- |||||||||| memantine / Generic mfg.
Enrollment open, Trial initiation date, Adverse events, Compliance: MONANTI: Monitoring Anti-Dementia Drugs by Serum Levels (clinicaltrials.gov) - Apr 28, 2020
P4, N=110, Recruiting,
Recruiting --> Active, not recruiting Not yet recruiting --> Recruiting | Initiation date: Nov 2019 --> Feb 2020
- |||||||||| memantine / Generic mfg.
Enrollment closed: MIND: Local Study of Akatinol Memantine in VaD in Russia (clinicaltrials.gov) - Apr 27, 2020
P3, N=126, Active, not recruiting,
Not yet recruiting --> Recruiting | Initiation date: Nov 2019 --> Feb 2020 Recruiting --> Active, not recruiting
- |||||||||| memantine / Generic mfg.
Journal: Acute and chronic effects of single dose memantine after controlled cortical impact injury in adult rats. (Pubmed Central) - Apr 24, 2020
Redundant trials were identified but their number depends on the criteria of futility used. Administration of memantine at a clinically-relevant delay after moderate-severe CCI injury has beneficial effects on acute outcomes, while more significant improvement on subacute and chronic outcomes may require repeated drug administration or its combination with another therapy.
- |||||||||| memantine / Generic mfg.
Clinical, Journal: Adjunctive Memantine Treatment of Schizophrenia: A Double-Blind, Randomized Placebo-Controlled Study. (Pubmed Central) - Apr 22, 2020
There was no significant difference in the Abnormal Involuntary Movement Scale and Barnes Akathisia Rating Scale scores between the 2 groups during the study. This study showed that adjunctive memantine to antipsychotic regimen improved the verbal memory, learning, verbal letter fluency, and working memory without improvement on psychotic symptoms in individuals with chronic schizophrenia.
- |||||||||| aripiprazole / Generic mfg., risperidone / Generic mfg., Egis, memantine / Generic mfg.
Journal: The psychopharmacology of autism spectrum disorder and Rett syndrome. (Pubmed Central) - Apr 19, 2020
Experimental drug treatments for ASD include oxytocin and vasopressin, bumetanide, sulforaphane, nutritional supplements, memantine, and d-cycloserine. Work performed on syndromic forms, represents an important source of information for experimental therapies of ASD and knowledge of the unique mechanisms underlying autism in each individual patient may in the future pave the path to personalized drug treatments.
- |||||||||| memantine / Generic mfg.
Add-On Memantine May Improve Cognition and Attenuate Inflammatory Status in Middle-To-Old Aged Bipolar II Disorder Patients (Americas Hall I & II) - Apr 17, 2020 - Abstract #SOBP2020SOBP_834;
We concluded that add-on MM may improve cognition and attenuate inflammation in middle-to-old aged BP-II patients. Funding Source: Taiwan Ministry of Science and Technology (MOST 108-2628-B-006-016, MOST 103-2622-B-006-006-CC2, MOST 104-2622-B-006-006-CC2, Taiwan Department of Health (DOH95-TD-M-113-055), Taiwan National Health Research Institute (NHRI-EX-97-9738NI), and a grant from the National Cheng Kung University Project for Promoting Academic Excellence and Developing World Class Research Centers
- |||||||||| galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
Meta-Analyses of Randomized Controlled Trials and Potential Novel Combination Treatments in Schizophrenia (Americas Hall I & II) - Apr 17, 2020 - Abstract #SOBP2020SOBP_777;
All the major symptoms and biomarkers of schizophrenia (brain-derived neurotrophic factor, mismatch negativity, prepulse inhibition, gamma oscillations, and kynurenic acid) are based on nicotinic and NMDA receptors. To date, only one receptor has been targeted at a time with partial response.
- |||||||||| ketamine / Generic mfg., memantine / Generic mfg.
Clinical, Journal: Dextromethorphan and memantine after ketamine analgesia: a randomized control trial. (Pubmed Central) - Apr 10, 2020
Future studies should include larger populations stratified on pharmacogenetics screening. Optimization of an oral drug that could extend ketamine antihyperalgesia, with fewer hospital admissions, remains a prime challenge in refractory neuropathic pain.
- |||||||||| memantine / Generic mfg.
Clinical, Journal: Placebo Response in Fragile X-associated Tremor/Ataxia Syndrome. (Pubmed Central) - Apr 9, 2020
To analyze placebo response from the first randomized controlled trial in FXTAS that evaluated cognitive and motor outcomes after 1 year of treatment with memantine...Patients with FXTAS exhibited low rates of placebo response in a randomized controlled trial. Further studies on the relationship between baseline insight and placebo responsivity are applicable to FXTAS and other disorders exhibiting cognitive impairment.
- |||||||||| memantine / Generic mfg.
[VIRTUAL] Therapy of post-stroke dementia on the example of memantine (Room: Screen A5) - Apr 9, 2020 - Abstract #EAN2020EAN_1912;
Recruiting --> Active, not recruiting | N=144 --> 46 This study showed that memantine effectively affects behavioral disorders, patient aggressiveness, thought processes, and the memory of patients with post-stroke dementia.
- |||||||||| Kinaction (masitinib) / AB Science
Trial completion date, Trial primary completion date: Masitinib in Patients With Mild to Moderate Alzheimer's Disease (clinicaltrials.gov) - Apr 7, 2020
P3, N=721, Active, not recruiting,
We plan to conduct further research with bigger group of patients in order to proof or refute effectiveness of memantine hydrochloride in reducing falls in VaP. Trial completion date: Sep 2020 --> Jun 2020 | Trial primary completion date: Sep 2020 --> Dec 2019
- |||||||||| memantine / Generic mfg.
[VIRTUAL] INHIBITION OF AMYLOID ΒETA PROTEIN AGGREGATION BY SELF-ASSEMBLING NANOPARTICLES OF MEMANTINE-ALPHA LIPOIC ACID CONJUGATE () - Apr 7, 2020 - Abstract #AATADPD2020AAT_ADPD_1116;
Self-assembled MEM-ALA nanoparticles were successfully prepared and the DLS curve of nanoparticles were found to be unimodal distribution with an average hydrodynamic diameter of 124.2 ± 2.05 nm and polydispersity index of 0.19 ± 0.04 which was in concurrence with FE-SEM analysis. Conclusions In summary, study demonstrated that self-assembled MEM-ALA nanoparticles inhibited the formation of β-amyloid1-42 fibrils and showed better effects than MEM alone.
- |||||||||| memantine / Generic mfg.
Journal: Validation Prognostic of the Baylor Profound Mental Status Examination. (Pubmed Central) - Apr 4, 2020
Conclusions In summary, study demonstrated that self-assembled MEM-ALA nanoparticles inhibited the formation of β-amyloid1-42 fibrils and showed better effects than MEM alone. BPMSE has a limited predictive value for the variables studied.
- |||||||||| memantine / Generic mfg.
Preclinical, Journal: A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice. (Pubmed Central) - Apr 3, 2020
Non-competitive N-Methyl-D-aspartate (NMDA) receptor antagonist memantine improved cognition and molecular alterations after preclinical treatment...Consequently, lower levels of hyperphosphorylated Tau (p-Tau) were found. In sum, these results demonstrate the neuroprotectant role of RL-208 through NMDAR blockade.
- |||||||||| Kinaction (masitinib) / AB Science
Trial completion date, Trial primary completion date: Masitinib in Patients With Mild to Moderate Alzheimer's Disease (clinicaltrials.gov) - Apr 1, 2020
P3, N=721, Active, not recruiting,
In sum, these results demonstrate the neuroprotectant role of RL-208 through NMDAR blockade. Trial completion date: Dec 2019 --> Sep 2020 | Trial primary completion date: Dec 2019 --> Sep 2020
- |||||||||| memantine / Generic mfg.
Review, Journal: The role of NMDA receptor in neurobiology and treatment of major depressive disorder: Evidence from translational research. (Pubmed Central) - Mar 31, 2020
Clinical studies have demonstrated that NMDA receptor antagonists, particularly ketamine, have rapid antidepressant effects in treatment-resistant depression, however, neurobiological mechanisms are not completely understood...This review provides a critical examination of the NMDA receptor involvement in the neurobiology of MDD including analyses of alterations in NMDA receptor subtypes and their interactive signaling cascades revealed by postmortem studies. Furthermore, to elucidate mechanisms underlying rapid-acting antidepressant properties of NMDA receptor antagonists we discussed their effects on the neuroplasticity, mostly based on signaling systems involved in synaptic plasticity of mood-related neurocircuitries.
- |||||||||| memantine / Generic mfg., amantadine / Generic mfg.
Journal: Automated Stopped-Flow Fluorimetric Sensor for Biologically Active Adamantane Derivatives Based on Zone Fluidics. (Pubmed Central) - Mar 31, 2020
Discrete zones of the analytes and reagents (o-phthalaldehyde and N-acetylcysteine) mix and react under stopped-flow conditions to yield fluorescent iso-indole derivatives (λ/ λ = 340/455 nm). The proposed ZF sensor was developed and validated to prove suitable for quality control tests (assay and content uniformity) of commercially available formulations purchased from the Greek market (EU licensed) and from non-EU web-pharmacies at a sampling rate of 16 h. Interestingly, a formulation obtained through the internet and produced in a third-non-EU-country (AMA capsules, 100 mg per cap), was found to be out of specifications (mean assay of 85.3%); a validated HPLC method was also applied for confirmatory purposes.
- |||||||||| memantine / Generic mfg.
Enrollment closed: Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors (clinicaltrials.gov) - Mar 30, 2020
P2, N=50, Active, not recruiting,
The proposed ZF sensor was developed and validated to prove suitable for quality control tests (assay and content uniformity) of commercially available formulations purchased from the Greek market (EU licensed) and from non-EU web-pharmacies at a sampling rate of 16 h. Interestingly, a formulation obtained through the internet and produced in a third-non-EU-country (AMA capsules, 100 mg per cap), was found to be out of specifications (mean assay of 85.3%); a validated HPLC method was also applied for confirmatory purposes. Recruiting --> Active, not recruiting
- |||||||||| memantine / Generic mfg.
Journal: Symptom reduction and improved function in chronic CRPS type 1 after 12-week integrated, interdisciplinary therapy. (Pubmed Central) - Mar 26, 2020
Rehabilitation program included memantine and morphine treatment (added to patient's prior pain medication) and concurrent psychological and physiotherapeutic intervention...After intervention, some CRPS symptoms reduced and function improved, but distress and quality of life were unchanged. This may be due to the relatively short duration of this program; to delayed effects; to particular cognitive problems of CPRS patients; and/or to low distress levels at baseline that make statistically significant reduction less likely.
- |||||||||| memantine / Generic mfg.
Trial completion date, Trial primary completion date: Predicting Treatment Response to Memantine in Autism Using Magnetic Resonance Spectroscopy (clinicaltrials.gov) - Mar 25, 2020
P1, N=25, Recruiting,
In conclusion, core CSF biomarkers reflect pathophysiology of AD in the early and late stages; the application of approved radiotracers have potential in amyloid-PET brain imaging to detect early AD. Trial completion date: Dec 2019 --> Dec 2020 | Trial primary completion date: Dec 2019 --> Dec 2020
- |||||||||| memantine / Generic mfg.
Review, Journal: Current and Future Treatments in Alzheimer Disease: An Update. (Pubmed Central) - Mar 14, 2020
Nowadays, only symptomatic treatments exist for this disease, all trying to counterbalance the neurotransmitter disturbance: 3 cholinesterase inhibitors and memantine...In the near future different specific agents for every patient might be used in a "precision medicine" context, where aberrant biomarkers accompanied with a particular pattern of neuropsychological and neuroimaging findings could determine a specific treatment regimen within a customized therapeutic framework. In this review, we discuss potential disease-modifying therapies that are currently being studied and potential individualized therapeutic frameworks that can be proved beneficial for patients with AD.
- |||||||||| memantine / Generic mfg.
Clinical, Journal: The effect of memantine in adult patients with attention deficit hyperactivity disorder. (Pubmed Central) - Mar 14, 2020
In this review, we discuss potential disease-modifying therapies that are currently being studied and potential individualized therapeutic frameworks that can be proved beneficial for patients with AD. The results of this study indicated that memantine was effective in reducing symptoms of Inattention/Memory Problems, Hyperactivity/Restlessness, Impulsivity/Emotional Lability.
- |||||||||| memantine / Generic mfg.
Journal: Dementia treatment versus prevention. (Pubmed Central) - Mar 13, 2020
Currently available treatment options, including acetylcholinesterase inhibitors and memantine, only have symptomatic effects and no drugs with disease-modifying properties are available...In parallel, nonpharmacological prevention trials are being conducted to modify dementia risk associated with known epidemiological risk factors. Some initial results are promising, but replication across independent cohorts remains a challenge.
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