- |||||||||| Aduhelm (aducanumab) / Eisai, Biogen
Journal: Dementia: Management and Controversies in Management. (Pubmed Central) - Nov 21, 2023
Common initial pharmacotherapy includes cholinesterase inhibitors and memantine, with use guided by dementia type, tolerability, patient goals, and disease stage...Newer treatments, such as aducanumab, can reduce beta-amyloid plaques, but evidence for cognitive improvements is lacking; these treatments also are expensive and patient access is limited, resulting in barriers to widespread use...Use of antipsychotics and benzodiazepines should be limited unless symptoms are placing the patient or others in imminent danger. Pharmacotherapy for these symptoms should be individualized, often requiring trials of various therapeutic options.
- |||||||||| galantamine hydrobromide / Generic mfg., memantine / Generic mfg., rivastigmine / Generic mfg.
Journal: Consumption of drugs for Alzheimer's disease on the Brazilian private market. (Pubmed Central) - Nov 21, 2023
The consumption of medicines indicated to treat Alzheimer's disease tripled in Brazil between 2014 and 2020, which may relate to the increase in the prevalence of the disease in the country, greater access to health services, and inappropriate use. This challenges managers and healthcare providers due to population aging and the increased prevalence of chronic-degenerative diseases.
- |||||||||| Aduhelm (aducanumab) / Eisai, Biogen, Leqembi (lecanemab-irmb) / Biogen, BioArctic, Eisai, Cognex (tacrine) / Shionogi
A historical review of interventions for Alzheimer's disease (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_14220;
The literature indicates that these FDA-approved pharmacological interventions have modest effects in slowing the progression and symptoms of AD.However, controversy arose in 2021 when the FDA granted accelerated approval to aducanumab, the first monoclonal antibody treatment for AD...In 2023, lecanemab, another monoclonal antibody treatment, also received FDA accelerated approval, despite criticism concerning its efficacy and safety.Nevertheless, published data suggest that pharmacological treatments for AD are effective in treating symptoms of AD...Several studies have demonstrated that behavioral lifestyle modifications, such as aerobic exercises, can be a treatment recommendation for AD. For instance, physical exercise has long been recognized to promote improved memory function and cognitive health, presumably by protecting against hippocampal volume loss in older adults.Although there are significant advancements in developing treatment recommendations for AD, further research is warranted on the efficacy of AD treatments, including both pharmacotherapy and non-pharmacotherapy options.
- |||||||||| memantine / Generic mfg.
Sex differences in NMDAR composition moderate efficacy of targeted therapeutics to reverse age-related memory loss (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_13731;
Ongoing work will focus on these sex differences and examine influences of MPC and NAMENDA on intracellular signaling cascades associated with synaptic plasticity and neuronal viability. Our experiments will uncover the neurobiological basis for sex disparities in age-related memory disorders and spur the development of NMDAR-directed therapeutics and adjuvants for aging men and women.
- |||||||||| lorazepam / Generic mfg., memantine / Generic mfg.
Shaping perceptual decision formation by GABA-A and NMDA receptor manipulation (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_10439;
We currently use simultaneously collected magnetoencephalography (MEG) data to analyse the encoding of sensory samples in visual cortex and the build-up of a decision variable in premotor cortex. Drug-induced changes in these cortical decision dynamics will help constrain mechanistic interpretations of our behavioral findings.
- |||||||||| memantine / Generic mfg.
Increased NMDA-receptor-mediated calcium influx in iPSC-derived neurons from individuals with Down syndrome (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_9797;
In a different set of neurons NMDAR blocker memantine (10 ?M) was added 2 min before the addition of NMDA...T21-iPSCs-derived neurons revealed alteration in NMDA receptor-mediated calcium influx, leading to increased Ca2+ activity. These findings provide supporting to the hypothesis of excessive NMDAR signaling based on previous observations in mouse models of DS and that NMDAR should be further investigated in DS.
- |||||||||| memantine / Generic mfg.
Behavioral comparison of the BTBR mouse model of autistic-like behavior against normo-social C57Bl/6J mice (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_7059;
Memantine, a therapeutic agent proposed for the treatment of core symptoms of ASD, with previously demonstrated efficacy in this model was used as a reference compound.Our findings revealed no significant differences in activity measures during the Open field assay, between the BTBR and C57 mice...In addition, striatal MRS showed alterations in several metabolites. Behavioral phenotypes observed in BTBR mice capture a subset of the key deficits of ASD and can prove to be a useful model for identification of therapeutic interventions.
- |||||||||| ketamine / Generic mfg., memantine / Generic mfg.
Pathway-specific differences in NMDA receptor function in adult PFC parvalbumin-positive inhibitory interneurons (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_5719;
Our preliminary analysis suggests that relative differences in NMDAR contribution to EPSCs across synaptic inputs to PV+ interneurons are more likely to be driven by differences in NMDAR composition than subcellular distribution of synaptic contacts on PV+ interneuron dendrites. Our findings indicate that NMDAR channel-blockers like ketamine and memantine that preferentially inhibit NMDARs containing specific subunits may be biased to more strongly inhibit glutamatergic excitation of PV+ interneurons coming from some upstream brain regions than others.
- |||||||||| memantine / Generic mfg.
Characterizing intracellular calcium dependence of triheteromeric NMDA receptors (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_5713;
Wehave shown that CDD is enhanced by the AD drug memantine (Mem) and proposedthat as a result, Mem preferentially inhibits NMDAR populations implicated indisease...We quantify contamination by GluN1/2B dihetcurrent by applying 10 mM Glu, which saturates GluN1/2B dihets withoutactivating trihets or GluN1/2A(T690I) dihets. Understanding CDD and its role inMem inhibition of trihets has broad implications for mechanisms of therapeutic drugaction.
- |||||||||| dizocilpine (MK801) / Merck (MSD)
Investigation of NMDAR membrane to channel inhibition by extracellular (+)-MK-801 (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_5712;
002 ?M) receptors, and to our surprise, found that the mutation did not increase MK-801 MCI IC50. These results suggest MK-801 and memantine may use different fenestrations to transit from the membrane to the deep site during MCI.
- |||||||||| memantine / Generic mfg.
Functional characterization of healthy and disease-related 3D neurospheres assembled using iPSC-derived neurons and astrocytes (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_3378;
In contrast, decreased activities were observed in Alzheimer-related ApoE 4/4 mutants, while the phenotype was reversed by addition of drugs used for treatment of Alzheimer disease memantine and donepezil. This biological system of 3D neurospheres paired with high-content imaging and detailed analysis of calcium oscillations demonstrates a promising tool for disease modeling and compound testing.
- |||||||||| memantine / Generic mfg.
Journal: Endogenous currents in HEK 293 cells are inhibited by memantine. (Pubmed Central) - Oct 30, 2023
This biological system of 3D neurospheres paired with high-content imaging and detailed analysis of calcium oscillations demonstrates a promising tool for disease modeling and compound testing. No abstract available
- |||||||||| memantine / Generic mfg.
Review, Journal: Glaucoma: neuroprotection with NAD-based therapeutic interventions. (Pubmed Central) - Oct 25, 2023
Unfortunately, failure of clinical trials with neuroprotective agents, in particular those testing the anti-excitotoxic drug memantine, generated widespread skepticism regarding the possibility of counteracting neurodegeneration during glaucoma...Positive results of proof-of-concept clinical studies based on sustaining axonal NAD homeostasis facilitated the design of Phase 2/3 trials. Here, I share my opinion on how neurodegeneration in glaucoma should be put into context, together with an appraisal of the pharmacological rationale of NAD-supporting therapies for use during glaucoma progression.
- |||||||||| memantine / Generic mfg.
Journal: Memantine administration prevented chorea movement in Huntington's disease: a case report. (Pubmed Central) - Oct 22, 2023
Here, I share my opinion on how neurodegeneration in glaucoma should be put into context, together with an appraisal of the pharmacological rationale of NAD-supporting therapies for use during glaucoma progression. We recorded changes in parameters such as the results of the N-isopropyl-p-iodoamphetamine-single-photon emission computed tomography and gait videos over 7
- |||||||||| Aduhelm (aducanumab) / Eisai, Biogen, Leqembi (lecanemab-irmb) / Biogen, BioArctic, Eisai
Review, Journal: Treatment of Alzheimer's Disease: Beyond Symptomatic Therapies. (Pubmed Central) - Oct 4, 2023
This review describes ongoing clinical trials with DMTs and non-pharmacological therapies. We will also present a future scenario based on new biomarkers that can detect AD in preclinical or prodromal stages, identify people at risk of developing AD, and allow an early and curative treatment.
- |||||||||| memantine / Generic mfg.
Review, Journal: Basic information about memantine and its treatment of Alzheimer's disease and other clinical applications. (Pubmed Central) - Oct 3, 2023
Over the past half-century, memantine's research and clinical application have been extensively developed. In this review, the basic composition of memantine, the mechanism and limitations of memantine in the treatment of AD, memantine combination therapy, comparison of memantine with other drugs for AD, and clinical studies of memantine in other diseases are reviewed to provide a valuable reference for further research and application of memantine for the treatment of AD.
- |||||||||| risperidone / Generic mfg., memantine / Generic mfg., amantadine / Generic mfg.
N-Methyl-D-Aspartate (NMDA) Receptor Antagonist and ASD: A Systematic Review (Rhinelander (New York Hilton Midtown); In-person) - Sep 30, 2023 - Abstract #AACAP2023AACAP_1575;
Conclusions The overall quality of evidence supporting the use of amantadine and memantine in youths with ASD is weak, and more powered studies are needed to establish true effect size. Findings linked with their off-label use generates a compelling hypothesis needing further systematic research.
- |||||||||| Trintellix (vortioxetine) / Lundbeck, Takeda
Psychopharmacological Augmentation Strategies in Pediatric OCD: A Systematic Review and Pooled Analysis (Americas Hall II (New York Hilton Midtown); In-person) - Sep 30, 2023 - Abstract #AACAP2023AACAP_1275;
An RCT that used riluzole failed to establish its superiority over placebo...Other reports included augmentation with clomipramine, memantine, ziprasidone, lamotrigine, stimulants, vortioxetine, and clonazepam...Independent case reports have showed positive effects from augmentation agents like risperidone and aripiprazole, and few RCTs have showed positive effects from N-acetylcysteine. Larger-scale RCTs are still needed to establish the optimal use of augmentation strategies in this population.
- |||||||||| lorazepam / Generic mfg., memantine / Generic mfg., amantadine / Generic mfg.
Catatonia: Characteristics and Challenges in Youth With Significant Medical Comorbidities (Americas Hall II (New York Hilton Midtown); In-person) - Sep 30, 2023 - Abstract #AACAP2023AACAP_815;
A thorough interdisciplinary workup is needed to determine possible medical etiologies once the diagnosis of catatonia is established. Overall, this case series helps illustrate the complexity and importance of treating catatonia in youths in a medical setting.
- |||||||||| Alternative Treatment Strategies for Pediatric Catatonia (Murray Hill East (New York Hilton Midtown); In-person) - Sep 30, 2023 - Abstract #AACAP2023AACAP_785;
Regarding pharmacologic treatments beyond benzodiazepines, 13/32 patients were treated with memantine (mean = 17.7 mg, SD = 5.8) and 4/31 with valproic acid (mean = 1050.0 mg, SD = 576.6)...The results indicated clinical improvement ( t = -21.3, df = 31, p < .001; 95% CI, 2.0-2.5). Conclusions Given the limited availability of pediatric ECT and recent lorazepam shortages, clinicians may consider alternative interventions for pediatric catatonia.
- |||||||||| memantine / Generic mfg.
Journal: The Role of NMDA Receptor Subunits in the Effect of Memantine on the Brain of Healthy Animals. (Pubmed Central) - Sep 28, 2023
For this, the expression of subunits GluN1, GluN2A, GluN2B, and GluN2C was studied in the hippocampus and prefrontal cortex of rats after single or five subchronic injections of memantine. The results showed that the GluN2C subunit (GRIN2C) plays an important role in the effects of memantine; against the background of memantine treatment, the expression of this subunit markedly decreased in the prefrontal cortex, but not in the hippocampus, which significantly affected the excitation/inhibition balance in cortical structures.
- |||||||||| riluzole / Generic mfg.
Review, Journal: Neuroprotective effects of riluzole in Alzheimer's disease: A comprehensive review. (Pubmed Central) - Sep 27, 2023
This methodology can be useful in formulation studies for estimating the BE probability between ODTs and CTs. In this review article, we aimed to review the neuroprotective properties of riluzole, a glutamate modulator, in AD, which could benefit patients with the disease.
- |||||||||| memantine / Generic mfg.
Predictors of Cognitive Impairment in Individuals with Systemic Lupus Erythematosus (Poster Hall; in person) - Sep 23, 2023 - Abstract #ACRConvergence2023ACR_Convergence_3524;
Disease activity did not appreciably affect cognition in this participant sample. As participant scores crossed thresholds for depression or fibromyalgia diagnosis, measurable declines in cognition, particularly immediate memory, were observed.
- |||||||||| memantine / Generic mfg.
Enrollment open: A Prospective Study of Memantine in Patients With Cirrhosis and Liver Cancer (clinicaltrials.gov) - Sep 21, 2023
P2/3, N=12, Recruiting,
Remarkably, pharmacokinetic evaluations of compound 2 showed a promising increase in brain uptake in comparison to compound 1, representing the starting point for further chemical optimizations. Not yet recruiting --> Recruiting
- |||||||||| memantine / Generic mfg.
Journal: Palliative whole brain radiation therapy: an international state of practice. (Pubmed Central) - Sep 21, 2023
This moment-in-time analysis confirms that patients with poor expected survival are being appropriately selected for WBRT-illustrating the dwindling indications for WBRT-and demonstrates the variance in global practice. Since poor survival precludes patients from deriving benefit, memantine and HA are best suited in carefully selected cases.
- |||||||||| memantine / Generic mfg.
Journal: Antidementia Medication Use in Nursing Home Residents. (Pubmed Central) - Sep 16, 2023
This, in turn, would lead to a remarkable reduction in medical expenses associated with hospitalization of AD patients in the US, totaling over 940 million dollars per year. These prescribing trends highlight the need for additional research on the effects of initiating and discontinuing antidementia medications in the NH to provide clear guidance for clinicians when making treatment decisions for individual residents.
- |||||||||| nimodipine / Generic mfg., memantine / Generic mfg., citicoline / Generic mfg.
Review: The efficacy and safety of post-stroke cognitive impairment therapies: an umbrella review. (Pubmed Central) - Sep 11, 2023
Our study demonstrated that ACEI inhibitors (Donepezil) and NMDA antagonists (Memantine), EGB761, and acupuncture are the ADL and BI, MoCA, and neurological function deficit medication/therapy, respectively, for patients with PSCI. Clinical Trial Registration: https://inplasy.com/inplasy-2022-11-0139/; Identifier: INPLASY2022110139.
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