor.
  • ||||||||||  doxycycline / Generic mfg.
    Exploring the Immunoregulatory Potential of Serpinb9 in Transplant Tolerance (118-ABC, Level 1) -  May 6, 2024 - Abstract #ATC2024ATC_136;    
    The presented cases offer distinct presentations on disease severity and graft function following Legionella infection from a shared donor. For deeper insights, we established PI-9 conditional knockout mice by crossbreeding inducible PI-9 RNA interference (PI-9rtTA) transgenic mice with macrophage-specific LyzM-Cre mice, resulting in macrophage-specific PI-9 knockouts upon doxycycline administration (PI-9rtTA
  • ||||||||||  Journal:  Emergence of NDM-producing Enterobacterales infections in companion animals from Argentina. (Pubmed Central) -  May 4, 2024   
    Even though different species and clones were observed, it is remarkable the finding of some major clones among K. pneumoniae and E. coli, as well as the circulation of NDM as the main carbapenemase. Surveillance in companion pets is needed to detect the spread of carbapenem-resistant Enterobacterales and to alert about the dissemination of these pathogens among pets and humans.
  • ||||||||||  doxycycline / Generic mfg.
    Doxycycline for bacterial sexually transmitted infection prevention in British Columbia, Canada (Poster board: 218) -  May 2, 2024 - Abstract #AIDS2024AIDS_1817;    
    The embargo on all abstracts, including oral abstract, poster exhibition, e-poster and late breakers, will lift on Tuesday, 23 July 2024, at 10:00 am Central European Summer Time (CEST). If an abstract is part of an official AIDS 2024 press conference that occurs before that time, the embargo on that abstract lifts at the start of the official press conference.
  • ||||||||||  Doxy-PEP proliferates among PrEP users in San Francisco, but inequities in awareness are present (Poster board: 240) -  May 2, 2024 - Abstract #AIDS2024AIDS_1813;    
    The embargo on all abstracts, including oral abstract, poster exhibition, e-poster and late breakers, will lift on Tuesday, 23 July 2024, at 10:00 am Central European Summer Time (CEST). If an abstract is part of an official AIDS 2024 press conference that occurs before that time, the embargo on that abstract lifts at the start of the official press conference.
  • ||||||||||  Knowledge, use and misuse of self-prescribed doxyPEP in a community-based PrEP service (Poster board: 212) -  May 2, 2024 - Abstract #AIDS2024AIDS_1801;    
    The embargo on all abstracts, including oral abstract, poster exhibition, e-poster and late breakers, will lift on Tuesday, 23 July 2024, at 10:00 am Central European Summer Time (CEST). If an abstract is part of an official AIDS 2024 press conference that occurs before that time, the embargo on that abstract lifts at the start of the official press conference.
  • ||||||||||  doxycycline / Generic mfg.
    Concerns about the use of doxycycline post-exposure prophylaxis among bathhouse clientele (Poster board: 211) -  May 2, 2024 - Abstract #AIDS2024AIDS_1798;    
    The embargo on all abstracts, including oral abstract, poster exhibition, e-poster and late breakers, will lift on Tuesday, 23 July 2024, at 10:00 am Central European Summer Time (CEST). If an abstract is part of an official AIDS 2024 press conference that occurs before that time, the embargo on that abstract lifts at the start of the official press conference.
  • ||||||||||  Intersection of chemsex, mental health, and substance use: findings from the Conectad@s study in Rio de Janeiro (Poster board: 130) -  May 2, 2024 - Abstract #AIDS2024AIDS_1493;    
    The embargo on all abstracts, including oral abstract, poster exhibition, e-poster and late breakers, will lift on Tuesday, 23 July 2024, at 10:00 am Central European Summer Time (CEST). If an abstract is part of an official AIDS 2024 press conference that occurs before that time, the embargo on that abstract lifts at the start of the official press conference.
  • ||||||||||  doxycycline / Generic mfg.
    Doxycycline PrEP prevents STIs without affecting vaginal bacterial flora in female sex workers (Hall B0a/Channel 4) -  May 2, 2024 - Abstract #AIDS2024AIDS_262;    
    The embargo on all abstracts, including oral abstract, poster exhibition, e-poster and late breakers, will lift on Tuesday, 23 July 2024, at 10:00 am Central European Summer Time (CEST). If an abstract is part of an official AIDS 2024 press conference that occurs before that time, the embargo on that abstract lifts at the start of the official press conference.
  • ||||||||||  ceftriaxone / Generic mfg., doxycycline / Generic mfg.
    Journal:  Susceptibility of nucleotide-binding oligomerization domain 2 mutations to Whipple's disease. (Pubmed Central) -  May 2, 2024   
    WD is regarded as a macrophage disease. NOD2 leucin-rich repeat-associated mutations in monocytes/macrophages cause functional impairment of these cells and consequently may make the host susceptible for TW infection and WD, especially in the setting of immunosuppression.
  • ||||||||||  Review, Journal:  Antibiotic prophylaxis for dental procedures. (Pubmed Central) -  May 1, 2024   
    Due to its advantages, this method holds great promise for application in the biomedical field for monitoring DC drug concentrations and ensuring quality control. No abstract available
  • ||||||||||  tetracycline / Generic mfg., isotretinoin / Generic mfg.
    Trial initiation date:  Weekly Isotretinoin vs Tetracycline for Moderate Acne (clinicaltrials.gov) -  May 1, 2024   
    P1,  N=50, Not yet recruiting, 
    No abstract available Initiation date: Feb 2024 --> Jan 2025
  • ||||||||||  doxycycline / Generic mfg.
    Journal:  Epsilon-poly-l-lysine microneedle patch loaded with amorphous doxycycline nanoparticles for synergistic treatment of skin infection. (Pubmed Central) -  Apr 30, 2024   
    In a Pseudomonas aeruginosa-induced deep cutaneous infection model, the EPL microneedles demonstrates potent and long-term effects by synergistically enhancing antibiotic activities and prolonging drug retention in infected lesions, resulting in remarkable therapeutic efficacy with 99.91?% (3.04 log) reduction in skin bacterial burden after a single administration. Overall, our study highlights the distinct advantages of EPL microneedles and their potential in clinical antibacterial practice when loaded with amorphous DOX nanoparticles.