- |||||||||| citicoline / Generic mfg.
Journal: Citicoline: A Cholinergic Precursor with a Pivotal Role in Dementia and Alzheimer's Disease. (Pubmed Central) - Jun 21, 2024
This study confirmed the effectiveness of combined citicoline treatment in patients with mixed dementia and Alzheimer's disease, with a significant effect on the increase of MMSE score over time. The treated group also showed a significant reduction in the Geriatric Depression Scale and a significant increase in the instrumental ADL scale.
- |||||||||| Vyepti (eptinezumab-jjmr) / Teva, Lundbeck, Nurtec ODT (rimegepant ODT) / Pfizer
Combined use of rimegepant and eptinezumab for treatment of chronic migraine () - Jun 18, 2024 - Abstract #AHS2024AHS_420;
The co-administration of gepants and CGRP targeted mAbs can be effective in reducing severity and frequency of chronic migraine headaches. Patient did not report any adverse side effects from the combined use of these medications.
- |||||||||| Which combination of comorbidity makes migraine treatment impossible? A graphical approach () - Jun 18, 2024 - Abstract #AHS2024AHS_411;
Despite the diverse comorbidities considered, no combination of abortive or prevention medications was found to be entirely contraindicated for migraine patients. However, cardiac comorbidities such as uncontrolled hypertension or hypotension, prior coronary artery disease, and heart failure could significantly limit the possibility of abortive and preventive treatments.
- |||||||||| memantine / Generic mfg.
Patient response to memantine as add-on preventive therapy for post-traumatic headache () - Jun 18, 2024 - Abstract #AHS2024AHS_379;
While these findings are preliminary and confounded by multimodal treatment approaches to headache management, they support memantine's potential efficacy in this context, meriting further controlled studies. FIGURE 1 Average numbers of headache days pre- and post-treatment in 8 patients who had improvement in the number of headache days after initiation of memantine therapy (p < 0.0001).
- |||||||||| memantine / Generic mfg.
A retrospective analysis of the use of memantine for migraine prevention in adolescents () - Jun 18, 2024 - Abstract #AHS2024AHS_327;
These results suggest that memantine is an effective prophylactic treatment option in pediatric patients with headache, especially those with chronic migraine. While this is a retrospective analysis of prophylactic use of memantine in children with chronic headache disorders, prospective studies should be performed to further explore its effects and benefits.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Hemangioma of the temporal bone triggering secondary occipital neuralgia () - Jun 18, 2024 - Abstract #AHS2024AHS_208;
We hypothesize that the expansion of the petrous bone triggered pain in the region of the lesser occipital nerve. This could be directly from the occipital nerve itself or from branches of the posterior auricular nerve which communicates with the lesser occipital nerve.
- |||||||||| memantine / Generic mfg.
Preclinical, Journal: Role of Memantine in Limiting Cochleotoxicity in Rats. (Pubmed Central) - Jun 17, 2024
On histologic exam, the cochlear structures of group C rats and, although to a lesser extent, group D rats showed less severe cochlea damage. Memantine plays a protective role, resulting in restoring partially cochlear structures when administered either simultaneously with or after completion of amikacin i.p. treatment in rats.
- |||||||||| lithium carbonate ER / Generic mfg.
Biomarker, Review, Journal: Pharmacotherapeutic value of inflammatory and neurotrophic biomarkers in bipolar disorder: A systematic review. (Pubmed Central) - Jun 16, 2024
Memantine plays a protective role, resulting in restoring partially cochlear structures when administered either simultaneously with or after completion of amikacin i.p. treatment in rats. Inflammation in BD requires further investigation to understand the underlying immunologic mechanism, to identify predictors of treatment response, and to make informed decisions about the use and development of more effective pharmacological interventions for BD.
- |||||||||| memantine / Generic mfg., perospirone / Generic mfg.
Journal: Delirium due to Trousseau syndrome treated with memantine and perospirone: A case report. (Pubmed Central) - Jun 13, 2024
We report the first case of Trousseau syndrome delirium treated by memantine used with perospirone. Although further studies are needed, memantine and perospirone might be candidates for the management of psychiatric symptoms associated with Trousseau syndrome.
- |||||||||| Aduhelm (aducanumab) / Neurimmune, Eisai, Leqembi (lecanemab-irmb) / Biogen, BioArctic, Eisai, donanemab (LY3002813) / Eli Lilly
Review, Journal: Alzheimer's disease and its treatment-yesterday, today, and tomorrow. (Pubmed Central) - Jun 13, 2024
monoclonal antibodies (MABs), namely, aducanumab, lecanemab and donanemab...A comparison of the benefits and disadvantages of the different classes of drugs forms the basis for determining new directions for research and alternative drug targets that are undergoing pre-clinical and clinical assessments. In addition, we discuss and stress the importance of the treatment of the co-morbidities, including hypertension, diabetes, obesity and depression that are known to increase the risk of developing AD.
- |||||||||| Journal: Update on central oculomotor disorders and nystagmus (Pubmed Central) - Jun 3, 2024
Many types of central nystagmus allow a precise neuroanatomical localization: for instance, downbeat nystagmus, which is most often caused by a bilateral floccular lesion or dysfunction, or upbeat nystagmus, which is caused by a lesion in the mesencephalon or medulla oblongata. Examples of pharmacotherapy are the use of 4-aminopyridine for downbeat and upbeat nystagmus, memantine or gabapentin for fixation pendular nystagmus or baclofen for periodic alternating nystagmus.
- |||||||||| memantine / Generic mfg.
Preclinical, Journal: Screening stabilisers for cyanoenone triterpenoid TX101 in rat plasma samples by simultaneous analysis of parent drug and the epoxidation product. (Pubmed Central) - Jun 3, 2024
The research explores the impact of antioxidants (L-ascorbic acid, sodium metabisulfite, sodium sulfite) and P450 enzyme inhibitors (sodium diethyldithiocarbamate, memantine hydrochloride, 1-aminobenzotriazole) on TX101 stability in rat plasma samples...Application of this method in a rat dose-range finding study confirms successful inhibition of TX101-epoxide formation in samples treated with sodium sulfite or sodium metabisulfite. Overall, the study emphasizes the importance of stabilizers in preventing nonenzymatic oxidation reactions during sample storage, providing valuable insights for bioanalytical method development and validation.
- |||||||||| memantine / Generic mfg., celecoxib oral / Generic mfg.
Journal: Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models. (Pubmed Central) - Jun 1, 2024
Of biomedical relevance, either pharmacological rescue of the autophagy deficiency or NAD precursor supplementation restored NAD levels and improved the viability of NPC1 patient fibroblasts and induced pluripotent stem cell (iPSC)-derived cortical neurons. Together, our findings identify the autophagy-NAD axis as a mechanism of cell death and a target for therapeutic interventions in NPC1 disease, with a potential relevance to other neurodegenerative disorders.
- |||||||||| Adlarity (donepezil transdermal system) / Corium
Review, Journal: The donepezil transdermal system for the treatment of patients with mild, moderate, or severe Alzheimer's disease: a critical review. (Pubmed Central) - May 24, 2024
Cholinesterase inhibitors, along with memantine, are the mainstay of symptomatic treatment for AD (Alzheimer's disease); however, these medications are typically administered orally, which can be difficult for people with AD and their caregivers...The authors also compare the patch to the only other transdermal cholinesterase inhibitor on the market, rivastigmine, and highlight the potential advantages and disadvantages between these two treatments...In addition, there is no high dose (e.g. 23?mg) equivalent. Nevertheless, transdermal donepezil will be useful for people with AD and their caregivers, given its effectiveness and potential convenience.
- |||||||||| oxaliplatin / Generic mfg.
Journal: The Association between Oxaliplatin-Induced Peripheral Neuropathy, Sociodemographic, and Clinical Characteristics with Falls in Older Adults with Colorectal Cancer. (Pubmed Central) - May 16, 2024
Memantine, opioids, cannabinoids, prior history of fall, female sex, advanced age and disease stage, chronic liver disease, diabetes, and chronic obstructive pulmonary disease all increased the hazard rate of fall. Incorporating fall prevention in cancer care is essential to minimize morbidity and mortality of this serious event in older colorectal cancer survivors.
- |||||||||| memantine / Generic mfg.
Review, Journal: Spectrum of NMDA Receptor Variants in Neurodevelopmental Disorders and Epilepsy. (Pubmed Central) - May 10, 2024
Currently, targeted treatment options for GRIN-related diseases are limited. However, treatment with memantine has been reported to significantly reduce seizure frequency in a few individuals with developmental and epileptic encephalopathies harboring de novo gain-of-function GRIN2A missense variants, and supplementary treatment with L-serine has been associated with improved motor and cognitive performance as well as reduced seizure frequency in patients with GRIN2B loss-of-function missense variants as well as GRIN2A and GRIN2B null variants.
- |||||||||| Tudcabil (tauroursodeoxycholic acid) / Bruschettini
Journal: Editorial: Promising therapeutic strategies for Alzheimer's disease: a focus on amyloid-? targeting. (Pubmed Central) - May 10, 2024
However, treatment with memantine has been reported to significantly reduce seizure frequency in a few individuals with developmental and epileptic encephalopathies harboring de novo gain-of-function GRIN2A missense variants, and supplementary treatment with L-serine has been associated with improved motor and cognitive performance as well as reduced seizure frequency in patients with GRIN2B loss-of-function missense variants as well as GRIN2A and GRIN2B null variants. No abstract available
- |||||||||| memantine / Generic mfg.
Preclinical, Journal: Memantine suppresses the excitotoxicity but fails to rescue the ataxic phenotype in SCA1 model mice. (Pubmed Central) - Apr 30, 2024
This resulted in an apparent initial reduction of ataxic phenotype, but memantine also affected cerebellar plasticity and ultimately compromised motor learning. We speculate that that clinical application of memantine in SCA1 might be hampered by its ability to suppress NMDA-dependent plasticity in cerebellar cortex.
- |||||||||| memantine / Generic mfg.
Journal: Time-Dependent Long-Term Effect of Memantine Following Repetitive Mild Traumatic Brain Injury. (Pubmed Central) - Apr 26, 2024
Although memantine is already being prescribed chronically to address persistent symptoms associated with rmTBI, this study represents the first evidence of which we are aware to suggest a small, but durable effect of memantine treatment in mild, concussive injuries. This effect suggests that memantine, while potentially beneficial, is insufficient to treat all aspects of rmTBI alone, and should be combined with other therapeutic agents in a multi-therapy approach, with attention given to the timing of treatment.
- |||||||||| fentanyl citrate / Generic mfg.
Review, Journal: Managing Opioid Withdrawal Symptoms During the Fentanyl Crisis: A Review. (Pubmed Central) - Apr 16, 2024
Outside of FDA-approved medications for OUD, lofexidine, gabapentin, and suvorexant have limited evidence for augmenting opioid agonist initiation...Maintenance treatment continues to be superior to detoxification without continued management. Shorter induction protocols allow patients to initiate evidence-based treatment more quickly, reducing the use of illicit or non-prescribed substances.
- |||||||||| Aduhelm (aducanumab) / Neurimmune, Eisai, Leqembi (lecanemab-irmb) / Biogen, BioArctic, Eisai, donanemab (LY3002813) / Eli Lilly
Journal: Recent Advances in the Treatment and Management of Alzheimer's Disease: A Precision Medicine Perspective. (Pubmed Central) - Apr 3, 2024
Another medication that can temporarily alleviate dementia symptoms is memantine, which blocks the N-methyl-D-aspartate (NMDA) receptor...For some Alzheimer's pa-tients, the FDA-approved monoclonal antibody, aducanumab, is an option; for others, phase 3 clinical studies are underway for drugs, like lecanemab and donanemab, which have demonstrat-ed potential in eliminating amyloid protein. However, additional study is required to identify and address these limitations in order to reduce the likelihood of side effects and maximize the thera-peutic efficacy.
- |||||||||| memantine / Generic mfg.
Journal: Morphing cholinesterase inhibitor amiridine into multipotent drugs for the treatment of Alzheimer's disease. (Pubmed Central) - Mar 27, 2024
The top-ranked amiridine-based compound 5d was also inspected by in silico to reveal the butyrylcholinesterase binding differences with its close structural analogue 5b. Our study provides insight into the discovery of novel amiridine-based drugs by broadening their target-engaged profile from cholinesterase inhibitors towards MTDLs with potential implications in AD therapy.
- |||||||||| memantine / Generic mfg.
Journal: The role of whole brain irradiation nowadays: more or less or different? (Pubmed Central) - Mar 18, 2024
In these patients if life expectancy is >4 months without small cell histology and without hippocampal lesions, hippocampal sparing WBRT with or without memantine is recommended...Prophylactic cranial irradiation (PCI) is still recommended in small cell lung cancer patients with complete remission. Hippocampal sparing WBRT needs further validation in this indication.
- |||||||||| semorinemab (RG6100) / AC Immune, solanezumab (LY2062430) / Eli Lilly
Fall-Related Risks with Pharmacological Interventions in Mild-to-Moderate Alzheimer () - Mar 8, 2024 - Abstract #ISPOR2024ISPOR_349;
The results should be interpreted cautiously as the risks and benefits alter with disease progression and change in symptoms. Further long-term studies directly comparing the effect of these interventions on risk of falls and confirmation of their sustainability is warranted.
- |||||||||| topiramate / Generic mfg.
The Remarkable Efficacy of Topiramate in Treating Oscillopsia in Neuromyelitis Optica Spectrum Disorder: A Video Case Report (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_4268;
Additionally, Donepezil and Memantine demonstrate cognitive benefits, as measured by MMSE. Medications such as memantine, gabapentin, and topiramate have been explored for treating oscillopsia in MS patients...Inebilizumab infusion was started after discharge...Topiramate demonstrated efficacy in NMO-associated oscillopsia in our case, along with the case recently published on Neurology reporting dramatic response of oscillopsia to topiramate in a MS patient, suggesting it could be a promising medication for this debilitating condition.
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